POU3F4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description POU class 3 homeobox 4|This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012] (NCBI Entrez Gene Database, 5456)
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Genes

340 genes differentially expressed following the POU3F4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLHL35 kelch-like family member 35 2.85117
SH2D6 SH2 domain containing 6 2.85117
GSTM5 glutathione S-transferase mu 5 2.85117
GJA10 gap junction protein, alpha 10, 62kDa 2.85117
ZNF560 zinc finger protein 560 2.85117
AADACL3 arylacetamide deacetylase-like 3 2.85117
FFAR4 free fatty acid receptor 4 2.85117
SLC16A6 solute carrier family 16, member 6 2.85117
CEP295NL CEP295 N-terminal like 2.85117
SSTR5 somatostatin receptor 5 2.85117
FCRL5 Fc receptor-like 5 2.85117
CXORF65 chromosome X open reading frame 65 2.85117
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.85117
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.85117
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.85117
HLX H2.0-like homeobox 2.85117
INHBC inhibin, beta C 2.85117
NPPB natriuretic peptide B 2.85117
KNG1 kininogen 1 2.85117
IGFL2 IGF-like family member 2 2.85117
HEATR9 HEAT repeat containing 9 2.85117
ZNF467 zinc finger protein 467 2.85117
SOX14 SRY (sex determining region Y)-box 14 2.85117
MTERF1 mitochondrial transcription termination factor 1 2.85117
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.85117
OR8S1 olfactory receptor, family 8, subfamily S, member 1 2.85117
TRPC5OS TRPC5 opposite strand 2.85117
BMP5 bone morphogenetic protein 5 2.85117
CPLX3 complexin 3 2.85117
STAP1 signal transducing adaptor family member 1 2.85117
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.85117
PCDHGA11 protocadherin gamma subfamily A, 11 2.85117
TWIST1 twist family bHLH transcription factor 1 2.85117
PSD4 pleckstrin and Sec7 domain containing 4 2.85117
ABRA actin binding Rho activating protein 2.85117
GNRHR gonadotropin-releasing hormone receptor 2.85117
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.85117
ADAMTSL2 ADAMTS-like 2 2.85117
BAAT bile acid CoA:amino acid N-acyltransferase 2.85117
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.85117
LCN12 lipocalin 12 2.85117
UBA7 ubiquitin-like modifier activating enzyme 7 2.85117
ACTL7B actin-like 7B 2.85117
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.85117
MCOLN1 mucolipin 1 2.85117
TCP11 t-complex 11, testis-specific 2.85117
OC90 otoconin 90 2.85117
PITX1 paired-like homeodomain 1 2.85117
NRN1 neuritin 1 2.85117
CIMIP4 ciliary microtubule inner protein 4 2.85117
DIPK2B divergent protein kinase domain 2B 2.85117
LORICRIN loricrin cornified envelope precursor protein 2.85117
PYDC5 pyrin domain containing 5 2.85117
ALDOB aldolase B, fructose-bisphosphate 2.85117
PROP1 PROP paired-like homeobox 1 2.85117
GPX6 glutathione peroxidase 6 2.85117
GPX5 glutathione peroxidase 5 2.85117
AANAT aralkylamine N-acetyltransferase 2.85117
SRGN serglycin 2.85117
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.85117
RNF227 ring finger protein 227 2.85117
CBY2 chibby family member 2 2.85117
IRF2-DT IRF2 divergent transcript 2.85117
C1ORF232 chromosome 1 open reading frame 230 2.85117
OOSP4B oocyte secreted protein family member 4B 2.85117
H3C13 H3 clustered histone 13 2.85117
C20ORF204 chromosome 20 open reading frame 204 2.85117
MYMK myomaker, myoblast fusion factor 2.85117
LY6L lymphocyte antigen 6 family member L 2.85117
PEAK3 PEAK family member 3 2.85117
IQCN IQ motif containing N 2.85117
CFAP276 cilia and flagella associated protein 276 2.85117
SPMIP1 sperm microtubule inner protein 1 2.85117
PAPOLB poly(A) polymerase beta (testis specific) 2.85117
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.85117
SLC22A25 solute carrier family 22, member 25 2.85117
FOSL2 FOS-like antigen 2 2.85117
EDAR ectodysplasin A receptor 2.85117
ARL5C ADP-ribosylation factor-like 5C 2.85117
PRB4 proline-rich protein BstNI subfamily 4 2.85117
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.85117
PCDHA2 protocadherin alpha 2 2.85117
ACTL8 actin-like 8 2.85117
TAS2R31 taste receptor, type 2, member 31 2.85117
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.85117
C10ORF67 chromosome 10 open reading frame 67 2.85117
TMEM190 transmembrane protein 190 2.85117
KHDC1L KH homology domain containing 1-like 2.85117
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.85117
GATA3 GATA binding protein 3 2.85117
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 2.85117
NDP Norrie disease (pseudoglioma) 2.85117
RNF183 ring finger protein 183 2.85117
IL16 interleukin 16 2.85117
OOSP1 oocyte secreted protein 1, pseudogene 2.85117
SIM2 single-minded family bHLH transcription factor 2 2.85117
RAET1E retinoic acid early transcript 1E 2.85117
GFI1B growth factor independent 1B transcription repressor 2.85117
TDRD10 tudor domain containing 10 2.85117
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.85117
NPBWR1 neuropeptides B/W receptor 1 2.85117
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.85117
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.85117
CCDC27 coiled-coil domain containing 27 2.85117
DRD3 dopamine receptor D3 2.85117
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.85117
C17ORF99 chromosome 17 open reading frame 99 2.85117
TEX19 testis expressed 19 2.85117
TDRD15 tudor domain containing 15 2.85117
PRM1 protamine 1 2.85117
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.85117
CNTF ciliary neurotrophic factor 2.85117
RNF112 ring finger protein 112 2.85117
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.85117
EDN3 endothelin 3 2.85117
TNF tumor necrosis factor 2.85117
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.85117
AQP7 aquaporin 7 2.85117
CTAGE4 CTAGE family, member 4 2.85117
LCN1 lipocalin 1 2.85117
CHI3L2 chitinase 3-like 2 2.85117
KLK15 kallikrein-related peptidase 15 2.85117
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.85117
FAM151A family with sequence similarity 151, member A 2.85117
LMX1A LIM homeobox transcription factor 1, alpha 2.85117
C10ORF105 chromosome 10 open reading frame 105 2.85117
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.85117
TTC22 tetratricopeptide repeat domain 22 2.85117
ZNF831 zinc finger protein 831 2.85117
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.85117
LRRC24 leucine rich repeat containing 24 2.85117
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.85117
SPATA16 spermatogenesis associated 16 2.85117
LRRC25 leucine rich repeat containing 25 2.85117
KLK12 kallikrein-related peptidase 12 2.85117
RBBP8NL RBBP8 N-terminal like 2.85117
ZFP92 ZFP92 zinc finger protein 2.85117
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.85117
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.85117
ITGA11 integrin, alpha 11 2.85117
TPPP3 tubulin polymerization-promoting protein family member 3 2.85117
MORN5 MORN repeat containing 5 2.85117
PDCD1LG2 programmed cell death 1 ligand 2 2.85117
FCRLB Fc receptor-like B 2.85117
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.85117
FNDC8 fibronectin type III domain containing 8 2.85117
A3GALT2 alpha 1,3-galactosyltransferase 2 2.85117
PF4V1 platelet factor 4 variant 1 2.85117
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.85117
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.85117
FZD1 frizzled class receptor 1 2.85117
TGM4 transglutaminase 4 2.85117
TBC1D21 TBC1 domain family, member 21 2.85117
TGM3 transglutaminase 3 2.85117
ADRA1D adrenoceptor alpha 1D 2.85117
PRR15L proline rich 15-like 2.85117
CIB3 calcium and integrin binding family member 3 2.85117
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.85117
RNF224 ring finger protein 224 2.85117
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.85117
LST1 leukocyte specific transcript 1 2.85117
NKPD1 NTPase, KAP family P-loop domain containing 1 2.85117
MYOZ2 myozenin 2 2.85117
AOC1 amine oxidase, copper containing 1 2.85117
POTEJ POTE ankyrin domain family, member J 2.85117
NGF nerve growth factor (beta polypeptide) 2.85117
POPDC2 popeye domain containing 2 2.85117
NLRP9 NLR family, pyrin domain containing 9 2.85117
FOXG1 forkhead box G1 2.85117
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.85117
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.85117
TBPL2 TATA box binding protein like 2 2.85117
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.85117
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.85117
PCDHGB1 protocadherin gamma subfamily B, 1 2.85117
SAAL1 serum amyloid A-like 1 2.83314
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 2.80789
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.73211
NKD2 naked cuticle homolog 2 (Drosophila) 2.73211
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 2.70043
PEX3 peroxisomal biogenesis factor 3 2.68168
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 2.61759
TCF15 transcription factor 15 (basic helix-loop-helix) 2.60385
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.55141
TRIM8 tripartite motif containing 8 2.49488
FBXO10 F-box protein 10 2.49365
DNAI1 dynein, axonemal, intermediate chain 1 2.49155
VIPR1 vasoactive intestinal peptide receptor 1 2.48137
MBTD1 mbt domain containing 1 2.47553
GCLM glutamate-cysteine ligase, modifier subunit 2.4512
PRRT2 proline-rich transmembrane protein 2 2.39474
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.38757
DOLPP1 dolichyldiphosphatase 1 2.34618
ZGPAT zinc finger, CCCH-type with G patch domain 2.29729
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 2.29729
GLRX5 glutaredoxin 5 2.28776
RAB5IF RAB5 interacting factor 2.249
FRS3 fibroblast growth factor receptor substrate 3 2.24311
C2CD2L C2CD2-like 2.24311
USP28 ubiquitin specific peptidase 28 2.23401
DOK6 docking protein 6 2.2256
MORN2 MORN repeat containing 2 2.21921
TRAP1 TNF receptor-associated protein 1 2.1885
COL1A1 collagen, type I, alpha 1 2.18218
POU6F1 POU class 6 homeobox 1 2.17459
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.17148
ZNF514 zinc finger protein 514 2.16749
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 2.15659
NEBL nebulette 2.14309
ARHGAP28 Rho GTPase activating protein 28 2.13643
GRB2 growth factor receptor-bound protein 2 2.11969
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.0975
TSPAN18 tetraspanin 18 2.09101
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.06121
NFASC neurofascin 2.057
SDC2 syndecan 2 2.04307
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 2.0251
DUSP12 dual specificity phosphatase 12 2.01353
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.00805
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.00805
PITPNB phosphatidylinositol transfer protein, beta 2.00511

decreased expression

Symbol Name Standardized Value
ELF4 E74-like factor 4 (ets domain transcription factor) -2.85117
KCNIP3 Kv channel interacting protein 3, calsenilin -2.85117
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.85117
CORO6 coronin 6 -2.85117
GTSF1 gametocyte specific factor 1 -2.85117
HIC1 hypermethylated in cancer 1 -2.85117
SGCZ sarcoglycan, zeta -2.85117
ABHD15 abhydrolase domain containing 15 -2.85117
FRK fyn-related Src family tyrosine kinase -2.85117
NRG1 neuregulin 1 -2.85117
ICAM5 intercellular adhesion molecule 5, telencephalin -2.85117
RASD1 RAS, dexamethasone-induced 1 -2.85117
ZNF609 zinc finger protein 609 -2.85117
FSCN3 fascin actin-bundling protein 3, testicular -2.85117
TDRD3 tudor domain containing 3 -2.85117
TDRD1 tudor domain containing 1 -2.85117
HLF hepatic leukemia factor -2.85117
FNBP1 formin binding protein 1 -2.85117
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.85117
SMOC1 SPARC related modular calcium binding 1 -2.85117
COX7C cytochrome c oxidase subunit VIIc -2.85117
CLDN5 claudin 5 -2.85117
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.85117
TM4SF20 transmembrane 4 L six family member 20 -2.85117
CD48 CD48 molecule -2.85117
TMEM11 transmembrane protein 11 -2.85117
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.85117
FAM186A family with sequence similarity 186, member A -2.85117
MGAM maltase-glucoamylase -2.85117
RAG2 recombination activating gene 2 -2.85117
H2BC17 H2B clustered histone 17 -2.85117
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.85117
LOC122526780 uncharacterized LOC122526780 -2.85117
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.85117
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.85117
LRRC3 leucine rich repeat containing 3 -2.85117
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -2.85117
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.85117
SPMIP9 sperm microtubule inner protein 9 -2.85117
LGALS14 lectin, galactoside-binding, soluble, 14 -2.85117
GFY golgi-associated, olfactory signaling regulator -2.85117
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.85117
CFAP65 cilia and flagella associated protein 65 -2.85117
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.85117
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.85117
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.85117
PHF24 PHD finger protein 24 -2.85117
NGFR nerve growth factor receptor -2.76037
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -2.74583
STK26 serine/threonine protein kinase 26 -2.73461
TMEM278 transmembrane protein 278 -2.70043
NRIP2 nuclear receptor interacting protein 2 -2.70043
RGPD1 RANBP2-like and GRIP domain containing 1 -2.65745
CACFD1 calcium channel flower domain containing 1 -2.61832
CCAR1 cell division cycle and apoptosis regulator 1 -2.61758
RPL41 ribosomal protein L41 -2.61395
ZBTB18 zinc finger and BTB domain containing 18 -2.51367
ZNF416 zinc finger protein 416 -2.45629
TTC6 tetratricopeptide repeat domain 6 -2.45629
PRKCG protein kinase C, gamma -2.45629
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.45389
RAB12 RAB12, member RAS oncogene family -2.4512
SPART spartin -2.42063
SMAD4 SMAD family member 4 -2.38892
ANXA4 annexin A4 -2.36684
MZT2B mitotic spindle organizing protein 2B -2.36684
CLK2 CDC-like kinase 2 -2.35964
GTPBP2 GTP binding protein 2 -2.32755
TMOD2 tropomodulin 2 (neuronal) -2.31774
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.31039
BPTF bromodomain PHD finger transcription factor -2.30551
AGBL5 ATP/GTP binding protein-like 5 -2.29729
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -2.29647
OVCH2 ovochymase 2 (gene/pseudogene) -2.29647
HAPLN1 hyaluronan and proteoglycan link protein 1 -2.29647
SLC25A48 solute carrier family 25, member 48 -2.29607
ZNF574 zinc finger protein 574 -2.29475
WIPF1 WAS/WASL interacting protein family, member 1 -2.27476
RHOXF1 Rhox homeobox family, member 1 -2.27476
MOAP1 modulator of apoptosis 1 -2.25407
SESTD1 SEC14 and spectrin domains 1 -2.25239
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.24749
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.24749
FBXO6 F-box protein 6 -2.23348
ANO4 anoctamin 4 -2.21406
OMA1 OMA1 zinc metallopeptidase -2.20449
NBPF14 neuroblastoma breakpoint family, member 14 -2.19348
CDHR4 cadherin-related family member 4 -2.19348
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.18218
ZNF749 zinc finger protein 749 -2.18056
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.18044
ASB13 ankyrin repeat and SOCS box containing 13 -2.18044
TMEM263 transmembrane protein 263 -2.17459
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.17449
RBM46 RNA binding motif protein 46 -2.17449
PDCL2 phosducin-like 2 -2.17449
PKLR pyruvate kinase, liver and RBC -2.17449
COLEC11 collectin sub-family member 11 -2.14734
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 -2.14414
EXOSC1 exosome component 1 -2.14309
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -2.14309
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.13728
VEZT vezatin, adherens junctions transmembrane protein -2.10541
MSRB2 methionine sulfoxide reductase B2 -2.0975
PLAA phospholipase A2-activating protein -2.09606
MRAP2 melanocortin 2 receptor accessory protein 2 -2.08648
DYSF dysferlin -2.0771
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.06232
RPL27 ribosomal protein L27 -2.06121
PDS5A PDS5 cohesin associated factor A -2.06121
NELFE negative elongation factor complex member E -2.05423
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.05061
ATPSCKMT ATP synthase c subunit lysine N-methyltransferase -2.03925
ATP13A3 ATPase type 13A3 -2.03391
HEXB hexosaminidase B (beta polypeptide) -2.02963
CNGA1 cyclic nucleotide gated channel alpha 1 -2.0263
HMBOX1 homeobox containing 1 -2.02175
CATSPERQ catsper channel auxiliary subunit theta -2.01166
ZNF480 zinc finger protein 480 -2.00805