PPAR signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. (Kyoto Encyclopedia of Genes and Genomes, hsa03320)
External Link https://www.kegg.jp/entry/hsa03320
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Genes

76 proteins participating in the PPAR signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACADL acyl-CoA dehydrogenase, long chain
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACOX2 acyl-CoA oxidase 2, branched chain
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ACSL4 acyl-CoA synthetase long-chain family member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ACSL6 acyl-CoA synthetase long-chain family member 6
ADIPOQ adiponectin, C1Q and collagen domain containing
ANGPTL4 angiopoietin-like 4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA5 apolipoprotein A-V
APOC3 apolipoprotein C-III
AQP7 aquaporin 7
CD36 CD36 molecule (thrombospondin receptor)
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CPT1C carnitine palmitoyltransferase 1C
CPT2 carnitine palmitoyltransferase 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1
DAAM2-AS1 DAAM2 antisense RNA 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP6 fatty acid binding protein 6, ileal
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
GK glycerol kinase
GK2 glycerol kinase 2
GK3 glycerol kinase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ILK integrin-linked kinase
LPL lipoprotein lipase
MMP1 matrix metallopeptidase 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCDHB16 protocadherin beta 16
PCDHGA5 protocadherin gamma subfamily A, 5
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDPK1 3-phosphoinositide dependent protein kinase 1
PLIN1 perilipin 1
PLIN2 perilipin 2
PLIN4 perilipin 4
PLIN5 perilipin 5
PLTP phospholipid transfer protein
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SYCP2 synaptonemal complex protein 2
UBC ubiquitin C
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)