PNU-0251126-4711 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the PNU-0251126-4711 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCK4 aarF domain containing kinase 4
AGFG1 ArfGAP with FG repeats 1
AJAP1 adherens junctions associated protein 1
AKR1C1 aldo-keto reductase family 1, member C1
ALDOB aldolase B, fructose-bisphosphate
ANGEL2 angel homolog 2 (Drosophila)
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARTN artemin
ATG2A autophagy related 2A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMP1 bone morphogenetic protein 1
BTG2 BTG family, member 2
C10ORF95 chromosome 10 open reading frame 95
C1ORF56 chromosome 1 open reading frame 56
CD58 CD58 molecule
CDC14A cell division cycle 14A
CFLAR CASP8 and FADD-like apoptosis regulator
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIC2 chloride intracellular channel 2
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CREM cAMP responsive element modulator
CXCR4 chemokine (C-X-C motif) receptor 4
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCTN2 dynactin 2 (p50)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EGR3 early growth response 3
EMP3 epithelial membrane protein 3
ETV5 ets variant 5
FAS Fas cell surface death receptor
FBXL7 F-box and leucine-rich repeat protein 7
FH fumarate hydratase
FHL1 four and a half LIM domains 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPATCH4 G patch domain containing 4
GRIP2 glutamate receptor interacting protein 2
GTPBP1 GTP binding protein 1
HFE hemochromatosis
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
HOXD9 homeobox D9
HRASLS2 HRAS-like suppressor 2
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICAM1 intercellular adhesion molecule 1
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
INO80D INO80 complex subunit D
INPP1 inositol polyphosphate-1-phosphatase
ITGA7 integrin, alpha 7
JAK3 Janus kinase 3
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCTD7 potassium channel tetramerization domain containing 7
KDM6A lysine (K)-specific demethylase 6A
KLF8 Kruppel-like factor 8
LOC100286895 cell division cycle 27 homolog pseudogene
LOC157562 uncharacterized LOC157562
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MBTPS2 membrane-bound transcription factor peptidase, site 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NF2 neurofibromin 2 (merlin)
NRP2 neuropilin 2
OSGIN1 oxidative stress induced growth inhibitor 1
PARD6B par-6 family cell polarity regulator beta
PAWR PRKC, apoptosis, WT1, regulator
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RANBP1 RAN binding protein 1
RB1 retinoblastoma 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
SC5D sterol-C5-desaturase
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEC14L5 SEC14-like 5 (S. cerevisiae)
SENP5 SUMO1/sentrin specific peptidase 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SSPN sarcospan
STOML1 stomatin (EPB72)-like 1
SYCE1L synaptonemal complex central element protein 1-like
TAPBP TAP binding protein (tapasin)
TCP11L1 t-complex 11, testis-specific-like 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THSD4 thrombospondin, type I, domain containing 4
TMPRSS4 transmembrane protease, serine 4
TRBC1 T cell receptor beta constant 1
VWA5A von Willebrand factor A domain containing 5A
WNT6 wingless-type MMTV integration site family, member 6
WSB1 WD repeat and SOCS box containing 1
ZNF286A zinc finger protein 286A
ZNF652 zinc finger protein 652
ZNF767P zinc finger family member 767, pseudogene

decreased expression

Symbol Name
ARHGAP4 Rho GTPase activating protein 4
BMP4 bone morphogenetic protein 4
C2ORF27A chromosome 2 open reading frame 27A
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CCNG2 cyclin G2
CDHR2 cadherin-related family member 2
CEL carboxyl ester lipase
CENPE centromere protein E, 312kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNR2 cannabinoid receptor 2 (macrophage)
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNALI1 dynein, axonemal, light intermediate chain 1
DOC2A double C2-like domains, alpha
EPHA4 EPH receptor A4
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM46C family with sequence similarity 46, member C
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
GEMIN8 gem (nuclear organelle) associated protein 8
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR27 G protein-coupled receptor 27
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HIST1H1D histone cluster 1, H1d
HIST1H2BN histone cluster 1, H2bn
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC10 homeobox C10
HOXC8 homeobox C8
HSPB6 heat shock protein, alpha-crystallin-related, B6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
KIF13A kinesin family member 13A
KLHL25 kelch-like family member 25
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRI1 KRI1 homolog (S. cerevisiae)
KRT31 keratin 31, type I
LHX6 LIM homeobox 6
LMNB1 lamin B1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
N4BP3 NEDD4 binding protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NOL10 nucleolar protein 10
OGFRL1 opioid growth factor receptor-like 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE12 phosphodiesterase 12
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PMEL premelanosome protein
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR4 proline rich 4 (lacrimal)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S100A9 S100 calcium binding protein A9
SAA3P serum amyloid A3 pseudogene
SAMD9 sterile alpha motif domain containing 9
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SIK1 salt-inducible kinase 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMTN smoothelin
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STEAP4 STEAP family member 4
STRN striatin, calmodulin binding protein
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TDRD12 tudor domain containing 12
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TRPC5 transient receptor potential cation channel, subfamily C, member 5
VASH1 vasohibin 1
VGF VGF nerve growth factor inducible
WDR91 WD repeat domain 91
ZBTB44 zinc finger and BTB domain containing 44
ZNF165 zinc finger protein 165
ZNF37BP zinc finger protein 37B, pseudogene
ZNF446 zinc finger protein 446
ZNF675 zinc finger protein 675
ZNF804A zinc finger protein 804A