POU3F3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description POU class 3 homeobox 3|This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 5455)
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Genes

343 genes differentially expressed following the POU3F3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RS1 retinoschisin 1 3.45436
GNLY granulysin 3.45436
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.45436
CD19 CD19 molecule 3.45436
IL22RA1 interleukin 22 receptor, alpha 1 3.45436
MILR1 mast cell immunoglobulin-like receptor 1 3.45436
ZNF467 zinc finger protein 467 3.45436
HYAL4 hyaluronoglucosaminidase 4 3.45436
RIMBP2 RIMS binding protein 2 3.45436
NOD2 nucleotide-binding oligomerization domain containing 2 3.45436
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.45436
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.45436
NAPSA napsin A aspartic peptidase 3.45436
MYBPHL myosin binding protein H-like 3.45436
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.45436
FPR1 formyl peptide receptor 1 3.45436
TBX20 T-box 20 3.45436
SCARA5 scavenger receptor class A, member 5 3.45436
WEE2 WEE1 homolog 2 (S. pombe) 3.45436
PDILT protein disulfide isomerase-like, testis expressed 3.45436
SBK3 SH3 domain binding kinase family, member 3 3.45436
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.45436
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.45436
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.45436
OSR2 odd-skipped related transciption factor 2 3.45436
ASB12 ankyrin repeat and SOCS box containing 12 3.45436
S100A5 S100 calcium binding protein A5 3.45436
HBB hemoglobin, beta 3.45436
KRT78 keratin 78, type II 3.45436
ATOH8 atonal homolog 8 (Drosophila) 3.45436
ADH6 alcohol dehydrogenase 6 (class V) 3.45436
MPL MPL proto-oncogene, thrombopoietin receptor 3.45436
LGALS9 lectin, galactoside-binding, soluble, 9 3.45436
CLEC14A C-type lectin domain family 14, member A 3.45436
GRP gastrin-releasing peptide 3.45436
KLLN killin, p53-regulated DNA replication inhibitor 3.45436
F2 coagulation factor II (thrombin) 3.45436
FABP12 fatty acid binding protein 12 3.45436
CPB1 carboxypeptidase B1 (tissue) 3.45436
SFXN3 sideroflexin 3 3.45436
UNC45B unc-45 homolog B (C. elegans) 3.45436
NRROS negative regulator of reactive oxygen species 3.45436
CXCL2 chemokine (C-X-C motif) ligand 2 3.45436
RAPSN receptor-associated protein of the synapse 3.45436
BHLHE40 basic helix-loop-helix family, member e40 3.45436
HCST hematopoietic cell signal transducer 3.45436
FSCN2 fascin actin-bundling protein 2, retinal 3.45436
MROH2B maestro heat-like repeat family member 2B 3.45436
TNS4 tensin 4 3.45436
ETV2 ets variant 2 3.45436
FAM240C family with sequence similarity 240 member C 3.45436
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.45436
VN1R2 vomeronasal 1 receptor 2 3.45436
MGAT4D MGAT4 family, member D 3.45436
KRT80 keratin 80, type II 3.45436
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 3.45436
TMPRSS7 transmembrane protease, serine 7 3.45436
TMPRSS4 transmembrane protease, serine 4 3.45436
MYEOV myeloma overexpressed 3.45436
ZNF441 zinc finger protein 441 3.45436
PCP4L1 Purkinje cell protein 4 like 1 3.45436
HTD2 hydroxyacyl-thioester dehydratase type 2 3.45436
SMIM38 small integral membrane protein 38 3.45436
CCN5 cellular communication network factor 5 3.45436
CPNE8-AS1 CPNE8 antisense RNA 1 3.45436
LOC124903372 uncharacterized LOC124903372 3.45436
H4C12 H4 clustered histone 12 3.45436
LHFPL7 LHFPL tetraspan subfamily member 7 3.45436
IHO1 interactor of HORMAD1 1 3.45436
TERB1 telomere repeat binding bouquet formation protein 1 3.45436
CFAP157 cilia and flagella associated protein 157 3.45436
CCDC190 coiled-coil domain containing 190 3.45436
RTL9 retrotransposon Gag like 9 3.45436
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.45436
GATA3 GATA binding protein 3 3.45436
OSTN osteocrin 3.45436
ZIC4 Zic family member 4 3.45436
UROC1 urocanate hydratase 1 3.45436
ZSWIM3 zinc finger, SWIM-type containing 3 3.45436
CHRD chordin 3.45436
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.45436
TRIM60 tripartite motif containing 60 3.45436
PTGDR2 prostaglandin D2 receptor 2 3.45436
C4ORF17 chromosome 4 open reading frame 17 3.45436
PTPRC protein tyrosine phosphatase, receptor type, C 3.45436
ACTL10 actin-like 10 3.45436
OVOL3 ovo-like zinc finger 3 3.45436
BHLHA9 basic helix-loop-helix family, member a9 3.45436
TBX3 T-box 3 3.45436
CSF1 colony stimulating factor 1 (macrophage) 3.45436
IL16 interleukin 16 3.45436
LGSN lengsin, lens protein with glutamine synthetase domain 3.45436
PNPLA1 patatin-like phospholipase domain containing 1 3.45436
BLNK B-cell linker 3.45436
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.45436
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.45436
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.45436
MYOT myotilin 3.45436
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.45436
IL12RB1 interleukin 12 receptor, beta 1 3.45436
ANKRD62 ankyrin repeat domain 62 3.45436
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.45436
C11ORF16 chromosome 11 open reading frame 16 3.45436
MEFV Mediterranean fever 3.45436
CLEC4D C-type lectin domain family 4, member D 3.45436
TRIM55 tripartite motif containing 55 3.45436
IRGM immunity-related GTPase family, M 3.45436
DRD2 dopamine receptor D2 3.45436
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.45436
HELT helt bHLH transcription factor 3.45436
F11 coagulation factor XI 3.45436
UBQLNL ubiquilin-like 3.45436
ZNF703 zinc finger protein 703 3.45436
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.45436
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.45436
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.45436
A3GALT2 alpha 1,3-galactosyltransferase 2 3.45436
ENDOU endonuclease, polyU-specific 3.45436
SEMG1 semenogelin I 3.45436
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.45436
GPR12 G protein-coupled receptor 12 3.45436
UTS2R urotensin 2 receptor 3.45436
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.45436
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.45436
ESPNL espin-like 3.45436
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 3.45436
CNR2 cannabinoid receptor 2 (macrophage) 3.45436
AGXT alanine-glyoxylate aminotransferase 3.45436
TEX29 testis expressed 29 3.45436
ZNF831 zinc finger protein 831 3.45436
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.45436
GOLGA8N golgin A8 family, member N 3.45436
ERVV-2 endogenous retrovirus group V, member 2 3.45436
MYLK2 myosin light chain kinase 2 3.45436
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.45436
LY96 lymphocyte antigen 96 3.45436
AICDA activation-induced cytidine deaminase 3.45436
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.45436
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.45436
PRSS33 protease, serine, 33 3.45436
ZIM2 zinc finger, imprinted 2 3.45436
SLC38A3 solute carrier family 38, member 3 3.45436
TRIM7 tripartite motif containing 7 3.45436
ITGAD integrin, alpha D 3.45436
XCR1 chemokine (C motif) receptor 1 3.45436
SNTN sentan, cilia apical structure protein 3.45436
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.45436
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 3.45436
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.45436
BIN2 bridging integrator 2 3.45436
C4BPA complement component 4 binding protein, alpha 3.45436
CIB3 calcium and integrin binding family member 3 3.45436
ICAM5 intercellular adhesion molecule 5, telencephalin 3.45436
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.45436
C5ORF46 chromosome 5 open reading frame 46 3.45436
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.45436
NLRP8 NLR family, pyrin domain containing 8 3.45436
RGPD5 RANBP2-like and GRIP domain containing 5 3.45436
TAS2R46 taste receptor, type 2, member 46 3.45436
CHAD chondroadherin 3.45436
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.45436
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.45436
FAM9C family with sequence similarity 9, member C 3.45436
PLA2G10 phospholipase A2, group X 3.45436
HIC1 hypermethylated in cancer 1 3.45436
CAMK1G calcium/calmodulin-dependent protein kinase IG 3.45436
TBC1D28 TBC1 domain family, member 28 3.45436
EPX eosinophil peroxidase 3.45436
RNASE6 ribonuclease, RNase A family, k6 3.45436
NWD1 NACHT and WD repeat domain containing 1 3.45436
PIKFYVE phosphoinositide kinase, FYVE finger containing 3.41814
TMPRSS11E transmembrane protease, serine 11E 3.41127
H4C11 H4 clustered histone 11 3.41127
PRKCZ protein kinase C, zeta 3.30878
BOK BCL2-related ovarian killer 3.19855
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like 2.97761
KPNA4 karyopherin alpha 4 (importin alpha 3) 2.94958
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.91285
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.91285
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.85591
COMMD7 COMM domain containing 7 2.81138
EFCAB5 EF-hand calcium binding domain 5 2.81094
MTMR9 myotubularin related protein 9 2.75099
KDM2B lysine (K)-specific demethylase 2B 2.73515
MROH1 maestro heat-like repeat family member 1 2.71035
WDR62 WD repeat domain 62 2.70203
FAT2 FAT atypical cadherin 2 2.69796
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 2.69446
TMEM132D transmembrane protein 132D 2.582
MCTP2 multiple C2 domains, transmembrane 2 2.5675
RANBP3 RAN binding protein 3 2.41466
ONECUT1 one cut homeobox 1 2.41466
COL6A6 collagen, type VI, alpha 6 2.41466
MSR1 macrophage scavenger receptor 1 2.41466
USP25 ubiquitin specific peptidase 25 2.41308
CRIP2 cysteine-rich protein 2 2.39342
PFN4 profilin family, member 4 2.3912
SFRP4 secreted frizzled-related protein 4 2.36167
LPXN leupaxin 2.30601
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.2844
CEP135 centrosomal protein 135kDa 2.2844
GPRIN3 GPRIN family member 3 2.2805
NRSN1 neurensin 1 2.27776
PRKG1 protein kinase, cGMP-dependent, type I 2.27335
DTNB dystrobrevin, beta 2.2673
NPTX2 neuronal pentraxin II 2.2673
NBPF26 neuroblastoma breakpoint family, member 26 2.25109
MPRIP myosin phosphatase Rho interacting protein 2.23927
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.20476
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.20476
MFSD11 major facilitator superfamily domain containing 11 2.19935
SMIM19 small integral membrane protein 19 2.19935
CFAP57 cilia and flagella associated protein 57 2.19935
ZNF493 zinc finger protein 493 2.19935
TMEM181 transmembrane protein 181 2.19768
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.18543
TPST2 tyrosylprotein sulfotransferase 2 2.17481
DNM1 dynamin 1 2.16193
WDR7 WD repeat domain 7 2.14822
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 2.09755
YEATS4 YEATS domain containing 4 2.08593
ST7 suppression of tumorigenicity 7 2.08593
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.08205
GRN granulin 2.04082
C16ORF95 chromosome 16 open reading frame 95 2.02284
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 2.00498

decreased expression

Symbol Name Standardized Value
H2BC21 H2B clustered histone 21 -3.45436
NABP1 nucleic acid binding protein 1 -3.45436
DPYD dihydropyrimidine dehydrogenase -3.45436
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -3.45436
SAMD14 sterile alpha motif domain containing 14 -3.45436
RPL18 ribosomal protein L18 -3.45436
CXCL14 chemokine (C-X-C motif) ligand 14 -3.45436
CORT cortistatin -3.45436
LIX1L Lix1 homolog (chicken) like -3.45436
PCDH17 protocadherin 17 -3.45436
IQCC IQ motif containing C -3.45436
C10ORF143 chromosome 10 open reading frame 143 -3.45436
VSTM2L V-set and transmembrane domain containing 2 like -3.45436
WDR24 WD repeat domain 24 -3.45436
MMP3 matrix metallopeptidase 3 -3.43402
GPR78 G protein-coupled receptor 78 -3.43402
ZMYND12 zinc finger, MYND-type containing 12 -3.43402
TMC8 transmembrane channel-like 8 -3.43402
ADAM33 ADAM metallopeptidase domain 33 -3.43402
NUTM2G NUT family member 2G -3.43402
MST1 macrophage stimulating 1 -3.43402
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -3.43402
ADAT3 adenosine deaminase, tRNA-specific 3 -3.43402
RGPD4 RANBP2-like and GRIP domain containing 4 -3.43402
TSKS testis-specific serine kinase substrate -3.43402
CLCNKA chloride channel, voltage-sensitive Ka -3.43402
MSC musculin -3.43402
TMEM150B transmembrane protein 150B -3.43402
TTC29 tetratricopeptide repeat domain 29 -3.43402
PLAC1 placenta-specific 1 -3.43402
ADGRG3 adhesion G protein-coupled receptor G3 -3.43402
ALX1 ALX homeobox 1 -3.43402
TMOD4 tropomodulin 4 (muscle) -3.43402
RORC RAR-related orphan receptor C -3.43402
CATSPERZ catsper channel auxiliary subunit zeta -3.43402
ABLIM3 actin binding LIM protein family, member 3 -3.43402
C20ORF204 chromosome 20 open reading frame 204 -3.43402
PDF peptide deformylase (mitochondrial) -3.43402
SPEF1 sperm flagellar 1 -3.43402
GJA9 gap junction protein, alpha 9, 59kDa -3.43402
RGS11 regulator of G-protein signaling 11 -3.43402
PARVG parvin, gamma -3.43402
RAB36 RAB36, member RAS oncogene family -3.43402
KLB klotho beta -3.43402
CD53 CD53 molecule -3.43402
MRAP melanocortin 2 receptor accessory protein -3.43402
DPPA3 developmental pluripotency associated 3 -3.43402
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -3.33841
SEC14L4 SEC14-like 4 (S. cerevisiae) -3.2944
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -3.2687
PAH phenylalanine hydroxylase -3.25515
ZMIZ2 zinc finger, MIZ-type containing 2 -3.23471
FUCA1 fucosidase, alpha-L- 1, tissue -3.09367
ACAD8 acyl-CoA dehydrogenase family, member 8 -3.07338
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) -2.88783
SBDS Shwachman-Bodian-Diamond syndrome -2.81094
BTF3 basic transcription factor 3 -2.7911
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.79046
RPLP2 ribosomal protein, large, P2 -2.77171
AMOT angiomotin -2.76483
PARD6A par-6 family cell polarity regulator alpha -2.73742
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.72968
ATG4B autophagy related 4B, cysteine peptidase -2.70203
PRDM14 PR domain containing 14 -2.66544
NEBL nebulette -2.64102
POLK polymerase (DNA directed) kappa -2.62542
MEAK7 MTOR associated protein, eak-7 homolog -2.61429
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.60731
RCE1 Ras converting CAAX endopeptidase 1 -2.59078
KIFBP kinesin family binding protein -2.5862
CALB2 calbindin 2 -2.51901
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -2.51901
DOCK4 dedicator of cytokinesis 4 -2.502
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.49358
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.49358
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.42492
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.41986
MOGS mannosyl-oligosaccharide glucosidase -2.41466
TMEM258 transmembrane protein 258 -2.41466
CCDC32 coiled-coil domain containing 32 -2.41466
SRRD SRR1 domain containing -2.39807
C5 complement component 5 -2.37863
SNAP23 synaptosomal-associated protein, 23kDa -2.34364
ANKRD44 ankyrin repeat domain 44 -2.32559
POU5F1 POU class 5 homeobox 1 -2.28012
NUP43 nucleoporin 43kDa -2.27335
PYCR1 pyrroline-5-carboxylate reductase 1 -2.27335
EIF4A1 eukaryotic translation initiation factor 4A1 -2.27335
H3C1 H3 clustered histone 1 -2.27218
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.27218
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.27218
DCDC2 doublecortin domain containing 2 -2.2673
DPH1 diphthamide biosynthesis 1 -2.2673
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.2673
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.25957
WDR89 WD repeat domain 89 -2.21149
CYCS cytochrome c, somatic -2.21149
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -2.20476
TAFA2 TAFA chemokine like family member 2 -2.19935
ABHD17C abhydrolase domain containing 17C -2.17326
WDR35 WD repeat domain 35 -2.16792
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -2.16792
S100PBP S100P binding protein -2.16687
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.16193
INTS8 integrator complex subunit 8 -2.11634
RPL29 ribosomal protein L29 -2.09282
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.08593
TIGD6 tigger transposable element derived 6 -2.08593
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.08593
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.07249
INO80D INO80 complex subunit D -2.06369
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.0495
RPL8 ribosomal protein L8 -2.04513
TMEM63B transmembrane protein 63B -2.04327
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.04082
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.01646
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.00498