PLAU Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description plasminogen activator, urokinase|This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5328)
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Genes

308 genes differentially expressed following the PLAU gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DTHD1 death domain containing 1 2.80031
SCGB3A1 secretoglobin, family 3A, member 1 2.80031
GLUD2 glutamate dehydrogenase 2 2.80031
PRSS41 protease, serine, 41 2.80031
PCDHB3 protocadherin beta 3 2.80031
SSTR1 somatostatin receptor 1 2.80031
PNMA5 paraneoplastic Ma antigen family member 5 2.80031
KRT20 keratin 20, type I 2.80031
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.80031
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.80031
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.80031
SPINK6 serine peptidase inhibitor, Kazal type 6 2.80031
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.80031
KRTDAP keratinocyte differentiation-associated protein 2.80031
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.80031
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.80031
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.80031
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.80031
SELPLG selectin P ligand 2.80031
MYBPHL myosin binding protein H-like 2.80031
ZNF492 zinc finger protein 492 2.80031
SCGN secretagogin, EF-hand calcium binding protein 2.80031
LRRC55 leucine rich repeat containing 55 2.80031
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.80031
C9ORF152 chromosome 9 open reading frame 152 2.80031
NLRP10 NLR family, pyrin domain containing 10 2.80031
GMFG glia maturation factor, gamma 2.80031
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.80031
F2 coagulation factor II (thrombin) 2.80031
NEUROG3 neurogenin 3 2.80031
HBZ hemoglobin, zeta 2.80031
MUC20 mucin 20, cell surface associated 2.80031
SLC44A5 solute carrier family 44, member 5 2.80031
OR13C3 olfactory receptor, family 13, subfamily C, member 3 2.80031
DRP2 dystrophin related protein 2 2.80031
RAPSN receptor-associated protein of the synapse 2.80031
NEU4 sialidase 4 2.80031
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.80031
CIITA class II, major histocompatibility complex, transactivator 2.80031
ADAD2 adenosine deaminase domain containing 2 2.80031
MYOM2 myomesin 2 2.80031
SP7 Sp7 transcription factor 2.80031
SLC9C2 solute carrier family 9, member C2 (putative) 2.80031
RFPL3 ret finger protein-like 3 2.80031
ADGB androglobin 2.80031
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.80031
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.80031
TMEM271 transmembrane protein 271 2.80031
H1-6 H1.6 linker histone, cluster member 2.80031
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.80031
C3AR1 complement component 3a receptor 1 2.80031
ROPN1L rhophilin associated tail protein 1-like 2.80031
FLAD1 flavin adenine dinucleotide synthetase 1 2.80031
GPX5 glutathione peroxidase 5 2.80031
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.80031
PNLIPRP1 pancreatic lipase-related protein 1 2.80031
DEPP1 DEPP autophagy regulator 1 2.80031
DNAI7 dynein axonemal intermediate chain 7 2.80031
CARMIL3 capping protein regulator and myosin 1 linker 3 2.80031
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.80031
SPMIP10 sperm microtubule inner protein 10 2.80031
CIMAP1C ciliary microtubule associated protein 1C 2.80031
SRARP steroid receptor associated and regulated protein 2.80031
AKAIN1 A-kinase anchor inhibitor 1 2.80031
EZHIP EZH inhibitory protein 2.80031
CCDC197 coiled-coil domain containing 197 2.80031
DUSP29 dual specificity phosphatase 29 2.80031
ELOA2 elongin A2 2.80031
VGLL1 vestigial-like family member 1 2.80031
FMOD fibromodulin 2.80031
F8A2 coagulation factor VIII-associated 2 2.80031
CXCL16 chemokine (C-X-C motif) ligand 16 2.80031
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.80031
LDHAL6B lactate dehydrogenase A-like 6B 2.80031
IL31RA interleukin 31 receptor A 2.80031
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.80031
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.80031
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.80031
TEX101 testis expressed 101 2.80031
NHLRC4 NHL repeat containing 4 2.80031
TPTE transmembrane phosphatase with tensin homology 2.80031
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.80031
OR52E6 olfactory receptor, family 52, subfamily E, member 6 2.80031
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.80031
NPIPB8 nuclear pore complex interacting protein family, member B8 2.80031
MTMR11 myotubularin related protein 11 2.80031
SAA4 serum amyloid A4, constitutive 2.80031
S100B S100 calcium binding protein B 2.80031
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.80031
EXOC3L4 exocyst complex component 3-like 4 2.80031
INSRR insulin receptor-related receptor 2.80031
PRB4 proline-rich protein BstNI subfamily 4 2.80031
FOXS1 forkhead box S1 2.80031
IL17REL interleukin 17 receptor E-like 2.80031
CTSS cathepsin S 2.80031
VAX2 ventral anterior homeobox 2 2.80031
KRT13 keratin 13, type I 2.80031
SLC38A3 solute carrier family 38, member 3 2.80031
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.80031
ELANE elastase, neutrophil expressed 2.80031
PLCD4 phospholipase C, delta 4 2.80031
EPX eosinophil peroxidase 2.80031
POTEJ POTE ankyrin domain family, member J 2.80031
CD27 CD27 molecule 2.80031
VTCN1 V-set domain containing T cell activation inhibitor 1 2.80031
PHOSPHO1 phosphatase, orphan 1 2.80031
CD8A CD8a molecule 2.80031
SNTN sentan, cilia apical structure protein 2.80031
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.80031
THEM5 thioesterase superfamily member 5 2.80031
PENK proenkephalin 2.80031
CCL25 chemokine (C-C motif) ligand 25 2.80031
SVOP SV2 related protein homolog (rat) 2.80031
AICDA activation-induced cytidine deaminase 2.80031
ZNF596 zinc finger protein 596 2.80031
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.80031
VWA3B von Willebrand factor A domain containing 3B 2.80031
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.80031
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.80031
MKRN3 makorin ring finger protein 3 2.80031
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.80031
EMX2 empty spiracles homeobox 2 2.80031
HHATL hedgehog acyltransferase-like 2.80031
SPANXC SPANX family, member C 2.80031
CST4 cystatin S 2.80031
CST5 cystatin D 2.80031
LYZ lysozyme 2.80031
HAMP hepcidin antimicrobial peptide 2.80031
EREG epiregulin 2.80031
CCNI2 cyclin I family, member 2 2.80031
CLEC14A C-type lectin domain family 14, member A 2.80031
ASCL1 achaete-scute family bHLH transcription factor 1 2.80031
LAMB4 laminin, beta 4 2.80031
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.80031
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.80031
FXYD3 FXYD domain containing ion transport regulator 3 2.80031
CCL27 chemokine (C-C motif) ligand 27 2.80031
BTC betacellulin 2.80031
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.80031
STAP1 signal transducing adaptor family member 1 2.80031
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.80031
LRRC24 leucine rich repeat containing 24 2.80031
SPACA7 sperm acrosome associated 7 2.80031
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.80031
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.80031
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.80031
WNT10B wingless-type MMTV integration site family, member 10B 2.80031
ZNF648 zinc finger protein 648 2.80031
TTC34 tetratricopeptide repeat domain 34 2.80031
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.80031
CAPSL calcyphosine-like 2.80031
C4BPA complement component 4 binding protein, alpha 2.80031
RAB7B RAB7B, member RAS oncogene family 2.80031
MYOZ2 myozenin 2 2.80031
HOXD10 homeobox D10 2.80031
LHB luteinizing hormone beta polypeptide 2.80031
GREM1 gremlin 1, DAN family BMP antagonist 2.80031
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 2.79463
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.77126
IFITM10 interferon induced transmembrane protein 10 2.77126
DCXR dicarbonyl/L-xylulose reductase 2.76151
CCNL2 cyclin L2 2.76151
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.74752
CD86 CD86 molecule 2.74752
NLRP1 NLR family, pyrin domain containing 1 2.74752
TRAF3IP2 TRAF3 interacting protein 2 2.68513
CHEK1 checkpoint kinase 1 2.66619
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2.64541
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing 2.5735
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.56411
SDC1 syndecan 1 2.54782
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 2.52581
C10ORF90 chromosome 10 open reading frame 90 2.52319
FPR3 formyl peptide receptor 3 2.49362
SPRED2 sprouty-related, EVH1 domain containing 2 2.48659
VAMP4 vesicle-associated membrane protein 4 2.46087
ANKRD52 ankyrin repeat domain 52 2.4313
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.42186
CALR3 calreticulin 3 2.41577
GLB1L2 galactosidase, beta 1-like 2 2.37657
ZNF574 zinc finger protein 574 2.37657
SPACA6 sperm acrosome associated 6 2.37657
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.37657
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.36979
LAMP3 lysosomal-associated membrane protein 3 2.36026
EIF5 eukaryotic translation initiation factor 5 2.2589
H3C1 H3 clustered histone 1 2.2589
APTX aprataxin 2.25426
IRX1 iroquois homeobox 1 2.24305
GFUS GDP-L-fucose synthase 2.24187
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.2263
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.19601
ANKH ANKH inorganic pyrophosphate transport regulator 2.189
CACHD1 cache domain containing 1 2.15322
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.1532
GMPS guanine monphosphate synthase 2.15293
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 2.15293
CDC123 cell division cycle 123 2.14563
RPAP1 RNA polymerase II associated protein 1 2.13382
PPP4R2 protein phosphatase 4, regulatory subunit 2 2.13382
RAB4B RAB4B, member RAS oncogene family 2.11295
ZNF853 zinc finger protein 853 2.10743
AVIL advillin 2.10503
PTPRE protein tyrosine phosphatase, receptor type, E 2.08604
KIAA1586 KIAA1586 2.08228
OTUD5 OTU deubiquitinase 5 2.06591
CNOT11 CCR4-NOT transcription complex, subunit 11 2.06407
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2.06407
MLX MLX, MAX dimerization protein 2.06407
ZNF706 zinc finger protein 706 2.0483
ANKRD13C ankyrin repeat domain 13C 2.04475
DNA2 DNA replication helicase/nuclease 2 2.03161
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.03161
MYO5C myosin VC 2.01863
TTLL6 tubulin tyrosine ligase-like family member 6 2.018
RP9 retinitis pigmentosa 9 (autosomal dominant) 2.0039

decreased expression

Symbol Name Standardized Value
CCDC174 coiled-coil domain containing 174 -2.80031
AGO2 argonaute RISC catalytic component 2 -2.80031
SF1 splicing factor 1 -2.80031
ZDHHC11B zinc finger, DHHC-type containing 11B -2.80031
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.80031
SMYD5 SMYD family member 5 -2.80031
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.80031
DENND6B DENN/MADD domain containing 6B -2.80031
RWDD3 RWD domain containing 3 -2.80031
ZNF175 zinc finger protein 175 -2.80031
PROSER1 proline and serine rich 1 -2.76151
RABL6 RAB, member RAS oncogene family-like 6 -2.6701
TMEM217 transmembrane protein 217 -2.66619
ASGR2 asialoglycoprotein receptor 2 -2.66619
SLC7A4 solute carrier family 7, member 4 -2.66619
PDCL2 phosducin-like 2 -2.66619
PTOV1 prostate tumor overexpressed 1 -2.66619
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.66619
NPPC natriuretic peptide C -2.66619
SAMD11 sterile alpha motif domain containing 11 -2.66619
GPRC5D G protein-coupled receptor, class C, group 5, member D -2.66619
FAM186B family with sequence similarity 186, member B -2.66619
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.66619
NSG2 neuronal vesicle trafficking associated 2 -2.66619
KLLN killin, p53-regulated DNA replication inhibitor -2.66619
RHOXF2 Rhox homeobox family, member 2 -2.66619
AKR1D1 aldo-keto reductase family 1, member D1 -2.66619
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.66619
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.66619
TMPPE transmembrane protein with metallophosphoesterase domain -2.66619
C16ORF78 chromosome 16 open reading frame 78 -2.66619
TMEM139 transmembrane protein 139 -2.66619
OTOF otoferlin -2.66619
CDHR4 cadherin-related family member 4 -2.66619
SIM1 single-minded family bHLH transcription factor 1 -2.66619
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.66619
F5 coagulation factor V (proaccelerin, labile factor) -2.66619
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.66619
VMO1 vitelline membrane outer layer 1 homolog (chicken) -2.66619
FABP12 fatty acid binding protein 12 -2.66619
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -2.65193
TRMO tRNA methyltransferase O -2.64541
IER2 immediate early response 2 -2.57991
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.57991
NMRK2 nicotinamide riboside kinase 2 -2.57328
PRKD2 protein kinase D2 -2.46087
RNF208 ring finger protein 208 -2.45146
RIN2 Ras and Rab interactor 2 -2.44079
PRB3 proline-rich protein BstNI subfamily 3 -2.43467
CTSO cathepsin O -2.43467
TMEM38B transmembrane protein 38B -2.43078
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.41577
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -2.41577
S1PR2 sphingosine-1-phosphate receptor 2 -2.3915
ZNF302 zinc finger protein 302 -2.38614
ITM2A integral membrane protein 2A -2.36102
MRPL44 mitochondrial ribosomal protein L44 -2.36102
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.34235
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.34036
C1ORF174 chromosome 1 open reading frame 174 -2.33805
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -2.32225
ALAS2 5'-aminolevulinate synthase 2 -2.25426
CTBS chitobiase, di-N-acetyl- -2.23665
RBBP8 retinoblastoma binding protein 8 -2.23303
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -2.23303
ZMPSTE24 zinc metallopeptidase STE24 -2.189
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.15965
POGLUT1 protein O-glucosyltransferase 1 -2.15399
RPL3L ribosomal protein L3-like -2.15322
PABPN1 poly(A) binding protein, nuclear 1 -2.14188
RNF11 ring finger protein 11 -2.14165
DOLPP1 dolichyldiphosphatase 1 -2.13382
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.13382
CLPSL1 colipase-like 1 -2.13255
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.13157
COPS7B COP9 signalosome subunit 7B -2.13157
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.08604
GMPR guanosine monophosphate reductase -2.08574
E2F1 E2F transcription factor 1 -2.08228
CDHR3 cadherin-related family member 3 -2.08228
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.07978
DYDC2 DPY30 domain containing 2 -2.06609
DRAM2 DNA-damage regulated autophagy modulator 2 -2.06407
CILP2 cartilage intermediate layer protein 2 -2.05722
RAD51AP1 RAD51 associated protein 1 -2.04891
CORIN corin, serine peptidase -2.04475
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.03161
SH2B3 SH2B adaptor protein 3 -2.03161
ACHE acetylcholinesterase (Yt blood group) -2.03161
MT2A metallothionein 2A -2.01677
TOX4 TOX high mobility group box family member 4 -2.01677
TPM4 tropomyosin 4 -2.0009