PLCG1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phospholipase C, gamma 1|The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5335)
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Genes

318 genes differentially expressed following the PLCG1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLE6 transducin-like enhancer of split 6 3.1979
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.1979
KLK4 kallikrein-related peptidase 4 3.1979
CEND1 cell cycle exit and neuronal differentiation 1 3.1979
UNC13C unc-13 homolog C (C. elegans) 3.1979
CRYGB crystallin, gamma B 3.1979
IZUMO1 izumo sperm-egg fusion 1 3.1979
SPDYE4 speedy/RINGO cell cycle regulator family member E4 3.1979
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.1979
BHLHE40 basic helix-loop-helix family, member e40 3.12887
MAGIX MAGI family member, X-linked 3.12887
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.12887
PDZD9 PDZ domain containing 9 3.12887
RLN1 relaxin 1 3.12887
LPAR5 lysophosphatidic acid receptor 5 3.12887
TGM1 transglutaminase 1 3.12887
ERVV-2 endogenous retrovirus group V, member 2 3.12887
ROPN1L rhophilin associated tail protein 1-like 3.12887
IRX5 iroquois homeobox 5 3.12887
MAMLD1 mastermind-like domain containing 1 3.12887
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.12887
POTEI POTE ankyrin domain family, member I 3.12887
SLC25A41 solute carrier family 25, member 41 3.11083
GJA10 gap junction protein, alpha 10, 62kDa 3.11083
PEAR1 platelet endothelial aggregation receptor 1 3.11083
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.11083
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.11083
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.11083
BTC betacellulin 3.11083
MILR1 mast cell immunoglobulin-like receptor 1 3.11083
ZNF492 zinc finger protein 492 3.11083
ADGRG1 adhesion G protein-coupled receptor G1 3.11083
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.11083
SKOR2 SKI family transcriptional corepressor 2 3.11083
SIGLEC7 sialic acid binding Ig-like lectin 7 3.11083
CCDC38 coiled-coil domain containing 38 3.11083
LGI1 leucine-rich, glioma inactivated 1 3.11083
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.11083
HBZ hemoglobin, zeta 3.11083
HBB hemoglobin, beta 3.11083
PTK6 protein tyrosine kinase 6 3.11083
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.11083
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.11083
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.11083
RGPD3 RANBP2-like and GRIP domain containing 3 3.11083
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.11083
SSTR3 somatostatin receptor 3 3.11083
ASPA aspartoacylase 3.11083
MYOM2 myomesin 2 3.11083
TNIP3 TNFAIP3 interacting protein 3 3.11083
HAS1 hyaluronan synthase 1 3.11083
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.11083
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.11083
CCDC87 coiled-coil domain containing 87 3.11083
FAM3D family with sequence similarity 3, member D 3.11083
LITAFD LITAF domain containing 3.11083
C10ORF53 chromosome 10 open reading frame 53 3.11083
MYL10 myosin, light chain 10, regulatory 3.11083
GATA3 GATA binding protein 3 3.11083
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.11083
PARVG parvin, gamma 3.11083
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 3.11083
SYT15 synaptotagmin XV 3.11083
TAS1R2 taste receptor, type 1, member 2 3.11083
TAS1R1 taste receptor, type 1, member 1 3.11083
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.11083
ACER1 alkaline ceramidase 1 3.11083
CFAP157 cilia and flagella associated protein 157 3.11083
CIROP ciliated left-right organizer metallopeptidase 3.11083
DEPP1 DEPP autophagy regulator 1 3.11083
CRAMP1 cramped chromatin regulator homolog 1 3.11083
NEMP2 nuclear envelope integral membrane protein 2 3.11083
HTD2 hydroxyacyl-thioester dehydratase type 2 3.11083
H1-6 H1.6 linker histone, cluster member 3.11083
CAPN9 calpain 9 3.11083
ADGRG7 adhesion G protein-coupled receptor G7 3.11083
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.11083
OOSP1 oocyte secreted protein 1, pseudogene 3.11083
CBLN3 cerebellin 3 precursor 3.11083
CD79A CD79a molecule, immunoglobulin-associated alpha 3.11083
LIX1 Lix1 homolog (chicken) 3.11083
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.11083
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.11083
CFAP99 cilia and flagella associated protein 99 3.11083
RAB41 RAB41, member RAS oncogene family 3.11083
LIPC lipase, hepatic 3.11083
RLBP1 retinaldehyde binding protein 1 3.11083
ZNF575 zinc finger protein 575 3.11083
TLR6 toll-like receptor 6 3.11083
SBSN suprabasin 3.11083
OVOL1 ovo-like zinc finger 1 3.11083
S100B S100 calcium binding protein B 3.11083
CCR3 chemokine (C-C motif) receptor 3 3.11083
FAM186A family with sequence similarity 186, member A 3.11083
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.11083
ZNF257 zinc finger protein 257 3.11083
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.11083
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.11083
PVRIG poliovirus receptor related immunoglobulin domain containing 3.11083
CCDC83 coiled-coil domain containing 83 3.11083
TBXA2R thromboxane A2 receptor 3.11083
OR2M3 olfactory receptor, family 2, subfamily M, member 3 3.11083
CERKL ceramide kinase-like 3.11083
CLDN34 claudin 34 3.11083
COL17A1 collagen, type XVII, alpha 1 3.11083
PRR20G proline rich 20G 3.11083
TBX1 T-box 1 3.11083
CT55 cancer/testis antigen 55 3.11083
IGFBP1 insulin-like growth factor binding protein 1 3.11083
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.11083
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.11083
FNDC9 fibronectin type III domain containing 9 3.11083
CCDC154 coiled-coil domain containing 154 3.11083
IL9R interleukin 9 receptor 3.11083
CRYBA1 crystallin, beta A1 3.11083
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.11083
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 3.11083
BTNL8 butyrophilin-like 8 3.11083
AQP4 aquaporin 4 3.11083
CLEC4D C-type lectin domain family 4, member D 3.11083
HKDC1 hexokinase domain containing 1 3.11083
C2CD4A C2 calcium-dependent domain containing 4A 3.11083
FAM177B family with sequence similarity 177, member B 3.11083
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.11083
MUC17 mucin 17, cell surface associated 3.11083
PRM1 protamine 1 3.11083
KLF1 Kruppel-like factor 1 (erythroid) 3.11083
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.11083
FAM163A family with sequence similarity 163, member A 3.11083
NOX1 NADPH oxidase 1 3.11083
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.11083
GLOD5 glyoxalase domain containing 5 3.11083
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.11083
ISL1 ISL LIM homeobox 1 3.11083
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.11083
ANKRD55 ankyrin repeat domain 55 3.11083
DYDC1 DPY30 domain containing 1 3.11083
ST18 suppression of tumorigenicity 18, zinc finger 3.11083
CTSW cathepsin W 3.11083
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.11083
HOXD10 homeobox D10 3.11083
TPSAB1 tryptase alpha/beta 1 3.11083
OTP orthopedia homeobox 3.11083
MEPE matrix extracellular phosphoglycoprotein 3.11083
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.11083
IL18RAP interleukin 18 receptor accessory protein 3.11083
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.11083
CCDC177 coiled-coil domain containing 177 3.11083
SPDEF SAM pointed domain containing ETS transcription factor 3.11083
FOXS1 forkhead box S1 3.11083
SNAI2 snail family zinc finger 2 3.11083
RNASE7 ribonuclease, RNase A family, 7 3.11083
NLRP14 NLR family, pyrin domain containing 14 3.11083
MSLN mesothelin 3.11083
APOL3 apolipoprotein L, 3 3.11083
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.11083
PTGDR prostaglandin D2 receptor (DP) 3.11083
DAND5 DAN domain family member 5, BMP antagonist 3.11083
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.11083
SLITRK1 SLIT and NTRK-like family, member 1 3.11083
PRSS57 protease, serine, 57 3.11083
ZMYND15 zinc finger, MYND-type containing 15 3.11083
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.11083
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.11083
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.11083
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 3.08417
ADAM21 ADAM metallopeptidase domain 21 3.06236
CATSPER4 cation channel, sperm associated 4 3.06236
ZNF506 zinc finger protein 506 2.83301
DTX1 deltex 1, E3 ubiquitin ligase 2.72389
KIAA1671 KIAA1671 2.69496
GPR141 G protein-coupled receptor 141 2.6744
MBD4 methyl-CpG binding domain protein 4 2.54377
ZGPAT zinc finger, CCCH-type with G patch domain 2.53727
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.53351
FBXO43 F-box protein 43 2.50852
FLRT2 fibronectin leucine rich transmembrane protein 2 2.50852
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 2.50777
AFG2A AFG2 AAA ATPase homolog A 2.50519
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.50467
BBS12 Bardet-Biedl syndrome 12 2.49008
LYRM1 LYR motif containing 1 2.48624
CCS copper chaperone for superoxide dismutase 2.48198
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.4721
ANKRD42-DT ANKRD42 divergent transcript 2.47149
STK39 serine threonine kinase 39 2.42128
FBXL15 F-box and leucine-rich repeat protein 15 2.41554
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 2.39577
RNGTT RNA guanylyltransferase and 5'-phosphatase 2.38216
SETD1A SET domain containing 1A 2.38216
GABPB1 GA binding protein transcription factor, beta subunit 1 2.33745
GPC3 glypican 3 2.33324
ZNF133 zinc finger protein 133 2.33235
OGN osteoglycin 2.33157
CNST consortin, connexin sorting protein 2.29035
POLR1F RNA polymerase I subunit F 2.29035
MGAM maltase-glucoamylase 2.26613
GMIP GEM interacting protein 2.25691
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2.25382
C22ORF15 chromosome 22 open reading frame 15 2.24397
NPY1R neuropeptide Y receptor Y1 2.23037
MFAP3L microfibrillar-associated protein 3-like 2.21197
ELOB elongin B 2.20718
SCYL1 SCY1-like 1 (S. cerevisiae) 2.15282
NCS1 neuronal calcium sensor 1 2.15282
OLFML2A olfactomedin-like 2A 2.13967
TTBK1 tau tubulin kinase 1 2.12843
CRLF2 cytokine receptor-like factor 2 2.12843
EMILIN2 elastin microfibril interfacer 2 2.12843
ASMT acetylserotonin O-methyltransferase 2.12843
ARMC12 armadillo repeat containing 12 2.12843
FER1L6 fer-1-like family member 6 2.12843
AMPH amphiphysin 2.12357
DTNBP1 dystrobrevin binding protein 1 2.11443
RHCE Rh blood group, CcEe antigens 2.09036
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.08588
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.06491
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 2.06491
ZBTB41 zinc finger and BTB domain containing 41 2.06491
STRN striatin, calmodulin binding protein 2.06152
DGKK diacylglycerol kinase, kappa 2.05768
CIBAR1 CBY1 interacting BAR domain containing 1 2.05275
BUB1B-PAK6 BUB1B-PAK6 readthrough 2.03444
ZC3H12B zinc finger CCCH-type containing 12B 2.03291
TRNP1 TMF1-regulated nuclear protein 1 2.02481
TUBG2 tubulin, gamma 2 2.02481
DPP10 dipeptidyl-peptidase 10 (non-functional) 2.02481
TUT7 terminal uridylyl transferase 7 2.01933
WDR35 WD repeat domain 35 2.01456

decreased expression

Symbol Name Standardized Value
SYPL2 synaptophysin-like 2 -3.1979
HSF2BP heat shock transcription factor 2 binding protein -3.12887
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) -3.11083
JAK3 Janus kinase 3 -3.11083
NEK4 NIMA-related kinase 4 -3.11083
EFNB1 ephrin-B1 -3.11083
ZDHHC13 zinc finger, DHHC-type containing 13 -3.11083
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -3.11083
GMPR guanosine monophosphate reductase -3.11083
SPAG4 sperm associated antigen 4 -3.11083
SYP synaptophysin -3.10147
NRK Nik related kinase -3.08538
SH2D7 SH2 domain containing 7 -3.06236
TMPRSS11E transmembrane protease, serine 11E -3.06236
LURAP1L leucine rich adaptor protein 1-like -3.06236
TXLNB taxilin beta -3.06236
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -3.06236
C10ORF90 chromosome 10 open reading frame 90 -3.06236
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -3.06236
RNF17 ring finger protein 17 -3.06236
DNAH2 dynein, axonemal, heavy chain 2 -3.06236
USP26 ubiquitin specific peptidase 26 -3.06236
C2ORF72 chromosome 2 open reading frame 72 -3.06236
DRP2 dystrophin related protein 2 -3.06236
MSC musculin -3.06236
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.06236
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.06236
PDCD1 programmed cell death 1 -3.06236
HLA-DOB major histocompatibility complex, class II, DO beta -3.06236
DAW1 dynein assembly factor with WDR repeat domains 1 -3.06236
PCDHA13 protocadherin alpha 13 -3.06236
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.06236
FYB2 FYN binding protein 2 -3.06236
TMEM272 transmembrane protein 272 -3.06236
NLRC3 NLR family, CARD domain containing 3 -3.06236
LY96 lymphocyte antigen 96 -3.06236
LY6G6D lymphocyte antigen 6 complex, locus G6D -3.06236
SMIM47 small integral membrane protein 47 -2.92458
CAPN11 calpain 11 -2.92458
ZSCAN20 zinc finger and SCAN domain containing 20 -2.90706
CD7 CD7 molecule -2.83742
TIMP1 TIMP metallopeptidase inhibitor 1 -2.75893
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.55706
PCDH10 protocadherin 10 -2.51145
FUZ fuzzy planar cell polarity protein -2.4721
N4BP2 NEDD4 binding protein 2 -2.43786
ZNF77 zinc finger protein 77 -2.43543
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.42452
YPEL3 yippee-like 3 (Drosophila) -2.42128
WASF3 WAS protein family, member 3 -2.39904
PHLDB3 pleckstrin homology-like domain, family B, member 3 -2.38695
CORO2A coronin, actin binding protein, 2A -2.38216
DUSP6 dual specificity phosphatase 6 -2.38216
CRYGS crystallin, gamma S -2.37579
ZIM3 zinc finger, imprinted 3 -2.37287
RBP1 retinol binding protein 1, cellular -2.3375
SFRP2 secreted frizzled-related protein 2 -2.33324
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.31358
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.29893
HYPK huntingtin interacting protein K -2.25268
LCA5L Leber congenital amaurosis 5-like -2.25268
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.2417
SEC14L1 SEC14-like 1 (S. cerevisiae) -2.2417
NOP10 NOP10 ribonucleoprotein -2.23197
LRRC34 leucine rich repeat containing 34 -2.21197
ZC2HC1A zinc finger, C2HC-type containing 1A -2.19287
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.18179
TKT transketolase -2.18063
FAHD2B fumarylacetoacetate hydrolase domain containing 2B -2.17151
SRCIN1 SRC kinase signaling inhibitor 1 -2.17151
ZBTB12 zinc finger and BTB domain containing 12 -2.17151
FAM120A family with sequence similarity 120A -2.13838
COL8A1 collagen, type VIII, alpha 1 -2.12634
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.12357
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.12261
BEX3 brain expressed X-linked 3 -2.11159
PTTG1 pituitary tumor-transforming 1 -2.10784
ECD ecdysoneless homolog (Drosophila) -2.06491
ACSF2 acyl-CoA synthetase family member 2 -2.06491
LMO4 LIM domain only 4 -2.05095
ZNF551 zinc finger protein 551 -2.03833
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -2.03284
GABARAP GABA(A) receptor-associated protein -2.02788
SIT1 signaling threshold regulating transmembrane adaptor 1 -2.02696
SPATS2L spermatogenesis associated, serine-rich 2-like -2.02696
THOC3 THO complex 3 -2.02696
NSL1 NSL1, MIS12 kinetochore complex component -2.01716
CRB2 crumbs family member 2 -2.01406
SLC38A5 solute carrier family 38, member 5 -2.00285