PNU-0251126-4714 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PNU-0251126-4714 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADCY2 adenylate cyclase 2 (brain)
ANP32A-IT1 ANP32A intronic transcript 1
ATM ATM serine/threonine kinase
ATN1 atrophin 1
C21ORF2 chromosome 21 open reading frame 2
C4ORF29 chromosome 4 open reading frame 29
CCDC186 coiled-coil domain containing 186
CD1E CD1e molecule
CD83 CD83 molecule
CDC25C cell division cycle 25C
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHRM3 cholinergic receptor, muscarinic 3
CST6 cystatin E/M
CYTH1 cytohesin 1
DMP1 dentin matrix acidic phosphoprotein 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK9 dedicator of cytokinesis 9
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF3 fibroblast growth factor 3
FMOD fibromodulin
FOXN2 forkhead box N2
FZD5 frizzled class receptor 5
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
GUSBP3 glucuronidase, beta pseudogene 3
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HCFC1 host cell factor C1
HMOX1 heme oxygenase 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
IFI6 interferon, alpha-inducible protein 6
IFT54 intraflagellar transport 54
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IQCK IQ motif containing K
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KLRC4 killer cell lectin-like receptor subfamily C, member 4
LAMP1 lysosomal-associated membrane protein 1
LEFTY2 left-right determination factor 2
LRP2 low density lipoprotein receptor-related protein 2
LRRC40 leucine rich repeat containing 40
MAP2K5 mitogen-activated protein kinase kinase 5
MED25 mediator complex subunit 25
MOCS1 molybdenum cofactor synthesis 1
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFM neurofilament, medium polypeptide
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NGLY1 N-glycanase 1
NME5 NME/NM23 family member 5
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRP1 neuropilin 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PAPPA2 pappalysin 2
PARVB parvin, beta
PCDHA6 protocadherin alpha 6
PCDHGA8 protocadherin gamma subfamily A, 8
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB2 phospholipase C, beta 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRDM2 PR domain containing 2, with ZNF domain
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB3B RAB3B, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RAI2 retinoic acid induced 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RFXAP regulatory factor X-associated protein
RNGTT RNA guanylyltransferase and 5'-phosphatase
RSL1D1 ribosomal L1 domain containing 1
RTEL1 regulator of telomere elongation helicase 1
SCD5 stearoyl-CoA desaturase 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMIM14 small integral membrane protein 14
SPRED2 sprouty-related, EVH1 domain containing 2
SRD5A3 steroid 5 alpha-reductase 3
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
THOC5 THO complex 5
TIMELESS timeless circadian clock
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
UBQLN4 ubiquilin 4
ZBTB7A zinc finger and BTB domain containing 7A
ZMYND8 zinc finger, MYND-type containing 8
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD17B abhydrolase domain containing 17B
ACBD4 acyl-CoA binding domain containing 4
AFF4 AF4/FMR2 family, member 4
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BHLHE41 basic helix-loop-helix family, member e41
C17ORF80 chromosome 17 open reading frame 80
C21ORF91 chromosome 21 open reading frame 91
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
C7ORF69 chromosome 7 open reading frame 69
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CENPO centromere protein O
CLIC2 chloride intracellular channel 2
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CUZD1 CUB and zona pellucida-like domains 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNALI1 dynein, axonemal, light intermediate chain 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ELSPBP1 epididymal sperm binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EXOC5 exocyst complex component 5
FAM155A family with sequence similarity 155, member A
FAM46C family with sequence similarity 46, member C
FAM63A family with sequence similarity 63, member A
FEM1C fem-1 homolog c (C. elegans)
FGF23 fibroblast growth factor 23
FILIP1L filamin A interacting protein 1-like
FLJ21369 uncharacterized protein FLJ21369
FRS2 fibroblast growth factor receptor substrate 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HAMP hepcidin antimicrobial peptide
HDAC5 histone deacetylase 5
HIST1H2BN histone cluster 1, H2bn
HOXC8 homeobox C8
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICK intestinal cell (MAK-like) kinase
IMPAD1 inositol monophosphatase domain containing 1
IPO8 importin 8
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLF13 Kruppel-like factor 13
KPNA5 karyopherin alpha 5 (importin alpha 6)
KREMEN2 kringle containing transmembrane protein 2
KRT31 keratin 31, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC390998 ribosomal protein L10 pseudogene
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MRPL41 mitochondrial ribosomal protein L41
N4BP3 NEDD4 binding protein 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NEUROD1 neuronal differentiation 1
NOL10 nucleolar protein 10
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PEX26 peroxisomal biogenesis factor 26
POM121 POM121 transmembrane nucleoporin
POTEKP POTE ankyrin domain family, member K, pseudogene
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF39 ring finger protein 39
SAMD9 sterile alpha motif domain containing 9
SCML2 sex comb on midleg-like 2 (Drosophila)
SKI SKI proto-oncogene
SLC25A40 solute carrier family 25, member 40
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNTA1 syntrophin, alpha 1
SP1 Sp1 transcription factor
STRN striatin, calmodulin binding protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TEAD3 TEA domain family member 3
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TMPRSS2 transmembrane protease, serine 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNRC6B trinucleotide repeat containing 6B
TPRA1 transmembrane protein, adipocyte asscociated 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
USP20 ubiquitin specific peptidase 20
VASH2 vasohibin 2
VIM vimentin
WDR62 WD repeat domain 62
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF250 zinc finger protein 250
ZNF804A zinc finger protein 804A