PP-242 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

67 genes differentially expressed following the PP-242 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
FXR1 fragile X mental retardation, autosomal homolog 1 4.97467
CUL4B cullin 4B 4.18473
TCEA2 transcription elongation factor A (SII), 2 3.9194
CCHCR1 coiled-coil alpha-helical rod protein 1 3.84599
TTLL3 tubulin tyrosine ligase-like family member 3 3.72361
IGBP1 immunoglobulin (CD79A) binding protein 1 3.72271
RPL32 ribosomal protein L32 3.67743
POLR1HASP POLR1H antisense, pseudogene 3.66107
ZCWPW1 zinc finger, CW type with PWWP domain 1 3.62879
SNHG32 small nucleolar RNA host gene 32 3.59452
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 3.54733
CAMLG calcium modulating ligand 3.50149
RPL13A ribosomal protein L13a 3.48788
TESMIN testis expressed metallothionein like protein 3.47558
EIF3F eukaryotic translation initiation factor 3, subunit F 3.4633
PPIEL peptidylprolyl isomerase E-like pseudogene 3.46138
RPL19 ribosomal protein L19 3.45358
ZNF83 zinc finger protein 83 3.44991
RPL10L ribosomal protein L10-like 3.38201
RPS5 ribosomal protein S5 3.38129
HSPA1L heat shock 70kDa protein 1-like 3.36578
ARL4D ADP-ribosylation factor-like 4D 3.35058
DNAI4 dynein axonemal intermediate chain 4 3.33019
HEATR1 HEAT repeat containing 1 3.32283
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 3.3209
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 3.29492
LETMD1 LETM1 domain containing 1 3.26044
RPL38 ribosomal protein L38 3.21803
RPL3 ribosomal protein L3 3.21419
AMT aminomethyltransferase 3.20533
NPEPL1 aminopeptidase-like 1 3.20249
EIF4B eukaryotic translation initiation factor 4B 3.19704
GRK4 G protein-coupled receptor kinase 4 3.18388
RPS9 ribosomal protein S9 3.17334
RPL31 ribosomal protein L31 3.16868
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 3.1192
SYF2 SYF2 pre-mRNA-splicing factor 3.09361
ZNF135 zinc finger protein 135 3.08991
R3HDM2 R3H domain containing 2 3.08737
RPL34 ribosomal protein L34 3.06772
CDKN2AIP CDKN2A interacting protein 3.05081
SAP18 Sin3A-associated protein, 18kDa 3.04755
RPL13 ribosomal protein L13 3.02431

decreased expression

Symbol Name Standardized Value
GLRX2 glutaredoxin 2 -4.23409
PREB prolactin regulatory element binding -4.10396
GYG1 glycogenin 1 -3.63108
TUBG1 tubulin, gamma 1 -3.5876
HES1 hes family bHLH transcription factor 1 -3.41427
SOX10 SRY (sex determining region Y)-box 10 -3.38289
C11ORF24 chromosome 11 open reading frame 24 -3.38227
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -3.36795
UBIAD1 UbiA prenyltransferase domain containing 1 -3.34235
APOB apolipoprotein B -3.34196
MSRB1 methionine sulfoxide reductase B1 -3.33974
DUSP3 dual specificity phosphatase 3 -3.27964
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -3.24523
TIGAR TP53 induced glycolysis regulatory phosphatase -3.22802
C4ORF19 chromosome 4 open reading frame 19 -3.22691
CPN1 carboxypeptidase N, polypeptide 1 -3.17851
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -3.17653
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -3.15615
RAD51 RAD51 recombinase -3.1256
ADRM1 adhesion regulating molecule 1 -3.11626
WDR77 WD repeat domain 77 -3.0525
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -3.03266
HEATR3 HEAT repeat containing 3 -3.03165
CCNB1 cyclin B1 -3.0138