PNP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description purine nucleoside phosphorylase|This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4860)
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Genes

356 genes differentially expressed following the PNP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TBXA2R thromboxane A2 receptor 2.89938
BBS5 Bardet-Biedl syndrome 5 2.89938
GCOM1 GRINL1A complex locus 1 2.89938
RHCE Rh blood group, CcEe antigens 2.89938
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.89938
GOLGA6A golgin A6 family, member A 2.89938
FAM135B family with sequence similarity 135, member B 2.89938
HPD 4-hydroxyphenylpyruvate dioxygenase 2.89938
SOX10 SRY (sex determining region Y)-box 10 2.89938
MFAP5 microfibrillar associated protein 5 2.89938
CSAG3 CSAG family, member 3 2.89938
TACSTD2 tumor-associated calcium signal transducer 2 2.89938
TREH trehalase (brush-border membrane glycoprotein) 2.89938
SSMEM1 serine-rich single-pass membrane protein 1 2.89938
ZNF324B zinc finger protein 324B 2.89938
PDZD9 PDZ domain containing 9 2.89938
NELL1 NEL-like 1 (chicken) 2.89938
POF1B premature ovarian failure, 1B 2.89938
DYTN dystrotelin 2.89938
PLAAT4 phospholipase A and acyltransferase 4 2.89938
SLC22A10 solute carrier family 22, member 10 2.89938
TTC24 tetratricopeptide repeat domain 24 2.89938
ZNF98 zinc finger protein 98 2.89938
CHCT1 CHD1 helical C-terminal domain containing 1 2.89938
ALOX15 arachidonate 15-lipoxygenase 2.89938
FAIM2 Fas apoptotic inhibitory molecule 2 2.89938
CFAP157 cilia and flagella associated protein 157 2.89938
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.89938
ACTL8 actin-like 8 2.89938
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.8152
RNF17 ring finger protein 17 2.8152
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.8152
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.8152
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.8152
GRPR gastrin-releasing peptide receptor 2.8152
ASPDH aspartate dehydrogenase domain containing 2.8152
CLEC19A C-type lectin domain family 19, member A 2.8152
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.8152
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.8152
NPAP1 nuclear pore associated protein 1 2.8152
SLC25A45 solute carrier family 25, member 45 2.8152
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.8152
MISP mitotic spindle positioning 2.8152
ABRA actin binding Rho activating protein 2.8152
CCL1 chemokine (C-C motif) ligand 1 2.8152
TAS2R19 taste receptor, type 2, member 19 2.8152
SPX spexin hormone 2.8152
C2ORF78 chromosome 2 open reading frame 78 2.8152
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.8152
KIAA1755 KIAA1755 2.8152
BOLA2 bolA family member 2 2.8152
NPR3 natriuretic peptide receptor 3 2.8152
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.8152
PLCH2 phospholipase C, eta 2 2.8152
ACTL7A actin-like 7A 2.8152
PAX5 paired box 5 2.8152
TYRP1 tyrosinase-related protein 1 2.8152
LRPPRC leucine-rich pentatricopeptide repeat containing 2.8152
OLFM4 olfactomedin 4 2.8152
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.8152
ADAD2 adenosine deaminase domain containing 2 2.8152
TRIM77 tripartite motif containing 77 2.8152
PTGFR prostaglandin F receptor (FP) 2.8152
SFTPB surfactant protein B 2.8152
UBA7 ubiquitin-like modifier activating enzyme 7 2.8152
RBP4 retinol binding protein 4, plasma 2.8152
FAM90A11 family with sequence similarity 90 member A11 2.8152
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.8152
ARX aristaless related homeobox 2.8152
SPRR2F small proline-rich protein 2F 2.8152
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.8152
ASB5 ankyrin repeat and SOCS box containing 5 2.8152
SRPK3 SRSF protein kinase 3 2.8152
C10ORF53 chromosome 10 open reading frame 53 2.8152
FCMR Fc fragment of IgM receptor 2.8152
XKRX XK, Kell blood group complex subunit-related, X-linked 2.8152
PWWP3B PWWP domain containing 3B 2.8152
TMEM271 transmembrane protein 271 2.8152
CBLIF cobalamin binding intrinsic factor 2.8152
LOC114841035 uncharacterized LOC114841035 2.8152
CPNE8-AS1 CPNE8 antisense RNA 1 2.8152
SPICP3 Spi-C transcription factor pseudogene 3 2.8152
CSP2 CS pseudogene 2 2.8152
ODAPH odontogenesis associated phosphoprotein 2.8152
ERFE erythroferrone 2.8152
CFAP141 cilia and flagella associated protein 141 2.8152
KASH5 KASH domain containing 5 2.8152
BNIP5 BCL2 interacting protein 5 2.8152
LY6H lymphocyte antigen 6 complex, locus H 2.8152
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.8152
ANXA10 annexin A10 2.8152
GOLGA6L4 golgin A6 family-like 4 2.8152
MAG myelin associated glycoprotein 2.8152
PTPRH protein tyrosine phosphatase, receptor type, H 2.8152
PCDHA3 protocadherin alpha 3 2.8152
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.8152
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.8152
SYCP1 synaptonemal complex protein 1 2.8152
NRN1 neuritin 1 2.8152
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.8152
TMCO2 transmembrane and coiled-coil domains 2 2.8152
GZMM granzyme M (lymphocyte met-ase 1) 2.8152
LTA lymphotoxin alpha 2.8152
CFAP52 cilia and flagella associated protein 52 2.8152
SLC35A4 solute carrier family 35, member A4 2.8152
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.8152
CDKN2A cyclin-dependent kinase inhibitor 2A 2.8152
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.8152
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.8152
SLC45A2 solute carrier family 45, member 2 2.8152
PGC progastricsin (pepsinogen C) 2.8152
HNF4A hepatocyte nuclear factor 4, alpha 2.8152
NTSR2 neurotensin receptor 2 2.8152
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.8152
TSPAN19 tetraspanin 19 2.8152
CCL25 chemokine (C-C motif) ligand 25 2.8152
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.8152
BRDT bromodomain, testis-specific 2.8152
EDN3 endothelin 3 2.8152
ZNF541 zinc finger protein 541 2.8152
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.8152
KLHL6 kelch-like family member 6 2.8152
PALMD palmdelphin 2.8152
PDCL2 phosducin-like 2 2.8152
IL12B interleukin 12B 2.8152
SMYD1 SET and MYND domain containing 1 2.8152
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.8152
SPINK9 serine peptidase inhibitor, Kazal type 9 2.8152
SMIM22 small integral membrane protein 22 2.8152
BMX BMX non-receptor tyrosine kinase 2.8152
COL6A5 collagen, type VI, alpha 5 2.8152
RPA4 replication protein A4, 30kDa 2.8152
ABI3 ABI family, member 3 2.8152
S100A14 S100 calcium binding protein A14 2.8152
KLHL11 kelch-like family member 11 2.8152
SLC36A3 solute carrier family 36, member 3 2.8152
RICTOR RPTOR independent companion of MTOR, complex 2 2.8152
PSG3 pregnancy specific beta-1-glycoprotein 3 2.8152
SAMD7 sterile alpha motif domain containing 7 2.8152
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.8152
ARL13A ADP-ribosylation factor-like 13A 2.8152
GLB1L2 galactosidase, beta 1-like 2 2.8152
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.8152
CLEC9A C-type lectin domain family 9, member A 2.8152
PLA1A phospholipase A1 member A 2.8152
PATE4 prostate and testis expressed 4 2.8152
HKDC1 hexokinase domain containing 1 2.8152
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.8152
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.8152
MAMLD1 mastermind-like domain containing 1 2.8152
MAB21L1 mab-21-like 1 (C. elegans) 2.8152
PSG8 pregnancy specific beta-1-glycoprotein 8 2.8152
LOC102723971 beta-lactoglobulin-like 2.8152
TEKT5 tektin 5 2.8152
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.8152
GSTA2 glutathione S-transferase alpha 2 2.8152
ERICH6 glutamate-rich 6 2.8152
ZNF534 zinc finger protein 534 2.8152
VTCN1 V-set domain containing T cell activation inhibitor 1 2.8152
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.8152
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.8152
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.8152
RERGL RERG/RAS-like 2.8152
RHAG Rh-associated glycoprotein 2.8152
ANGPTL3 angiopoietin-like 3 2.8152
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.8152
CETP cholesteryl ester transfer protein, plasma 2.8152
PADI4 peptidyl arginine deiminase, type IV 2.8152
ARGFX arginine-fifty homeobox 2.8152
TEX36 testis expressed 36 2.8152
LYZL1 lysozyme-like 1 2.8152
FADS6 fatty acid desaturase 6 2.8152
UPK1B uroplakin 1B 2.8152
IRX5 iroquois homeobox 5 2.8152
IRX4 iroquois homeobox 4 2.8152
LOXL4 lysyl oxidase-like 4 2.8152
IL17D interleukin 17D 2.8152
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.8152
WNT10B wingless-type MMTV integration site family, member 10B 2.8152
FGF16 fibroblast growth factor 16 2.8152
SOX30 SRY (sex determining region Y)-box 30 2.8152
AHSG alpha-2-HS-glycoprotein 2.8152
TUBA8 tubulin, alpha 8 2.77538
ARSA arylsulfatase A 2.75561
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.62263
TPH1 tryptophan hydroxylase 1 2.60036
MPZL2 myelin protein zero-like 2 2.60036
CDCA5 cell division cycle associated 5 2.59398
AJUBA ajuba LIM protein 2.56836
MAP1B microtubule-associated protein 1B 2.55222
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.5212
IRF8 interferon regulatory factor 8 2.51796
SLC25A41 solute carrier family 25, member 41 2.51796
TFRC transferrin receptor 2.50715
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.46027
C1R complement component 1, r subcomponent 2.46027
TMEM255A transmembrane protein 255A 2.46027
RP1L1 retinitis pigmentosa 1-like 1 2.46027
ALCAM activated leukocyte cell adhesion molecule 2.44533
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.43449
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.42394
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 2.3905
GFM2 G elongation factor, mitochondrial 2 2.38416
ANXA3 annexin A3 2.33479
RRP1B ribosomal RNA processing 1B 2.33323
ATG3 autophagy related 3 2.32946
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.29543
SCART1 scavenger receptor protein family member 2.29543
TBCC tubulin folding cofactor C 2.29286
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.29286
RUSC2 RUN and SH3 domain containing 2 2.29225
HMGXB4 HMG box domain containing 4 2.27217
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.26594
AGRN agrin 2.26156
MCM4 minichromosome maintenance complex component 4 2.25807
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.25807
CCNB1 cyclin B1 2.23382
ZNF589 zinc finger protein 589 2.23283
PIAS3 protein inhibitor of activated STAT, 3 2.227
NEK2 NIMA-related kinase 2 2.20206
ANKRD34B ankyrin repeat domain 34B 2.18214
NRBP2 nuclear receptor binding protein 2 2.17368
MRPL11 mitochondrial ribosomal protein L11 2.16101
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.15092
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.14463
PDAP1 PDGFA associated protein 1 2.14175
TPRG1 tumor protein p63 regulated 1 2.1305
IGSF21 immunoglobin superfamily, member 21 2.11895
RGL1 ral guanine nucleotide dissociation stimulator-like 1 2.11203
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.11141
ZDHHC5 zinc finger, DHHC-type containing 5 2.10667
DNM3 dynamin 3 2.10667
CEP170B centrosomal protein 170B 2.09479
STK32C serine/threonine kinase 32C 2.08411
UBA3 ubiquitin-like modifier activating enzyme 3 2.06422
MCM5 minichromosome maintenance complex component 5 2.063
AVEN apoptosis, caspase activation inhibitor 2.05085
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.04953
MSANTD7 Myb/SANT DNA binding domain containing 7 2.03922
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 2.03591
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 2.02099
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.01989
SPATC1 spermatogenesis and centriole associated 1 2.01989
CDC42SE2 CDC42 small effector 2 2.01554
CLPTM1L CLPTM1-like 2.00564
PCED1B PC-esterase domain containing 1B 2.00497

decreased expression

Symbol Name Standardized Value
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -2.89938
KAT2A K(lysine) acetyltransferase 2A -2.87714
DNAH5 dynein, axonemal, heavy chain 5 -2.87256
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.87256
ZC3H11A zinc finger CCCH-type containing 11A -2.87256
KLHL34 kelch-like family member 34 -2.87256
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.87256
TAOK3 TAO kinase 3 -2.8152
WFDC2 WAP four-disulfide core domain 2 -2.8152
TRIM45 tripartite motif containing 45 -2.8152
PROX1 prospero homeobox 1 -2.8152
DTX1 deltex 1, E3 ubiquitin ligase -2.8152
LRRC58 leucine rich repeat containing 58 -2.8152
XKR4 XK, Kell blood group complex subunit-related family, member 4 -2.8152
KIF1A kinesin family member 1A -2.8152
GHR growth hormone receptor -2.8152
TUBB2B tubulin, beta 2B class IIb -2.8152
RNF208 ring finger protein 208 -2.8152
HIPK4 homeodomain interacting protein kinase 4 -2.77459
SMIM47 small integral membrane protein 47 -2.77459
DIO1 deiodinase, iodothyronine, type I -2.77459
PRDM1 PR domain containing 1, with ZNF domain -2.77459
IL23A interleukin 23, alpha subunit p19 -2.77459
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.77459
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.77459
GPR179 G protein-coupled receptor 179 -2.77459
VSIG1 V-set and immunoglobulin domain containing 1 -2.77459
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.77459
RUNX3 runt-related transcription factor 3 -2.77459
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.77459
MEOX2 mesenchyme homeobox 2 -2.77459
LMNTD1 lamin tail domain containing 1 -2.77459
SIX3 SIX homeobox 3 -2.77459
CXCL13 chemokine (C-X-C motif) ligand 13 -2.77459
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.77459
NHLH2 nescient helix loop helix 2 -2.77459
CD160 CD160 molecule -2.77459
H4C4 H4 clustered histone 4 -2.77459
DRICH1 aspartate-rich 1 -2.77459
SMIM35 small integral membrane protein 35 -2.77459
TICAM1 toll-like receptor adaptor molecule 1 -2.77459
GPER1 G protein-coupled estrogen receptor 1 -2.77459
AMIGO1 adhesion molecule with Ig-like domain 1 -2.77459
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.77459
SLC38A8 solute carrier family 38, member 8 -2.77459
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.77459
COL5A1 collagen, type V, alpha 1 -2.76956
NBR1 neighbor of BRCA1 gene 1 -2.7539
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -2.73142
REEP4 receptor accessory protein 4 -2.70853
USP51 ubiquitin specific peptidase 51 -2.65411
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.61789
COPS8 COP9 signalosome subunit 8 -2.6042
TOMM34 translocase of outer mitochondrial membrane 34 -2.60036
CEP95 centrosomal protein 95kDa -2.57761
CLUL1 clusterin-like 1 (retinal) -2.56546
C5ORF24 chromosome 5 open reading frame 24 -2.56546
ARHGAP30 Rho GTPase activating protein 30 -2.56546
PBX4 pre-B-cell leukemia homeobox 4 -2.4665
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.44376
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.42394
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -2.41599
IQSEC1 IQ motif and Sec7 domain 1 -2.40441
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -2.39112
ZNF714 zinc finger protein 714 -2.36773
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) -2.34938
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.34599
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -2.34599
ZNF287 zinc finger protein 287 -2.34599
C8ORF58 chromosome 8 open reading frame 58 -2.34579
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.34103
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.33941
CCDC126 coiled-coil domain containing 126 -2.33323
IGSF5 immunoglobulin superfamily, member 5 -2.3152
RND3 Rho family GTPase 3 -2.30202
FBXO30 F-box protein 30 -2.28782
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -2.264
TCAIM T cell activation inhibitor, mitochondrial -2.25956
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.25807
KRTCAP3 keratinocyte associated protein 3 -2.25807
CEP164 centrosomal protein 164kDa -2.23776
RPS16 ribosomal protein S16 -2.23484
FXYD6 FXYD domain containing ion transport regulator 6 -2.21949
RAB26 RAB26, member RAS oncogene family -2.21412
ARSD arylsulfatase D -2.17709
ZNF839 zinc finger protein 839 -2.17457
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.17368
GDI1 GDP dissociation inhibitor 1 -2.17368
SMIM14 small integral membrane protein 14 -2.16933
SCO2 SCO2 cytochrome c oxidase assembly protein -2.16135
JADE1 jade family PHD finger 1 -2.16101
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.15912
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.15912
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -2.14772
ZNF462 zinc finger protein 462 -2.11999
TEAD4 TEA domain family member 4 -2.11999
TCEAL1 transcription elongation factor A (SII)-like 1 -2.11999
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.11664
FABP6 fatty acid binding protein 6, ileal -2.11664
AKR1E2 aldo-keto reductase family 1, member E2 -2.115
TTF1 transcription termination factor, RNA polymerase I -2.11289
FBXL3 F-box and leucine-rich repeat protein 3 -2.095
EFCAB13 EF-hand calcium binding domain 13 -2.095
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -2.08475
NPTX2 neuronal pentraxin II -2.08411
EIF3L eukaryotic translation initiation factor 3, subunit L -2.08411
ZNF443 zinc finger protein 443 -2.08411
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.07212
SDF4 stromal cell derived factor 4 -2.01015
ARSG arylsulfatase G -2.00699