POU2F3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description POU class 2 homeobox 3|This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 25833)
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Genes

314 genes differentially expressed following the POU2F3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 4.24261
AZGP1 alpha-2-glycoprotein 1, zinc-binding 4.24261
SIRPB2 signal-regulatory protein beta 2 4.24261
TMEM191B transmembrane protein 191B 4.24261
GJA10 gap junction protein, alpha 10, 62kDa 4.24261
WT1 Wilms tumor 1 4.24261
LRRC53 leucine rich repeat containing 53 4.24261
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 4.24261
PAX3 paired box 3 4.24261
DDN dendrin 4.24261
PGBDF plakoglobin binding and degradation factor 4.24261
TM4SF1 transmembrane 4 L six family member 1 4.24261
VWA5B2 von Willebrand factor A domain containing 5B2 4.24261
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 4.24261
KLRK1 killer cell lectin-like receptor subfamily K, member 1 4.24261
HEATR9 HEAT repeat containing 9 4.24261
PLIN1 perilipin 1 4.24261
PRELP proline/arginine-rich end leucine-rich repeat protein 4.24261
GLUD2 glutamate dehydrogenase 2 4.24261
PRSS41 protease, serine, 41 4.24261
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 4.24261
OPRL1 opiate receptor-like 1 4.24261
TRIM73 tripartite motif containing 73 4.24261
PTK6 protein tyrosine kinase 6 4.24261
ACOT12 acyl-CoA thioesterase 12 4.24261
ASGR2 asialoglycoprotein receptor 2 4.24261
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 4.24261
THEMIS thymocyte selection associated 4.24261
RXRG retinoid X receptor, gamma 4.24261
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 4.24261
SLC10A5 solute carrier family 10, member 5 4.24261
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 4.24261
NPIPA3 nuclear pore complex interacting protein family, member A3 4.24261
TMEM121 transmembrane protein 121 4.24261
TRIM77 tripartite motif containing 77 4.24261
RFPL2 ret finger protein-like 2 4.24261
AVPR2 arginine vasopressin receptor 2 4.24261
TRPV5 transient receptor potential cation channel, subfamily V, member 5 4.24261
LY6G6F lymphocyte antigen 6 complex, locus G6F 4.24261
LCN12 lipocalin 12 4.24261
F2 coagulation factor II (thrombin) 4.24261
S100A1 S100 calcium binding protein A1 4.24261
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 4.24261
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 4.24261
LOC124906892 uncharacterized LOC124906892 4.24261
PTH1R parathyroid hormone 1 receptor 4.24261
C3AR1 complement component 3a receptor 1 4.24261
AVPR1A arginine vasopressin receptor 1A 4.24261
AVPR1B arginine vasopressin receptor 1B 4.24261
LTB4R2 leukotriene B4 receptor 2 4.24261
HBG2 hemoglobin, gamma G 4.24261
LOC124901449 uncharacterized LOC124901449 4.24261
CXCL13 chemokine (C-X-C motif) ligand 13 4.24261
TCIM transcriptional and immune response regulator 4.24261
DEPP1 DEPP autophagy regulator 1 4.24261
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 4.24261
PRR20G proline rich 20G 4.24261
CIMAP1C ciliary microtubule associated protein 1C 4.24261
SPAAR small regulatory polypeptide of amino acid response 4.24261
ACP7 acid phosphatase 7, tartrate resistant (putative) 4.24261
CIBAR2 CBY1 interacting BAR domain containing 2 4.24261
CFAP97D1 CFAP97 domain containing 1 4.24261
H2BC3 H2B clustered histone 3 4.24261
ALKAL1 ALK and LTK ligand 1 4.24261
HTRA4 HtrA serine peptidase 4 4.24261
FOXN4 forkhead box N4 4.24261
PDC phosducin 4.24261
NR1I3 nuclear receptor subfamily 1, group I, member 3 4.24261
CATSPER4 cation channel, sperm associated 4 4.24261
CBLN3 cerebellin 3 precursor 4.24261
CLDN9 claudin 9 4.24261
CFAP99 cilia and flagella associated protein 99 4.24261
CD300LG CD300 molecule-like family member g 4.24261
SCARA5 scavenger receptor class A, member 5 4.24261
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 4.24261
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 4.24261
FAM186A family with sequence similarity 186, member A 4.24261
CCR3 chemokine (C-C motif) receptor 3 4.24261
C20ORF202 chromosome 20 open reading frame 202 4.24261
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 4.24261
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 4.24261
WDR64 WD repeat domain 64 4.24261
FOXD4L5 forkhead box D4-like 5 4.24261
GPR83 G protein-coupled receptor 83 4.24261
PLEK2 pleckstrin 2 4.24261
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.24261
GJA5 gap junction protein, alpha 5, 40kDa 4.24261
IL23R interleukin 23 receptor 4.24261
CFH complement factor H 4.24261
C8ORF89 chromosome 8 open reading frame 89 4.24261
HOPX HOP homeobox 4.24261
VWA7 von Willebrand factor A domain containing 7 4.24261
CCL15 chemokine (C-C motif) ligand 15 4.24261
COX7B2 cytochrome c oxidase subunit VIIb2 4.24261
TTC9B tetratricopeptide repeat domain 9B 4.24261
WFDC8 WAP four-disulfide core domain 8 4.24261
SCML4 sex comb on midleg-like 4 (Drosophila) 4.24261
CTAGE9 CTAGE family, member 9 4.24261
C11ORF91 chromosome 11 open reading frame 91 4.24261
BTNL3 butyrophilin-like 3 4.24261
CERKL ceramide kinase-like 4.24261
RBMXL2 RNA binding motif protein, X-linked-like 2 4.24261
MR1 major histocompatibility complex, class I-related 4.24261
NIM1K NIM1 serine/threonine protein kinase 4.24261
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 4.24261
DUSP26 dual specificity phosphatase 26 (putative) 4.24261
KLK14 kallikrein-related peptidase 14 4.24261
EGR4 early growth response 4 4.24261
CCDC154 coiled-coil domain containing 154 4.24261
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 4.24261
GJC2 gap junction protein, gamma 2, 47kDa 4.24261
ZNF831 zinc finger protein 831 4.24261
CXORF49C chromosome X open reading frame 49C 4.24261
FAIM2 Fas apoptotic inhibitory molecule 2 4.24261
IGIP IgA-inducing protein 4.24261
LY6G6D lymphocyte antigen 6 complex, locus G6D 4.24261
LGALS14 lectin, galactoside-binding, soluble, 14 4.24261
ORM2 orosomucoid 2 4.24261
NCR3 natural cytotoxicity triggering receptor 3 4.24261
IDI2 isopentenyl-diphosphate delta isomerase 2 4.24261
PGR progesterone receptor 4.24261
GSTA1 glutathione S-transferase alpha 1 4.24261
SMIM17 small integral membrane protein 17 4.24261
TPPP2 tubulin polymerization-promoting protein family member 2 4.24261
RIPPLY2 ripply transcriptional repressor 2 4.24261
IGF2 insulin-like growth factor 2 4.24261
APOF apolipoprotein F 4.24261
TMIGD2 transmembrane and immunoglobulin domain containing 2 4.24261
PDCD1 programmed cell death 1 4.24261
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 4.24261
BANF2 barrier to autointegration factor 2 4.24261
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 4.24261
TBC1D28 TBC1 domain family, member 28 4.24261
NRGN neurogranin (protein kinase C substrate, RC3) 4.24261
MMEL1 membrane metallo-endopeptidase-like 1 4.24261
CLCNKA chloride channel, voltage-sensitive Ka 4.24261
WFDC10A WAP four-disulfide core domain 10A 4.24261
AOC3 amine oxidase, copper containing 3 4.24261
NLRP6 NLR family, pyrin domain containing 6 4.24261
CD226 CD226 molecule 4.24261
FGF10 fibroblast growth factor 10 4.24261
CABP5 calcium binding protein 5 4.24261
SMCO3 single-pass membrane protein with coiled-coil domains 3 4.24261
TIGIT T cell immunoreceptor with Ig and ITIM domains 4.24261
NGB neuroglobin 4.24261
COL11A2 collagen, type XI, alpha 2 4.24261
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 4.24261
FER1L6 fer-1-like family member 6 4.13967
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 3.77819
MYRF myelin regulatory factor 3.62426
S1PR1 sphingosine-1-phosphate receptor 1 3.61845
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 3.51439
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.3295
SLC31A2 solute carrier family 31 (copper transporter), member 2 3.0535
NPIPA6 nuclear pore complex interacting protein family, member A6 3.0535
MYH2 myosin, heavy chain 2, skeletal muscle, adult 3.0535
INSM1 insulinoma-associated 1 3.0535
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.0535
MEI1 meiosis inhibitor 1 3.0535
DOCK1 dedicator of cytokinesis 1 2.93754
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.888
LRP5 low density lipoprotein receptor-related protein 5 2.80319
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 2.80319
FIG4 FIG4 phosphoinositide 5-phosphatase 2.74618
SMYD3 SET and MYND domain containing 3 2.6196
NRBP2 nuclear receptor binding protein 2 2.57864
PRR11 proline rich 11 2.52268
CHMP4A charged multivesicular body protein 4A 2.4966
EFR3A EFR3 homolog A (S. cerevisiae) 2.49258
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 2.44719
CBY3 chibby homolog 3 (Drosophila) 2.43054
SPAG4 sperm associated antigen 4 2.43054
GPX8 glutathione peroxidase 8 (putative) 2.34878
TDRD5 tudor domain containing 5 2.32402
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.29909
RTN3 reticulon 3 2.29022
KCTD8 potassium channel tetramerization domain containing 8 2.28975
EEA1 early endosome antigen 1 2.28975
VWC2L von Willebrand factor C domain containing protein 2-like 2.27212
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 2.22563
SLCO1A2 solute carrier organic anion transporter family, member 1A2 2.22479
SP100 SP100 nuclear antigen 2.22162
GADL1 glutamate decarboxylase-like 1 2.22162
IPO5 importin 5 2.16537
TMEM242 transmembrane protein 242 2.1527
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.14078
GRB7 growth factor receptor-bound protein 7 2.14078
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.12207
ARL8B ADP-ribosylation factor-like 8B 2.12207
RCAN1 regulator of calcineurin 1 2.12207
NADK NAD kinase 2.12207
TMEM9 transmembrane protein 9 2.09066
EFCAB7 EF-hand calcium binding domain 7 2.07893
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.06149
CCHCR1 coiled-coil alpha-helical rod protein 1 2.0603
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 2.058
ZNF398 zinc finger protein 398 2.05567
STIMATE STIM activating enhancer 2.05207
CEBPZOS CEBPZ opposite strand 2.0327
OTUD7B OTU deubiquitinase 7B 2.01846
AGBL5 ATP/GTP binding protein-like 5 2.01789
MRPS11 mitochondrial ribosomal protein S11 2.01299
PHF8 PHD finger protein 8 2.01262
NAGA N-acetylgalactosaminidase, alpha- 2.01124

decreased expression

Symbol Name Standardized Value
PRDM1 PR domain containing 1, with ZNF domain -4.24261
ERVFRD-1 endogenous retrovirus group FRD, member 1 -4.24261
CD48 CD48 molecule -4.24261
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -4.24261
SACK1A scaffolding CK1 anchoring protein A -4.24261
C1QTNF1 C1q and tumor necrosis factor related protein 1 -4.24261
PRSS22 protease, serine, 22 -4.24261
GAB3 GRB2-associated binding protein 3 -4.24261
ALOX15 arachidonate 15-lipoxygenase -4.24261
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -4.24261
LGALS7B lectin, galactoside-binding, soluble, 7B -4.24261
PANO1 proapoptotic nucleolar protein 1 -4.24261
UPK3A uroplakin 3A -4.24261
LOX lysyl oxidase -4.24261
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -4.24261
KLHL35 kelch-like family member 35 -4.24261
PVRIG poliovirus receptor related immunoglobulin domain containing -4.24261
SLC51B solute carrier family 51, beta subunit -4.24261
LRRC61 leucine rich repeat containing 61 -4.24261
TTLL10 tubulin tyrosine ligase-like family member 10 -4.24261
SPINK1 serine peptidase inhibitor, Kazal type 1 -4.24261
CLRN1 clarin 1 -4.24261
CATSPERT catsper channel auxiliary subunit tau -4.24261
GBX1 gastrulation brain homeobox 1 -4.24261
ASB14 ankyrin repeat and SOCS box containing 14 -4.24261
PCDHAC1 protocadherin alpha subfamily C, 1 -4.24261
ITGB7 integrin, beta 7 -4.24261
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -4.24261
DMRT1 doublesex and mab-3 related transcription factor 1 -4.24261
FLACC1 flagellum associated containing coiled-coil domains 1 -4.24261
PDZD9 PDZ domain containing 9 -4.24261
UPK1A uroplakin 1A -4.24261
CXCR6 chemokine (C-X-C motif) receptor 6 -4.24261
TMPRSS6 transmembrane protease, serine 6 -4.24261
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -4.24261
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -4.24261
TMEM139 transmembrane protein 139 -4.24261
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -4.24261
PCDHA13 protocadherin alpha 13 -4.24261
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -4.23087
SH2D5 SH2 domain containing 5 -4.23087
FUNDC1 FUN14 domain containing 1 -4.0179
ZNF181 zinc finger protein 181 -3.75646
HHIPL1 HHIP-like 1 -3.75646
DGKI diacylglycerol kinase, iota -3.33661
CA7 carbonic anhydrase VII -3.21199
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.21199
IKZF1 IKAROS family zinc finger 1 (Ikaros) -3.21029
ZNF675 zinc finger protein 675 -3.17855
DDT D-dopachrome tautomerase -3.0535
IL6ST-DT IL6ST divergent transcript -3.01146
CFAP418 cilia and flagella associated protein 418 -3.01146
RBM46 RNA binding motif protein 46 -2.96816
IL17RD interleukin 17 receptor D -2.93754
SH3GL1 SH3-domain GRB2-like 1 -2.93442
GPHA2 glycoprotein hormone alpha 2 -2.82787
MRPL44 mitochondrial ribosomal protein L44 -2.74236
FNBP1 formin binding protein 1 -2.67751
SLC67A1 solute carrier family 67 member 1 -2.56703
RBBP9 retinoblastoma binding protein 9 -2.55912
NAIP NLR family, apoptosis inhibitory protein -2.51898
COL8A2 collagen, type VIII, alpha 2 -2.4966
SLC68A1 solute carrier family 68 member 1 -2.42581
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.40897
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 -2.40085
RNF135 ring finger protein 135 -2.38606
CASC3 cancer susceptibility candidate 3 -2.36778
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -2.3627
POLR1H RNA polymerase I subunit H -2.34878
TTI2 TELO2 interacting protein 2 -2.3202
HCST hematopoietic cell signal transducer -2.30126
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.29909
C2CD4D C2 calcium-dependent domain containing 4D -2.29909
CROT carnitine O-octanoyltransferase -2.29511
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.28975
CELA2B chymotrypsin-like elastase family, member 2B -2.28975
GIGYF2 GRB10 interacting GYF protein 2 -2.28975
CNN3 calponin 3, acidic -2.28975
DEUP1 deuterosome assembly protein 1 -2.28975
FGF16 fibroblast growth factor 16 -2.28975
CCDC69 coiled-coil domain containing 69 -2.27439
UBE2F ubiquitin-conjugating enzyme E2F (putative) -2.26139
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.25499
MOCS3 molybdenum cofactor synthesis 3 -2.2512
AKNA AT-hook transcription factor -2.23872
SFMBT1 Scm-like with four mbt domains 1 -2.23208
TXNDC17 thioredoxin domain containing 17 -2.22479
ADCY1 adenylate cyclase 1 (brain) -2.22349
TGOLN2 trans-golgi network protein 2 -2.22162
MMP2 matrix metallopeptidase 2 -2.20317
SCML1 sex comb on midleg-like 1 (Drosophila) -2.19081
MARCHF11 membrane associated ring-CH-type finger 11 -2.17373
DUSP4 dual specificity phosphatase 4 -2.17361
MLF2 myeloid leukemia factor 2 -2.14078
GRHL2 grainyhead-like 2 (Drosophila) -2.12207
CHRM2 cholinergic receptor, muscarinic 2 -2.10173
TINCR tissue differentiation-inducing non-protein coding RNA -2.09866
NEK11 NIMA-related kinase 11 -2.09836
TRIM22 tripartite motif containing 22 -2.07673
LONP1 lon peptidase 1, mitochondrial -2.04703
TSPAN15 tetraspanin 15 -2.04134
KIAA0319 KIAA0319 -2.03375
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.0327
ZNF256 zinc finger protein 256 -2.0327
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.0253
LASP1 LIM and SH3 protein 1 -2.01262
HNRNPA1L3 heterogeneous nuclear ribonucleoprotein A1 like 3 -2.01124
RWDD2A RWD domain containing 2A -2.01124
AKAP8 A kinase (PRKA) anchor protein 8 -2.01124
DAAM1 dishevelled associated activator of morphogenesis 1 -2.00281