PPBP Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)|The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 5473)
External Link https://ncbi.nlm.nih.gov/gene/5473
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Genes

498 genes differentially expressed following the PPBP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen 0.0154796
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0150335
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0138565
CD9 CD9 molecule 0.0133638
KRT18 keratin 18, type I 0.0122996
PRDX2 peroxiredoxin 2 0.0121292
CTSZ cathepsin Z 0.0119686
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.011588
KRT19 keratin 19, type I 0.0114512
NBPF10 neuroblastoma breakpoint family, member 10 0.0112721
MMP2 matrix metallopeptidase 2 0.0111293
CHP1 calcineurin-like EF-hand protein 1 0.0108256
ANPEP alanyl (membrane) aminopeptidase 0.0107758
S100A11 S100 calcium binding protein A11 0.0106643
HP haptoglobin 0.0105127
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.0104603
PHACTR2 phosphatase and actin regulator 2 0.010385
AEBP1 AE binding protein 1 0.0102486
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0100538
SLIT2 slit homolog 2 (Drosophila) 0.0100483
LEF1 lymphoid enhancer-binding factor 1 0.0100275
TGIF1 TGFB-induced factor homeobox 1 0.010001
PLBD1 phospholipase B domain containing 1 0.00977473
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00975285
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.00937994
AKR1C2 aldo-keto reductase family 1, member C2 0.00937026
FBLN1 fibulin 1 0.00931775
HMGB1 high mobility group box 1 0.00912624
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.00911664
SPINK1 serine peptidase inhibitor, Kazal type 1 0.00901606
AGR2 anterior gradient 2 0.00885849
CHD7 chromodomain helicase DNA binding protein 7 0.00885541
GOLIM4 golgi integral membrane protein 4 0.008853
SFRP4 secreted frizzled-related protein 4 0.00885248
RNPS1 RNA binding protein S1, serine-rich domain 0.0088499
GATA2 GATA binding protein 2 0.00875972
SMAD7 SMAD family member 7 0.00874548
AUTS2 autism susceptibility candidate 2 0.00871876
STK39 serine threonine kinase 39 0.0086912
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.00868595
EPCAM epithelial cell adhesion molecule 0.00862889
WFDC2 WAP four-disulfide core domain 2 0.00847513
ANKRD11 ankyrin repeat domain 11 0.00842512
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.00829917
H2AX H2A.X variant histone 0.00827162
PRKCZ protein kinase C, zeta 0.00823314
TBL1X transducin (beta)-like 1X-linked 0.00817855
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.00816377
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.00812547
ABAT 4-aminobutyrate aminotransferase 0.00811355
SPRY2 sprouty homolog 2 (Drosophila) 0.00810161
PBK PDZ binding kinase 0.00806675
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.00797827
CUX1 cut-like homeobox 1 0.00795836
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00794638
TFF3 trefoil factor 3 (intestinal) 0.00791587
PTGIS prostaglandin I2 (prostacyclin) synthase 0.0079131
TCL1A T-cell leukemia/lymphoma 1A 0.00788452
BTG2 BTG family, member 2 0.00781978
TENM4 teneurin transmembrane protein 4 0.00780967
SULF1 sulfatase 1 0.00752557
COMP cartilage oligomeric matrix protein 0.00752209
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.00749264
MLXIP MLX interacting protein 0.00748475
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.00742876
TPSAB1 tryptase alpha/beta 1 0.00741426
ALB albumin 0.00741077
MYB v-myb avian myeloblastosis viral oncogene homolog 0.00737867
GPX2 glutathione peroxidase 2 0.00736802
ZNF423 zinc finger protein 423 0.00736314
PDIA4 protein disulfide isomerase family A, member 4 0.00734654
KRAS Kirsten rat sarcoma viral oncogene homolog 0.00734508
PCP4 Purkinje cell protein 4 0.0073171
MBL2 mannose-binding lectin (protein C) 2, soluble 0.0072857
ARMT1 acidic residue methyltransferase 1 0.00726142
POU2AF1 POU class 2 associating factor 1 0.00725639
FOXO1 forkhead box O1 0.00725445
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.0072451
AKR1C1 aldo-keto reductase family 1, member C1 0.00723481
SNX7 sorting nexin 7 0.00720678
TYMS thymidylate synthetase 0.00720555
IL1R1 interleukin 1 receptor, type I 0.00720482
RTN3 reticulon 3 0.00720394
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.00717922
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.00717603
EML3 echinoderm microtubule associated protein like 3 0.00717082
RBPMS RNA binding protein with multiple splicing 0.00716811
ELN elastin 0.00715663
GPC3 glypican 3 0.0071525
AURKB aurora kinase B 0.00710225
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.00706803
TTC39A tetratricopeptide repeat domain 39A 0.00705196
VTCN1 V-set domain containing T cell activation inhibitor 1 0.00699788
CEL carboxyl ester lipase 0.00698743
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.00694294
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.00693059
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0069234
MYO5C myosin VC 0.0069168
TACC3 transforming, acidic coiled-coil containing protein 3 0.00689197
APOH apolipoprotein H (beta-2-glycoprotein I) 0.00685583
BMP4 bone morphogenetic protein 4 0.00684353
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.00684353
SCAMP1 secretory carrier membrane protein 1 0.00683027
STC2 stanniocalcin 2 0.00678146
NOP56 NOP56 ribonucleoprotein 0.00677767
CHD4 chromodomain helicase DNA binding protein 4 0.006764
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00675763
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.00675554
SLC46A3 solute carrier family 46, member 3 0.00675097
AK1 adenylate kinase 1 0.00674482
SIRT3 sirtuin 3 0.00671962
ADD3 adducin 3 (gamma) 0.00670826
GAS7 growth arrest-specific 7 0.0066794
CAPN1 calpain 1, (mu/I) large subunit 0.00667484
EXPH5 exophilin 5 0.00665869
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00665275
TOP2B topoisomerase (DNA) II beta 180kDa 0.00663528
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.00663408
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.00663084
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.0066251
MB myoglobin 0.0066242
HOXB6 homeobox B6 0.00662315
MCOLN1 mucolipin 1 0.0066175
BRD2 bromodomain containing 2 0.00659068
BGN biglycan 0.00658635
ADAM9 ADAM metallopeptidase domain 9 0.00656868
PTCH1 patched 1 0.00654993
KLF5 Kruppel-like factor 5 (intestinal) 0.00654941
TCF4 transcription factor 4 0.00654146
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.00652699
MPZL2 myelin protein zero-like 2 0.00650617
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.00647458
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.00646994
RRBP1 ribosome binding protein 1 0.00646485
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00646061
PFN2 profilin 2 0.00644785
CNTNAP2 contactin associated protein-like 2 0.00643839
FADS3 fatty acid desaturase 3 0.00641872
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 0.0064175
CALCA calcitonin-related polypeptide alpha 0.00639784
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00639718
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.00639341
MECOM MDS1 and EVI1 complex locus 0.00638979
SOX2 SRY (sex determining region Y)-box 2 0.00638294
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.0063656
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.00634783
MCM7 minichromosome maintenance complex component 7 0.00634543
SELENBP1 selenium binding protein 1 0.0063444
PSRC1 proline/serine-rich coiled-coil 1 0.00634187
GSTT1 glutathione S-transferase theta 1 0.00632529
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00629759
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.00627369
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.00626087
RESF1 retroelement silencing factor 1 0.00624824
PFKL phosphofructokinase, liver 0.00624027
CPA3 carboxypeptidase A3 (mast cell) 0.00620466
ADSL adenylosuccinate lyase 0.0062017
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.00619877
ADAM10 ADAM metallopeptidase domain 10 0.00617995
PNN pinin, desmosome associated protein 0.00615022
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.00613787
FUCA1 fucosidase, alpha-L- 1, tissue 0.00613619
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.00612751
BAG2 BCL2-associated athanogene 2 0.00611786
SC5D sterol-C5-desaturase 0.00611781
KLF13 Kruppel-like factor 13 0.00610675
SOX17 SRY (sex determining region Y)-box 17 0.00610338
HGD homogentisate 1,2-dioxygenase 0.00608191
MYH11 myosin, heavy chain 11, smooth muscle 0.00606611
GOLGA8A golgin A8 family, member A 0.00605784
MRPS30 mitochondrial ribosomal protein S30 0.00602565
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.00601574
SYNE1 spectrin repeat containing, nuclear envelope 1 0.00601132
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.00600981
PTGDR prostaglandin D2 receptor (DP) 0.00600044
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00598264
ADGRL2 adhesion G protein-coupled receptor L2 0.00596748
IPO5 importin 5 0.0059562
TMEM260 transmembrane protein 260 0.00594612
FAAH fatty acid amide hydrolase 0.00594103
XIC X chromosome inactivation center 0.00593225
ISLR immunoglobulin superfamily containing leucine-rich repeat 0.00593186
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.00592291
TSPYL5 TSPY-like 5 0.00589899
GAS6 growth arrest-specific 6 0.00589832
SLC38A1 solute carrier family 38, member 1 0.00589355
TMPRSS4 transmembrane protease, serine 4 0.00588877
TNK2 tyrosine kinase, non-receptor, 2 0.00588307
RBL2 retinoblastoma-like 2 0.00588155
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.00586554
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.00585872
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.00585441
STK26 serine/threonine protein kinase 26 0.0058427
ESRP2 epithelial splicing regulatory protein 2 0.00583382
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00582691
CNOT7 CCR4-NOT transcription complex, subunit 7 0.00580839
ADD1 adducin 1 (alpha) 0.00580524
DSP desmoplakin 0.00579246
SFRP1 secreted frizzled-related protein 1 0.00578873
MAP7 microtubule-associated protein 7 0.00578787
KIF1B kinesin family member 1B 0.00578256
HYOU1 hypoxia up-regulated 1 0.00578046
SPIN1 spindlin 1 0.00574726
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00574657
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.00573792
CBX6 chromobox homolog 6 0.00573272
HSPG2 heparan sulfate proteoglycan 2 0.00572094
CST3 cystatin C 0.0057063
COL16A1 collagen, type XVI, alpha 1 0.0057027
C5ORF28 chromosome 5 open reading frame 28 0.00569895
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.00569649
BTBD3 BTB (POZ) domain containing 3 0.00567214
LTBP1 latent transforming growth factor beta binding protein 1 0.0056685
BIK BCL2-interacting killer (apoptosis-inducing) 0.00566594
DPT dermatopontin 0.00563339
IQGAP2 IQ motif containing GTPase activating protein 2 0.00562367
SYT11 synaptotagmin XI 0.00561849
ZBED5 zinc finger, BED-type containing 5 0.00561149
APMAP adipocyte plasma membrane associated protein 0.00559623
ELAC2 elaC ribonuclease Z 2 0.00559562
COL9A3 collagen, type IX, alpha 3 0.00559034
ANKRD10 ankyrin repeat domain 10 0.00558777
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.00558371
TRIO trio Rho guanine nucleotide exchange factor 0.00558215
MGP matrix Gla protein 0.00558189
GLUL glutamate-ammonia ligase 0.00557859
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 0.00557829
MAEA macrophage erythroblast attacher 0.00556202
AVL9 AVL9 homolog (S. cerevisiase) 0.0055587
DHCR24 24-dehydrocholesterol reductase 0.00555414
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.0055538
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.00554499
S100A4 S100 calcium binding protein A4 0.00552905
TUBB4B tubulin, beta 4B class IVb 0.00552714
CES1 carboxylesterase 1 0.0055101
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.0055065
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.00548939
NOTCH1 notch 1 0.00547475
HMGB3 high mobility group box 3 0.00546664
ICA1 islet cell autoantigen 1, 69kDa 0.00546367
USP20 ubiquitin specific peptidase 20 0.00546324
PAX5 paired box 5 0.00544488
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.00543903
PTPRA protein tyrosine phosphatase, receptor type, A 0.00543675
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00542386
COL6A1 collagen, type VI, alpha 1 0.00540787
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0054011
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00539897
ZCCHC14 zinc finger, CCHC domain containing 14 0.00539735

decreased expression

Symbol Name Standardized Value
KYNU kynureninase -0.0173895
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0168599
MEF2C myocyte enhancer factor 2C -0.0165553
IFI44 interferon-induced protein 44 -0.0156827
GRB7 growth factor receptor-bound protein 7 -0.0156639
GJA1 gap junction protein, alpha 1, 43kDa -0.0153676
IFI44L interferon-induced protein 44-like -0.0151842
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0145453
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0137824
IFI27 interferon, alpha-inducible protein 27 -0.0136478
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0131647
COG7 component of oligomeric golgi complex 7 -0.0127357
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0124442
S100A7 S100 calcium binding protein A7 -0.012354
ATF3 activating transcription factor 3 -0.0119737
IFI6 interferon, alpha-inducible protein 6 -0.0117097
PDE4B phosphodiesterase 4B, cAMP-specific -0.0116513
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.0115019
MYBPC1 myosin binding protein C, slow type -0.011143
TNNT1 troponin T type 1 (skeletal, slow) -0.0106287
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.0103326
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.0103269
MX1 MX dynamin-like GTPase 1 -0.0102889
SH2B3 SH2B adaptor protein 3 -0.0102285
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.0101912
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0101407
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0100818
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.010029
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.00996155
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00979121
RTN2 reticulon 2 -0.009739
STOM stomatin -0.00970779
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -0.00963615
SRGN serglycin -0.00947697
LPAR6 lysophosphatidic acid receptor 6 -0.00945028
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0093643
CSTA cystatin A (stefin A) -0.0093452
HOPX HOP homeobox -0.00924833
LAMP3 lysosomal-associated membrane protein 3 -0.00918539
TUBA1A tubulin, alpha 1a -0.00914645
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00897033
NPTX2 neuronal pentraxin II -0.00891599
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -0.00875501
GPM6A glycoprotein M6A -0.00860958
MX2 MX dynamin-like GTPase 2 -0.00860017
CALML5 calmodulin-like 5 -0.00856961
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.00851454
USP18 ubiquitin specific peptidase 18 -0.00845766
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00845541
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -0.00842712
AQP1 aquaporin 1 (Colton blood group) -0.00842235
TUBB2A tubulin, beta 2A class IIa -0.00841076
FKBP4 FK506 binding protein 4, 59kDa -0.00832742
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -0.00830202
LMO2 LIM domain only 2 (rhombotin-like 1) -0.0082704
FABP7 fatty acid binding protein 7, brain -0.00826364
ISG15 ISG15 ubiquitin-like modifier -0.00813864
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.00811261
WDR61 WD repeat domain 61 -0.00808509
C9ORF91 chromosome 9 open reading frame 91 -0.00792911
CXCL10 chemokine (C-X-C motif) ligand 10 -0.00788881
CAV1 caveolin 1, caveolae protein, 22kDa -0.00788854
LYPD3 LY6/PLAUR domain containing 3 -0.00785898
CYBRD1 cytochrome b reductase 1 -0.00783384
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00778328
TMEM45A transmembrane protein 45A -0.00777768
GPX1 glutathione peroxidase 1 -0.00776582
CA2 carbonic anhydrase II -0.00770245
ORC1 origin recognition complex, subunit 1 -0.00766281
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0075526
MYO1C myosin IC -0.00754211
PDZK1IP1 PDZK1 interacting protein 1 -0.00753558
DUSP5 dual specificity phosphatase 5 -0.00752219
OLFM1 olfactomedin 1 -0.00750837
CD36 CD36 molecule (thrombospondin receptor) -0.00748428
KRT14 keratin 14, type I -0.00748419
MYOT myotilin -0.00744749
NXT2 nuclear transport factor 2-like export factor 2 -0.00744711
ANOS1 anosmin 1 -0.00741698
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -0.00738184
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00735363
VNN1 vanin 1 -0.0073518
GPRC5B G protein-coupled receptor, class C, group 5, member B -0.0073465
IQCG IQ motif containing G -0.00733704
ATOX1 antioxidant 1 copper chaperone -0.00731695
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00730039
PADI2 peptidyl arginine deiminase, type II -0.00728948
KRT5 keratin 5, type II -0.00727242
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.00721707
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00720421
CCP110 centriolar coiled coil protein 110kDa -0.00720051
SAT1 spermidine/spermine N1-acetyltransferase 1 -0.00718553
SOX9 SRY (sex determining region Y)-box 9 -0.00715179
ALCAM activated leukocyte cell adhesion molecule -0.00713481
ISG20 interferon stimulated exonuclease gene 20kDa -0.00710545
NPY1R neuropeptide Y receptor Y1 -0.00708288
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0070797
GSDME gasdermin E -0.00703778
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.00703665
REEP1 receptor accessory protein 1 -0.00702107
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -0.00701482
C1ORF115 chromosome 1 open reading frame 115 -0.00701242
FHL1 four and a half LIM domains 1 -0.00698445
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.00697798
DAXX death-domain associated protein -0.00696922
AMZ2 archaelysin family metallopeptidase 2 -0.00693725
TGFBI transforming growth factor, beta-induced, 68kDa -0.00693368
WIF1 WNT inhibitory factor 1 -0.00692146
FABP4 fatty acid binding protein 4, adipocyte -0.00691542
ARMCX1 armadillo repeat containing, X-linked 1 -0.00691301
CHMP5 charged multivesicular body protein 5 -0.00691034
PDLIM5 PDZ and LIM domain 5 -0.00690628
IER2 immediate early response 2 -0.00690019
LST1 leukocyte specific transcript 1 -0.00682818
CXCL14 chemokine (C-X-C motif) ligand 14 -0.0068224
DMD dystrophin -0.00677035
JCHAIN joining chain of multimeric IgA and IgM -0.00675537
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -0.0067516
AVPI1 arginine vasopressin-induced 1 -0.00671807
ADRA2A adrenoceptor alpha 2A -0.00671741
H1-2 H1.2 linker histone, cluster member -0.00670186
PSAP prosaposin -0.00669775
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00668823
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00668679
CLEC2B C-type lectin domain family 2, member B -0.0066619
RPL36 ribosomal protein L36 -0.00665704
AQP3 aquaporin 3 (Gill blood group) -0.00665613
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.00665584
ACTN2 actinin, alpha 2 -0.00662203
RPP40 ribonuclease P/MRP 40kDa subunit -0.00660437
TESK1 testis-specific kinase 1 -0.00659427
IFI16 interferon, gamma-inducible protein 16 -0.00656297
GYPC glycophorin C (Gerbich blood group) -0.00651181
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0065016
SP110 SP110 nuclear body protein -0.00649785
VEGFA vascular endothelial growth factor A -0.00649717
HIST1H2BD histone cluster 1, H2bd -0.00649277
KRT81 keratin 81, type II -0.00646624
ACOT9 acyl-CoA thioesterase 9 -0.00646578
ACTA1 actin, alpha 1, skeletal muscle -0.00645799
SCRG1 stimulator of chondrogenesis 1 -0.00645708
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00641821
FRZB frizzled-related protein -0.0063926
CRYAB crystallin, alpha B -0.00638321
COL21A1 collagen, type XXI, alpha 1 -0.00637867
MXI1 MAX interactor 1, dimerization protein -0.0063741
IER5 immediate early response 5 -0.00633524
PYCARD PYD and CARD domain containing -0.00632104
RFTN1 raftlin, lipid raft linker 1 -0.00629785
CHPT1 choline phosphotransferase 1 -0.00625439
SNX10 sorting nexin 10 -0.00625394
FSCN1 fascin actin-bundling protein 1 -0.00625014
CD86 CD86 molecule -0.0062428
KLHL41 kelch-like family member 41 -0.00621775
BAMBI BMP and activin membrane-bound inhibitor -0.00619647
RPS14P3 ribosomal protein S14 pseudogene 3 -0.00618964
CKM creatine kinase, muscle -0.00618833
IRF7 interferon regulatory factor 7 -0.00618394
GBP1 guanylate binding protein 1, interferon-inducible -0.00617757
UQCRC2 ubiquinol-cytochrome c reductase core protein II -0.00614036
NVL nuclear VCP-like -0.00613916
HLA-B major histocompatibility complex, class I, B -0.00613637
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -0.00613463
INAVA innate immunity activator -0.00612417
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -0.00611751
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.00608725
KCTD12 potassium channel tetramerization domain containing 12 -0.00608521
SMPX small muscle protein, X-linked -0.0060835
CD93 CD93 molecule -0.00607949
PGAP3 post-GPI attachment to proteins 3 -0.00607681
TNNI1 troponin I type 1 (skeletal, slow) -0.00607624
HILPDA hypoxia inducible lipid droplet-associated -0.00607421
HNMT histamine N-methyltransferase -0.00606394
RAB38 RAB38, member RAS oncogene family -0.00602676
IL15 interleukin 15 -0.00600384
NEBL nebulette -0.00600378
GALC galactosylceramidase -0.00599049
CHN1 chimerin 1 -0.00598949
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.00598734
GSTO1 glutathione S-transferase omega 1 -0.00598721
ELOVL4 ELOVL fatty acid elongase 4 -0.00597702
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -0.0059606
SCGB1D2 secretoglobin, family 1D, member 2 -0.0059585
RAB4A RAB4A, member RAS oncogene family -0.0059566
PTEN phosphatase and tensin homolog -0.00595567
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.00592821
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.00592306
SYNM synemin, intermediate filament protein -0.00592084
TEAD4 TEA domain family member 4 -0.00591671
ITPRID2 ITPR interacting domain containing 2 -0.00590945
TMED3 transmembrane emp24 protein transport domain containing 3 -0.00589912
TTN titin -0.00586723
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.00586388
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00586347
PRUNE2 prune homolog 2 (Drosophila) -0.00585709
HINT1 histidine triad nucleotide binding protein 1 -0.00585107
GIMAP6 GTPase, IMAP family member 6 -0.00583378
HIST1H2AC histone cluster 1, H2ac -0.00582526
DOCK4 dedicator of cytokinesis 4 -0.00581068
OLFML2A olfactomedin-like 2A -0.00581052
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -0.00580596
ADA adenosine deaminase -0.00580287
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -0.00579312
C1ORF54 chromosome 1 open reading frame 54 -0.00577944
RSL1D1 ribosomal L1 domain containing 1 -0.00576902
RAB8B RAB8B, member RAS oncogene family -0.00576124
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -0.00574169
SPARCL1 SPARC-like 1 (hevin) -0.00570458
CORO1C coronin, actin binding protein, 1C -0.00569929
ACOX2 acyl-CoA oxidase 2, branched chain -0.00569474
TMEM59 transmembrane protein 59 -0.00569291
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -0.00568796
RHOC ras homolog family member C -0.00568584
PDLIM3 PDZ and LIM domain 3 -0.00568325
IFIH1 interferon induced with helicase C domain 1 -0.00567449
WWC1 WW and C2 domain containing 1 -0.00567091
SH3BGR SH3 domain binding glutamate-rich protein -0.00565747
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.00564824
ECI2 enoyl-CoA delta isomerase 2 -0.00564698
BPHL biphenyl hydrolase-like (serine hydrolase) -0.00564428
POPDC3 popeye domain containing 3 -0.00563932
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.00562343
CLDN10 claudin 10 -0.0056165
BAALC brain and acute leukemia, cytoplasmic -0.0056158
VDAC1 voltage-dependent anion channel 1 -0.00561526
JPT1 Jupiter microtubule associated homolog 1 -0.005611
HLA-F major histocompatibility complex, class I, F -0.0056105
EIF3I eukaryotic translation initiation factor 3, subunit I -0.00560882
C3ORF14 chromosome 3 open reading frame 14 -0.0056027
UBFD1 ubiquitin family domain containing 1 -0.00558065
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.00557035
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -0.00556799
GIMAP4 GTPase, IMAP family member 4 -0.00556565
CXCL2 chemokine (C-X-C motif) ligand 2 -0.00555995
SSPN sarcospan -0.00555383
CXCL11 chemokine (C-X-C motif) ligand 11 -0.00554734
COCH cochlin -0.00554243
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.00553871
EVI2A ecotropic viral integration site 2A -0.00553591
SLN sarcolipin -0.00553209
CD44 CD44 molecule (Indian blood group) -0.00551182
EAF2 ELL associated factor 2 -0.00549943
LRP4 low density lipoprotein receptor-related protein 4 -0.00549395
KIF2C kinesin family member 2C -0.00548892
CCN2 cellular communication network factor 2 -0.00548732
TMEM14B transmembrane protein 14B -0.00548345
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -0.00548302
C19ORF53 chromosome 19 open reading frame 53 -0.00546754
VIM vimentin -0.00546548