| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | polymerase (DNA directed), epsilon, catalytic subunit|This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 5426) |
| External Link | https://ncbi.nlm.nih.gov/gene/5426 |
| Similar Terms | |
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499 genes differentially expressed following the POLE gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | 0.0312413 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0283703 |
| MX1 | MX dynamin-like GTPase 1 | 0.0224824 |
| IFI44L | interferon-induced protein 44-like | 0.0222923 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0210734 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0206733 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.018867 |
| RNF167 | ring finger protein 167 | 0.0181628 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0180986 |
| S100A9 | S100 calcium binding protein A9 | 0.0171775 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0165264 |
| IL32 | interleukin 32 | 0.0164475 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.0163122 |
| ATF3 | activating transcription factor 3 | 0.0162079 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.0154489 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0151944 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.015184 |
| S100A8 | S100 calcium binding protein A8 | 0.0151807 |
| S100A7 | S100 calcium binding protein A7 | 0.0150119 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.014688 |
| IFI44 | interferon-induced protein 44 | 0.0146299 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0144539 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0142034 |
| KRT14 | keratin 14, type I | 0.0141603 |
| DEFB1 | defensin, beta 1 | 0.0141326 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.0140866 |
| HSPA2 | heat shock 70kDa protein 2 | 0.0140479 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.0140166 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.0140101 |
| COG7 | component of oligomeric golgi complex 7 | 0.0139917 |
| GPX2 | glutathione peroxidase 2 | 0.0139583 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0139369 |
| LCN2 | lipocalin 2 | 0.0139145 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0137268 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0136445 |
| FCGBP | Fc fragment of IgG binding protein | 0.0136017 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.0134869 |
| TRIM22 | tripartite motif containing 22 | 0.0134765 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0132041 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0129201 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0128411 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0128405 |
| IL1RN | interleukin 1 receptor antagonist | 0.0126691 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0125884 |
| TCTA | T-cell leukemia translocation altered | 0.0125031 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0124811 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0124489 |
| XAF1 | XIAP associated factor 1 | 0.0124245 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.0123132 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0123038 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0121925 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.0121852 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.0121329 |
| KLK10 | kallikrein-related peptidase 10 | 0.0119813 |
| CSTA | cystatin A (stefin A) | 0.0119311 |
| PLBD1 | phospholipase B domain containing 1 | 0.0118025 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.0117888 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.0117227 |
| USP18 | ubiquitin specific peptidase 18 | 0.011691 |
| IFI35 | interferon-induced protein 35 | 0.0116821 |
| EGR2 | early growth response 2 | 0.0116737 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0116044 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.011437 |
| TRIM29 | tripartite motif containing 29 | 0.0114251 |
| TUBB2B | tubulin, beta 2B class IIb | 0.0114109 |
| CRYAB | crystallin, alpha B | 0.0114062 |
| RNASET2 | ribonuclease T2 | 0.0113187 |
| MX2 | MX dynamin-like GTPase 2 | 0.0112194 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0112164 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.0111319 |
| GPR137B | G protein-coupled receptor 137B | 0.0111289 |
| TSPAN8 | tetraspanin 8 | 0.0110793 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.0110641 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0110037 |
| PADI2 | peptidyl arginine deiminase, type II | 0.0109533 |
| OPTN | optineurin | 0.0109039 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.010903 |
| NCF2 | neutrophil cytosolic factor 2 | 0.0108225 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.0108191 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0107944 |
| AOC1 | amine oxidase, copper containing 1 | 0.0107461 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0107442 |
| ASS1 | argininosuccinate synthase 1 | 0.0107424 |
| CST7 | cystatin F (leukocystatin) | 0.0107391 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.0106563 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.0105443 |
| ANXA1 | annexin A1 | 0.0105176 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.0105167 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0104743 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.0104686 |
| SPRR1B | small proline-rich protein 1B | 0.0104106 |
| IRF9 | interferon regulatory factor 9 | 0.01041 |
| MAL | mal, T-cell differentiation protein | 0.0102816 |
| KLK11 | kallikrein-related peptidase 11 | 0.0102343 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.0101238 |
| C5AR1 | complement component 5a receptor 1 | 0.0100971 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.0100597 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0100564 |
| ECM1 | extracellular matrix protein 1 | 0.0100361 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.0100294 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0100271 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0100101 |
| KRT5 | keratin 5, type II | 0.0099984 |
| MMP10 | matrix metallopeptidase 10 | 0.00983895 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00981476 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00978513 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00977506 |
| CFI | complement factor I | 0.00972474 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00962548 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00959357 |
| SYNGR3 | synaptogyrin 3 | 0.00957109 |
| GPR65 | G protein-coupled receptor 65 | 0.00955544 |
| KRT1 | keratin 1, type II | 0.00951915 |
| GPM6B | glycoprotein M6B | 0.00950998 |
| KRT6A | keratin 6A, type II | 0.00948337 |
| GIMAP4 | GTPase, IMAP family member 4 | 0.00944455 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00938092 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00931267 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00929876 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.00928852 |
| SELENBP1 | selenium binding protein 1 | 0.00927083 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.00926143 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00924658 |
| SPRR2B | small proline-rich protein 2B | 0.00923792 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00911894 |
| LTF | lactotransferrin | 0.00909992 |
| KRT15 | keratin 15, type I | 0.00909544 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00909192 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00907318 |
| CD53 | CD53 molecule | 0.00902926 |
| SPRR3 | small proline-rich protein 3 | 0.00901897 |
| IRF7 | interferon regulatory factor 7 | 0.00900962 |
| MXRA7 | matrix-remodelling associated 7 | 0.00900791 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00898557 |
| GM2A | GM2 ganglioside activator | 0.00897976 |
| MVP | major vault protein | 0.00897393 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.00894679 |
| COCH | cochlin | 0.00893493 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00892002 |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.00891927 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00890581 |
| CTSS | cathepsin S | 0.00889959 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00889947 |
| THBD | thrombomodulin | 0.00884715 |
| MCAM | melanoma cell adhesion molecule | 0.00883177 |
| TADA2A | transcriptional adaptor 2A | 0.00882198 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00880905 |
| ATP10B | ATPase, class V, type 10B | 0.00880504 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00880296 |
| IL2RG | interleukin 2 receptor, gamma | 0.00879814 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00879251 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00879038 |
| MSN | moesin | 0.00878911 |
| CAPN3 | calpain 3, (p94) | 0.0087802 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.008777 |
| BLVRB | biliverdin reductase B | 0.00875347 |
| TMEM176B | transmembrane protein 176B | 0.00872851 |
| NKG7 | natural killer cell granule protein 7 | 0.00870173 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00869214 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | 0.00867051 |
| PRF1 | perforin 1 (pore forming protein) | 0.00865476 |
| HLA-B | major histocompatibility complex, class I, B | 0.00863538 |
| TMEM140 | transmembrane protein 140 | 0.00862542 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0086253 |
| SP110 | SP110 nuclear body protein | 0.00862111 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00861674 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00858204 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00857137 |
| FAR2 | fatty acyl CoA reductase 2 | 0.00856977 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00856468 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00856225 |
| C1S | complement component 1, s subcomponent | 0.0085582 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00854492 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00851318 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | 0.00845592 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00839064 |
| MYO1C | myosin IC | 0.00837656 |
| CFB | complement factor B | 0.00836526 |
| SLC22A18 | solute carrier family 22, member 18 | 0.00835731 |
| SLAMF7 | SLAM family member 7 | 0.00834386 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 0.00834233 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.00833369 |
| C3 | complement component 3 | 0.00829349 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00828091 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00826035 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00824444 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00824398 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 0.00820546 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.0082046 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00819461 |
| LAMA3 | laminin, alpha 3 | 0.00817703 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.00817 |
| TRIM16 | tripartite motif containing 16 | 0.00816746 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00813876 |
| PTHLH | parathyroid hormone-like hormone | 0.00812328 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00811893 |
| ADORA2B | adenosine A2b receptor | 0.00810141 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00809725 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00808495 |
| RCAN1 | regulator of calcineurin 1 | 0.00806479 |
| ETHE1 | ethylmalonic encephalopathy 1 | 0.00801009 |
| CD93 | CD93 molecule | 0.00801001 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.00800813 |
| JAG1 | jagged 1 | 0.00799816 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.00799382 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.00798477 |
| DENND1B | DENN/MADD domain containing 1B | 0.00795785 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.00792422 |
| IRF1 | interferon regulatory factor 1 | 0.00791853 |
| FSCN1 | fascin actin-bundling protein 1 | 0.00790644 |
| SPRR1A | small proline-rich protein 1A | 0.00790468 |
| FOSL2 | FOS-like antigen 2 | 0.0079026 |
| CH25H | cholesterol 25-hydroxylase | 0.00790176 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00789343 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.00789235 |
| CLCA2 | chloride channel accessory 2 | 0.00786694 |
| RRAD | Ras-related associated with diabetes | 0.0078615 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00784738 |
| OLFML3 | olfactomedin-like 3 | 0.00781898 |
| SYNPO | synaptopodin | 0.00779763 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00778673 |
| KLK13 | kallikrein-related peptidase 13 | 0.0077758 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.00776573 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00775354 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.00773488 |
| PRKCA | protein kinase C, alpha | 0.00773263 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00770937 |
| VEGFA | vascular endothelial growth factor A | 0.00769152 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00767507 |
| MMP12 | matrix metallopeptidase 12 | 0.00764706 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.00764368 |
| S100P | S100 calcium binding protein P | 0.00763845 |
| CLIC5 | chloride intracellular channel 5 | 0.00762479 |
| CLTB | clathrin, light chain B | 0.00761294 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00755293 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.0075492 |
| APOL6 | apolipoprotein L, 6 | 0.00754329 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00754018 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.007522 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.00751158 |
| KIFAP3 | kinesin-associated protein 3 | 0.00749907 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00746753 |
| GPI | glucose-6-phosphate isomerase | 0.00746243 |
| NEFH | neurofilament, heavy polypeptide | 0.00746069 |
| MMP1 | matrix metallopeptidase 1 | 0.00745596 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00744204 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.0074381 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 0.0074252 |
| IL2RB | interleukin 2 receptor, beta | 0.00742107 |
| KYNU | kynureninase | 0.0074017 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.031006 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0133135 |
| SLC38A1 | solute carrier family 38, member 1 | -0.012669 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.0123863 |
| TMSB15A | thymosin beta 15a | -0.0115565 |
| HOXC6 | homeobox C6 | -0.0115061 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.0112466 |
| CCNE2 | cyclin E2 | -0.0112005 |
| BAD | BCL2-associated agonist of cell death | -0.0110851 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.0106598 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0104832 |
| SDC2 | syndecan 2 | -0.010383 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.0103365 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0103276 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.0102599 |
| NPR3 | natriuretic peptide receptor 3 | -0.0102319 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0101035 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.0100199 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00940478 |
| NOTCH2 | notch 2 | -0.0093454 |
| EDRF1 | erythroid differentiation regulatory factor 1 | -0.00931172 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.00928528 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0092194 |
| PNN | pinin, desmosome associated protein | -0.00918339 |
| TNC | tenascin C | -0.0091704 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00914491 |
| APOB | apolipoprotein B | -0.00908941 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00908438 |
| TMEM165 | transmembrane protein 165 | -0.0090805 |
| APOA2 | apolipoprotein A-II | -0.00899372 |
| NNMT | nicotinamide N-methyltransferase | -0.00897218 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00893533 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00885103 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00877598 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00873854 |
| DGKZ | diacylglycerol kinase, zeta | -0.00867224 |
| C3ORF52 | chromosome 3 open reading frame 52 | -0.00860921 |
| EPCAM | epithelial cell adhesion molecule | -0.00856935 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.00835292 |
| CD1E | CD1e molecule | -0.00834165 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00828696 |
| HOMER2 | homer scaffolding protein 2 | -0.0082838 |
| PCP4 | Purkinje cell protein 4 | -0.00826021 |
| HHEX | hematopoietically expressed homeobox | -0.00817206 |
| MACROH2A1 | macroH2A.1 histone | -0.0081675 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00812851 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00804862 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.00796739 |
| COL2A1 | collagen, type II, alpha 1 | -0.00795932 |
| ATP5MG | ATP synthase membrane subunit g | -0.00795045 |
| CLGN | calmegin | -0.00794717 |
| FBXO5 | F-box protein 5 | -0.007939 |
| ODC1 | ornithine decarboxylase 1 | -0.00787178 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00785686 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00784093 |
| BEX1 | brain expressed, X-linked 1 | -0.00783907 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00783803 |
| APOC3 | apolipoprotein C-III | -0.00780385 |
| TMEM126B | transmembrane protein 126B | -0.00778523 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00777615 |
| KIF14 | kinesin family member 14 | -0.0077748 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.00775033 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.00774853 |
| THAP12 | THAP domain containing 12 | -0.00771299 |
| NEK2 | NIMA-related kinase 2 | -0.00766172 |
| ESR1 | estrogen receptor 1 | -0.00765526 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00764381 |
| MED23 | mediator complex subunit 23 | -0.00761908 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00761085 |
| H2AX | H2A.X variant histone | -0.00760257 |
| PRELID3B | PRELI domain containing 3B | -0.00758035 |
| THAP9-AS1 | THAP9 antisense RNA 1 | -0.00755537 |
| ATF1 | activating transcription factor 1 | -0.00746777 |
| DBF4 | DBF4 zinc finger | -0.00746244 |
| IFT57 | intraflagellar transport 57 | -0.00742847 |
| PDGFC | platelet derived growth factor C | -0.00740741 |
| FANCI | Fanconi anemia, complementation group I | -0.00739311 |
| LRP2 | low density lipoprotein receptor-related protein 2 | -0.00737782 |
| FASN | fatty acid synthase | -0.00736841 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00736222 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.00729638 |
| NPY | neuropeptide Y | -0.00726207 |
| EPHA4 | EPH receptor A4 | -0.00723029 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.00723005 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0072286 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00721943 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00721037 |
| KRT7 | keratin 7, type II | -0.00720736 |
| BRD2 | bromodomain containing 2 | -0.00717605 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.00716405 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | -0.0071509 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00714517 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00714072 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00711926 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00710991 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.00710811 |
| REV1 | REV1, polymerase (DNA directed) | -0.00709033 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.00708143 |
| COMMD8 | COMM domain containing 8 | -0.00707976 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00706812 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00706236 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00706075 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.0070565 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00702425 |
| GRK2 | G protein-coupled receptor kinase 2 | -0.00702015 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00701982 |
| TARDBP | TAR DNA binding protein | -0.00699652 |
| PRKCZ | protein kinase C, zeta | -0.00696706 |
| HPN | hepsin | -0.00695367 |
| TFAM | transcription factor A, mitochondrial | -0.00691907 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00689108 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00688385 |
| RWDD1 | RWD domain containing 1 | -0.00686333 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.00685401 |
| KLHL23 | kelch-like family member 23 | -0.00685008 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | -0.00684729 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | -0.00684631 |
| SC5D | sterol-C5-desaturase | -0.0068337 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00680778 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.00679396 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | -0.00678322 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00676625 |
| TMX1 | thioredoxin-related transmembrane protein 1 | -0.00676485 |
| SIKE1 | suppressor of IKBKE 1 | -0.00674625 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein | -0.0067383 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00673375 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | -0.006728 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.00670182 |
| FBXL14 | F-box and leucine-rich repeat protein 14 | -0.00669631 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.00669252 |
| NAXD | NAD(P)HX dehydratase | -0.00668811 |
| HEBP2 | heme binding protein 2 | -0.00668699 |
| NOTCH2NL | notch 2 N-terminal like | -0.00668495 |
| PGC | progastricsin (pepsinogen C) | -0.00668146 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00667537 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.00667396 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00667166 |
| AHSG | alpha-2-HS-glycoprotein | -0.00666884 |
| HOXB6 | homeobox B6 | -0.00666137 |
| HMGB2 | high mobility group box 2 | -0.00665544 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00665437 |
| APOA1 | apolipoprotein A-I | -0.00663312 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.00661231 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00659949 |
| NPTX2 | neuronal pentraxin II | -0.00656943 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.00653967 |
| CKAP2 | cytoskeleton associated protein 2 | -0.00653713 |
| PRDX3 | peroxiredoxin 3 | -0.00653637 |
| TSEN34 | TSEN34 tRNA splicing endonuclease subunit | -0.00652787 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00651244 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00647906 |
| UBP1 | upstream binding protein 1 (LBP-1a) | -0.0064694 |
| SLBP | stem-loop binding protein | -0.00646663 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.00645392 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00644082 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | -0.00642965 |
| E2F8 | E2F transcription factor 8 | -0.00641796 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00641128 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.00639579 |
| GOLGA8A | golgin A8 family, member A | -0.00637835 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00637559 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00636974 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.006359 |
| EFHC2 | EF-hand domain (C-terminal) containing 2 | -0.00635579 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | -0.00635456 |
| METTL3 | methyltransferase like 3 | -0.00634691 |
| TAF5 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | -0.00634313 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00630818 |
| ANXA10 | annexin A10 | -0.00629773 |
| PAX5 | paired box 5 | -0.00629026 |
| INSIG1 | insulin induced gene 1 | -0.00625544 |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | -0.00625211 |
| OVGP1 | oviductal glycoprotein 1, 120kDa | -0.00624186 |
| OIP5 | Opa interacting protein 5 | -0.00623546 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.00623439 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -0.00621547 |
| NUP58 | nucleoporin 58 | -0.00621491 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.0062132 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00620869 |
| CNNM3 | cyclin and CBS domain divalent metal cation transport mediator 3 | -0.00619899 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00619705 |
| BRINP2 | bone morphogenetic protein/retinoic acid inducible neural-specific 2 | -0.00619507 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | -0.00619095 |
| KIF20A | kinesin family member 20A | -0.00615347 |
| LMNB1 | lamin B1 | -0.00615128 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -0.00614805 |
| NCAPG | non-SMC condensin I complex, subunit G | -0.00614662 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00612864 |
| CHKA | choline kinase alpha | -0.00612524 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | -0.00612334 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00612318 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00609841 |
| CRIP2 | cysteine-rich protein 2 | -0.00609258 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.00607931 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.00607589 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | -0.00607153 |
| CNR1 | cannabinoid receptor 1 (brain) | -0.00606882 |
| USO1 | USO1 vesicle transport factor | -0.0060657 |
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | -0.00605385 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00605207 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00604924 |
| ZWINT | ZW10 interacting kinetochore protein | -0.00603837 |
| NXT2 | nuclear transport factor 2-like export factor 2 | -0.00603683 |
| TMEM38B | transmembrane protein 38B | -0.006034 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00601303 |
| CRYM | crystallin, mu | -0.00601035 |
| KATNA1 | katanin p60 (ATPase containing) subunit A 1 | -0.00600339 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | -0.00598415 |
| EFNB2 | ephrin-B2 | -0.00598367 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00597036 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00596829 |
| ARMT1 | acidic residue methyltransferase 1 | -0.0059611 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -0.00596105 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -0.00594758 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00593347 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00592336 |
| CEP55 | centrosomal protein 55kDa | -0.00591801 |
| PDZK1 | PDZ domain containing 1 | -0.00591306 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | -0.0059099 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.0059078 |
| KRT8 | keratin 8, type II | -0.0059016 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.00589087 |
| AURKA | aurora kinase A | -0.00588404 |
| NUP107 | nucleoporin 107kDa | -0.00587826 |
| IRX5 | iroquois homeobox 5 | -0.00587363 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | -0.00587229 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.00587221 |
| SHLD2 | shieldin complex subunit 2 | -0.00586902 |
| TWF1 | twinfilin actin binding protein 1 | -0.0058431 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.00583543 |
| FEN1 | flap structure-specific endonuclease 1 | -0.00582894 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.00582547 |
| LIMD2 | LIM domain containing 2 | -0.00582376 |
| HRASLS | HRAS-like suppressor | -0.00576651 |
| NXN | nucleoredoxin | -0.00575285 |
| PEX3 | peroxisomal biogenesis factor 3 | -0.00574705 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00574472 |
| TPH1 | tryptophan hydroxylase 1 | -0.00574312 |
| PRPF38B | pre-mRNA processing factor 38B | -0.00574284 |
| TPD52L1 | tumor protein D52-like 1 | -0.00573871 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.00573493 |
| MAGEB2 | melanoma antigen family B2 | -0.00570581 |
| GPC3 | glypican 3 | -0.00570498 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0057009 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00569308 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | -0.00569159 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.00568148 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00566783 |
| ANXA5 | annexin A5 | -0.00566008 |
