POLG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description polymerase (DNA directed), gamma|Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5428)
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Genes

339 genes differentially expressed following the POLG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ANKRD33 ankyrin repeat domain 33 2.74373
SIGLEC15 sialic acid binding Ig-like lectin 15 2.74373
VAX2 ventral anterior homeobox 2 2.74373
PPID peptidylprolyl isomerase D 2.74373
ACOX2 acyl-CoA oxidase 2, branched chain 2.74373
TLR6 toll-like receptor 6 2.74373
KCNIP3 Kv channel interacting protein 3, calsenilin 2.74373
CREG2 cellular repressor of E1A-stimulated genes 2 2.74373
MCHR1 melanin-concentrating hormone receptor 1 2.74373
NXNL1 nucleoredoxin-like 1 2.74373
PLIN4 perilipin 4 2.74373
POSTN periostin, osteoblast specific factor 2.74373
TMEM37 transmembrane protein 37 2.74373
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.74373
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.74373
LTB4R2 leukotriene B4 receptor 2 2.74373
SMYD1 SET and MYND domain containing 1 2.74373
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.74373
CTRC chymotrypsin C (caldecrin) 2.68588
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.68588
LIPN lipase, family member N 2.68588
CENPP centromere protein P 2.68588
ZNF501 zinc finger protein 501 2.68588
KLHL35 kelch-like family member 35 2.68588
HLX H2.0-like homeobox 2.68588
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.68588
PDILT protein disulfide isomerase-like, testis expressed 2.68588
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.68588
FABP9 fatty acid binding protein 9, testis 2.68588
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.68588
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.68588
RAB41 RAB41, member RAS oncogene family 2.68588
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.68588
ISM2 isthmin 2 2.68588
TSGA13 testis specific, 13 2.68588
HERPUD2 HERPUD family member 2 2.68588
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.68588
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.68588
OR1L6 olfactory receptor, family 1, subfamily L, member 6 2.68588
NPR3 natriuretic peptide receptor 3 2.68588
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.68588
CD68 CD68 molecule 2.68588
CRH corticotropin releasing hormone 2.68588
DLX4 distal-less homeobox 4 2.68588
S100A3 S100 calcium binding protein A3 2.68588
TAL1 T-cell acute lymphocytic leukemia 1 2.68588
LRG1 leucine-rich alpha-2-glycoprotein 1 2.68588
MGAM2 maltase-glucoamylase 2 (putative) 2.68588
HBA1 hemoglobin, alpha 1 2.68588
MILR1 mast cell immunoglobulin-like receptor 1 2.68588
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.68588
HES3 hes family bHLH transcription factor 3 2.68588
TMEM191B transmembrane protein 191B 2.68588
SKOR1 SKI family transcriptional corepressor 1 2.68588
FETUB fetuin B 2.68588
OLIG2 oligodendrocyte lineage transcription factor 2 2.68588
SIGLEC7 sialic acid binding Ig-like lectin 7 2.68588
S100A1 S100 calcium binding protein A1 2.68588
SPMAP1 sperm microtubule associated protein 1 2.68588
DEFB131B defensin beta 131B 2.68588
MSANTD5 Myb/SANT DNA binding domain containing 5 2.68588
FAM237B family with sequence similarity 237 member B 2.68588
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.68588
DEFB108B defensin, beta 108B 2.68588
CES4A carboxylesterase 4A 2.68588
TMOD3 tropomodulin 3 (ubiquitous) 2.68588
HAO2 hydroxyacid oxidase 2 (long chain) 2.68588
YIPF7 Yip1 domain family, member 7 2.68588
CFAP206 cilia and flagella associated protein 206 2.68588
GARIN3 golgi associated RAB2B interactor family member 3 2.68588
DORIP1 dopamine receptor interacting protein 1 2.68588
SPATA31H1 SPATA31 subfamily H member 1 2.68588
CIMIP4 ciliary microtubule inner protein 4 2.68588
FAM240C family with sequence similarity 240 member C 2.68588
DEFB109B defensin beta 109B 2.68588
SMIM45 small integral membrane protein 45 2.68588
AKR1C8 aldo-keto reductase family 1 member C8 2.68588
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.68588
TMEM225B transmembrane protein 225B 2.68588
AVPR1A arginine vasopressin receptor 1A 2.68588
SAA1 serum amyloid A1 2.68588
RAX2 retina and anterior neural fold homeobox 2 2.68588
LTK leukocyte receptor tyrosine kinase 2.68588
ACE2 angiotensin I converting enzyme 2 2.68588
LGSN lengsin, lens protein with glutamine synthetase domain 2.68588
GPR83 G protein-coupled receptor 83 2.68588
LRRC71 leucine rich repeat containing 71 2.68588
PTH parathyroid hormone 2.68588
SBSN suprabasin 2.68588
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.68588
GDF10 growth differentiation factor 10 2.68588
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.68588
SYT15 synaptotagmin XV 2.68588
HBG2 hemoglobin, gamma G 2.68588
OTOR otoraplin 2.68588
MLN motilin 2.68588
ACSL5 acyl-CoA synthetase long-chain family member 5 2.68588
PAPOLB poly(A) polymerase beta (testis specific) 2.68588
NBPF10 neuroblastoma breakpoint family, member 10 2.68588
SAG S-antigen; retina and pineal gland (arrestin) 2.68588
ZNF705G zinc finger protein 705G 2.68588
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.68588
BHLHA9 basic helix-loop-helix family, member a9 2.68588
GPR101 G protein-coupled receptor 101 2.68588
ZNF534 zinc finger protein 534 2.68588
ELANE elastase, neutrophil expressed 2.68588
TSPAN32 tetraspanin 32 2.68588
SPRN shadow of prion protein homolog (zebrafish) 2.68588
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.68588
PLA2G4E phospholipase A2, group IVE 2.68588
KRT16 keratin 16, type I 2.68588
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.68588
C18ORF63 chromosome 18 open reading frame 63 2.68588
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 2.68588
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.68588
TRIM29 tripartite motif containing 29 2.68588
HHIPL2 HHIP-like 2 2.68588
CARNS1 carnosine synthase 1 2.68588
NUTM2F NUT family member 2F 2.68588
TECRL trans-2,3-enoyl-CoA reductase-like 2.68588
PRRX1 paired related homeobox 1 2.68588
LPAR5 lysophosphatidic acid receptor 5 2.68588
CCL27 chemokine (C-C motif) ligand 27 2.68588
CRTAM cytotoxic and regulatory T cell molecule 2.68588
NTSR2 neurotensin receptor 2 2.68588
CERKL ceramide kinase-like 2.68588
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.68588
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.68588
GSTA2 glutathione S-transferase alpha 2 2.68588
PRSS33 protease, serine, 33 2.68588
PSG9 pregnancy specific beta-1-glycoprotein 9 2.68588
RGS8 regulator of G-protein signaling 8 2.68588
TCAP titin-cap 2.68588
CSF1R colony stimulating factor 1 receptor 2.68588
CLEC1A C-type lectin domain family 1, member A 2.68588
IL27 interleukin 27 2.68588
ZC3H12D zinc finger CCCH-type containing 12D 2.68588
TH tyrosine hydroxylase 2.68588
TBC1D10C TBC1 domain family, member 10C 2.68588
GLT1D1 glycosyltransferase 1 domain containing 1 2.68588
APOC2 apolipoprotein C-II 2.68588
IRGM immunity-related GTPase family, M 2.68588
SLC22A24 solute carrier family 22, member 24 2.68588
ZCCHC12 zinc finger, CCHC domain containing 12 2.68588
FAM135B family with sequence similarity 135, member B 2.68588
BSPH1 binder of sperm protein homolog 1 2.68588
TICRR TOPBP1-interacting checkpoint and replication regulator 2.68588
EOMES eomesodermin 2.68588
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.68588
C2ORF78 chromosome 2 open reading frame 78 2.68588
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.68588
SP6 Sp6 transcription factor 2.68588
ADRA1B adrenoceptor alpha 1B 2.68588
ASCL3 achaete-scute family bHLH transcription factor 3 2.68588
TPRX1 tetra-peptide repeat homeobox 1 2.68588
LOC105378220 macrophage receptor MARCO-like 2.68588
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.68588
NEUROD1 neuronal differentiation 1 2.68588
RTP4 receptor (chemosensory) transporter protein 4 2.68588
TSHZ1 teashirt zinc finger homeobox 1 2.68588
LGALS7 lectin, galactoside-binding, soluble, 7 2.68588
GRAP2 GRB2-related adaptor protein 2 2.68588
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.68588
FOXP3 forkhead box P3 2.68588
ATOH1 atonal homolog 1 (Drosophila) 2.68588
NLRP11 NLR family, pyrin domain containing 11 2.68588
LRRC31 leucine rich repeat containing 31 2.68588
TRPC5OS TRPC5 opposite strand 2.68588
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.68588
TCEAL5 transcription elongation factor A (SII)-like 5 2.68256
TPD52L1 tumor protein D52-like 1 2.67448
TMEM208 transmembrane protein 208 2.64824
SKP1 S-phase kinase-associated protein 1 2.64758
DOP1A DOP1 leucine zipper like protein A 2.64131
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.58431
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.57355
FLRT2 fibronectin leucine rich transmembrane protein 2 2.50943
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 2.50236
HMSD histocompatibility (minor) serpin domain containing 2.45502
TEP1 telomerase-associated protein 1 2.44725
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.40465
MR1 major histocompatibility complex, class I-related 2.40453
RNF39 ring finger protein 39 2.40453
MTERF3 mitochondrial transcription termination factor 3 2.40152
WDR64 WD repeat domain 64 2.39211
RERGL RERG/RAS-like 2.39211
FRMD4A FERM domain containing 4A 2.39211
LDHC lactate dehydrogenase C 2.38263
ZC3H15 zinc finger CCCH-type containing 15 2.36731
ADAM20 ADAM metallopeptidase domain 20 2.34242
PGM5 phosphoglucomutase 5 2.32944
MT1G metallothionein 1G 2.32473
PCYOX1 prenylcysteine oxidase 1 2.2944
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.2944
SLC35B1 solute carrier family 35, member B1 2.27224
CAAP1 caspase activity and apoptosis inhibitor 1 2.26768
NIPSNAP2 nipsnap homolog 2 2.26768
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.2622
SEPTIN8 septin 8 2.26011
KCTD9 potassium channel tetramerization domain containing 9 2.25128
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.24707
FXYD5 FXYD domain containing ion transport regulator 5 2.21036
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.20751
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 2.19524
HCFC1 host cell factor C1 2.18279
METTL13 methyltransferase like 13 2.16973
NATD1 N-acetyltransferase domain containing 1 2.16973
POU3F1 POU class 3 homeobox 1 2.16973
SNX29 sorting nexin 29 2.16242
DNAL4 dynein, axonemal, light chain 4 2.14932
DRC3 dynein regulatory complex subunit 3 2.14542
SRP9 signal recognition particle 9kDa 2.12207
RNF187 ring finger protein 187 2.11954
ECPAS Ecm29 proteasome adaptor and scaffold 2.07549
MRPS16 mitochondrial ribosomal protein S16 2.07501
TTC17 tetratricopeptide repeat domain 17 2.07451
RFT1 RFT1 homolog (S. cerevisiae) 2.04827
CUEDC2 CUE domain containing 2 2.04461
LCA5L Leber congenital amaurosis 5-like 2.03831
LRRC34 leucine rich repeat containing 34 2.03809
SFMBT2 Scm-like with four mbt domains 2 2.03441
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like 2.03117
NGLY1 N-glycanase 1 2.02882
E2F3 E2F transcription factor 3 2.02015
SRRM5 serine/arginine repetitive matrix 5 2.01164
DPF2 D4, zinc and double PHD fingers family 2 2.01164
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.00446

decreased expression

Symbol Name Standardized Value
CCDC177 coiled-coil domain containing 177 -2.74373
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.74373
PRRT1 proline-rich transmembrane protein 1 -2.74373
BMX BMX non-receptor tyrosine kinase -2.74373
GADL1 glutamate decarboxylase-like 1 -2.74373
DYDC1 DPY30 domain containing 1 -2.74373
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.74373
GTF2I general transcription factor IIi -2.74373
GNMT glycine N-methyltransferase -2.74373
GCKR glucokinase (hexokinase 4) regulator -2.74373
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.74373
SNAI2 snail family zinc finger 2 -2.74373
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.74373
TMEM151A transmembrane protein 151A -2.74373
BTNL2 butyrophilin-like 2 -2.68588
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.68588
COL8A2 collagen, type VIII, alpha 2 -2.68588
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.68588
CHERP calcium homeostasis endoplasmic reticulum protein -2.68588
MYOM3 myomesin 3 -2.68588
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.68588
ZNF804A zinc finger protein 804A -2.68588
ETV7 ets variant 7 -2.68588
DGKK diacylglycerol kinase, kappa -2.68588
ASGR2 asialoglycoprotein receptor 2 -2.68588
PSD2 pleckstrin and Sec7 domain containing 2 -2.68588
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -2.68588
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.68588
TGM1 transglutaminase 1 -2.68588
BIN2 bridging integrator 2 -2.68588
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.68588
NOX1 NADPH oxidase 1 -2.68588
MAP7 microtubule-associated protein 7 -2.68588
ARL13A ADP-ribosylation factor-like 13A -2.68588
CTSS cathepsin S -2.68588
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.68588
CFAP61 cilia and flagella associated protein 61 -2.68588
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 -2.68588
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -2.68588
PTH1R parathyroid hormone 1 receptor -2.68588
CNR2 cannabinoid receptor 2 (macrophage) -2.68588
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.68588
PRPF38A pre-mRNA processing factor 38A -2.68588
ZBTB20 zinc finger and BTB domain containing 20 -2.68588
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -2.68588
SKIDA1 SKI/DACH domain containing 1 -2.68588
NPFFR1 neuropeptide FF receptor 1 -2.68588
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.68588
RERE arginine-glutamic acid dipeptide (RE) repeats -2.68588
IL11 interleukin 11 -2.68588
NHLRC4 NHL repeat containing 4 -2.68588
DCDC2B doublecortin domain containing 2B -2.68588
ARMH4 armadillo like helical domain containing 4 -2.68588
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.68232
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.65409
CLDN15 claudin 15 -2.62919
CAPN3 calpain 3, (p94) -2.60399
CELA2B chymotrypsin-like elastase family, member 2B -2.58973
SPICP3 Spi-C transcription factor pseudogene 3 -2.58431
FAM222B family with sequence similarity 222, member B -2.57418
FNBP1L formin binding protein 1-like -2.57355
ARHGAP35 Rho GTPase activating protein 35 -2.56723
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.55206
RNF180 ring finger protein 180 -2.53627
ACBD4 acyl-CoA binding domain containing 4 -2.53627
WWC1 WW and C2 domain containing 1 -2.51961
C2ORF76 chromosome 2 open reading frame 76 -2.50915
MYO1B myosin IB -2.46533
WDR46 WD repeat domain 46 -2.45465
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.4145
FCGBP Fc fragment of IgG binding protein -2.39805
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.39805
C17ORF100 chromosome 17 open reading frame 100 -2.39805
CHMP4C charged multivesicular body protein 4C -2.37633
TNS1 tensin 1 -2.36881
SKIC3 SKI3 subunit of superkiller complex -2.36223
FANCC Fanconi anemia, complementation group C -2.34242
APOC1 apolipoprotein C-I -2.33571
EBPL emopamil binding protein-like -2.30441
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.30383
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.30017
CPN1 carboxypeptidase N, polypeptide 1 -2.27908
PCIF1 PDX1 C-terminal inhibiting factor 1 -2.27097
LEF1 lymphoid enhancer-binding factor 1 -2.26043
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.26043
PVR poliovirus receptor -2.24229
XPO6 exportin 6 -2.23344
BLCAP bladder cancer associated protein -2.19477
CCNB2 cyclin B2 -2.17929
INF2 inverted formin, FH2 and WH2 domain containing -2.16973
ADGRL3 adhesion G protein-coupled receptor L3 -2.16973
NCOA2 nuclear receptor coactivator 2 -2.16211
CNTNAP1 contactin associated protein 1 -2.15726
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.15089
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.13289
ACOT8 acyl-CoA thioesterase 8 -2.12744
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.09603
C5AR1 complement component 5a receptor 1 -2.09603
IER2 immediate early response 2 -2.09603
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.09603
ANKRD13D ankyrin repeat domain 13 family, member D -2.09195
ARF3 ADP-ribosylation factor 3 -2.09072
CANX calnexin -2.08686
RICTOR RPTOR independent companion of MTOR, complex 2 -2.07451
SAFB scaffold attachment factor B -2.05991
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.05925
FAM124A family with sequence similarity 124A -2.05422
CD164 CD164 molecule, sialomucin -2.04515
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -2.03831
EXO1 exonuclease 1 -2.02617
FGF2 fibroblast growth factor 2 (basic) -2.02015
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -2.00792