PLAT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description plasminogen activator, tissue|This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5327)
External Link http://www.ncbi.nlm.nih.gov/gene/5327
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Genes

34 interacting proteins for PLAT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ANXA2 annexin A2
CALR calreticulin
CKAP4 cytoskeleton-associated protein 4
CLEC3B C-type lectin domain family 3, member B
F10 coagulation factor X
F2 coagulation factor II (thrombin)
FGA fibrinogen alpha chain
FN1 fibronectin 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HMGB1 high mobility group box 1
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KRT8 keratin 8, type II
LAMA1 laminin, alpha 1
LAMA3 laminin, alpha 3
LAMA5 laminin, alpha 5
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PLAU plasminogen activator, urokinase
PLG plasminogen
POT1 protection of telomeres 1
S100A10 S100 calcium binding protein A10
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TERF2 telomeric repeat binding factor 2