PPARG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisome proliferator-activated receptor gamma|This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5468)
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Genes

331 genes differentially expressed following the PPARG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PAX3 paired box 3 3.83096
GATA2 GATA binding protein 2 3.83096
ZNF705D zinc finger protein 705D 3.83096
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.83096
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.83096
VSIG8 V-set and immunoglobulin domain containing 8 3.83096
TDRD9 tudor domain containing 9 3.83096
SELL selectin L 3.83096
CRH corticotropin releasing hormone 3.83096
OSTN osteocrin 3.83096
C11ORF87 chromosome 11 open reading frame 87 3.83096
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.83096
PAX1 paired box 1 3.83096
GPR88 G protein-coupled receptor 88 3.83096
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.83096
SIGLEC6 sialic acid binding Ig-like lectin 6 3.83096
PXDC1 PX domain containing 1 3.83096
TLX2 T-cell leukemia homeobox 2 3.83096
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.83096
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.83096
SOWAHB sosondowah ankyrin repeat domain family member B 3.83096
DLL4 delta-like 4 (Drosophila) 3.83096
COL15A1 collagen, type XV, alpha 1 3.83096
BOLA2 bolA family member 2 3.83096
LEP leptin 3.83096
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.83096
WFDC11 WAP four-disulfide core domain 11 3.83096
GALP galanin-like peptide 3.83096
TMEM40 transmembrane protein 40 3.83096
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.83096
AMPD1 adenosine monophosphate deaminase 1 3.83096
FAM9A family with sequence similarity 9, member A 3.83096
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.83096
TMEM132C transmembrane protein 132C 3.83096
LRRC63 leucine rich repeat containing 63 3.83096
PCP4L1 Purkinje cell protein 4 like 1 3.83096
TAS2R19 taste receptor, type 2, member 19 3.83096
TRPC5OS TRPC5 opposite strand 3.83096
MYO1G myosin IG 3.83096
C10ORF53 chromosome 10 open reading frame 53 3.83096
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.83096
RNF39 ring finger protein 39 3.83096
PASD1 PAS domain containing 1 3.83096
ATP13A5 ATPase type 13A5 3.83096
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.83096
TMPRSS11D transmembrane protease, serine 11D 3.83096
GGT5 gamma-glutamyltransferase 5 3.83096
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.83096
DMP1 dentin matrix acidic phosphoprotein 1 3.83096
CDH5 cadherin 5, type 2 (vascular endothelium) 3.83096
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.83096
RXFP2 relaxin/insulin-like family peptide receptor 2 3.83096
KLHL30 kelch-like family member 30 3.83096
GJA5 gap junction protein, alpha 5, 40kDa 3.83096
CAPN14 calpain 14 3.83096
ACOT4 acyl-CoA thioesterase 4 3.83096
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.83096
ISM2 isthmin 2 3.83096
TBX20 T-box 20 3.83096
RAET1E retinoic acid early transcript 1E 3.83096
SLC22A10 solute carrier family 22, member 10 3.83096
SYCP2 synaptonemal complex protein 2 3.83096
PDILT protein disulfide isomerase-like, testis expressed 3.83096
DUXA double homeobox A 3.83096
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.83096
WDR38 WD repeat domain 38 3.83096
TMEM236 transmembrane protein 236 3.83096
SIM2 single-minded family bHLH transcription factor 2 3.83096
SCRT2 scratch family zinc finger 2 3.83096
FAM186A family with sequence similarity 186, member A 3.83096
SLC25A41 solute carrier family 25, member 41 3.83096
CDKN2A cyclin-dependent kinase inhibitor 2A 3.83096
GJB4 gap junction protein, beta 4, 30.3kDa 3.83096
GJB5 gap junction protein, beta 5, 31.1kDa 3.83096
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.83096
UPB1 ureidopropionase, beta 3.83096
UNC13C unc-13 homolog C (C. elegans) 3.83096
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.83096
C4ORF17 chromosome 4 open reading frame 17 3.83096
MAGEB3 melanoma antigen family B3 3.83096
SLC35G5 solute carrier family 35, member G5 3.83096
CIMIP2B ciliary microtubule inner protein 2B 3.83096
OLAH oleoyl-ACP hydrolase 3.83096
PGBDF plakoglobin binding and degradation factor 3.83096
MEOX1 mesenchyme homeobox 1 3.83096
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.83096
NLRP4 NLR family, pyrin domain containing 4 3.83096
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.83096
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.83096
TEX19 testis expressed 19 3.83096
SMIM45 small integral membrane protein 45 3.83096
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.83096
COL6A5 collagen, type VI, alpha 5 3.83096
ASTL astacin-like metallo-endopeptidase (M12 family) 3.83096
SIRPD signal-regulatory protein delta 3.83096
ITGB7 integrin, beta 7 3.83096
ALOXE3 arachidonate lipoxygenase 3 3.83096
MUSK muscle, skeletal, receptor tyrosine kinase 3.83096
NUPR1 nuclear protein, transcriptional regulator, 1 3.83096
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.83096
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.83096
MAB21L2 mab-21-like 2 (C. elegans) 3.83096
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.83096
RANBP3L RAN binding protein 3-like 3.83096
MEIOSIN meiosis initiator 3.83096
CCDC27 coiled-coil domain containing 27 3.83096
EMP1 epithelial membrane protein 1 3.83096
LOC124903372 uncharacterized LOC124903372 3.83096
LOC122526780 uncharacterized LOC122526780 3.83096
FAM240A family with sequence similarity 240 member A 3.83096
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.83096
EVI2A ecotropic viral integration site 2A 3.83096
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.83096
FOXS1 forkhead box S1 3.83096
PNMA6F PNMA family member 6F 3.83096
HSFX4 heat shock transcription factor family, X-linked member 4 3.83096
DRC10 dynein regulatory complex subunit 10 3.83096
WNT2 wingless-type MMTV integration site family member 2 3.83096
ESPNL espin-like 3.83096
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.83096
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.83096
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.83096
CIMAP1B ciliary microtubule associated protein 1B 3.83096
BCL2L15 BCL2-like 15 3.83096
NOTCH2NLB notch 2 N-terminal like B 3.83096
TYR tyrosinase 3.83096
ERVV-2 endogenous retrovirus group V, member 2 3.83096
POU4F1 POU class 4 homeobox 1 3.83096
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.83096
TENT5D terminal nucleotidyltransferase 5D 3.83096
TMPRSS3 transmembrane protease, serine 3 3.83096
TMEM86A transmembrane protein 86A 3.83096
FMOD fibromodulin 3.83096
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.83096
POTEJ POTE ankyrin domain family, member J 3.83096
PAQR7 progestin and adipoQ receptor family member VII 3.83096
SPRR2F small proline-rich protein 2F 3.83096
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.83096
ADGRG3 adhesion G protein-coupled receptor G3 3.83096
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.83096
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 3.83096
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.83096
LPO lactoperoxidase 3.83096
PLA2G1B phospholipase A2, group IB (pancreas) 3.83096
TGM5 transglutaminase 5 3.83096
TGM4 transglutaminase 4 3.83096
BPIFC BPI fold containing family C 3.83096
ADRA1B adrenoceptor alpha 1B 3.83096
LHB luteinizing hormone beta polypeptide 3.83096
IFNK interferon, kappa 3.83096
RAG2 recombination activating gene 2 3.83096
GBP1 guanylate binding protein 1, interferon-inducible 3.83096
CT55 cancer/testis antigen 55 3.83096
S100A14 S100 calcium binding protein A14 3.83096
BTNL2 butyrophilin-like 2 3.83096
AQP6 aquaporin 6, kidney specific 3.83096
CYSLTR1 cysteinyl leukotriene receptor 1 3.83096
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.83096
LCN1 lipocalin 1 3.83096
GSTT4 glutathione S-transferase theta 4 3.83096
H3-5 H3.5 histone 3.83096
CCL20 chemokine (C-C motif) ligand 20 3.83096
ADAM7 ADAM metallopeptidase domain 7 3.83096
CES4A carboxylesterase 4A 3.83096
TSPAN32 tetraspanin 32 3.83096
NECTIN4 nectin cell adhesion molecule 4 3.83096
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.83096
APOB apolipoprotein B 3.83096
APOD apolipoprotein D 3.83096
H2BC1 H2B clustered histone 1 3.83096
STING1 stimulator of interferon response cGAMP interactor 1 3.83096
SPDYE10 speedy/RINGO cell cycle regulator family member E10 3.68808
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 3.48256
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 3.36373
GCAT glycine C-acetyltransferase 3.18505
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 3.09101
PDIA3 protein disulfide isomerase family A, member 3 3.06315
RAP1B RAP1B, member of RAS oncogene family 3.04862
SH2D6 SH2 domain containing 6 2.9703
CPZ carboxypeptidase Z 2.9703
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.96491
IPO11 importin 11 2.95777
COL9A3 collagen, type IX, alpha 3 2.90447
RPL39 ribosomal protein L39 2.88468
UBE2S ubiquitin-conjugating enzyme E2S 2.83537
BMP8A bone morphogenetic protein 8a 2.83214
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.83214
CLPSL1 colipase-like 1 2.83214
FAM131C family with sequence similarity 131, member C 2.83214
INSL3 insulin-like 3 (Leydig cell) 2.83214
KCTD21 potassium channel tetramerization domain containing 21 2.83214
F11 coagulation factor XI 2.83214
LCAT lecithin-cholesterol acyltransferase 2.83214
GAK cyclin G associated kinase 2.7677
NFIL3 nuclear factor, interleukin 3 regulated 2.73295
RBM5 RNA binding motif protein 5 2.66232
DDT D-dopachrome tautomerase 2.66232
LTO1 LTO1 maturation factor of ABCE1 2.64514
ZDHHC4 zinc finger, DHHC-type containing 4 2.63888
SNAP47 synaptosomal-associated protein, 47kDa 2.61666
PRPS1 phosphoribosyl pyrophosphate synthetase 1 2.56608
PTCD1 pentatricopeptide repeat domain 1 2.55221
DOCK1 dedicator of cytokinesis 1 2.52216
INSR insulin receptor 2.49259
CIAO2A cytosolic iron-sulfur assembly component 2A 2.44621
FAM209B family with sequence similarity 209, member B 2.39655
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.39655
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 2.37972
ELAC1 elaC ribonuclease Z 1 2.37717
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.37663
SEPTIN8 septin 8 2.36053
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.35262
PCDHB3 protocadherin beta 3 2.35018
NAPSA napsin A aspartic peptidase 2.33464
ZBTB47 zinc finger and BTB domain containing 47 2.33448
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.28597
BAG1 BCL2-associated athanogene 2.27649
MRPL54 mitochondrial ribosomal protein L54 2.26121
ZNF513 zinc finger protein 513 2.2499
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.22722
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.22722
FUBP3 far upstream element (FUSE) binding protein 3 2.22377
TGDS TDP-glucose 4,6-dehydratase 2.21676
LRP10 low density lipoprotein receptor-related protein 10 2.2158
AK5 adenylate kinase 5 2.17505
ZNG1E Zn regulated GTPase metalloprotein activator 1E 2.16039
MRPS36 mitochondrial ribosomal protein S36 2.14309
NOMO2 NODAL modulator 2 2.13381
SOCS5 suppressor of cytokine signaling 5 2.13381
RGPD8 RANBP2-like and GRIP domain containing 8 2.11822
DMTF1 cyclin D binding myb-like transcription factor 1 2.10358
BRD2 bromodomain containing 2 2.09114
STMN1 stathmin 1 2.09114
TAC3 tachykinin 3 2.08185
SMIM10L2A small integral membrane protein 10 like 2A 2.07963
RUNDC3B RUN domain containing 3B 2.07617
CEP83 centrosomal protein 83kDa 2.07617
PAK1IP1 PAK1 interacting protein 1 2.07392
CCDC160 coiled-coil domain containing 160 2.06063
ZNF215 zinc finger protein 215 2.06063
PTGR2 prostaglandin reductase 2 2.04804
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.04669
OGFR opioid growth factor receptor 2.03747
FAM171A2 family with sequence similarity 171, member A2 2.034
TMSB10 thymosin beta 10 2.02369
CEP295 centrosomal protein 295kDa 2.02183
BSG basigin (Ok blood group) 2.02059
HAVCR2 hepatitis A virus cellular receptor 2 2.02059
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.00561

decreased expression

Symbol Name Standardized Value
LYST lysosomal trafficking regulator -3.83096
FGF20 fibroblast growth factor 20 -3.83096
SLFN5 schlafen family member 5 -3.83096
SPON2 spondin 2, extracellular matrix protein -3.72697
LRRTM1 leucine rich repeat transmembrane neuronal 1 -3.72697
AQP4 aquaporin 4 -3.72697
HAS1 hyaluronan synthase 1 -3.72697
RAI2 retinoic acid induced 2 -3.72697
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -3.72697
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.72697
ICAM5 intercellular adhesion molecule 5, telencephalin -3.72697
DAND5 DAN domain family member 5, BMP antagonist -3.72697
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.72697
TMEM151A transmembrane protein 151A -3.72697
CLEC4G C-type lectin domain family 4, member G -3.72697
AKAP14 A kinase (PRKA) anchor protein 14 -3.72697
HAL histidine ammonia-lyase -3.72697
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -3.72697
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -3.72697
PFN4 profilin family, member 4 -3.72697
KLHL31 kelch-like family member 31 -3.72697
VCX variable charge, X-linked -3.72697
EGFLAM EGF-like, fibronectin type III and laminin G domains -3.72697
CHIT1 chitinase 1 (chitotriosidase) -3.72697
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -3.72697
CHCT1 CHD1 helical C-terminal domain containing 1 -3.72697
SSC5D scavenger receptor cysteine rich family, 5 domains -3.72697
PCDHGA7 protocadherin gamma subfamily A, 7 -3.72697
TM4SF20 transmembrane 4 L six family member 20 -3.72697
GREM2 gremlin 2, DAN family BMP antagonist -3.61307
VILL villin-like -3.61307
GARIN2 golgi associated RAB2 interactor family member 2 -3.61307
LMO2 LIM domain only 2 (rhombotin-like 1) -3.51252
MYLIP myosin regulatory light chain interacting protein -3.14879
HRH3 histamine receptor H3 -3.06982
ASPN asporin -3.01675
ZDHHC11B zinc finger, DHHC-type containing 11B -3.0057
CLCN2 chloride channel, voltage-sensitive 2 -2.98772
RALB v-ral simian leukemia viral oncogene homolog B -2.98626
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.84987
FBXW2 F-box and WD repeat domain containing 2 -2.75559
CLVS2 clavesin 2 -2.75229
LIG4 ligase IV, DNA, ATP-dependent -2.74014
INSIG1 insulin induced gene 1 -2.68407
ZIC5 Zic family member 5 -2.67545
CYB5RL cytochrome b5 reductase-like -2.65908
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.65818
TCAF1 TRPM8 channel-associated factor 1 -2.6418
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.62416
WWTR1 WW domain containing transcription regulator 1 -2.57893
CCNG2 cyclin G2 -2.57103
GIGYF1 GRB10 interacting GYF protein 1 -2.55221
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -2.54793
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.51316
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.49178
QTRT1 queuine tRNA-ribosyltransferase 1 -2.47023
FHIT fragile histidine triad -2.44272
PGRMC2 progesterone receptor membrane component 2 -2.43505
PHB2 prohibitin 2 -2.39531
EYS eyes shut homolog (Drosophila) -2.37656
ANKRD28 ankyrin repeat domain 28 -2.35262
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.35262
LMNTD2 lamin tail domain containing 2 -2.33682
STX19 syntaxin 19 -2.33682
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.33682
FAT2 FAT atypical cadherin 2 -2.31285
NUP160 nucleoporin 160kDa -2.31165
C19ORF18 chromosome 19 open reading frame 18 -2.30328
DST dystonin -2.25727
LNPEP leucyl/cystinyl aminopeptidase -2.25727
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -2.23338
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.2002
ZNF425 zinc finger protein 425 -2.15412
MEF2C myocyte enhancer factor 2C -2.14748
AGBL3 ATP/GTP binding protein-like 3 -2.14038
CORT cortistatin -2.13543
UBALD1 UBA-like domain containing 1 -2.11642
SPON1 spondin 1, extracellular matrix protein -2.11042
HSPA1A heat shock 70kDa protein 1A -2.08373
SORBS3 sorbin and SH3 domain containing 3 -2.07726
NICN1 nicolin 1 -2.04669
GORAB golgin, RAB6-interacting -2.0464