PNU-0251126-3689 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PNU-0251126-3689 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADGRB2 adhesion G protein-coupled receptor B2
AFF1 AF4/FMR2 family, member 1
AMELY amelogenin, Y-linked
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BLZF1 basic leucine zipper nuclear factor 1
C5AR1 complement component 5a receptor 1
C9ORF16 chromosome 9 open reading frame 16
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CHAT choline O-acetyltransferase
CNGB3 cyclic nucleotide gated channel beta 3
CNTNAP2 contactin associated protein-like 2
COL1A2 collagen, type I, alpha 2
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CREBZF CREB/ATF bZIP transcription factor
CRTC1 CREB regulated transcription coactivator 1
DCT dopachrome tautomerase
DENND2D DENN/MADD domain containing 2D
DKFZP434L187 uncharacterized LOC26082
DNAAF1 dynein, axonemal, assembly factor 1
DOCK9 dedicator of cytokinesis 9
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EDA ectodysplasin A
EGR4 early growth response 4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FBXL15 F-box and leucine-rich repeat protein 15
FGL2 fibrinogen-like 2
FOXN3 forkhead box N3
FZD1 frizzled class receptor 1
GAB1 GRB2-associated binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GGT1 gamma-glutamyltransferase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRK4 G protein-coupled receptor kinase 4
HCFC1 host cell factor C1
HPCAL4 hippocalcin like 4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IL1RN interleukin 1 receptor antagonist
IRF4 interferon regulatory factor 4
ITGA7 integrin, alpha 7
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLF15 Kruppel-like factor 15
KLK3 kallikrein-related peptidase 3
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LGALS9 lectin, galactoside-binding, soluble, 9
LIMK2 LIM domain kinase 2
LINC00312 long intergenic non-protein coding RNA 312
LOC157562 uncharacterized LOC157562
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MEF2D myocyte enhancer factor 2D
MUC3B mucin 3B, cell surface associated
MYO7B myosin VIIB
NME5 NME/NM23 family member 5
NRCAM neuronal cell adhesion molecule
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OCM2 oncomodulin 2
OMD osteomodulin
OVOL1 ovo-like zinc finger 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPN podoplanin
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLG plasminogen
PMFBP1 polyamine modulated factor 1 binding protein 1
PML promyelocytic leukemia
POLL polymerase (DNA directed), lambda
PRB1 proline-rich protein BstNI subfamily 1
PSG4 pregnancy specific beta-1-glycoprotein 4
PVRIG poliovirus receptor related immunoglobulin domain containing
RAD51B RAD51 paralog B
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RNF208 ring finger protein 208
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A1 S100 calcium binding protein A1
SIX3 SIX homeobox 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOX30 SRY (sex determining region Y)-box 30
SP110 SP110 nuclear body protein
SPHK2 sphingosine kinase 2
SPRR1B small proline-rich protein 1B
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STARD8 StAR-related lipid transfer (START) domain containing 8
SVIL supervillin
TBC1D30 TBC1 domain family, member 30
THRB thyroid hormone receptor, beta
TMPRSS15 transmembrane protease, serine 15
TMPRSS5 transmembrane protease, serine 5
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TREM2 triggering receptor expressed on myeloid cells 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIPR2 vasoactive intestinal peptide receptor 2
WDR55 WD repeat domain 55

decreased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
ALS2CL ALS2 C-terminal like
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APH1B APH1B gamma secretase subunit
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARL14 ADP-ribosylation factor-like 14
AURKA aurora kinase A
BCL2L2 BCL2-like 2
C10ORF88 chromosome 10 open reading frame 88
C14ORF79 chromosome 14 open reading frame 79
C5ORF45 chromosome 5 open reading frame 45
CCDC85C coiled-coil domain containing 85C
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CENPE centromere protein E, 312kDa
CHRM3 cholinergic receptor, muscarinic 3
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLEC2B C-type lectin domain family 2, member B
CLEC4E C-type lectin domain family 4, member E
COL16A1 collagen, type XVI, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DEPDC1 DEP domain containing 1
DIO3 deiodinase, iodothyronine, type III
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK2 delta-like 2 homolog (Drosophila)
DLL3 delta-like 3 (Drosophila)
DNAH7 dynein, axonemal, heavy chain 7
DNM3 dynamin 3
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
EGR2 early growth response 2
EHF ets homologous factor
ERO1LB ERO1-like beta (S. cerevisiae)
EXOC5 exocyst complex component 5
FAM64A family with sequence similarity 64, member A
FGL1 fibrinogen-like 1
FPGT fucose-1-phosphate guanylyltransferase
GALK1 galactokinase 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRAMD4 GRAM domain containing 4
H2AFJ H2A histone family, member J
HCG4 HLA complex group 4 (non-protein coding)
HDAC11 histone deacetylase 11
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA2 homeobox A2
HOXA4 homeobox A4
INPPL1 inositol polyphosphate phosphatase-like 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LINC00260 long intergenic non-protein coding RNA 260
LMO7 LIM domain 7
MAK male germ cell-associated kinase
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
OSMR oncostatin M receptor
PBLD phenazine biosynthesis-like protein domain containing
PC pyruvate carboxylase
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGP phosphoglycolate phosphatase
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLK1 polo-like kinase 1
POMT1 protein-O-mannosyltransferase 1
PRR15L proline rich 15-like
PWAR5 Prader Willi/Angelman region RNA 5
RAB4B RAB4B, member RAS oncogene family
RCOR3 REST corepressor 3
RNF126P1 ring finger protein 126 pseudogene 1
RNF146 ring finger protein 146
SCD5 stearoyl-CoA desaturase 5
SLITRK5 SLIT and NTRK-like family, member 5
SNRPN small nuclear ribonucleoprotein polypeptide N
SPC25 SPC25, NDC80 kinetochore complex component
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUGCT succinyl-CoA:glutarate-CoA transferase
SYNGR3 synaptogyrin 3
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBKBP1 TBK1 binding protein 1
THBD thrombomodulin
TSPAN8 tetraspanin 8
TTC30A tetratricopeptide repeat domain 30A
TWISTNB TWIST neighbor
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF219 zinc finger protein 219
ZNF76 zinc finger protein 76
ZNRD1-AS1 ZNRD1 antisense RNA 1
ZW10 zw10 kinetochore protein