PLAU Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description plasminogen activator, urokinase|This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5328)
External Link http://www.ncbi.nlm.nih.gov/gene/5328
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Genes

36 interacting proteins for PLAU from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALAS1 5'-aminolevulinate synthase 1
BTK Bruton agammaglobulinemia tyrosine kinase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CTSB cathepsin B
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
F2 coagulation factor II (thrombin)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRG histidine-rich glycoprotein
IGF2R insulin-like growth factor 2 receptor
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LRP2 low density lipoprotein receptor-related protein 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NID1 nidogen 1
PDGFC platelet derived growth factor C
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PRKCA protein kinase C, alpha
SCAMP5 secretory carrier membrane protein 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUMO1 small ubiquitin-like modifier 1
UBC ubiquitin C
VLDLR very low density lipoprotein receptor
VTN vitronectin