| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4878 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in PP2 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFBP1 | fibroblast growth factor binding protein 1 | 2.41 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | 1.1 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 1.06 |
| DCLRE1C | DNA cross-link repair 1C | 1.06 |
| CAPN6 | calpain 6 | 1.03 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.97 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.95 |
| FAM199X | family with sequence similarity 199, X-linked | 0.95 |
| TBX3 | T-box 3 | 0.94 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.88 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.86 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.83 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.81 |
| GRB7 | growth factor receptor-bound protein 7 | 0.79 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.79 |
| DUSP4 | dual specificity phosphatase 4 | 0.76 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.74 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 0.73 |
| UNKL | unkempt family zinc finger-like | 0.73 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.71 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.7 |
| RREB1 | ras responsive element binding protein 1 | 0.69 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.69 |
| HAS3 | hyaluronan synthase 3 | 0.69 |
| RNF26 | ring finger protein 26 | 0.67 |
| SYTL3 | synaptotagmin-like 3 | 0.64 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.64 |
| REPS2 | RALBP1 associated Eps domain containing 2 | 0.64 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.64 |
| PDLIM5 | PDZ and LIM domain 5 | 0.63 |
| MEGF6 | multiple EGF-like-domains 6 | 0.63 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.63 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.62 |
| HOXB8 | homeobox B8 | 0.61 |
| DENND5B | DENN/MADD domain containing 5B | 0.6 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.59 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.58 |
| FOXC1 | forkhead box C1 | 0.58 |
| BMP4 | bone morphogenetic protein 4 | 0.57 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.57 |
| IL27RA | interleukin 27 receptor, alpha | 0.57 |
| SEMA4G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 0.57 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 0.57 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.56 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.56 |
| LAMB1 | laminin, beta 1 | 0.56 |
| MROH6 | maestro heat-like repeat family member 6 | 0.55 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.55 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | 0.55 |
| MINDY4 | MINDY lysine 48 deubiquitinase 4 | 0.55 |
| TMEM87B | transmembrane protein 87B | 0.54 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.54 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.54 |
| RBL2 | retinoblastoma-like 2 | 0.54 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.54 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.54 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.53 |
| ALS2CL | ALS2 C-terminal like | 0.53 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.53 |
| COQ8A | coenzyme Q8A | 0.53 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.52 |
| GCAT | glycine C-acetyltransferase | 0.52 |
| DENND5A | DENN/MADD domain containing 5A | 0.52 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.52 |
| ARG2 | arginase 2 | 0.52 |
| VGF | VGF nerve growth factor inducible | 0.52 |
| AMZ2 | archaelysin family metallopeptidase 2 | 0.52 |
| TTC30B | tetratricopeptide repeat domain 30B | 0.51 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.51 |
| CLDN3 | claudin 3 | 0.51 |
| ADD3 | adducin 3 (gamma) | 0.5 |
| ZFYVE27 | zinc finger, FYVE domain containing 27 | 0.5 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.5 |
| LDHD | lactate dehydrogenase D | 0.5 |
| OTX1 | orthodenticle homeobox 1 | 0.5 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.5 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.49 |
| DUSP22 | dual specificity phosphatase 22 | 0.49 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.49 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.49 |
| CCDC170 | coiled-coil domain containing 170 | 0.48 |
| TMC4 | transmembrane channel-like 4 | 0.48 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.48 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.48 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.48 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.48 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.47 |
| TMEM179B | transmembrane protein 179B | 0.47 |
| SKI | SKI proto-oncogene | 0.47 |
| R3HDM2 | R3H domain containing 2 | 0.47 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.47 |
| FOXO1 | forkhead box O1 | 0.46 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.46 |
| MLPH | melanophilin | 0.46 |
| GNPAT | glyceronephosphate O-acyltransferase | 0.46 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | 0.46 |
| MIER3 | mesoderm induction early response 1, family member 3 | 0.46 |
| MAP3K6 | mitogen-activated protein kinase kinase kinase 6 | 0.46 |
| DENND3 | DENN/MADD domain containing 3 | 0.46 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALPK3 | alpha-kinase 3 | -3.81 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -2.19 |
| C5ORF24 | chromosome 5 open reading frame 24 | -1.23 |
| ARHGAP44 | Rho GTPase activating protein 44 | -1.22 |
| FBRSL1 | fibrosin-like 1 | -1.06 |
| RPGRIP1L | RPGRIP1-like | -0.95 |
| POF1B | premature ovarian failure, 1B | -0.88 |
| SASH1 | SAM and SH3 domain containing 1 | -0.84 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.82 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.81 |
| GLMP | glycosylated lysosomal membrane protein | -0.8 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.79 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.78 |
| SESN2 | sestrin 2 | -0.77 |
| SYCP1 | synaptonemal complex protein 1 | -0.73 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.73 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.72 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.71 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.71 |
| KLHL18 | kelch-like family member 18 | -0.68 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -0.67 |
| AXL | AXL receptor tyrosine kinase | -0.67 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.63 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | -0.63 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.62 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -0.62 |
| SDC4 | syndecan 4 | -0.62 |
| PAH | phenylalanine hydroxylase | -0.61 |
| CCND3 | cyclin D3 | -0.6 |
| ZNF264 | zinc finger protein 264 | -0.6 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.59 |
| LAMB3 | laminin, beta 3 | -0.59 |
| NPHP4 | nephronophthisis 4 | -0.59 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.57 |
| MID1IP1 | MID1 interacting protein 1 | -0.57 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.57 |
| AEN | apoptosis enhancing nuclease | -0.56 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.55 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.55 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.55 |
| PLIN2 | perilipin 2 | -0.54 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.54 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.54 |
| CCN1 | cellular communication network factor 1 | -0.53 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.52 |
| TSPAN3 | tetraspanin 3 | -0.52 |
| JUN | jun proto-oncogene | -0.52 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | -0.52 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.52 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.51 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.51 |
| FTL | ferritin, light polypeptide | -0.51 |
| RUBCN | rubicon autophagy regulator | -0.51 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.51 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.51 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.5 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.5 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.5 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.5 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.5 |
| SMTN | smoothelin | -0.5 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.5 |
| ZNF808 | zinc finger protein 808 | -0.49 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.49 |
| KRT8 | keratin 8, type II | -0.49 |
| ATF3 | activating transcription factor 3 | -0.49 |
| DUSP14 | dual specificity phosphatase 14 | -0.49 |
| PIP | prolactin-induced protein | -0.48 |
| EIF1AD | eukaryotic translation initiation factor 1A domain containing | -0.48 |
| SELENOM | selenoprotein M | -0.48 |
| CORO2B | coronin, actin binding protein, 2B | -0.48 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.47 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | -0.46 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.46 |
| HLA-E | major histocompatibility complex, class I, E | -0.46 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.45 |
| RNF126 | ring finger protein 126 | -0.45 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.45 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.45 |
| BSG | basigin (Ok blood group) | -0.45 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.45 |
| FGA | fibrinogen alpha chain | -0.45 |
| SLC38A2 | solute carrier family 38, member 2 | -0.44 |
| ITGA1 | integrin, alpha 1 | -0.44 |
| GLS | glutaminase | -0.44 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.44 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | -0.44 |
| IFRD1 | interferon-related developmental regulator 1 | -0.44 |
| ZFHX4 | zinc finger homeobox 4 | -0.43 |
| POMP | proteasome maturation protein | -0.43 |
| SARS | seryl-tRNA synthetase | -0.43 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.43 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.43 |
| MICA | MHC class I polypeptide-related sequence A | -0.43 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.42 |
| MAP1B | microtubule-associated protein 1B | -0.42 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.42 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.42 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.42 |
