PP 1 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/1400
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Genes

200 proteins with high or low expression in PP 1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.77
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.0
FOXC1 forkhead box C1 1.0
ABLIM2 actin binding LIM protein family, member 2 0.96
PPARG peroxisome proliferator-activated receptor gamma 0.87
TM7SF2 transmembrane 7 superfamily member 2 0.79
FAM219B family with sequence similarity 219, member B 0.79
ERBB3 erb-b2 receptor tyrosine kinase 3 0.77
RREB1 ras responsive element binding protein 1 0.73
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.72
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.7
DHRS1 dehydrogenase/reductase (SDR family) member 1 0.7
FBXL8 F-box and leucine-rich repeat protein 8 0.69
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.69
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.68
IFI35 interferon-induced protein 35 0.68
SIDT2 SID1 transmembrane family, member 2 0.67
FAAH fatty acid amide hydrolase 0.65
IDUA iduronidase, alpha-L- 0.64
OASL 2'-5'-oligoadenylate synthetase-like 0.64
DENND5B DENN/MADD domain containing 5B 0.63
FOXRED2 FAD-dependent oxidoreductase domain containing 2 0.62
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.61
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.6
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.6
TREX1 three prime repair exonuclease 1 0.6
TRIM2 tripartite motif containing 2 0.6
FZD7 frizzled class receptor 7 0.6
ZMYND19 zinc finger, MYND-type containing 19 0.59
LAMB1 laminin, beta 1 0.59
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.59
SKI SKI proto-oncogene 0.59
REPS2 RALBP1 associated Eps domain containing 2 0.58
MEGF8 multiple EGF-like-domains 8 0.58
AASS aminoadipate-semialdehyde synthase 0.57
ADCK5 aarF domain containing kinase 5 0.57
LIPH lipase, member H 0.57
GDF15 growth differentiation factor 15 0.57
MYO15B myosin XVB 0.57
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.57
NMI N-myc (and STAT) interactor 0.56
RBL2 retinoblastoma-like 2 0.56
LIX1L Lix1 homolog (chicken) like 0.56
COPRS coordinator of PRMT5, differentiation stimulator 0.55
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.55
TMEM179B transmembrane protein 179B 0.55
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.55
DUSP4 dual specificity phosphatase 4 0.55
CBR3 carbonyl reductase 3 0.55
COQ8A coenzyme Q8A 0.55
PGPEP1 pyroglutamyl-peptidase I 0.54
GALT galactose-1-phosphate uridylyltransferase 0.54
VWDE von Willebrand factor D and EGF domains 0.54
ZBTB4 zinc finger and BTB domain containing 4 0.54
RNASET2 ribonuclease T2 0.53
GRTP1 growth hormone regulated TBC protein 1 0.53
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.53
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.53
HDDC3 HD domain containing 3 0.53
RBKS ribokinase 0.53
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.53
DTX3L deltex 3 like, E3 ubiquitin ligase 0.53
SYTL1 synaptotagmin-like 1 0.52
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.52
LIMCH1 LIM and calponin homology domains 1 0.51
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 0.51
PBX3 pre-B-cell leukemia homeobox 3 0.51
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.51
C6ORF47 chromosome 6 open reading frame 47 0.51
CLDN3 claudin 3 0.5
GNPAT glyceronephosphate O-acyltransferase 0.5
ADD3 adducin 3 (gamma) 0.5
HECA headcase homolog (Drosophila) 0.5
CTSH cathepsin H 0.5
ADGRG6 adhesion G protein-coupled receptor G6 0.5
GRN granulin 0.5
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.5
PLCD1 phospholipase C, delta 1 0.5
KHK ketohexokinase (fructokinase) 0.49
HINFP histone H4 transcription factor 0.49
AMACR alpha-methylacyl-CoA racemase 0.49
ACSF2 acyl-CoA synthetase family member 2 0.49
CDK18 cyclin-dependent kinase 18 0.49
BCL3 B-cell CLL/lymphoma 3 0.48
ZNF226 zinc finger protein 226 0.48
GSTM4 glutathione S-transferase mu 4 0.48
ABAT 4-aminobutyrate aminotransferase 0.48
FBXL6 F-box and leucine-rich repeat protein 6 0.48
KDM4D lysine (K)-specific demethylase 4D 0.48
CNTNAP3 contactin associated protein-like 3 0.48
ISYNA1 inositol-3-phosphate synthase 1 0.48
ZBTB38 zinc finger and BTB domain containing 38 0.48
EPHX2 epoxide hydrolase 2, cytoplasmic 0.48
CASKIN1 CASK interacting protein 1 0.47
ADPRH ADP-ribosylarginine hydrolase 0.47
CES3 carboxylesterase 3 0.47
PDLIM3 PDZ and LIM domain 3 0.47
BMP8A bone morphogenetic protein 8a 0.47
CUL7 cullin 7 0.47

low expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.23
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -1.12
KLF2 Kruppel-like factor 2 -0.98
RHOBTB3 Rho-related BTB domain containing 3 -0.91
IFRD1 interferon-related developmental regulator 1 -0.9
TMEM67 transmembrane protein 67 -0.86
SESN2 sestrin 2 -0.81
STC2 stanniocalcin 2 -0.81
F3 coagulation factor III (thromboplastin, tissue factor) -0.78
ANKRD10 ankyrin repeat domain 10 -0.78
SPRY4 sprouty homolog 4 (Drosophila) -0.75
PRKCH protein kinase C, eta -0.74
PTPDC1 protein tyrosine phosphatase domain containing 1 -0.71
MFAP3 microfibrillar-associated protein 3 -0.7
CLN3 ceroid-lipofuscinosis, neuronal 3 -0.66
FOSL2 FOS-like antigen 2 -0.66
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.66
ENO1 enolase 1, (alpha) -0.64
ONECUT2 one cut homeobox 2 -0.63
CPA4 carboxypeptidase A4 -0.63
MICA MHC class I polypeptide-related sequence A -0.62
SLC38A2 solute carrier family 38, member 2 -0.62
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -0.62
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -0.61
JUNB jun B proto-oncogene -0.61
LAMB3 laminin, beta 3 -0.61
FAR1 fatty acyl CoA reductase 1 -0.6
ZNF675 zinc finger protein 675 -0.6
IFFO2 intermediate filament family orphan 2 -0.59
SLC38A1 solute carrier family 38, member 1 -0.58
KIF1B kinesin family member 1B -0.58
ZNF711 zinc finger protein 711 -0.57
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.57
NDFIP2 Nedd4 family interacting protein 2 -0.57
FITM2 fat storage-inducing transmembrane protein 2 -0.56
MFAP3L microfibrillar-associated protein 3-like -0.55
UBE2S ubiquitin-conjugating enzyme E2S -0.55
KCTD12 potassium channel tetramerization domain containing 12 -0.55
NAGS N-acetylglutamate synthase -0.55
PROS1 protein S (alpha) -0.54
NAV3 neuron navigator 3 -0.54
BAIAP2 BAI1-associated protein 2 -0.54
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.53
AEN apoptosis enhancing nuclease -0.53
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.53
PLK1 polo-like kinase 1 -0.53
KLHL18 kelch-like family member 18 -0.51
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.51
VSIR V-set immunoregulatory receptor -0.5
GAS6 growth arrest-specific 6 -0.5
SH3RF1 SH3 domain containing ring finger 1 -0.5
PSAT1 phosphoserine aminotransferase 1 -0.5
AXL AXL receptor tyrosine kinase -0.5
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.49
BCAR3 breast cancer anti-estrogen resistance 3 -0.49
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.49
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.49
ZNF689 zinc finger protein 689 -0.48
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.48
PLIN2 perilipin 2 -0.48
WSB2 WD repeat and SOCS box containing 2 -0.48
TUBE1 tubulin, epsilon 1 -0.48
CCN1 cellular communication network factor 1 -0.47
NFE2L3 nuclear factor, erythroid 2-like 3 -0.47
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -0.47
PER1 period circadian clock 1 -0.46
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -0.46
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.46
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.46
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.46
ZNF169 zinc finger protein 169 -0.46
MID1IP1 MID1 interacting protein 1 -0.45
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.45
GLI2 GLI family zinc finger 2 -0.45
TGFB1 transforming growth factor, beta 1 -0.45
PER2 period circadian clock 2 -0.45
KMT5A lysine methyltransferase 5A -0.45
ZFYVE28 zinc finger, FYVE domain containing 28 -0.44
PRICKLE3 prickle homolog 3 (Drosophila) -0.44
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -0.43
ZCCHC2 zinc finger, CCHC domain containing 2 -0.43
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.43
VCAN versican -0.43
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.43
CEP295 centrosomal protein 295kDa -0.43
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -0.42
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.42
ZNF160 zinc finger protein 160 -0.42
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.42
UCK1 uridine-cytidine kinase 1 -0.42
BAK1 BCL2-antagonist/killer 1 -0.42
KLF10 Kruppel-like factor 10 -0.42
HLA-E major histocompatibility complex, class I, E -0.42
IER2 immediate early response 2 -0.42
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.42
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.42
CDC25B cell division cycle 25B -0.41
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.41
SMTN smoothelin -0.41
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.41