PPARD Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description peroxisome proliferator-activated receptor delta|This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 5467)
External Link http://www.ncbi.nlm.nih.gov/gene/5467
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Genes

45 interacting proteins for PPARD from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
CEP350 centrosomal protein 350kDa
DLAT dihydrolipoamide S-acetyltransferase
DLD dihydrolipoamide dehydrogenase
DUT deoxyuridine triphosphatase
EIF3I eukaryotic translation initiation factor 3, subunit I
EP300 E1A binding protein p300
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GLUL glutamate-ammonia ligase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC7 histone deacetylase 7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ITGB5 integrin, beta 5
KCTD9 potassium channel tetramerization domain containing 9
KDM1A lysine (K)-specific demethylase 1A
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRIP1 nuclear receptor interacting protein 1
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHB pyruvate dehydrogenase (lipoamide) beta
PDHX pyruvate dehydrogenase complex, component X
PEBP1 phosphatidylethanolamine binding protein 1
PRDX6 peroxiredoxin 6
PRMT3 protein arginine methyltransferase 3
PROX1 prospero homeobox 1
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RANBP9 RAN binding protein 9
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SMAD9 SMAD family member 9
SPEN spen family transcriptional repressor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TNP1 transition protein 1 (during histone to protamine replacement)