| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | proopiomelanocortin|This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 5443) |
| External Link | https://ncbi.nlm.nih.gov/gene/5443 |
| Similar Terms | |
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499 genes differentially expressed following the POMC gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHP1 | calcineurin-like EF-hand protein 1 | 0.0200719 |
| SCG5 | secretogranin V | 0.0184454 |
| TLCD3A | TLC domain containing 3A | 0.0168428 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.0163916 |
| TMSB15A | thymosin beta 15a | 0.0126603 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0125402 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0120358 |
| COMP | cartilage oligomeric matrix protein | 0.0119078 |
| PCP4 | Purkinje cell protein 4 | 0.0118148 |
| WT1 | Wilms tumor 1 | 0.0117896 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0112179 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.0111967 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0111335 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.010883 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0108117 |
| HMG20B | high mobility group 20B | 0.0107955 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0107559 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 0.0106775 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.0105844 |
| CDC20 | cell division cycle 20 | 0.010358 |
| FABP1 | fatty acid binding protein 1, liver | 0.0103344 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.0102421 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.0100763 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 0.0100234 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.0100088 |
| TSPYL5 | TSPY-like 5 | 0.00986391 |
| PENK | proenkephalin | 0.00962786 |
| BCHE | butyrylcholinesterase | 0.00946886 |
| PDE10A | phosphodiesterase 10A | 0.00932011 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00931488 |
| PEG3 | paternally expressed 3 | 0.00930393 |
| APOA1 | apolipoprotein A-I | 0.00929023 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.0092764 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.0091065 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00895122 |
| SFRP4 | secreted frizzled-related protein 4 | 0.00894666 |
| COL1A2 | collagen, type I, alpha 2 | 0.00890356 |
| TBL1X | transducin (beta)-like 1X-linked | 0.00871873 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00868016 |
| BRD4 | bromodomain containing 4 | 0.00866114 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00859864 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.00853787 |
| MGP | matrix Gla protein | 0.00850777 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.00847214 |
| LPIN2 | lipin 2 | 0.0084432 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00835481 |
| CLDN3 | claudin 3 | 0.00835058 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.00822573 |
| RESF1 | retroelement silencing factor 1 | 0.00816669 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00815238 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00813202 |
| SLBP | stem-loop binding protein | 0.00810167 |
| GOLIM4 | golgi integral membrane protein 4 | 0.00809142 |
| HELLS | helicase, lymphoid-specific | 0.00805896 |
| INSIG1 | insulin induced gene 1 | 0.00802924 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | 0.00799351 |
| RAPSN | receptor-associated protein of the synapse | 0.00782824 |
| MAGEA3 | melanoma antigen family A3 | 0.00782043 |
| TUBG1 | tubulin, gamma 1 | 0.00780838 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00780357 |
| E2F2 | E2F transcription factor 2 | 0.00780118 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00777945 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | 0.00776379 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 0.00772919 |
| GSPT2 | G1 to S phase transition 2 | 0.00772445 |
| SI | sucrase-isomaltase (alpha-glucosidase) | 0.00772249 |
| TRAPPC4 | trafficking protein particle complex 4 | 0.00770777 |
| WTAP | Wilms tumor 1 associated protein | 0.00769925 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.00769666 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00762922 |
| SAC3D1 | SAC3 domain containing 1 | 0.00759995 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00757537 |
| ARHGAP6 | Rho GTPase activating protein 6 | 0.00756752 |
| DACH1 | dachshund family transcription factor 1 | 0.00753931 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00753889 |
| CLCA1 | chloride channel accessory 1 | 0.00753459 |
| CD320 | CD320 molecule | 0.00752326 |
| MT1M | metallothionein 1M | 0.00749203 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00747497 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00742529 |
| PRKCA | protein kinase C, alpha | 0.00741447 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.00741444 |
| TYMS | thymidylate synthetase | 0.00737452 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00736842 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00734671 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.00734205 |
| GPR88 | G protein-coupled receptor 88 | 0.00731727 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00731399 |
| PTCH1 | patched 1 | 0.00731031 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.00728782 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00728536 |
| RAP2A | RAP2A, member of RAS oncogene family | 0.00727997 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 0.00727972 |
| COLEC12 | collectin sub-family member 12 | 0.00726787 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.00724505 |
| CCND2 | cyclin D2 | 0.00721956 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00720045 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.00719379 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.0071879 |
| TARP | TCR gamma alternate reading frame protein | 0.00714611 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00711712 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.0071153 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00711215 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00705584 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.0070556 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0070349 |
| MARCKSL1 | MARCKS-like 1 | 0.00698108 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | 0.00697904 |
| TBC1D16 | TBC1 domain family, member 16 | 0.00697011 |
| NSG1 | neuron specific gene family member 1 | 0.00695467 |
| HOXD1 | homeobox D1 | 0.00695033 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00691593 |
| NDP | Norrie disease (pseudoglioma) | 0.00690709 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00684828 |
| MYO5C | myosin VC | 0.00683786 |
| LOC283683 | uncharacterized LOC283683 | 0.00682058 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.00680347 |
| CD164 | CD164 molecule, sialomucin | 0.00677475 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase | 0.00672369 |
| BRD2 | bromodomain containing 2 | 0.00671531 |
| CBX5 | chromobox homolog 5 | 0.00671428 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00668008 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 0.00667617 |
| COL3A1 | collagen, type III, alpha 1 | 0.0066731 |
| ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif, 3 | 0.00666105 |
| H2AX | H2A.X variant histone | 0.00665811 |
| PLBD1 | phospholipase B domain containing 1 | 0.00664648 |
| ABAT | 4-aminobutyrate aminotransferase | 0.00660544 |
| TSPAN5 | tetraspanin 5 | 0.0066027 |
| CBS | cystathionine-beta-synthase | 0.00659967 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0065942 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 0.00659178 |
| PAEP | progestagen-associated endometrial protein | 0.00657704 |
| OLFM4 | olfactomedin 4 | 0.00657156 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00656615 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.00656314 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.00655139 |
| ITGB5 | integrin, beta 5 | 0.00653832 |
| NPY | neuropeptide Y | 0.00652571 |
| OIP5 | Opa interacting protein 5 | 0.00651802 |
| E2F3 | E2F transcription factor 3 | 0.00651413 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.00651014 |
| CIT | citron rho-interacting serine/threonine kinase | 0.00650414 |
| NDN | necdin, melanoma antigen (MAGE) family member | 0.00648253 |
| LBR | lamin B receptor | 0.00648122 |
| PRDX2 | peroxiredoxin 2 | 0.0064745 |
| KIF5B | kinesin family member 5B | 0.0064717 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00642855 |
| TSPYL1 | TSPY-like 1 | 0.00642033 |
| SFTPC | surfactant protein C | 0.0064145 |
| NDNF | neuron-derived neurotrophic factor | 0.00641197 |
| HEPH | hephaestin | 0.00640547 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.00640091 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00639041 |
| FBXO11 | F-box protein 11 | 0.00638604 |
| ATP5ME | ATP synthase membrane subunit e | 0.00635103 |
| CCDC47 | coiled-coil domain containing 47 | 0.00633658 |
| USP1 | ubiquitin specific peptidase 1 | 0.00631212 |
| SV2C | synaptic vesicle glycoprotein 2C | 0.00630707 |
| GSTT2 | glutathione S-transferase theta 2 (gene/pseudogene) | 0.00629089 |
| HMGB3 | high mobility group box 3 | 0.00627866 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 0.00627252 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00627212 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00627161 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.006256 |
| GOLM1 | golgi membrane protein 1 | 0.00624274 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.00621006 |
| CDC7 | cell division cycle 7 | 0.0062021 |
| PGLS | 6-phosphogluconolactonase | 0.00620182 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00616806 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | 0.00615551 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00614881 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.0061486 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00614073 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00613264 |
| MMP2 | matrix metallopeptidase 2 | 0.00611803 |
| PIMREG | PICALM interacting mitotic regulator | 0.00611574 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00611525 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.00611523 |
| KRT20 | keratin 20, type I | 0.00611314 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.00610697 |
| TMEM106C | transmembrane protein 106C | 0.00610599 |
| GEMIN4 | gem (nuclear organelle) associated protein 4 | 0.00609993 |
| SEC24D | SEC24 family member D | 0.0060618 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00604934 |
| PRKCZ | protein kinase C, zeta | 0.00604148 |
| SPG21 | spastic paraplegia 21 (autosomal recessive, Mast syndrome) | 0.00603412 |
| MAEA | macrophage erythroblast attacher | 0.00602637 |
| MSLN | mesothelin | 0.00601903 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.00601834 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00601034 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | 0.00599822 |
| MELK | maternal embryonic leucine zipper kinase | 0.00598008 |
| APOB | apolipoprotein B | 0.00597677 |
| DSC1 | desmocollin 1 | 0.00597242 |
| ABHD2 | abhydrolase domain containing 2 | 0.00596044 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.00595635 |
| PRKD1 | protein kinase D1 | 0.00594213 |
| LONP2 | lon peptidase 2, peroxisomal | 0.00593777 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 0.00593306 |
| FASTKD3 | FAST kinase domains 3 | 0.00591674 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00591538 |
| DPP4 | dipeptidyl-peptidase 4 | 0.00591271 |
| XYLT1 | xylosyltransferase I | 0.00591001 |
| YPEL1 | yippee-like 1 (Drosophila) | 0.00590619 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.00589092 |
| GUSB | glucuronidase, beta | 0.00588772 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.00588474 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00587276 |
| LRRC15 | leucine rich repeat containing 15 | 0.00587269 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00584907 |
| KIF20A | kinesin family member 20A | 0.00584781 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00584672 |
| TYRP1 | tyrosinase-related protein 1 | 0.00584464 |
| REV1 | REV1, polymerase (DNA directed) | 0.00583106 |
| NOTCH2 | notch 2 | 0.00582707 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 0.00582662 |
| CDK17 | cyclin-dependent kinase 17 | 0.00581958 |
| BGN | biglycan | 0.00581588 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.00580955 |
| THYN1 | thymocyte nuclear protein 1 | 0.00580604 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.00580229 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00579537 |
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 0.00579027 |
| RPA3 | replication protein A3, 14kDa | 0.00577574 |
| PRKCB | protein kinase C, beta | 0.00574601 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00574312 |
| ANO3 | anoctamin 3 | 0.00573782 |
| CSK | c-src tyrosine kinase | 0.00572033 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0057187 |
| KIF1A | kinesin family member 1A | 0.00570584 |
| DNMBP | dynamin binding protein | 0.00569332 |
| MFAP2 | microfibrillar-associated protein 2 | 0.00569034 |
| MINK1 | misshapen-like kinase 1 | 0.00568946 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00568602 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.0056846 |
| SUCO | SUN domain containing ossification factor | 0.0056835 |
| NEO1 | neogenin 1 | 0.00567647 |
| GABRA2 | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 0.00567587 |
| MATN2 | matrilin 2 | 0.0056713 |
| STK25 | serine/threonine kinase 25 | 0.00566599 |
| SERF2 | small EDRK-rich factor 2 | 0.00565522 |
| SMTN | smoothelin | 0.00565521 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.00564637 |
| THAP11 | THAP domain containing 11 | 0.00564518 |
| PLA2G12A | phospholipase A2, group XIIA | 0.00562608 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00562307 |
| NARF | nuclear prelamin A recognition factor | 0.00562284 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.0056179 |
| Symbol | Name | Standardized Value |
|---|---|---|
| S100A8 | S100 calcium binding protein A8 | -0.0290376 |
| CSTA | cystatin A (stefin A) | -0.0232482 |
| KRT5 | keratin 5, type II | -0.020049 |
| S100A9 | S100 calcium binding protein A9 | -0.0196639 |
| KRT6A | keratin 6A, type II | -0.0180613 |
| S100A7 | S100 calcium binding protein A7 | -0.0174827 |
| DEFB1 | defensin, beta 1 | -0.017431 |
| KRT14 | keratin 14, type I | -0.0172764 |
| KYNU | kynureninase | -0.0171528 |
| ADM | adrenomedullin | -0.0168741 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0161963 |
| S100A2 | S100 calcium binding protein A2 | -0.0161871 |
| KRT17 | keratin 17, type I | -0.0161722 |
| S100P | S100 calcium binding protein P | -0.016096 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0149815 |
| RB1 | retinoblastoma 1 | -0.0147042 |
| SPRR3 | small proline-rich protein 3 | -0.0145745 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0142099 |
| PERP | PERP, TP53 apoptosis effector | -0.0140983 |
| KRT13 | keratin 13, type I | -0.0139701 |
| KRT6B | keratin 6B, type II | -0.0138738 |
| KRT23 | keratin 23, type I | -0.0138574 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0133701 |
| COG7 | component of oligomeric golgi complex 7 | -0.0133609 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0133087 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.0132103 |
| KRT81 | keratin 81, type II | -0.0130633 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0129933 |
| RCAN1 | regulator of calcineurin 1 | -0.0126793 |
| SPRR1B | small proline-rich protein 1B | -0.0126556 |
| MYO1B | myosin IB | -0.0125982 |
| CAV2 | caveolin 2 | -0.0125907 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0125028 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0123633 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.0122566 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0122293 |
| LTF | lactotransferrin | -0.0121862 |
| TRIM29 | tripartite motif containing 29 | -0.0121724 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0121078 |
| KRT7 | keratin 7, type II | -0.0120286 |
| HIST1H2AC | histone cluster 1, H2ac | -0.0118684 |
| STC1 | stanniocalcin 1 | -0.0118377 |
| MAL | mal, T-cell differentiation protein | -0.0116859 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.0116237 |
| JAG1 | jagged 1 | -0.011607 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | -0.0114384 |
| RHCG | Rh family, C glycoprotein | -0.0113482 |
| IL1RN | interleukin 1 receptor antagonist | -0.0112723 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0111682 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0111242 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0109398 |
| GLUL | glutamate-ammonia ligase | -0.0106959 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0106912 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0106139 |
| CLCA2 | chloride channel accessory 2 | -0.0105562 |
| RGCC | regulator of cell cycle | -0.01051 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0104434 |
| EHBP1 | EH domain binding protein 1 | -0.0104138 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.010392 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.0103251 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.0102553 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.0102512 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0102337 |
| PLAU | plasminogen activator, urokinase | -0.0102079 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0101902 |
| PTHLH | parathyroid hormone-like hormone | -0.0101719 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0101237 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0100739 |
| KRT15 | keratin 15, type I | -0.0100632 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00996729 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00996155 |
| VSNL1 | visinin-like 1 | -0.0098892 |
| CLDN10 | claudin 10 | -0.00986261 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00983094 |
| POPDC3 | popeye domain containing 3 | -0.00975018 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00973515 |
| INHBB | inhibin, beta B | -0.00969616 |
| DSG3 | desmoglein 3 | -0.00966285 |
| CRYAB | crystallin, alpha B | -0.00963775 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00956299 |
| PLVAP | plasmalemma vesicle associated protein | -0.00949794 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00949582 |
| PITX1 | paired-like homeodomain 1 | -0.0094247 |
| SCEL | sciellin | -0.00939043 |
| RND3 | Rho family GTPase 3 | -0.00936925 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00936734 |
| FABP7 | fatty acid binding protein 7, brain | -0.00933939 |
| CSRP2 | cysteine and glycine-rich protein 2 | -0.00932632 |
| SPRR1A | small proline-rich protein 1A | -0.00926565 |
| C3 | complement component 3 | -0.00923894 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00923643 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00922873 |
| TRIM16 | tripartite motif containing 16 | -0.00921977 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00919163 |
| SDC1 | syndecan 1 | -0.00916916 |
| AREG | amphiregulin | -0.00916343 |
| IRF6 | interferon regulatory factor 6 | -0.00915297 |
| ATF3 | activating transcription factor 3 | -0.00910697 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00910479 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00908175 |
| CLCA4 | chloride channel accessory 4 | -0.00905729 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00902499 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.00899503 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0089598 |
| CCN2 | cellular communication network factor 2 | -0.00890022 |
| EGR1 | early growth response 1 | -0.0087196 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00868992 |
| TSPAN7 | tetraspanin 7 | -0.00866752 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00865774 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0086492 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00864821 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.00861599 |
| TP63 | tumor protein p63 | -0.0085731 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.00855955 |
| ANXA1 | annexin A1 | -0.00850315 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00850205 |
| ANXA2P2 | annexin A2 pseudogene 2 | -0.00847136 |
| CTSC | cathepsin C | -0.008441 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00842878 |
| SPRR2B | small proline-rich protein 2B | -0.00841136 |
| ZFP36 | ZFP36 ring finger protein | -0.00840994 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.00837596 |
| TPM2 | tropomyosin 2 (beta) | -0.00826903 |
| KLK10 | kallikrein-related peptidase 10 | -0.00826716 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00825549 |
| DUSP5 | dual specificity phosphatase 5 | -0.00824495 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00818352 |
| H1-2 | H1.2 linker histone, cluster member | -0.00811207 |
| MYOF | myoferlin | -0.00810092 |
| PALLD | palladin, cytoskeletal associated protein | -0.00809534 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00807397 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00806463 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00805004 |
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | -0.00803538 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00802261 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00801059 |
| NMD3 | NMD3 ribosome export adaptor | -0.00796873 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00796135 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00796066 |
| ABHD4 | abhydrolase domain containing 4 | -0.00792814 |
| MPO | myeloperoxidase | -0.00788975 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00788854 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00788215 |
| PSCA | prostate stem cell antigen | -0.00787442 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00785433 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.00785104 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.00784945 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00784391 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.00782771 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | -0.00779469 |
| IPO13 | importin 13 | -0.00775794 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00772153 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00767629 |
| DAXX | death-domain associated protein | -0.00766702 |
| EFHD1 | EF-hand domain family, member D1 | -0.00764716 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | -0.00761496 |
| IL1A | interleukin 1, alpha | -0.00759968 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00759125 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00756736 |
| CFD | complement factor D (adipsin) | -0.00754853 |
| TSPAN1 | tetraspanin 1 | -0.00748257 |
| STATH | statherin | -0.00744047 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00743676 |
| DUSP10 | dual specificity phosphatase 10 | -0.00743289 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00741708 |
| SLC25A46 | solute carrier family 25, member 46 | -0.00741356 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00741262 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.00740909 |
| MMP10 | matrix metallopeptidase 10 | -0.00739078 |
| ANXA2 | annexin A2 | -0.00737827 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | -0.00737565 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00736346 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | -0.00735889 |
| OPHN1 | oligophrenin 1 | -0.00734074 |
| KRT16 | keratin 16, type I | -0.00733572 |
| NEBL | nebulette | -0.00731776 |
| FHL1 | four and a half LIM domains 1 | -0.00727997 |
| GPR87 | G protein-coupled receptor 87 | -0.00725846 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00724871 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00723489 |
| TGFA | transforming growth factor, alpha | -0.00720157 |
| S100A14 | S100 calcium binding protein A14 | -0.00719647 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00719392 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.00716955 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.00715252 |
| KLF6 | Kruppel-like factor 6 | -0.00714779 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.00713703 |
| ITGB4 | integrin, beta 4 | -0.00708335 |
| LAMB3 | laminin, beta 3 | -0.00707826 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00706016 |
| PPL | periplakin | -0.00704687 |
| UBASH3A | ubiquitin associated and SH3 domain containing A | -0.00704445 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.00703766 |
| MMP12 | matrix metallopeptidase 12 | -0.00701322 |
| CDK14 | cyclin-dependent kinase 14 | -0.00700471 |
| PRTN3 | proteinase 3 | -0.00699437 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00696851 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0069641 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00693592 |
| MEIS1 | Meis homeobox 1 | -0.00692326 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.00692018 |
| CHGB | chromogranin B | -0.00691421 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00691389 |
| STC2 | stanniocalcin 2 | -0.00691239 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | -0.00687318 |
| ADA | adenosine deaminase | -0.00686253 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00684327 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00684248 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.00683985 |
| IL1B | interleukin 1, beta | -0.00683395 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00681551 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0067892 |
| ANXA3 | annexin A3 | -0.00675081 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0067255 |
| CES1 | carboxylesterase 1 | -0.00672239 |
| PHF11 | PHD finger protein 11 | -0.00671972 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00671896 |
| EMP1 | epithelial membrane protein 1 | -0.00671846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.00670796 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00668881 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00668345 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00667447 |
| ELANE | elastase, neutrophil expressed | -0.00667025 |
| XPO7 | exportin 7 | -0.00665747 |
| CANX | calnexin | -0.00665633 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00665319 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00664411 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00663707 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.00662997 |
| CALML3 | calmodulin-like 3 | -0.00662099 |
| PRNP | prion protein | -0.00660659 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00659707 |
| SIRPA | signal-regulatory protein alpha | -0.00658958 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0065856 |
| CNTN1 | contactin 1 | -0.00655168 |
| ZIC1 | Zic family member 1 | -0.00654983 |
| STOM | stomatin | -0.00654752 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.0065447 |
| AHSA1 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | -0.00652938 |
| AZU1 | azurocidin 1 | -0.00652275 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00652223 |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 | -0.00651385 |
| MED6 | mediator complex subunit 6 | -0.0065069 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00650155 |
| SLAMF7 | SLAM family member 7 | -0.0064923 |
| MXI1 | MAX interactor 1, dimerization protein | -0.00648628 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00647679 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00644073 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.00642748 |
| CRNN | cornulin | -0.00641493 |
