PPARD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisome proliferator-activated receptor delta|This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 5467)
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Genes

300 genes differentially expressed following the PPARD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SECTM1 secreted and transmembrane 1 3.19772
MYBPC3 myosin binding protein C, cardiac 3.19772
CLEC19A C-type lectin domain family 19, member A 3.19772
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 3.19772
PDZD9 PDZ domain containing 9 3.19772
DUSP10 dual specificity phosphatase 10 3.19772
CCL5 chemokine (C-C motif) ligand 5 3.19772
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.19772
PAX3 paired box 3 3.19772
GPR55 G protein-coupled receptor 55 3.19772
NPAP1 nuclear pore associated protein 1 3.19772
LAX1 lymphocyte transmembrane adaptor 1 3.19772
CD300LG CD300 molecule-like family member g 3.19772
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 3.19772
ZNF99 zinc finger protein 99 3.19772
HBA2 hemoglobin, alpha 2 3.19772
SLC22A10 solute carrier family 22, member 10 3.19772
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.19772
INHBC inhibin, beta C 3.19772
P3H3 prolyl 3-hydroxylase 3 3.19772
PAX7 paired box 7 3.19772
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.19772
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 3.19772
SPP2 secreted phosphoprotein 2, 24kDa 3.19772
OR7A17 olfactory receptor, family 7, subfamily A, member 17 3.19772
C8ORF74 chromosome 8 open reading frame 74 3.19772
CCDC38 coiled-coil domain containing 38 3.19772
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.19772
S100A1 S100 calcium binding protein A1 3.19772
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 3.19772
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.19772
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.19772
TDRD6 tudor domain containing 6 3.19772
RPL3L ribosomal protein L3-like 3.19772
BATF basic leucine zipper transcription factor, ATF-like 3.19772
RSPO3 R-spondin 3 3.19772
MUSK muscle, skeletal, receptor tyrosine kinase 3.19772
GIMAP2 GTPase, IMAP family member 2 3.19772
ALPK2 alpha-kinase 2 3.19772
SFTPB surfactant protein B 3.19772
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.19772
PCDH8 protocadherin 8 3.19772
TREML1 triggering receptor expressed on myeloid cells-like 1 3.19772
CIMIP2B ciliary microtubule inner protein 2B 3.19772
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 3.19772
ACER1 alkaline ceramidase 1 3.19772
OTOR otoraplin 3.19772
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.19772
ASB4 ankyrin repeat and SOCS box containing 4 3.19772
TTR transthyretin 3.19772
DOK7 docking protein 7 3.19772
ZNF705G zinc finger protein 705G 3.19772
YIPF7 Yip1 domain family, member 7 3.19772
ZNF726 zinc finger protein 726 3.19772
ALPG alkaline phosphatase, germ cell 3.19772
CIMIP2C ciliary microtubule inner protein 2C 3.19772
LY6L lymphocyte antigen 6 family member L 3.19772
ACP4 acid phosphatase 4 3.19772
H2AC1 H2A clustered histone 1 3.19772
GARIN5B golgi associated RAB2 interactor family member 5B 3.19772
CCDC198 coiled-coil domain containing 198 3.19772
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.19772
TMEM271 transmembrane protein 271 3.19772
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.19772
GATA4 GATA binding protein 4 3.19772
NPIPB8 nuclear pore complex interacting protein family, member B8 3.19772
MSX2 msh homeobox 2 3.19772
RAB36 RAB36, member RAS oncogene family 3.19772
CATSPERD catsper channel auxiliary subunit delta 3.19772
SLPI secretory leukocyte peptidase inhibitor 3.19772
IL31RA interleukin 31 receptor A 3.19772
HPR haptoglobin-related protein 3.19772
TUBA3E tubulin, alpha 3e 3.19772
PCDHB13 protocadherin beta 13 3.19772
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.19772
DNASE2B deoxyribonuclease II beta 3.19772
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.19772
SAMD11 sterile alpha motif domain containing 11 3.19772
PGLYRP2 peptidoglycan recognition protein 2 3.19772
GJD2 gap junction protein, delta 2, 36kDa 3.19772
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.19772
RUNX3 runt-related transcription factor 3 3.19772
RNF113B ring finger protein 113B 3.19772
UBL4B ubiquitin-like 4B 3.19772
MIP major intrinsic protein of lens fiber 3.19772
PRB2 proline-rich protein BstNI subfamily 2 3.19772
C2ORF66 chromosome 2 open reading frame 66 3.19772
WFDC9 WAP four-disulfide core domain 9 3.19772
SUN3 Sad1 and UNC84 domain containing 3 3.19772
HAVCR1 hepatitis A virus cellular receptor 1 3.19772
NUTM2A NUT family member 2A 3.19772
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.19772
CARNS1 carnosine synthase 1 3.19772
POTEE POTE ankyrin domain family, member E 3.19772
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.19772
UBQLNL ubiquilin-like 3.19772
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.19772
SNTN sentan, cilia apical structure protein 3.19772
TREH trehalase (brush-border membrane glycoprotein) 3.19772
PSKH2 protein serine kinase H2 3.19772
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.19772
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.19772
ANKRD61 ankyrin repeat domain 61 3.19772
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.19772
GPR12 G protein-coupled receptor 12 3.19772
EFCAB3 EF-hand calcium binding domain 3 3.19772
CST1 cystatin SN 3.19772
RGS11 regulator of G-protein signaling 11 3.19772
APLNR apelin receptor 3.19772
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.19772
MAGEA2B melanoma antigen family A2B 3.19772
ENDOU endonuclease, polyU-specific 3.19772
MORC1 MORC family CW-type zinc finger 1 3.19772
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 3.19772
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.19772
MAGEB17 melanoma antigen family B17 3.19772
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.19772
KLF4 Kruppel-like factor 4 (gut) 3.19772
PRSS55 protease, serine, 55 3.19772
TMPRSS13 transmembrane protease, serine 13 3.19772
TEX38 testis expressed 38 3.19772
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.19772
LY9 lymphocyte antigen 9 3.19772
RGS4 regulator of G-protein signaling 4 3.19772
STK31 serine/threonine kinase 31 3.19772
ACY3 aminoacylase 3 3.19772
C2ORF78 chromosome 2 open reading frame 78 3.19772
GYS2 glycogen synthase 2 (liver) 3.19772
LMX1A LIM homeobox transcription factor 1, alpha 3.19772
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.19772
TSHZ1 teashirt zinc finger homeobox 1 3.19772
LGALS2 lectin, galactoside-binding, soluble, 2 3.19772
C22ORF31 chromosome 22 open reading frame 31 3.19772
PRDM12 PR domain containing 12 3.19772
FAM216B family with sequence similarity 216, member B 3.19772
CFP complement factor properdin 3.19772
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 3.19772
ANXA2R annexin A2 receptor 3.19772
ZC2HC1B zinc finger, C2HC-type containing 1B 3.19772
ADRA1B adrenoceptor alpha 1B 3.19772
SDSL serine dehydratase-like 3.19772
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.19772
MMP13 matrix metallopeptidase 13 3.19772
SCTR secretin receptor 3.19772
DEFB134 defensin, beta 134 3.19772
AOC1 amine oxidase, copper containing 1 3.19772
IL1B interleukin 1, beta 3.19772
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 3.19772
FAM135B family with sequence similarity 135, member B 3.19772
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.19772
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.19772
CD177 CD177 molecule 3.13152
SPATA2 spermatogenesis associated 2 3.08319
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.99739
NPSR1 neuropeptide S receptor 1 2.94084
BKGD beta-keto-L-gulonate decarboxylase 2.65398
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.59923
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.59923
PBLD phenazine biosynthesis-like protein domain containing 2.59923
TMEM236 transmembrane protein 236 2.59923
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 2.59441
RBM18 RNA binding motif protein 18 2.5545
GJC1 gap junction protein, gamma 1, 45kDa 2.5545
RRAGC Ras-related GTP binding C 2.49436
INAVA innate immunity activator 2.44265
BAG4 BCL2-associated athanogene 4 2.3727
RAD18 RAD18 E3 ubiquitin protein ligase 2.3727
HADH hydroxyacyl-CoA dehydrogenase 2.36899
SMIM31 small integral membrane protein 31 2.33408
OTUD6B OTU domain containing 6B 2.33408
XRN2 5'-3' exoribonuclease 2 2.31093
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.30508
FOXO4 forkhead box O4 2.26873
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.24663
MVB12B multivesicular body subunit 12B 2.24663
CAPN11 calpain 11 2.24564
CELA2A chymotrypsin-like elastase family, member 2A 2.24564
RHOF ras homolog family member F (in filopodia) 2.24564
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.24564
CFAP54 cilia and flagella associated 54 2.24564
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 2.2343
TMEM183A transmembrane protein 183A 2.21905
PRTFDC1 phosphoribosyl transferase domain containing 1 2.21426
PDHX pyruvate dehydrogenase complex, component X 2.19045
GPR107 G protein-coupled receptor 107 2.18946
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 2.15995
ULK2 unc-51 like autophagy activating kinase 2 2.15604
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 2.14104
ERCC8 excision repair cross-complementation group 8 2.13968
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.13732
SPDL1 spindle apparatus coiled-coil protein 1 2.1309
SEPTIN2 septin 2 2.13013
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.13013
CCSER1 coiled-coil serine-rich protein 1 2.12923
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 2.12923
SPATA2L spermatogenesis associated 2-like 2.11096
ARSG arylsulfatase G 2.10189
TEX261 testis expressed 261 2.05344
UTP25 UTP25 small subunit processome component 2.03935
SOX5 SRY (sex determining region Y)-box 5 2.00928
SMC2 structural maintenance of chromosomes 2 2.00222

decreased expression

Symbol Name Standardized Value
TLL1 tolloid-like 1 -3.19772
CSRP1 cysteine and glycine-rich protein 1 -3.19772
DHDH dihydrodiol dehydrogenase (dimeric) -3.19772
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -3.19772
ZSWIM3 zinc finger, SWIM-type containing 3 -3.19772
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.19772
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.19772
EIF2A eukaryotic translation initiation factor 2A, 65kDa -3.19772
BGN biglycan -3.19772
NKPD1 NTPase, KAP family P-loop domain containing 1 -3.13152
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -3.13152
KRT222 keratin 222, type II -3.13152
LRRC38 leucine rich repeat containing 38 -3.13152
DPRX divergent-paired related homeobox -3.13152
ZBTB42 zinc finger and BTB domain containing 42 -3.13152
KLLN killin, p53-regulated DNA replication inhibitor -3.13152
BHLHE40 basic helix-loop-helix family, member e40 -3.13152
THSD1 thrombospondin, type I, domain containing 1 -3.13152
SLC16A6 solute carrier family 16, member 6 -3.13152
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -3.13152
SPATS1 spermatogenesis associated, serine-rich 1 -3.13152
PPP1R27 protein phosphatase 1, regulatory subunit 27 -3.13152
GIPC3 GIPC PDZ domain containing family, member 3 -3.13152
ZNF441 zinc finger protein 441 -3.13152
TF transferrin -3.13152
TTC16 tetratricopeptide repeat domain 16 -3.13152
PCDH12 protocadherin 12 -3.13152
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 -3.13152
LMOD3 leiomodin 3 (fetal) -3.13152
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -3.13152
F2RL2 coagulation factor II (thrombin) receptor-like 2 -3.13152
KLHL34 kelch-like family member 34 -3.13152
TRAF3IP3 TRAF3 interacting protein 3 -3.13152
COPB1 coatomer protein complex, subunit beta 1 -3.06405
MAN2A2 mannosidase, alpha, class 2A, member 2 -3.01157
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -3.01157
ACOT12 acyl-CoA thioesterase 12 -2.98257
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.98257
GLUD1 glutamate dehydrogenase 1 -2.94973
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.94973
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 -2.94973
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 -2.83743
SPICP3 Spi-C transcription factor pseudogene 3 -2.69497
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.66916
CLIC1 chloride intracellular channel 1 -2.50059
EBF1 early B-cell factor 1 -2.47885
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.4609
ASB1 ankyrin repeat and SOCS box containing 1 -2.45756
MXD3 MAX dimerization protein 3 -2.39816
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.38548
TXNDC9 thioredoxin domain containing 9 -2.3727
PLCB4 phospholipase C, beta 4 -2.3727
BST2 bone marrow stromal cell antigen 2 -2.36838
CELF5 CUGBP, Elav-like family member 5 -2.33408
STAT5A signal transducer and activator of transcription 5A -2.33408
SCN2A sodium channel, voltage gated, type II alpha subunit -2.33408
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.33408
TTLL12 tubulin tyrosine ligase-like family member 12 -2.33408
ZNF660 zinc finger protein 660 -2.32275
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -2.29302
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.29302
DYNLRB1 dynein, light chain, roadblock-type 1 -2.29302
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.29302
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -2.2666
LAMB2 laminin, beta 2 (laminin S) -2.25822
TMEM167B transmembrane protein 167B -2.24721
ADAP1 ArfGAP with dual PH domains 1 -2.24564
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.24564
XK X-linked Kx blood group -2.24564
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.24564
ALX1 ALX homeobox 1 -2.24564
KIF9 kinesin family member 9 -2.24564
ZNF850 zinc finger protein 850 -2.23324
GSTO1 glutathione S-transferase omega 1 -2.23324
C6ORF163 chromosome 6 open reading frame 163 -2.21905
CRYGB crystallin, gamma B -2.21905
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.21905
ECT2L epithelial cell transforming 2 like -2.21905
FBP2 fructose-1,6-bisphosphatase 2 -2.21905
KLF5 Kruppel-like factor 5 (intestinal) -2.21905
EGFL6 EGF-like-domain, multiple 6 -2.21905
TUBA8 tubulin, alpha 8 -2.21905
SACK1G scaffolding CK1 anchoring protein G -2.21426
SNX24 sorting nexin 24 -2.19212
CSNK1G1 casein kinase 1, gamma 1 -2.17951
PGAM1 phosphoglycerate mutase 1 (brain) -2.1309
POLI polymerase (DNA directed) iota -2.13013
ATG4D autophagy related 4D, cysteine peptidase -2.12312
MAP2K3 mitogen-activated protein kinase kinase 3 -2.11898
TEAD4 TEA domain family member 4 -2.08853
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -2.05943
EMC6 ER membrane protein complex subunit 6 -2.05424
ZNF302 zinc finger protein 302 -2.052
ZFAND5 zinc finger, AN1-type domain 5 -2.04421
MTMR10 myotubularin related protein 10 -2.01969
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -2.01617
TBC1D17 TBC1 domain family, member 17 -2.0124
GHRHR growth hormone releasing hormone receptor -2.0119
CYGB cytoglobin -2.0119