PPARA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description peroxisome proliferator-activated receptor alpha|Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5465)
External Link http://www.ncbi.nlm.nih.gov/gene/5465
Similar Terms
Downloads & Tools

Genes

52 interacting proteins for PPARA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
AIP aryl hydrocarbon receptor interacting protein
AKAP13 A kinase (PRKA) anchor protein 13
CDK3 cyclin-dependent kinase 3
CEP350 centrosomal protein 350kDa
CHD9 chromodomain helicase DNA binding protein 9
CREBBP CREB binding protein
DAP3 death associated protein 3
DUT deoxyuridine triphosphatase
EP300 E1A binding protein p300
FABP1 fatty acid binding protein 1, liver
FOXA3 forkhead box A3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LPIN1 lipin 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MECR mitochondrial trans-2-enoyl-CoA reductase
MED1 mediator complex subunit 1
MED24 mediator complex subunit 24
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
POU1F1 POU class 1 homeobox 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRMT1 protein arginine methyltransferase 1
PRMT2 protein arginine methyltransferase 2
PRMT8 protein arginine methyltransferase 8
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RXRA retinoid X receptor, alpha
RXRG retinoid X receptor, gamma
SIRT1 sirtuin 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAC3 SH3 and cysteine rich domain 3
SUMO1 small ubiquitin-like modifier 1
TGS1 trimethylguanosine synthase 1
TNP1 transition protein 1 (during histone to protamine replacement)
UBE2I ubiquitin-conjugating enzyme E2I
WRB tryptophan rich basic protein