PLK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description polo-like kinase 1| (NCBI Entrez Gene Database, 5347)
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Genes

127 genes differentially expressed following the PLK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZFPM1 zinc finger protein, FOG family member 1 2.26345
LAMA3 laminin, alpha 3 2.26345
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 2.26345
PHF11 PHD finger protein 11 2.26345
IQANK1 IQ motif and ankyrin repeat containing 1 2.26345
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.26345
TGFBR3L transforming growth factor, beta receptor III-like 2.26345
NOP9 NOP9 nucleolar protein 2.26345
SPRYD4 SPRY domain containing 4 2.26345
CFAP418 cilia and flagella associated protein 418 2.26345
TMCO6 transmembrane and coiled-coil domains 6 2.26345
TERT telomerase reverse transcriptase 2.26345
PLBD2 phospholipase B domain containing 2 2.26345
LIPE lipase, hormone-sensitive 2.23187
ACBD7 acyl-CoA binding domain containing 7 2.23187
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.23187
DNAI1 dynein, axonemal, intermediate chain 1 2.21854
KLF11 Kruppel-like factor 11 2.21854
FRMD3 FERM domain containing 3 2.21854
MVK mevalonate kinase 2.21854
PARP6 poly (ADP-ribose) polymerase family, member 6 2.21854
MED27 mediator complex subunit 27 2.21854
PTGES prostaglandin E synthase 2.21854
H2AC4 H2A clustered histone 4 2.21854
GDA guanine deaminase 2.21854
MYH11 myosin, heavy chain 11, smooth muscle 2.21854
LYSET lysosomal enzyme trafficking factor 2.21854
CLBA1 clathrin binding box of aftiphilin containing 1 2.21854
H1-4 H1.4 linker histone, cluster member 2.21854
NKAPD1 NKAP domain containing 1 2.21854
TENT4B terminal nucleotidyltransferase 4B 2.21854
CLDN19 claudin 19 2.21854
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.21854
ARMC5 armadillo repeat containing 5 2.21854
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.21854
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.21854
GSTM4 glutathione S-transferase mu 4 2.21854
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.21854
ADAP2 ArfGAP with dual PH domains 2 2.21854
ABHD4 abhydrolase domain containing 4 2.21854
CLUL1 clusterin-like 1 (retinal) 2.21854
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 2.21854
MINDY1 MINDY lysine 48 deubiquitinase 1 2.21854
AGER advanced glycosylation end product-specific receptor 2.21854
PCSK9 proprotein convertase subtilisin/kexin type 9 2.21854
ERCC5 excision repair cross-complementation group 5 2.21854
EAF2 ELL associated factor 2 2.21854
EXOSC8 exosome component 8 2.21854
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.21854
RGPD6 RANBP2-like and GRIP domain containing 6 2.21854
WDR90 WD repeat domain 90 2.21854
TTLL6 tubulin tyrosine ligase-like family member 6 2.21854
LRRC9 leucine rich repeat containing 9 2.21854
CAB39L calcium binding protein 39-like 2.21854
GNMT glycine N-methyltransferase 2.21854
DNAH6 dynein, axonemal, heavy chain 6 2.21854
LRRC39 leucine rich repeat containing 39 2.21854
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.21854
CHMP5 charged multivesicular body protein 5 2.19007
CHIT1 chitinase 1 (chitotriosidase) 2.1816
INTS15 integrator complex subunit 15 2.1814
LRRC41 leucine rich repeat containing 41 2.16042
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.15167
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.13647
B3GAT2 beta-1,3-glucuronyltransferase 2 2.12137
ASB12 ankyrin repeat and SOCS box containing 12 2.12137
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.12137
SNURF SNRPN upstream reading frame 2.12137
TOX3 TOX high mobility group box family member 3 2.08727
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.08201
ZNF114 zinc finger protein 114 2.01972
KDF1 keratinocyte differentiation factor 1 2.01972
NMT1 N-myristoyltransferase 1 2.01972
PCBP2 poly(rC) binding protein 2 2.01972
VEGFA vascular endothelial growth factor A 2.01972

decreased expression

Symbol Name Standardized Value
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.26345
PEX16 peroxisomal biogenesis factor 16 -2.26345
GSN gelsolin -2.26345
MTO1 mitochondrial tRNA translation optimization 1 -2.26345
ALKAL2 ALK and LTK ligand 2 -2.26345
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.26345
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -2.26345
EMC9 ER membrane protein complex subunit 9 -2.26345
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -2.26345
C15ORF61 chromosome 15 open reading frame 61 -2.26345
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -2.26345
GLT8D2 glycosyltransferase 8 domain containing 2 -2.26345
NT5DC2 5'-nucleotidase domain containing 2 -2.26345
RELL1 RELT-like 1 -2.26345
GIPC1 GIPC PDZ domain containing family, member 1 -2.24419
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -2.24419
DERL1 derlin 1 -2.24419
LZIC leucine zipper and CTNNBIP1 domain containing -2.24419
CPNE1 copine I -2.23592
DAD1 defender against cell death 1 -2.23187
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -2.23187
SPRTN SprT-like N-terminal domain -2.21854
ZNF689 zinc finger protein 689 -2.21854
ZSWIM8 zinc finger, SWIM-type containing 8 -2.21854
IFNGR1 interferon gamma receptor 1 -2.21854
NBPF12 neuroblastoma breakpoint family, member 12 -2.21854
SRPX sushi-repeat containing protein, X-linked -2.21854
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.21854
NADSYN1 NAD synthetase 1 -2.21854
GDAP2 ganglioside induced differentiation associated protein 2 -2.21854
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.21854
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.21854
RAD9A RAD9 homolog A (S. pombe) -2.21854
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.21854
LHX4 LIM homeobox 4 -2.21854
SMIM13 small integral membrane protein 13 -2.21854
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.18309
PHPT1 phosphohistidine phosphatase 1 -2.16219
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -2.16042
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.13647
UQCC6 ubiquinol-cytochrome c reductase complex assembly factor 6 -2.13647
KDM4C lysine (K)-specific demethylase 4C -2.12715
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.08201
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -2.08056
EXOSC10 exosome component 10 -2.08056
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -2.06734
LTBP1 latent transforming growth factor beta binding protein 1 -2.06734
RPL11 ribosomal protein L11 -2.0654
MYO1F myosin IF -2.01972
SRRM4 serine/arginine repetitive matrix 4 -2.01972
IQCK IQ motif containing K -2.01972
TADA2A transcriptional adaptor 2A -2.01972