PPARGC1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisome proliferator-activated receptor gamma, coactivator 1 alpha|The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10891)
Similar Terms
Downloads & Tools

Genes

318 genes differentially expressed following the PPARGC1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NAPSA napsin A aspartic peptidase 2.83415
GJA10 gap junction protein, alpha 10, 62kDa 2.83415
CCL5 chemokine (C-C motif) ligand 5 2.83415
WT1 Wilms tumor 1 2.83415
UCN2 urocortin 2 2.83415
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.83415
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.83415
ORAI2 ORAI calcium release-activated calcium modulator 2 2.83415
GPR25 G protein-coupled receptor 25 2.83415
SIRPB2 signal-regulatory protein beta 2 2.83415
TM4SF20 transmembrane 4 L six family member 20 2.83415
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.83415
NKAPL NFKB activating protein-like 2.83415
CTRC chymotrypsin C (caldecrin) 2.83415
ADGRE1 adhesion G protein-coupled receptor E1 2.83415
NANOS3 nanos homolog 3 (Drosophila) 2.83415
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.83415
GLYAT glycine-N-acyltransferase 2.83415
PNMA5 paraneoplastic Ma antigen family member 5 2.83415
FAM221B family with sequence similarity 221, member B 2.83415
NCKAP1L NCK-associated protein 1-like 2.83415
ZNF556 zinc finger protein 556 2.83415
CRYAA crystallin, alpha A 2.83415
PCDHGA12 protocadherin gamma subfamily A, 12 2.83415
METTL21C methyltransferase like 21C 2.83415
FAM81B family with sequence similarity 81, member B 2.83415
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.83415
CD34 CD34 molecule 2.83415
VPREB3 pre-B lymphocyte 3 2.83415
APOA5 apolipoprotein A-V 2.83415
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.83415
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.83415
TMEM217 transmembrane protein 217 2.83415
UBA7 ubiquitin-like modifier activating enzyme 7 2.83415
SMIM9 small integral membrane protein 9 2.83415
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.83415
CD68 CD68 molecule 2.83415
IVL involucrin 2.83415
DPPA3 developmental pluripotency associated 3 2.83415
TCP11 t-complex 11, testis-specific 2.83415
IRX1 iroquois homeobox 1 2.83415
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.83415
ERLN endoregulin 2.83415
C20ORF202 chromosome 20 open reading frame 202 2.83415
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.83415
IQCF3 IQ motif containing F3 2.83415
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.83415
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.83415
ASB9 ankyrin repeat and SOCS box containing 9 2.83415
SPATA25 spermatogenesis associated 25 2.83415
GCSAM germinal center-associated, signaling and motility 2.83415
STMN4 stathmin-like 4 2.83415
SCEL sciellin 2.83415
MINDY4B MINDY family member 4B 2.83415
CHCT1 CHD1 helical C-terminal domain containing 1 2.83415
CFAP97D1 CFAP97 domain containing 1 2.83415
DIPK1C divergent protein kinase domain 1C 2.83415
MSANTD5 Myb/SANT DNA binding domain containing 5 2.83415
DERPC DERPC proline and glycine rich nuclear protein 2.83415
OTOS otospiralin 2.83415
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.83415
IMPG1 interphotoreceptor matrix proteoglycan 1 2.83415
KL klotho 2.83415
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.83415
SLC45A2 solute carrier family 45, member 2 2.83415
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.83415
TMEM236 transmembrane protein 236 2.83415
ULBP1 UL16 binding protein 1 2.83415
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.83415
PTPRH protein tyrosine phosphatase, receptor type, H 2.83415
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.83415
PVRIG poliovirus receptor related immunoglobulin domain containing 2.83415
CREB3L3 cAMP responsive element binding protein 3-like 3 2.83415
LSP1 lymphocyte-specific protein 1 2.83415
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.83415
ACE2 angiotensin I converting enzyme 2 2.83415
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.83415
PNPLA1 patatin-like phospholipase domain containing 1 2.83415
IL1R1 interleukin 1 receptor, type I 2.83415
CLDN22 claudin 22 2.83415
S100B S100 calcium binding protein B 2.83415
INSRR insulin receptor-related receptor 2.83415
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.83415
ADAM7 ADAM metallopeptidase domain 7 2.83415
SAMD7 sterile alpha motif domain containing 7 2.83415
ENDOU endonuclease, polyU-specific 2.83415
A3GALT2 alpha 1,3-galactosyltransferase 2 2.83415
ALAS2 5'-aminolevulinate synthase 2 2.83415
CCDC9 coiled-coil domain containing 9 2.83415
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.83415
TBX1 T-box 1 2.83415
TSPAN32 tetraspanin 32 2.83415
OCM oncomodulin 2.83415
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.83415
IHH indian hedgehog 2.83415
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.83415
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.83415
FNDC8 fibronectin type III domain containing 8 2.83415
MYF6 myogenic factor 6 (herculin) 2.83415
SCML4 sex comb on midleg-like 4 (Drosophila) 2.83415
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.83415
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.83415
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.83415
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.83415
HOPX HOP homeobox 2.83415
LCNL1 lipocalin-like 1 2.83415
THBD thrombomodulin 2.83415
ANKRD20A1 ankyrin repeat domain 20 family, member A1 2.83415
LENEP lens epithelial protein 2.83415
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.83415
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.83415
AKR1B15 aldo-keto reductase family 1, member B15 2.83415
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.83415
LGALS9C lectin, galactoside-binding, soluble, 9C 2.83415
OR56B4 olfactory receptor, family 56, subfamily B, member 4 2.83415
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.83415
IL27 interleukin 27 2.83415
GRAP2 GRB2-related adaptor protein 2 2.83415
ANGPTL3 angiopoietin-like 3 2.83415
IL19 interleukin 19 2.83415
LRRC31 leucine rich repeat containing 31 2.83415
LRRN4 leucine rich repeat neuronal 4 2.83415
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.83415
C4BPA complement component 4 binding protein, alpha 2.83415
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.83415
PATE2 prostate and testis expressed 2 2.83415
ZNF648 zinc finger protein 648 2.83415
SUN3 Sad1 and UNC84 domain containing 3 2.83415
CA5A carbonic anhydrase VA, mitochondrial 2.83415
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.83415
IL10RA interleukin 10 receptor, alpha 2.83415
MAGEC3 melanoma antigen family C3 2.83415
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.83415
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.83415
MB myoglobin 2.83415
TSPAN16 tetraspanin 16 2.83415
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.82404
CD79B CD79b molecule, immunoglobulin-associated beta 2.78512
PDLIM2 PDZ and LIM domain 2 (mystique) 2.70115
NBEAL1 neurobeachin-like 1 2.67241
ZNF211 zinc finger protein 211 2.66688
ARHGAP19 Rho GTPase activating protein 19 2.66659
NCAPD2 non-SMC condensin I complex, subunit D2 2.66659
SAP30 Sin3A-associated protein, 30kDa 2.6495
SRPK2 SRSF protein kinase 2 2.60284
DUSP16 dual specificity phosphatase 16 2.59629
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.55939
ZC3H13 zinc finger CCCH-type containing 13 2.52707
SNN stannin 2.49522
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.4576
CHP1 calcineurin-like EF-hand protein 1 2.4576
ANKRD36 ankyrin repeat domain 36 2.45091
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.44694
THAP5 THAP domain containing 5 2.44073
NOL4 nucleolar protein 4 2.42408
CTSF cathepsin F 2.41806
NT5C1B 5'-nucleotidase, cytosolic IB 2.41806
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.41806
QSER1 glutamine and serine rich 1 2.37308
TLCD1 TLC domain containing 1 2.31897
ERVV-2 endogenous retrovirus group V, member 2 2.28459
UBXN1 UBX domain protein 1 2.28133
CFAP251 cilia and flagella associated protein 251 2.28133
HTATSF1 HIV-1 Tat specific factor 1 2.26943
GSAP gamma-secretase activating protein 2.26797
RAB37 RAB37, member RAS oncogene family 2.26797
CDT1 chromatin licensing and DNA replication factor 1 2.23833
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.2121
SBF1 SET binding factor 1 2.20771
TXLNA taxilin alpha 2.20448
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.20215
HAPLN4 hyaluronan and proteoglycan link protein 4 2.18985
ENOSF1 enolase superfamily member 1 2.17188
ZDHHC11 zinc finger, DHHC-type containing 11 2.17188
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.16392
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.15835
LUC7L LUC7-like (S. cerevisiae) 2.11602
ZNF213 zinc finger protein 213 2.09235
WDR70 WD repeat domain 70 2.08704
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.08704
DNAH11 dynein, axonemal, heavy chain 11 2.07581
C9ORF40 chromosome 9 open reading frame 40 2.06873
C1ORF21 chromosome 1 open reading frame 21 2.05167
LAMP2 lysosomal-associated membrane protein 2 2.04731
NPTXR neuronal pentraxin receptor 2.04731
MAK male germ cell-associated kinase 2.04713
PIGBOS1 PIGB opposite strand 1 2.04713
NOM1 nucleolar protein with MIF4G domain 1 2.0461
ADGRD1 adhesion G protein-coupled receptor D1 2.04309
KIF12 kinesin family member 12 2.04309
ACSS1 acyl-CoA synthetase short-chain family member 1 2.04309
MKI67 marker of proliferation Ki-67 2.04309
OPRK1 opioid receptor, kappa 1 2.04309
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.04309
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.03996
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2.03982
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.03982
PNKP polynucleotide kinase 3'-phosphatase 2.0276
PGM2L1 phosphoglucomutase 2-like 1 2.0276
SCGB2B2 secretoglobin, family 2B, member 2 2.0276
LOC124902694 uncharacterized LOC124902694 2.01944
SCRG1 stimulator of chondrogenesis 1 2.01889
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.01086
ZSCAN5A zinc finger and SCAN domain containing 5A 2.00153

decreased expression

Symbol Name Standardized Value
APP-DT APP divergent transcript -2.83415
PDGFA platelet-derived growth factor alpha polypeptide -2.83415
FRMPD2 FERM and PDZ domain containing 2 -2.83415
IQCH IQ motif containing H -2.83415
C2ORF80 chromosome 2 open reading frame 80 -2.83415
FBXO27 F-box protein 27 -2.83415
HLA-G major histocompatibility complex, class I, G -2.83415
RAG1 recombination activating gene 1 -2.83415
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.81347
ARL9 ADP-ribosylation factor-like 9 -2.70115
TSFM Ts translation elongation factor, mitochondrial -2.69331
ZNF273 zinc finger protein 273 -2.69331
PIWIL1 piwi-like RNA-mediated gene silencing 1 -2.66659
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.66659
IL18R1 interleukin 18 receptor 1 -2.66659
PODN podocan -2.66659
EBI3 Epstein-Barr virus induced 3 -2.66659
SGK2 serum/glucocorticoid regulated kinase 2 -2.66659
POPDC2 popeye domain containing 2 -2.66659
WDR93 WD repeat domain 93 -2.66659
CLCNKB chloride channel, voltage-sensitive Kb -2.66659
LOC124906010 uncharacterized LOC124906010 -2.66659
WBP2NL WBP2 N-terminal like -2.66659
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) -2.66659
COL15A1 collagen, type XV, alpha 1 -2.66659
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.66659
CCR6 chemokine (C-C motif) receptor 6 -2.66659
DMP1 dentin matrix acidic phosphoprotein 1 -2.66659
IL4I1 interleukin 4 induced 1 -2.66659
INHBA inhibin, beta A -2.66659
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.66659
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.66659
PEAR1 platelet endothelial aggregation receptor 1 -2.66659
KRT86 keratin 86, type II -2.66659
FAM131C family with sequence similarity 131, member C -2.66659
TTLL2 tubulin tyrosine ligase-like family member 2 -2.66659
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.66659
GOLGA6C golgin A6 family, member C -2.66659
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.66659
DHH desert hedgehog -2.66659
GPR83 G protein-coupled receptor 83 -2.66659
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.66659
IL1A interleukin 1, alpha -2.66659
PAGE4 P antigen family, member 4 (prostate associated) -2.66659
CLEC4D C-type lectin domain family 4, member D -2.66659
CTXN2 cortexin 2 -2.66659
CDH17 cadherin 17, LI cadherin (liver-intestine) -2.66659
GBX1 gastrulation brain homeobox 1 -2.66659
KISS1 KiSS-1 metastasis-suppressor -2.66659
NPFFR1 neuropeptide FF receptor 1 -2.66659
CCL27 chemokine (C-C motif) ligand 27 -2.66659
ZNF835 zinc finger protein 835 -2.66659
DPEP3 dipeptidase 3 -2.6525
CSMD1 CUB and Sushi multiple domains 1 -2.63558
MTX2 metaxin 2 -2.59225
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.57132
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.52844
EXOSC3 exosome component 3 -2.49451
RUNDC3A RUN domain containing 3A -2.47442
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -2.43127
INAVA innate immunity activator -2.42976
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.42301
MTFMT mitochondrial methionyl-tRNA formyltransferase -2.37804
BCL6B B-cell CLL/lymphoma 6, member B -2.33531
DCK deoxycytidine kinase -2.33091
DCP2 decapping mRNA 2 -2.31718
CENPK centromere protein K -2.31718
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.31696
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.31627
KIAA2013 KIAA2013 -2.30114
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.28459
PI15 peptidase inhibitor 15 -2.28133
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.28133
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -2.28133
ZSCAN26 zinc finger and SCAN domain containing 26 -2.28133
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.27318
GTPBP3 GTP binding protein 3 (mitochondrial) -2.26034
ZGPAT zinc finger, CCCH-type with G patch domain -2.25308
ADD2 adducin 2 (beta) -2.25085
MKS1 Meckel syndrome, type 1 -2.24805
SLC38A10 solute carrier family 38, member 10 -2.22614
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.21511
KCTD16 potassium channel tetramerization domain containing 16 -2.21511
BKGD beta-keto-L-gulonate decarboxylase -2.20731
PGGT1B protein geranylgeranyltransferase type I, beta subunit -2.2062
COPG2 coatomer protein complex, subunit gamma 2 -2.1956
VSTM2A V-set and transmembrane domain containing 2A -2.19033
STBD1 starch binding domain 1 -2.18792
PTGR3 prostaglandin reductase 3 -2.17419
IQGAP3 IQ motif containing GTPase activating protein 3 -2.14099
LOC730098 uncharacterized LOC730098 -2.12876
DNMBP dynamin binding protein -2.11602
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) -2.11602
FAAH2 fatty acid amide hydrolase 2 -2.09735
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.09557
ZGRF1 zinc finger, GRF-type containing 1 -2.07663
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.06873
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.06873
HDAC8 histone deacetylase 8 -2.06873
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -2.06681
RABGAP1 RAB GTPase activating protein 1 -2.04731
SPATS2L spermatogenesis associated, serine-rich 2-like -2.04731
FUZ fuzzy planar cell polarity protein -2.04731
SMG7 SMG7 nonsense mediated mRNA decay factor -2.04731
CATSPERG catsper channel auxiliary subunit gamma -2.04731
ZNF280D zinc finger protein 280D -2.0461
MRPS23 mitochondrial ribosomal protein S23 -2.03982
CPNE3 copine III -2.03982
CTTNBP2NL CTTNBP2 N-terminal like -2.03982
RAD51B RAD51 paralog B -2.0276
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.0249
MAPK1 mitogen-activated protein kinase 1 -2.0249
FAM217B family with sequence similarity 217, member B -2.01479
LY6E lymphocyte antigen 6 complex, locus E -2.00514