PNMT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phenylethanolamine N-methyltransferase|The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] (NCBI Entrez Gene Database, 5409)
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Genes

319 genes differentially expressed following the PNMT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 4.28566
OR2A1 olfactory receptor, family 2, subfamily A, member 1 4.28566
SPDYE6 speedy/RINGO cell cycle regulator family member E6 4.28566
PLVAP plasmalemma vesicle associated protein 4.28566
NDRG1 N-myc downstream regulated 1 4.28566
LY86 lymphocyte antigen 86 4.28566
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 4.28566
CARD18 caspase recruitment domain family, member 18 4.28566
WDR87 WD repeat domain 87 4.28566
IYD iodotyrosine deiodinase 4.28566
SLC26A4 solute carrier family 26 (anion exchanger), member 4 4.28566
SLC46A3 solute carrier family 46, member 3 4.28566
RS1 retinoschisin 1 4.28566
ATP13A5 ATPase type 13A5 4.28566
TMEM236 transmembrane protein 236 4.28566
OR51B5 olfactory receptor, family 51, subfamily B, member 5 4.28566
PSAPL1 prosaposin-like 1 (gene/pseudogene) 4.28566
DAO D-amino-acid oxidase 4.28566
CLEC3A C-type lectin domain family 3, member A 4.28566
PTPRC protein tyrosine phosphatase, receptor type, C 4.28566
KLHL33 kelch-like family member 33 4.28566
NKX2-4 NK2 homeobox 4 4.28566
RAB44 RAB44, member RAS oncogene family 4.28566
HDC histidine decarboxylase 4.28566
LIPM lipase, family member M 4.28566
SPINK4 serine peptidase inhibitor, Kazal type 4 4.28566
TEX13B testis expressed 13B 4.28566
PECAM1 platelet/endothelial cell adhesion molecule 1 4.28566
CA1 carbonic anhydrase I 4.28566
LYZL6 lysozyme-like 6 4.28566
NRROS negative regulator of reactive oxygen species 4.28566
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 4.28566
TPSD1 tryptase delta 1 4.28566
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 4.28566
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 4.28566
TTLL2 tubulin tyrosine ligase-like family member 2 4.28566
IVD isovaleryl-CoA dehydrogenase 4.28566
OR1D2 olfactory receptor, family 1, subfamily D, member 2 4.28566
GPR22 G protein-coupled receptor 22 4.28566
RPE65 retinal pigment epithelium-specific protein 65kDa 4.28566
PCDHB9 protocadherin beta 9 4.28566
TNNI1 troponin I type 1 (skeletal, slow) 4.28566
HES7 hes family bHLH transcription factor 7 4.28566
PNMA5 paraneoplastic Ma antigen family member 5 4.28566
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.28566
TKTL1 transketolase-like 1 4.28566
PAX7 paired box 7 4.28566
PAX5 paired box 5 4.28566
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 4.28566
TUBB1 tubulin, beta 1 class VI 4.28566
SLC30A4 solute carrier family 30 (zinc transporter), member 4 4.28566
ACOT12 acyl-CoA thioesterase 12 4.28566
ZIC4 Zic family member 4 4.28566
CATSPERH catsper channel auxiliary subunit eta 4.28566
ELOA2 elongin A2 4.28566
CABCOCO1 ciliary associated calcium binding coiled-coil 1 4.28566
GK3 glycerol kinase 3 4.28566
LORICRIN loricrin cornified envelope precursor protein 4.28566
HTD2 hydroxyacyl-thioester dehydratase type 2 4.28566
H3-5 H3.5 histone 4.28566
SELE selectin E 4.28566
ZNF728 zinc finger protein 728 4.28566
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 4.28566
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 4.28566
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 4.28566
SOFU1 sperm-oocyte fusion factor 1 4.28566
GSTT4 glutathione S-transferase theta 4 4.28566
SPMAP1 sperm microtubule associated protein 1 4.28566
CIROZ ciliated left-right organizer protein containing ZP-N domains 4.28566
LOC114841035 uncharacterized LOC114841035 4.28566
NHERF4 NHERF family PDZ scaffold protein 4 4.28566
LOC122526780 uncharacterized LOC122526780 4.28566
TMA7B translation machinery associated 7 homolog B 4.28566
LY6L lymphocyte antigen 6 family member L 4.28566
GLYATL1B glycine-N-acyltransferase like 1B 4.28566
ARMH2 armadillo like helical domain containing 2 4.28566
CFAP107 cilia and flagella associated protein 107 4.28566
GARIN4 golgi associated RAB2 interactor family member 4 4.28566
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 4.28566
TMPRSS3 transmembrane protease, serine 3 4.28566
VCX3A variable charge, X-linked 3A 4.28566
CCR4 chemokine (C-C motif) receptor 4 4.28566
EXOC3L4 exocyst complex component 3-like 4 4.28566
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 4.28566
IFNL2 interferon, lambda 2 4.28566
C1QTNF9 C1q and tumor necrosis factor related protein 9 4.28566
RNF113B ring finger protein 113B 4.28566
SMLR1 small leucine-rich protein 1 4.28566
IL5 interleukin 5 4.28566
HAPLN2 hyaluronan and proteoglycan link protein 2 4.28566
SCRT1 scratch family zinc finger 1 4.28566
FGFBP1 fibroblast growth factor binding protein 1 4.28566
GPR85 G protein-coupled receptor 85 4.28566
ACSL5 acyl-CoA synthetase long-chain family member 5 4.28566
SAG S-antigen; retina and pineal gland (arrestin) 4.28566
LY6K lymphocyte antigen 6 complex, locus K 4.28566
REP15 RAB15 effector protein 4.28566
DYNLRB2 dynein, light chain, roadblock-type 2 4.28566
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 4.28566
PARVG parvin, gamma 4.28566
KL klotho 4.28566
CSF3 colony stimulating factor 3 (granulocyte) 4.28566
DLK2 delta-like 2 homolog (Drosophila) 4.28566
NPIPB8 nuclear pore complex interacting protein family, member B8 4.28566
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 4.28566
PRDM16 PR domain containing 16 4.28566
LDLRAD1 low density lipoprotein receptor class A domain containing 1 4.28566
FZD1 frizzled class receptor 1 4.28566
AGR2 anterior gradient 2 4.28566
SPRN shadow of prion protein homolog (zebrafish) 4.28566
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 4.28566
KRT15 keratin 15, type I 4.28566
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 4.28566
DES desmin 4.28566
APOD apolipoprotein D 4.28566
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 4.28566
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 4.28566
PRRX1 paired related homeobox 1 4.28566
GRAP2 GRB2-related adaptor protein 2 4.28566
CD8B CD8b molecule 4.28566
TCAP titin-cap 4.28566
LAMP3 lysosomal-associated membrane protein 3 4.28566
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 4.28566
POTEF POTE ankyrin domain family, member F 4.28566
SP100 SP100 nuclear antigen 4.28566
CARD9 caspase recruitment domain family, member 9 4.28566
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 4.28566
IGFBP1 insulin-like growth factor binding protein 1 4.28566
CDHR4 cadherin-related family member 4 4.28566
MKRN3 makorin ring finger protein 3 4.28566
PRM1 protamine 1 4.28566
GOLGA6A golgin A6 family, member A 4.28566
WFDC8 WAP four-disulfide core domain 8 4.28566
SCGB1D4 secretoglobin, family 1D, member 4 4.28566
NPBWR1 neuropeptides B/W receptor 1 4.28566
CYS1 cystin 1 4.28566
VWA7 von Willebrand factor A domain containing 7 4.28566
MYLK2 myosin light chain kinase 2 4.28566
ADORA3 adenosine A3 receptor 4.28566
SMAD9 SMAD family member 9 4.28566
KLK7 kallikrein-related peptidase 7 4.28566
ZNF541 zinc finger protein 541 4.28566
PCDHA11 protocadherin alpha 11 4.28566
CST9 cystatin 9 (testatin) 4.28566
KLK11 kallikrein-related peptidase 11 4.28566
EBLN1 endogenous Bornavirus-like nucleoprotein 1 4.28566
C11ORF91 chromosome 11 open reading frame 91 4.28566
TBC1D28 TBC1 domain family, member 28 4.28566
MAGEA10 melanoma antigen family A10 4.28566
MRC1 mannose receptor, C type 1 4.28566
TMEM255A transmembrane protein 255A 4.28566
WFDC11 WAP four-disulfide core domain 11 4.28566
CD22 CD22 molecule 4.28566
LKAAEAR1 LKAAEAR motif containing 1 4.28566
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 4.28566
LOXL4 lysyl oxidase-like 4 4.28566
ASCL5 achaete-scute family bHLH transcription factor 5 4.28566
ASCL2 achaete-scute family bHLH transcription factor 2 4.28566
NPY2R neuropeptide Y receptor Y2 4.28566
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 4.28566
TRIML1 tripartite motif family-like 1 4.28566
SPACA1 sperm acrosome associated 1 4.28566
SPACA4 sperm acrosome associated 4 4.28566
ITGAD integrin, alpha D 4.28566
NLRP14 NLR family, pyrin domain containing 14 4.28566
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 4.28566
KIAA1755 KIAA1755 4.28566
ARSH arylsulfatase family, member H 4.28566
CCDC87 coiled-coil domain containing 87 4.28566
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 4.28566
NLRP3 NLR family, pyrin domain containing 3 4.28566
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 4.28566
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 4.28566
TGM7 transglutaminase 7 4.28566
TGM5 transglutaminase 5 4.28566
BPIFC BPI fold containing family C 4.28566
PHGR1 proline/histidine/glycine-rich 1 4.28566
TEX35 testis expressed 35 4.28566
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 4.28566
CAPSL calcyphosine-like 4.28566
PADI3 peptidyl arginine deiminase, type III 4.28566
PPP1R3G protein phosphatase 1, regulatory subunit 3G 4.28566
C4BPB complement component 4 binding protein, beta 4.28566
ADAM18 ADAM metallopeptidase domain 18 4.28566
TRAF3IP3 TRAF3 interacting protein 3 4.28566
IFITM10 interferon induced transmembrane protein 10 4.28566
HRH1 histamine receptor H1 4.23447
PEX12 peroxisomal biogenesis factor 12 4.23447
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 4.23447
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 3.67697
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 3.58612
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.41551
GLRB glycine receptor, beta 3.16367
SLC18B1 solute carrier family 18, subfamily B, member 1 3.16367
SYVN1 synovial apoptosis inhibitor 1, synoviolin 3.16367
SLC15A5 solute carrier family 15, member 5 3.16367
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.16367
NPSR1 neuropeptide S receptor 1 3.16367
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 3.16367
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 3.13076
LAP3 leucine aminopeptidase 3 3.06871
ANKIB1 ankyrin repeat and IBR domain containing 1 3.06044
SRFBP1 serum response factor binding protein 1 2.97537
MEIOC meiosis specific with coiled-coil domain 2.96602
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 2.92174
ZNF835 zinc finger protein 835 2.90356
IWS1 IWS1 homolog (S. cerevisiae) 2.89968
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.89134
DENND11 DENN domain containing 11 2.82547
GCH1 GTP cyclohydrolase 1 2.81327
CD7 CD7 molecule 2.6055
FOXO6 forkhead box O6 2.6055
SCIMP SLP adaptor and CSK interacting membrane protein 2.6055
ERBB3 erb-b2 receptor tyrosine kinase 3 2.57431
ADI1 acireductone dioxygenase 1 2.57382
LBH limb bud and heart development 2.46892
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.39052
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.33511
CCDC186 coiled-coil domain containing 186 2.33114
TMEM40 transmembrane protein 40 2.31396
WDR7 WD repeat domain 7 2.29966
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 2.28253
SLFNL1 schlafen-like 1 2.26431
FBXO42 F-box protein 42 2.21366
ETFDH electron-transferring-flavoprotein dehydrogenase 2.19129
FKRP fukutin related protein 2.1824
RAB14 RAB14, member RAS oncogene family 2.17342
RPS28 ribosomal protein S28 2.16651
MYO15B myosin XVB 2.13821
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.12393
OPTN optineurin 2.09156
EBF1 early B-cell factor 1 2.0532
UBAP2 ubiquitin associated protein 2 2.02675
NCK1 NCK adaptor protein 1 2.0224
HHIP hedgehog interacting protein 2.01784
IFITM1 interferon induced transmembrane protein 1 2.01748
C19ORF38 chromosome 19 open reading frame 38 2.01224
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 2.00601
MTERF2 mitochondrial transcription termination factor 2 2.00118
STEAP2 STEAP family member 2, metalloreductase 2.00118
POFUT4 protein O-fucosyltransferase 4 2.00063

decreased expression

Symbol Name Standardized Value
SPMIP10 sperm microtubule inner protein 10 -4.28566
NOD2 nucleotide-binding oligomerization domain containing 2 -4.28566
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -4.28566
C11ORF86 chromosome 11 open reading frame 86 -4.28566
MOGAT3 monoacylglycerol O-acyltransferase 3 -4.28566
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -4.28566
BRICD5 BRICHOS domain containing 5 -4.28566
CLCF1 cardiotrophin-like cytokine factor 1 -4.28566
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -4.28566
SSTR1 somatostatin receptor 1 -4.28566
TM4SF1 transmembrane 4 L six family member 1 -4.28566
H4C12 H4 clustered histone 12 -4.28566
VN1R1 vomeronasal 1 receptor 1 -4.28566
BNC1 basonuclin 1 -4.28566
LGSN lengsin, lens protein with glutamine synthetase domain -4.28566
GPR83 G protein-coupled receptor 83 -4.28566
ABHD15 abhydrolase domain containing 15 -4.28566
AMBP alpha-1-microglobulin/bikunin precursor -4.28566
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -4.28566
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -4.28566
OPRK1 opioid receptor, kappa 1 -4.28566
KLF1 Kruppel-like factor 1 (erythroid) -4.28566
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -4.28566
CCNA1 cyclin A1 -4.28566
EMP1 epithelial membrane protein 1 -4.28566
TF transferrin -4.28566
IPO9 importin 9 -3.34509
ACSM3 acyl-CoA synthetase medium-chain family member 3 -3.16813
BMP2 bone morphogenetic protein 2 -3.16367
ZNF471 zinc finger protein 471 -3.16367
STAC2 SH3 and cysteine rich domain 2 -3.16367
BHLHE41 basic helix-loop-helix family, member e41 -3.16367
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -3.106
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -3.09732
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.9563
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.80857
METTL5 methyltransferase like 5 -2.79531
FHL3 four and a half LIM domains 3 -2.70047
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -2.60943
C11ORF52 chromosome 11 open reading frame 52 -2.6055
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.6055
EFHB EF-hand domain family, member B -2.6055
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.6055
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.52648
ZCCHC10 zinc finger, CCHC domain containing 10 -2.49564
HSPA2 heat shock 70kDa protein 2 -2.45571
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.40728
YBX3 Y box binding protein 3 -2.3949
GYG1 glycogenin 1 -2.3914
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.3914
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -2.3635
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.35053
NT5E 5'-nucleotidase, ecto (CD73) -2.28326
CA3 carbonic anhydrase III -2.28253
PODNL1 podocan-like 1 -2.28253
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.26016
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.23031
IL23A interleukin 23, alpha subunit p19 -2.20205
AMDHD1 amidohydrolase domain containing 1 -2.16306
NPPC natriuretic peptide C -2.16306
KLF10 Kruppel-like factor 10 -2.15654
BICRAL BICRA like chromatin remodeling complex associated protein -2.14464
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.12789
CABLES1 Cdk5 and Abl enzyme substrate 1 -2.12333
SART1 squamous cell carcinoma antigen recognized by T cells -2.12333
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.12333
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.11329
ARHGAP1 Rho GTPase activating protein 1 -2.11025
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.09619
HMGN4 high mobility group nucleosomal binding domain 4 -2.08432
TRAPPC12 trafficking protein particle complex 12 -2.08161
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.06387
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.02619
PDGFRL platelet-derived growth factor receptor-like -2.01647
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.0143
PFDN4 prefoldin subunit 4 -2.0124
CEP15 centrosomal protein 15 -2.01224
DVL1 dishevelled segment polarity protein 1 -2.00122