PPCS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphopantothenoylcysteine synthetase|Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 79717)
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Genes

315 genes differentially expressed following the PPCS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11D transmembrane protease, serine 11D 2.90584
BDKRB2 bradykinin receptor B2 2.90584
IL1A interleukin 1, alpha 2.90584
KRTAP13-4 keratin associated protein 13-4 2.90584
CD22 CD22 molecule 2.90584
MUCL1 mucin-like 1 2.90584
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.90584
CNTN6 contactin 6 2.90584
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.90584
FETUB fetuin B 2.90584
ERICH6B glutamate-rich 6B 2.90584
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.90584
CNTNAP4 contactin associated protein-like 4 2.90584
SPMAP1 sperm microtubule associated protein 1 2.90584
AMER2 APC membrane recruitment protein 2 2.90584
ALX3 ALX homeobox 3 2.90584
ZAR1 zygote arrest 1 2.90584
INSM1 insulinoma-associated 1 2.90584
CBLIF cobalamin binding intrinsic factor 2.90584
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.90584
LGALS4 lectin, galactoside-binding, soluble, 4 2.90584
CCN5 cellular communication network factor 5 2.90584
TREML2 triggering receptor expressed on myeloid cells-like 2 2.89705
UPB1 ureidopropionase, beta 2.89705
DDN dendrin 2.89705
HES7 hes family bHLH transcription factor 7 2.89705
SLC35G5 solute carrier family 35, member G5 2.89705
UBE2I ubiquitin-conjugating enzyme E2I 2.89705
GFRA3 GDNF family receptor alpha 3 2.89705
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.89705
IL22RA1 interleukin 22 receptor, alpha 1 2.89705
CD14 CD14 molecule 2.89705
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.89705
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.89705
DSG3 desmoglein 3 2.89705
ADGRE3 adhesion G protein-coupled receptor E3 2.89705
COLEC10 collectin sub-family member 10 (C-type lectin) 2.89705
ZNF492 zinc finger protein 492 2.89705
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.89705
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.89705
APLN apelin 2.89705
CA1 carbonic anhydrase I 2.89705
GIMAP4 GTPase, IMAP family member 4 2.89705
TAL2 T-cell acute lymphocytic leukemia 2 2.89705
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.89705
GPR22 G protein-coupled receptor 22 2.89705
OTUD6A OTU deubiquitinase 6A 2.89705
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.89705
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.89705
XCL1 chemokine (C motif) ligand 1 2.89705
OLIG1 oligodendrocyte transcription factor 1 2.89705
MEF2B myocyte enhancer factor 2B 2.89705
LACTBL1 lactamase, beta-like 1 2.89705
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.89705
DLL4 delta-like 4 (Drosophila) 2.89705
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.89705
SKOR2 SKI family transcriptional corepressor 2 2.89705
ARSF arylsulfatase F 2.89705
FGF21 fibroblast growth factor 21 2.89705
CIMIP2B ciliary microtubule inner protein 2B 2.89705
RHCG Rh family, C glycoprotein 2.89705
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.89705
MYEOV myeloma overexpressed 2.89705
PELI1 pellino E3 ubiquitin protein ligase 1 2.89705
GATA6 GATA binding protein 6 2.89705
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.89705
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.89705
LRRC73 leucine rich repeat containing 73 2.89705
IL7R interleukin 7 receptor 2.89705
HTRA4 HtrA serine peptidase 4 2.89705
LTB4R2 leukotriene B4 receptor 2 2.89705
RHOXF2 Rhox homeobox family, member 2 2.89705
SPMIP10 sperm microtubule inner protein 10 2.89705
DRC5 dynein regulatory complex subunit 5 2.89705
LINC02798 long intergenic non-protein coding RNA 2798 2.89705
LOC124906010 uncharacterized LOC124906010 2.89705
ACP4 acid phosphatase 4 2.89705
ARMH2 armadillo like helical domain containing 2 2.89705
STPG3 sperm-tail PG-rich repeat containing 3 2.89705
FLACC1 flagellum associated containing coiled-coil domains 1 2.89705
KASH5 KASH domain containing 5 2.89705
OPN4 opsin 4 2.89705
TACR2 tachykinin receptor 2 2.89705
KLHL33 kelch-like family member 33 2.89705
PCDHA3 protocadherin alpha 3 2.89705
LIPJ lipase, family member J 2.89705
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.89705
OR6T1 olfactory receptor, family 6, subfamily T, member 1 2.89705
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.89705
TSSK4 testis-specific serine kinase 4 2.89705
GJA3 gap junction protein, alpha 3, 46kDa 2.89705
SOX1 SRY (sex determining region Y)-box 1 2.89705
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.89705
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.89705
TMIE transmembrane inner ear 2.89705
CCR4 chemokine (C-C motif) receptor 4 2.89705
SPDYC speedy/RINGO cell cycle regulator family member C 2.89705
TLR8 toll-like receptor 8 2.89705
IL6 interleukin 6 2.89705
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.89705
CD79B CD79b molecule, immunoglobulin-associated beta 2.89705
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.89705
DSG1 desmoglein 1 2.89705
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.89705
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.89705
CRYGA crystallin, gamma A 2.89705
ANKRD31 ankyrin repeat domain 31 2.89705
THTPA thiamine triphosphatase 2.89705
CLRN3 clarin 3 2.89705
CXCR2 chemokine (C-X-C motif) receptor 2 2.89705
ANKRD63 ankyrin repeat domain 63 2.89705
HSPA1L heat shock 70kDa protein 1-like 2.89705
CDHR4 cadherin-related family member 4 2.89705
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.89705
DCAF8 DDB1 and CUL4 associated factor 8 2.89705
LCT lactase 2.89705
CCDC154 coiled-coil domain containing 154 2.89705
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.89705
DBX2 developing brain homeobox 2 2.89705
IER5L immediate early response 5-like 2.89705
DMBT1 deleted in malignant brain tumors 1 2.89705
ONECUT3 one cut homeobox 3 2.89705
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.89705
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.89705
VAX1 ventral anterior homeobox 1 2.89705
PCDHGB2 protocadherin gamma subfamily B, 2 2.89705
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.89705
MAMLD1 mastermind-like domain containing 1 2.89705
ARL13A ADP-ribosylation factor-like 13A 2.89705
ANKRD52 ankyrin repeat domain 52 2.89705
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.89705
CPN2 carboxypeptidase N, polypeptide 2 2.89705
C10ORF105 chromosome 10 open reading frame 105 2.89705
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.89705
WNT4 wingless-type MMTV integration site family, member 4 2.89705
CLEC18A C-type lectin domain family 18, member A 2.89705
CHIT1 chitinase 1 (chitotriosidase) 2.89705
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.89705
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.89705
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.89705
DRD5 dopamine receptor D5 2.89705
PCDHGA4 protocadherin gamma subfamily A, 4 2.89705
BAHCC1 BAH domain and coiled-coil containing 1 2.89705
EVI2A ecotropic viral integration site 2A 2.89705
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.89705
TTC16 tetratricopeptide repeat domain 16 2.89705
TEX12 testis expressed 12 2.89705
LGALS9B lectin, galactoside-binding, soluble, 9B 2.89705
ASCL5 achaete-scute family bHLH transcription factor 5 2.89705
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.89705
FGF9 fibroblast growth factor 9 2.89705
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.89705
LGALS2 lectin, galactoside-binding, soluble, 2 2.89705
CCDC87 coiled-coil domain containing 87 2.89705
CIB4 calcium and integrin binding family member 4 2.89705
XCR1 chemokine (C motif) receptor 1 2.89705
ADAM29 ADAM metallopeptidase domain 29 2.89705
ANGPTL5 angiopoietin-like 5 2.89705
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.89705
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.89705
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.89705
PCDHB6 protocadherin beta 6 2.89705
ICAM2 intercellular adhesion molecule 2 2.89705
FGF10 fibroblast growth factor 10 2.89705
MMP3 matrix metallopeptidase 3 2.89705
ALOX15B arachidonate 15-lipoxygenase, type B 2.89705
STMND1 stathmin domain containing 1 2.89705
FAM216B family with sequence similarity 216, member B 2.89705
ATOH7 atonal homolog 7 (Drosophila) 2.89705
ADGRF5 adhesion G protein-coupled receptor F5 2.89705
DAND5 DAN domain family member 5, BMP antagonist 2.89705
CDCP2 CUB domain containing protein 2 2.89705
GH1 growth hormone 1 2.89705
MPL MPL proto-oncogene, thrombopoietin receptor 2.89705
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.89705
C2ORF78 chromosome 2 open reading frame 78 2.89705
TSKS testis-specific serine kinase substrate 2.89518
EIF4E eukaryotic translation initiation factor 4E 2.81306
PVALB parvalbumin 2.80474
CCDC92B coiled-coil domain containing 92B 2.79697
PATL2 protein associated with topoisomerase II homolog 2 (yeast) 2.78094
RAB8A RAB8A, member RAS oncogene family 2.73203
TP53I13 tumor protein p53 inducible protein 13 2.65624
RAD51D RAD51 paralog D 2.59892
POLR1B polymerase (RNA) I polypeptide B, 128kDa 2.57995
PGF placental growth factor 2.55784
FGF22 fibroblast growth factor 22 2.53463
NSUN5 NOP2/Sun domain family, member 5 2.53251
C5ORF47 chromosome 5 open reading frame 47 2.48046
UBE2Z ubiquitin-conjugating enzyme E2Z 2.47294
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.46574
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.46574
DEPDC1 DEP domain containing 1 2.45528
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.40933
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.40479
FIGNL2 fidgetin-like 2 2.36631
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.35248
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.32297
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.31906
IRF8 interferon regulatory factor 8 2.31906
L2HGDH L-2-hydroxyglutarate dehydrogenase 2.31785
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 2.28627
C1ORF210 chromosome 1 open reading frame 210 2.26471
ZCCHC14 zinc finger, CCHC domain containing 14 2.26233
TBC1D13 TBC1 domain family, member 13 2.25072
DDTL D-dopachrome tautomerase-like 2.23712
SCAMP4 secretory carrier membrane protein 4 2.23712
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 2.22886
FAM110A family with sequence similarity 110, member A 2.1582
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.15704
ZNG1E Zn regulated GTPase metalloprotein activator 1E 2.11756
KHSRP KH-type splicing regulatory protein 2.11455
RWDD3 RWD domain containing 3 2.11386
PTDSS2 phosphatidylserine synthase 2 2.11196
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.11181
YIPF4 Yip1 domain family, member 4 2.10889
NONO non-POU domain containing, octamer-binding 2.09208
ILF3 interleukin enhancer binding factor 3, 90kDa 2.06144
CLIP2 CAP-GLY domain containing linker protein 2 2.0589
FRMD4A FERM domain containing 4A 2.0589
NRG3 neuregulin 3 2.0589
ZCCHC9 zinc finger, CCHC domain containing 9 2.04845
PDE8A phosphodiesterase 8A 2.02955
ATRNL1 attractin-like 1 2.00123

decreased expression

Symbol Name Standardized Value
CCDC51 coiled-coil domain containing 51 -2.90584
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.90584
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.90584
RAB9B RAB9B, member RAS oncogene family -2.90584
DNAI7 dynein axonemal intermediate chain 7 -2.90584
CDH24 cadherin 24, type 2 -2.90584
BMX BMX non-receptor tyrosine kinase -2.89705
XG Xg blood group -2.89705
SHISA7 shisa family member 7 -2.89705
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.89705
FOLR1 folate receptor 1 (adult) -2.89705
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.89705
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.89705
SLC16A11 solute carrier family 16, member 11 -2.89705
ACRBP acrosin binding protein -2.89705
GADL1 glutamate decarboxylase-like 1 -2.89705
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.89705
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase -2.89705
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.89705
GCKR glucokinase (hexokinase 4) regulator -2.89705
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.89705
RGN regucalcin -2.89705
CD177 CD177 molecule -2.89705
CATSPERT catsper channel auxiliary subunit tau -2.89705
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -2.89705
BBS5 Bardet-Biedl syndrome 5 -2.89705
LDB3 LIM domain binding 3 -2.89705
CFAP141 cilia and flagella associated protein 141 -2.89705
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -2.89705
RSRC2 arginine/serine-rich coiled-coil 2 -2.89705
C2ORF81 chromosome 2 open reading frame 81 -2.89705
H2BC4 H2B clustered histone 4 -2.89705
STRC stereocilin -2.89705
NOTCH2NLB notch 2 N-terminal like B -2.89705
FMO3 flavin containing monooxygenase 3 -2.89705
LEP leptin -2.89705
COL23A1 collagen, type XXIII, alpha 1 -2.89705
SCT secretin -2.89705
RABAC1 Rab acceptor 1 (prenylated) -2.89705
GPR139 G protein-coupled receptor 139 -2.89705
MRC2 mannose receptor, C type 2 -2.89705
ANO3 anoctamin 3 -2.89705
VSTM1 V-set and transmembrane domain containing 1 -2.89705
ANKRD53 ankyrin repeat domain 53 -2.89705
TRPV1 transient receptor potential cation channel, subfamily V, member 1 -2.83469
GPNMB glycoprotein (transmembrane) nmb -2.79697
C19ORF38 chromosome 19 open reading frame 38 -2.79039
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.79039
AKAP5 A kinase (PRKA) anchor protein 5 -2.755
NUMBL numb homolog (Drosophila)-like -2.60624
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.5933
ELMO1 engulfment and cell motility 1 -2.55173
CARD14 caspase recruitment domain family, member 14 -2.51449
RPL18 ribosomal protein L18 -2.49102
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.47659
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.45274
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) -2.44733
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.44578
PREPL prolyl endopeptidase-like -2.44578
RBMX RNA binding motif protein, X-linked -2.41295
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.33584
GXYLT1 glucoside xylosyltransferase 1 -2.31906
SCN1B sodium channel, voltage gated, type I beta subunit -2.31767
ALS2CL ALS2 C-terminal like -2.31767
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.31486
TMOD2 tropomodulin 2 (neuronal) -2.31486
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.26562
PQBP1 polyglutamine binding protein 1 -2.22908
SETD1B SET domain containing 1B -2.21423
GLMN glomulin, FKBP associated protein -2.20552
SLC38A1 solute carrier family 38, member 1 -2.19023
SIMC1 SUMO-interacting motifs containing 1 -2.15704
PDCD10 programmed cell death 10 -2.11489
ITM2A integral membrane protein 2A -2.11196
PHC3 polyhomeotic homolog 3 (Drosophila) -2.10889
IL20RA interleukin 20 receptor, alpha -2.10809
RPS6 ribosomal protein S6 -2.09892
HJURP Holliday junction recognition protein -2.07794
HLA-DRA major histocompatibility complex, class II, DR alpha -2.07418
SCD5 stearoyl-CoA desaturase 5 -2.07418
ABTB3 ankyrin repeat and BTB domain containing 3 -2.07257
PODXL2 podocalyxin-like 2 -2.06113
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.0589
HLA-E major histocompatibility complex, class I, E -2.0589
TMEM253 transmembrane protein 253 -2.0589
FNTA farnesyltransferase, CAAX box, alpha -2.03914
ZNF740 zinc finger protein 740 -2.02955
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.02955
TCTN2 tectonic family member 2 -2.02955
FKBP15 FK506 binding protein 15, 133kDa -2.02268
EID2B EP300 interacting inhibitor of differentiation 2B -2.00475