POU5F1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description POU class 5 homeobox 1|This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] (NCBI Entrez Gene Database, 5460)
External Link http://www.ncbi.nlm.nih.gov/gene/5460
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74 interacting proteins for POU5F1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTG1 actin gamma 1
AGR2 anterior gradient 2
AR androgen receptor
CAPNS1 calpain, small subunit 1
CETN2 centrin, EF-hand protein, 2
CTCF CCCTC-binding factor (zinc finger protein)
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF2 eukaryotic translation elongation factor 2
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF5B eukaryotic translation initiation factor 5B
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EWSR1 EWS RNA-binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FKBP7 FK506 binding protein 7
FOXD3 forkhead box D3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
HIST1H1T histone cluster 1, H1t
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
ITCH itchy E3 ubiquitin protein ligase
KDM6A lysine (K)-specific demethylase 6A
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT2 keratin 2, type II
KRT9 keratin 9, type I
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBD3 methyl-CpG binding domain protein 3
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCL nucleolin
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PURA purine-rich element binding protein A
PURB purine-rich element binding protein B
RAD23B RAD23 homolog B (S. cerevisiae)
RNF2 ring finger protein 2
RPL22 ribosomal protein L22
RPL24 ribosomal protein L24
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPS19 ribosomal protein S19
RPS23 ribosomal protein S23
RPS25 ribosomal protein S25
SALL4 spalt-like transcription factor 4
SETDB1 SET domain, bifurcated 1
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SOX8 SRY (sex determining region Y)-box 8
SRSF3 serine/arginine-rich splicing factor 3
SUMO1 small ubiquitin-like modifier 1
TRA2B transformer 2 beta homolog (Drosophila)
TRIM28 tripartite motif containing 28
TUBA1A tubulin, alpha 1a
TUBB4A tubulin, beta 4A class IVa
UBC ubiquitin C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
WDR5 WD repeat domain 5
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPC xeroderma pigmentosum, complementation group C
YBX1 Y box binding protein 1
ZNF143 zinc finger protein 143
ZNF281 zinc finger protein 281