PLCG2 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description phospholipase C, gamma 2 (phosphatidylinositol-specific)|The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 5336)
External Link http://www.ncbi.nlm.nih.gov/gene/5336
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111 interacting proteins for hub protein PLCG2 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD19 CD19 molecule
CHP1 calcineurin-like EF-hand protein 1
CHP2 calcineurin-like EF-hand protein 2
CRYAB crystallin, alpha B
CTTN cortactin
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DVL2 dishevelled segment polarity protein 2
DYNLT1 dynein, light chain, Tctex-type 1
EGFR epidermal growth factor receptor
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERRFI1 ERBB receptor feedback inhibitor 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HCST hematopoietic cell signal transducer
ICAM1 intercellular adhesion molecule 1
IGF1R insulin-like growth factor 1 receptor
IGH immunoglobulin heavy locus
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIME1 Lck interacting transmembrane adaptor 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPT microtubule-associated protein tau
MED28 mediator complex subunit 28
MERTK MER proto-oncogene, tyrosine kinase
NBR1 neighbor of BRCA1 gene 1
NDC80 NDC80 kinetochore complex component
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PDCD6IP programmed cell death 6 interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PHC2 polyhomeotic homolog 2 (Drosophila)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PLA2G12B phospholipase A2, group XIIB
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G2C phospholipase A2, group IIC
PLA2G2D phospholipase A2, group IID
PLA2G2E phospholipase A2, group IIE
PLA2G2F phospholipase A2, group IIF
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G5 phospholipase A2, group V
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLXNB1 plexin B1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKD1 protein kinase D1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
REPS1 RALBP1 associated Eps domain containing 1
SH2D2A SH2 domain containing 2A
SH3BP2 SH3-domain binding protein 2
SH3KBP1 SH3-domain kinase binding protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
TMED9 transmembrane emp24 protein transport domain containing 9
TOX4 TOX high mobility group box family member 4
TRB T cell receptor beta locus
TRIM27 tripartite motif containing 27
UCK1 uridine-cytidine kinase 1
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
ZBTB7B zinc finger and BTB domain containing 7B
ZNF512B zinc finger protein 512B