PML Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description promyelocytic leukemia|The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5371)
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Genes

274 genes differentially expressed following the PML gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LRRC63 leucine rich repeat containing 63 2.51169
SPATS1 spermatogenesis associated, serine-rich 1 2.51169
ZFP92 ZFP92 zinc finger protein 2.51169
PCDH19 protocadherin 19 2.51169
RERGL RERG/RAS-like 2.51169
CELA2A chymotrypsin-like elastase family, member 2A 2.51169
FGF23 fibroblast growth factor 23 2.51169
NUGGC nuclear GTPase, germinal center associated 2.51169
ZAR1L zygote arrest 1-like 2.51169
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 2.51169
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.51169
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.51169
RAB7B RAB7B, member RAS oncogene family 2.51169
IZUMO3 IZUMO family member 3 2.51169
ZNF750 zinc finger protein 750 2.51169
SPATA31H1 SPATA31 subfamily H member 1 2.51169
ZMYND10 zinc finger, MYND-type containing 10 2.51169
GREP1 glycine rich extracellular protein 1 2.51169
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.51169
FOLR1 folate receptor 1 (adult) 2.51169
LOXHD1 lipoxygenase homology domains 1 2.51169
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.51169
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.51169
PROKR1 prokineticin receptor 1 2.47101
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.47101
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.47101
MILR1 mast cell immunoglobulin-like receptor 1 2.47101
NPPC natriuretic peptide C 2.47101
ZNF662 zinc finger protein 662 2.47101
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.47101
CABP4 calcium binding protein 4 2.47101
ZNF208 zinc finger protein 208 2.47101
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.47101
IGFL4 IGF-like family member 4 2.47101
CARD16 caspase recruitment domain family, member 16 2.47101
PKP1 plakophilin 1 2.47101
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.47101
CCDC38 coiled-coil domain containing 38 2.47101
C8ORF74 chromosome 8 open reading frame 74 2.47101
C1ORF146 chromosome 1 open reading frame 146 2.47101
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.47101
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.47101
BSX brain-specific homeobox 2.47101
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.47101
FAM240B family with sequence similarity 240 member B 2.47101
REN renin 2.47101
GIMAP4 GTPase, IMAP family member 4 2.47101
TAL2 T-cell acute lymphocytic leukemia 2 2.47101
GYPB glycophorin B (MNS blood group) 2.47101
KCNRG potassium channel regulator 2.47101
CXORF65 chromosome X open reading frame 65 2.47101
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.47101
SSTR1 somatostatin receptor 1 2.47101
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.47101
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.47101
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.47101
FOXN4 forkhead box N4 2.47101
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.47101
PAPOLB poly(A) polymerase beta (testis specific) 2.47101
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.47101
SOAT2 sterol O-acyltransferase 2 2.47101
TMEM119 transmembrane protein 119 2.47101
RBM48 RNA binding motif protein 48 2.47101
GSC goosecoid homeobox 2.47101
STMN4 stathmin-like 4 2.47101
SEPTIN14 septin 14 2.47101
SPMIP10 sperm microtubule inner protein 10 2.47101
KIF1C-AS1 KIF1C antisense RNA 1 2.47101
C8ORF90 chromosome 8 open reading frame 90 2.47101
CFAP276 cilia and flagella associated protein 276 2.47101
DNAAF6 dynein axonemal assembly factor 6 2.47101
GARIN1A golgi associated RAB2 interactor 1A 2.47101
DYNLT4 dynein light chain Tctex-type 4 2.47101
SMIM36 small integral membrane protein 36 2.47101
S100B S100 calcium binding protein B 2.47101
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.47101
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.47101
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.47101
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.47101
TAS2R5 taste receptor, type 2, member 5 2.47101
NRN1 neuritin 1 2.47101
HLF hepatic leukemia factor 2.47101
LY86 lymphocyte antigen 86 2.47101
ZACN zinc activated ligand-gated ion channel 2.47101
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.47101
RS1 retinoschisin 1 2.47101
ZNF20 zinc finger protein 20 2.47101
TPTE transmembrane phosphatase with tensin homology 2.47101
CCDC92 coiled-coil domain containing 92 2.47101
HPR haptoglobin-related protein 2.47101
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.47101
GGT6 gamma-glutamyltransferase 6 2.47101
CAPN14 calpain 14 2.47101
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.47101
LOC124901449 uncharacterized LOC124901449 2.47101
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.47101
AQP7 aquaporin 7 2.47101
CRYBB2 crystallin, beta B2 2.47101
HSPA1L heat shock 70kDa protein 1-like 2.47101
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.47101
RPL4 ribosomal protein L4 2.47101
CALHM3 calcium homeostasis modulator 3 2.47101
HPX hemopexin 2.47101
GLT1D1 glycosyltransferase 1 domain containing 1 2.47101
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 2.47101
C18ORF63 chromosome 18 open reading frame 63 2.47101
HSPB2 heat shock 27kDa protein 2 2.47101
ZMYND12 zinc finger, MYND-type containing 12 2.47101
FBXO39 F-box protein 39 2.47101
EBF3 early B-cell factor 3 2.47101
FNDC9 fibronectin type III domain containing 9 2.47101
MYF6 myogenic factor 6 (herculin) 2.47101
CH25H cholesterol 25-hydroxylase 2.47101
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.47101
CPA6 carboxypeptidase A6 2.47101
CD244 CD244 molecule, natural killer cell receptor 2B4 2.47101
C2CD4B C2 calcium-dependent domain containing 4B 2.47101
B9D2 B9 protein domain 2 2.47101
CSF1R colony stimulating factor 1 receptor 2.47101
LAMB4 laminin, beta 4 2.47101
PLA2G3 phospholipase A2, group III 2.47101
TEX26 testis expressed 26 2.47101
ZNF831 zinc finger protein 831 2.47101
MB myoglobin 2.47101
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.47101
DMRT1 doublesex and mab-3 related transcription factor 1 2.47101
SLC36A3 solute carrier family 36, member 3 2.47101
MUC13 mucin 13, cell surface associated 2.47101
MPC1L mitochondrial pyruvate carrier 1-like 2.47101
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 2.47101
CHI3L2 chitinase 3-like 2 2.47101
DHH desert hedgehog 2.47101
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.47101
CTXN2 cortexin 2 2.47101
RIPPLY2 ripply transcriptional repressor 2 2.47101
UPK1B uroplakin 1B 2.47101
DMTN dematin actin binding protein 2.47101
ANXA8 annexin A8 2.47101
HMX3 H6 family homeobox 3 2.47101
NMUR2 neuromedin U receptor 2 2.47101
KCTD4 potassium channel tetramerization domain containing 4 2.47101
ANGPTL3 angiopoietin-like 3 2.47101
DIO3 deiodinase, iodothyronine, type III 2.47101
AOC1 amine oxidase, copper containing 1 2.47101
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.47101
LPO lactoperoxidase 2.47101
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.47101
PMCH pro-melanin-concentrating hormone 2.47101
PCDHGA11 protocadherin gamma subfamily A, 11 2.47101
BRAP BRCA1 associated protein 2.47101
ALLC allantoicase 2.47101
LGALS2 lectin, galactoside-binding, soluble, 2 2.47101
CIB3 calcium and integrin binding family member 3 2.47101
TREML4 triggering receptor expressed on myeloid cells-like 4 2.47101
TRIM29 tripartite motif containing 29 2.47101
TREML2 triggering receptor expressed on myeloid cells-like 2 2.47101
KRT72 keratin 72, type II 2.47101
ATOH8 atonal homolog 8 (Drosophila) 2.47101
FZD1 frizzled class receptor 1 2.47101
TARBP1 TAR (HIV-1) RNA binding protein 1 2.47101
TAS2R19 taste receptor, type 2, member 19 2.47101
GH1 growth hormone 1 2.47101
CHRM4 cholinergic receptor, muscarinic 4 2.47101
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.47101
FOXP3 forkhead box P3 2.47101
MSLN mesothelin 2.47101
CEP295NL CEP295 N-terminal like 2.41691
STRIP2 striatin interacting protein 2 2.41507
SNAPIN SNAP-associated protein 2.38462
TYSND1 trypsin domain containing 1 2.37554
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.37554
TRIM52 tripartite motif containing 52 2.30693
CCR10 chemokine (C-C motif) receptor 10 2.28931
USP9X ubiquitin specific peptidase 9, X-linked 2.28931
ATXN10 ataxin 10 2.28894
ARID4A AT rich interactive domain 4A (RBP1-like) 2.24536
IL17RB interleukin 17 receptor B 2.24037
FAM229B family with sequence similarity 229, member B 2.13323
ASNSD1 asparagine synthetase domain containing 1 2.12895
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 2.12335
TUBG2 tubulin, gamma 2 2.11956
PPP1R9A protein phosphatase 1, regulatory subunit 9A 2.11837
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.11117
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 2.10139
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2.09954
SMIM14 small integral membrane protein 14 2.09809
KIAA2013 KIAA2013 2.07896
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.06402
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.05618
MICU2 mitochondrial calcium uptake 2 2.03155
ACER2 alkaline ceramidase 2 2.01527
NINJ2 ninjurin 2 2.00723

decreased expression

Symbol Name Standardized Value
FAM219A family with sequence similarity 219, member A -2.51169
FBLL1 fibrillarin-like 1 -2.48056
YEATS2 YEATS domain containing 2 -2.47101
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.47101
TYRO3 TYRO3 protein tyrosine kinase -2.47101
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.47101
ACTA1 actin, alpha 1, skeletal muscle -2.47101
KLHL32 kelch-like family member 32 -2.47101
CRB2 crumbs family member 2 -2.47101
MARVELD2 MARVEL domain containing 2 -2.47101
INSL6 insulin-like 6 -2.47101
ZNF266 zinc finger protein 266 -2.47101
EFNA3 ephrin-A3 -2.47101
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -2.47101
CHST10 carbohydrate sulfotransferase 10 -2.41801
SOCS6 suppressor of cytokine signaling 6 -2.40401
PNMA1 paraneoplastic Ma antigen 1 -2.40314
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.37554
GLIS1 GLIS family zinc finger 1 -2.37419
MAP2K2 mitogen-activated protein kinase kinase 2 -2.32726
ZNF395 zinc finger protein 395 -2.30202
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.28931
H2BC21 H2B clustered histone 21 -2.28931
SH2D7 SH2 domain containing 7 -2.28931
MUCL3 mucin like 3 -2.28931
GJB5 gap junction protein, beta 5, 31.1kDa -2.28931
MYMK myomaker, myoblast fusion factor -2.28931
MFAP5 microfibrillar associated protein 5 -2.28931
IFT70B intraflagellar transport 70B -2.28931
TMEM196 transmembrane protein 196 -2.28931
PNMA5 paraneoplastic Ma antigen family member 5 -2.28931
HORMAD2 HORMA domain containing 2 -2.28931
FOXI3 forkhead box I3 -2.28931
MYH15 myosin, heavy chain 15 -2.28931
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.28931
FAM167A family with sequence similarity 167, member A -2.28931
FOSL2 FOS-like antigen 2 -2.28931
PCDHB13 protocadherin beta 13 -2.28931
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -2.28931
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.28931
ARL11 ADP-ribosylation factor-like 11 -2.28931
ALOX15B arachidonate 15-lipoxygenase, type B -2.28931
C5AR2 complement component 5a receptor 2 -2.28931
PRSS51 protease, serine, 51 -2.28931
LRRC38 leucine rich repeat containing 38 -2.28931
RAD21L1 RAD21-like 1 (S. pombe) -2.28931
CRTAC1 cartilage acidic protein 1 -2.28931
ASCL3 achaete-scute family bHLH transcription factor 3 -2.28931
KRTAP13-4 keratin associated protein 13-4 -2.28931
PHOX2A paired-like homeobox 2a -2.28931
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.28931
ATOH7 atonal homolog 7 (Drosophila) -2.28931
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.28931
SYT5 synaptotagmin V -2.28931
TMEM82 transmembrane protein 82 -2.28931
KDM2B lysine (K)-specific demethylase 2B -2.27563
PADI2 peptidyl arginine deiminase, type II -2.27135
ALDOA aldolase A, fructose-bisphosphate -2.24037
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.24037
BTBD18 BTB (POZ) domain containing 18 -2.19262
PPP4C protein phosphatase 4, catalytic subunit -2.19262
EFCAB5 EF-hand calcium binding domain 5 -2.19262
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.19262
LINGO3 leucine rich repeat and Ig domain containing 3 -2.19262
GPN3 GPN-loop GTPase 3 -2.19262
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.17283
UQCC6 ubiquinol-cytochrome c reductase complex assembly factor 6 -2.17283
SAP30L SAP30-like -2.17237
SRRM2 serine/arginine repetitive matrix 2 -2.15526
PEX2 peroxisomal biogenesis factor 2 -2.14711
NTPCR nucleoside-triphosphatase, cancer-related -2.14711
HELQ helicase, POLQ-like -2.13883
GCLC glutamate-cysteine ligase, catalytic subunit -2.12895
KLC3 kinesin light chain 3 -2.12309
SIRT2 sirtuin 2 -2.12309
PTOV1 prostate tumor overexpressed 1 -2.1192
PML promyelocytic leukemia -2.10019
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.0569
COQ6 coenzyme Q6 monooxygenase -2.03957
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.03957
SF1 splicing factor 1 -2.03155
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.00723