PNU-120596 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/311434
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Genes

198 proteins with high or low expression in PNU-120596 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SNED1 sushi, nidogen and EGF-like domains 1 2.28
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 1.6
MCM9 minichromosome maintenance complex component 9 1.14
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 1.1
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 0.95
DNAAF2 dynein, axonemal, assembly factor 2 0.77
SOX4 SRY (sex determining region Y)-box 4 0.69
IQSEC2 IQ motif and Sec7 domain 2 0.68
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.65
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.65
CCNA1 cyclin A1 0.65
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.65
SYTL3 synaptotagmin-like 3 0.63
RPS13 ribosomal protein S13 0.62
CDKN3 cyclin-dependent kinase inhibitor 3 0.62
NAV3 neuron navigator 3 0.56
JPT1 Jupiter microtubule associated homolog 1 0.56
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.55
PIMREG PICALM interacting mitotic regulator 0.55
USP3 ubiquitin specific peptidase 3 0.55
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.54
KLHL21 kelch-like family member 21 0.53
REX1BD required for excision 1-B domain containing 0.53
BCL9 B-cell CLL/lymphoma 9 0.53
CINP cyclin-dependent kinase 2 interacting protein 0.53
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.52
DEPDC1 DEP domain containing 1 0.51
ZNF160 zinc finger protein 160 0.51
RAET1G retinoic acid early transcript 1G 0.5
ZMYM6 zinc finger, MYM-type 6 0.5
RFLNB refilin B 0.49
KITLG KIT ligand 0.49
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.48
TRAF5 TNF receptor-associated factor 5 0.48
SLC25A39 solute carrier family 25, member 39 0.47
KIF18B kinesin family member 18B 0.47
KMT5B lysine methyltransferase 5B 0.47
SNX10 sorting nexin 10 0.46
PRELID3B PRELI domain containing 3B 0.46
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 0.46
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.46
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.45
SDC1 syndecan 1 0.44
SLBP stem-loop binding protein 0.44
RNF166 ring finger protein 166 0.43
AP4M1 adaptor-related protein complex 4, mu 1 subunit 0.42
F3 coagulation factor III (thromboplastin, tissue factor) 0.42
SH2B1 SH2B adaptor protein 1 0.42
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 0.42
PSRC1 proline/serine-rich coiled-coil 1 0.41
M1AP meiosis 1 associated protein 0.41
DUOX1 dual oxidase 1 0.41
PRXL2C peroxiredoxin like 2C 0.41
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.4
TM2D3 TM2 domain containing 3 0.4
DIXDC1 DIX domain containing 1 0.4
ASB1 ankyrin repeat and SOCS box containing 1 0.39
KRIT1 KRIT1, ankyrin repeat containing 0.39
NQO2 NAD(P)H dehydrogenase, quinone 2 0.39
AZIN1 antizyme inhibitor 1 0.39
ZNF436 zinc finger protein 436 0.39
DCLRE1B DNA cross-link repair 1B 0.38
ITGB1BP1 integrin beta 1 binding protein 1 0.38
CFAP97 cilia and flagella associated protein 97 0.38
ZWINT ZW10 interacting kinetochore protein 0.37
FKBP7 FK506 binding protein 7 0.37
PCLAF PCNA clamp associated factor 0.37
PLD6 phospholipase D family, member 6 0.36
PROCR protein C receptor, endothelial 0.36
MARCHF7 membrane associated ring-CH-type finger 7 0.36
PLK2 polo-like kinase 2 0.36
HSF2 heat shock transcription factor 2 0.36
TNS3 tensin 3 0.36
PITX2 paired-like homeodomain 2 0.36
CDC6 cell division cycle 6 0.36
JDP2 Jun dimerization protein 2 0.36
AMDHD1 amidohydrolase domain containing 1 0.36
NMU neuromedin U 0.35
MAGEA6 melanoma antigen family A6 0.35
TANK TRAF family member-associated NFKB activator 0.35
NTAN1 N-terminal asparagine amidase 0.34
ZNF557 zinc finger protein 557 0.34
LSM10 LSM10, U7 small nuclear RNA associated 0.34
TTK TTK protein kinase 0.34
QSER1 glutamine and serine rich 1 0.34
HDDC2 HD domain containing 2 0.34
C12ORF66 chromosome 12 open reading frame 66 0.34
EFCAB7 EF-hand calcium binding domain 7 0.34
SPHK2 sphingosine kinase 2 0.33
DONSON downstream neighbor of SON 0.33
N4BP2L2 NEDD4 binding protein 2-like 2 0.33
ABHD17C abhydrolase domain containing 17C 0.33
NECTIN2 nectin cell adhesion molecule 2 0.33
FANCL Fanconi anemia, complementation group L 0.33
BORCS7 BLOC-1 related complex subunit 7 0.33
UBE2T ubiquitin-conjugating enzyme E2T 0.33
RUFY3 RUN and FYVE domain containing 3 0.33
TROAP trophinin associated protein 0.33
FCHSD2 FCH and double SH3 domains 2 0.32

low expression

Symbol Name Standardized Value
MDM1 Mdm1 nuclear protein homolog (mouse) -2.44
DNAH12 dynein, axonemal, heavy chain 12 -1.38
PIP prolactin-induced protein -0.83
FGFBP1 fibroblast growth factor binding protein 1 -0.8
TSPAN3 tetraspanin 3 -0.71
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.61
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.61
PARP12 poly (ADP-ribose) polymerase family, member 12 -0.59
PGPEP1 pyroglutamyl-peptidase I -0.58
DENND4A DENN/MADD domain containing 4A -0.58
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.56
H1-0 H1.0 linker histone -0.51
ADGRF1 adhesion G protein-coupled receptor F1 -0.5
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.46
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.45
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -0.43
C19ORF54 chromosome 19 open reading frame 54 -0.42
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.42
USP19 ubiquitin specific peptidase 19 -0.41
PIGO phosphatidylinositol glycan anchor biosynthesis, class O -0.4
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.4
SERINC5 serine incorporator 5 -0.39
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.38
ICAM5 intercellular adhesion molecule 5, telencephalin -0.38
CD63 CD63 molecule -0.38
CCDC88A coiled-coil domain containing 88A -0.37
TREX1 three prime repair exonuclease 1 -0.37
PUM2 pumilio RNA-binding family member 2 -0.35
TUBAL3 tubulin, alpha-like 3 -0.34
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -0.34
EPHA5 EPH receptor A5 -0.34
TMEM59 transmembrane protein 59 -0.33
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.33
CPOX coproporphyrinogen oxidase -0.33
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.31
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.31
PRMT6 protein arginine methyltransferase 6 -0.31
NDRG1 N-myc downstream regulated 1 -0.31
APOB apolipoprotein B -0.31
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.3
VTN vitronectin -0.3
TMSB10 thymosin beta 10 -0.3
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.3
SPEG SPEG complex locus -0.3
ATP13A2 ATPase type 13A2 -0.3
MB21D2 Mab-21 domain containing 2 -0.3
TXNRD1 thioredoxin reductase 1 -0.29
MEGF8 multiple EGF-like-domains 8 -0.29
FTL ferritin, light polypeptide -0.29
FAM133B family with sequence similarity 133, member B -0.28
TPPP tubulin polymerization promoting protein -0.28
PRG4 proteoglycan 4 -0.28
LAPTM4A lysosomal protein transmembrane 4 alpha -0.28
SPRED2 sprouty-related, EVH1 domain containing 2 -0.28
BTBD3 BTB (POZ) domain containing 3 -0.27
HM13 histocompatibility (minor) 13 -0.27
PKLR pyruvate kinase, liver and RBC -0.27
BAK1 BCL2-antagonist/killer 1 -0.27
ZNF740 zinc finger protein 740 -0.26
HAL histidine ammonia-lyase -0.26
PNPLA8 patatin-like phospholipase domain containing 8 -0.26
TMEM200A transmembrane protein 200A -0.26
CCDC158 coiled-coil domain containing 158 -0.26
ANGPTL4 angiopoietin-like 4 -0.26
NGLY1 N-glycanase 1 -0.26
SLC49A4 solute carrier family 49 member 4 -0.26
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.26
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -0.26
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.26
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 -0.26
F8 coagulation factor VIII, procoagulant component -0.26
SGSH N-sulfoglucosamine sulfohydrolase -0.26
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.25
SEC14L2 SEC14-like 2 (S. cerevisiae) -0.25
GDA guanine deaminase -0.25
FBXL15 F-box and leucine-rich repeat protein 15 -0.25
GTF2A2 general transcription factor IIA, 2, 12kDa -0.25
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.25
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.25
PRMT8 protein arginine methyltransferase 8 -0.25
MSLN mesothelin -0.25
ITM2C integral membrane protein 2C -0.24
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -0.24
CDK10 cyclin-dependent kinase 10 -0.24
NAXD NAD(P)HX dehydratase -0.24
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.24
GALE UDP-galactose-4-epimerase -0.24
LMBRD1 LMBR1 domain containing 1 -0.24
GPRASP2 G protein-coupled receptor associated sorting protein 2 -0.24
NLGN2 neuroligin 2 -0.23
PLPP3 phospholipid phosphatase 3 -0.23
G6PD glucose-6-phosphate dehydrogenase -0.23
HES1 hes family bHLH transcription factor 1 -0.23
CRIP2 cysteine-rich protein 2 -0.23
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.23
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.23
INHBA inhibin, beta A -0.23
ACP6 acid phosphatase 6, lysophosphatidic -0.23
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.23