POU5F1 Gene Set

Dataset JASPAR Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description POU class 5 homeobox 1|This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] (NCBI Entrez Gene Database, 5460)
External Link http://www.ncbi.nlm.nih.gov/gene/5460
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5 target genes of the POU5F1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

Symbol Name
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
CCL28 chemokine (C-C motif) ligand 28
PRSS35 protease, serine, 35
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
VAMP7 vesicle-associated membrane protein 7