PPFIA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1|The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8500)
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Genes

330 genes differentially expressed following the PPFIA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 3.42905
GPR55 G protein-coupled receptor 55 3.42905
SLC46A3 solute carrier family 46, member 3 3.42905
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.42905
PGAM2 phosphoglycerate mutase 2 (muscle) 3.42905
PCDHB6 protocadherin beta 6 3.42905
TM4SF4 transmembrane 4 L six family member 4 3.42905
OSGIN1 oxidative stress induced growth inhibitor 1 3.42905
MYBPC3 myosin binding protein C, cardiac 3.42905
PEAR1 platelet endothelial aggregation receptor 1 3.42905
C6ORF58 chromosome 6 open reading frame 58 3.42905
COLEC10 collectin sub-family member 10 (C-type lectin) 3.42905
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.42905
HBA2 hemoglobin, alpha 2 3.42905
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.42905
TSSK4 testis-specific serine kinase 4 3.42905
CFHR5 complement factor H-related 5 3.42905
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.42905
UPK3B uroplakin 3B 3.42905
TXLNB taxilin beta 3.42905
CEMP1 cementum protein 1 3.42905
CHADL chondroadherin-like 3.42905
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.42905
BATF basic leucine zipper transcription factor, ATF-like 3.42905
GYPB glycophorin B (MNS blood group) 3.42905
TNIP3 TNFAIP3 interacting protein 3 3.42905
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 3.42905
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.42905
CAPS calcyphosine 3.42905
LGALS2 lectin, galactoside-binding, soluble, 2 3.42905
MYO1A myosin IA 3.42905
TMC2 transmembrane channel-like 2 3.42905
PRR22 proline rich 22 3.42905
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.42905
RBM39 RNA binding motif protein 39 3.42905
BTBD16 BTB (POZ) domain containing 16 3.42905
SHD Src homology 2 domain containing transforming protein D 3.42905
DRGX dorsal root ganglia homeobox 3.42905
C12ORF71 chromosome 12 open reading frame 71 3.42905
SLC9C2 solute carrier family 9, member C2 (putative) 3.42905
THRSP thyroid hormone responsive 3.42905
GADL1 glutamate decarboxylase-like 1 3.42905
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 3.42905
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.42905
C1ORF146 chromosome 1 open reading frame 146 3.42905
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.42905
ARPP21 cAMP-regulated phosphoprotein, 21kDa 3.42905
KCNIP3 Kv channel interacting protein 3, calsenilin 3.42905
FAM81B family with sequence similarity 81, member B 3.42905
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.42905
SPATA31G1 SPATA31 subfamily G member 1 3.42905
GARIN1A golgi associated RAB2 interactor 1A 3.42905
DIPK2B divergent protein kinase domain 2B 3.42905
MAB21L4 mab-21 like 4 3.42905
TMEM275 transmembrane protein 275 3.42905
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.42905
ERVW-1 endogenous retrovirus group W, member 1 3.42905
GBP3 guanylate binding protein 3 3.42905
RCVRN recoverin 3.42905
PKD2L1 polycystic kidney disease 2-like 1 3.42905
PLCZ1 phospholipase C, zeta 1 3.42905
MAJIN membrane anchored junction protein 3.42905
TMEM225B transmembrane protein 225B 3.42905
CIMAP2 ciliary microtubule associated protein 2 3.42905
SPMIP9 sperm microtubule inner protein 9 3.42905
TEKTL1 tektin like 1 3.42905
CIMIP2C ciliary microtubule inner protein 2C 3.42905
EPCIP exosomal polycystin 1 interacting protein 3.42905
CIMAP1C ciliary microtubule associated protein 1C 3.42905
H4C12 H4 clustered histone 12 3.42905
RHEX regulator of hemoglobinization and erythroid cell expansion 3.42905
H3C14 H3 clustered histone 14 3.42905
EZHIP EZH inhibitory protein 3.42905
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 3.42905
TMPRSS5 transmembrane protease, serine 5 3.42905
TRIM31 tripartite motif containing 31 3.42905
MIP major intrinsic protein of lens fiber 3.42905
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.42905
IL4 interleukin 4 3.42905
MEX3B mex-3 RNA binding family member B 3.42905
ULBP3 UL16 binding protein 3 3.42905
CATSPER3 cation channel, sperm associated 3 3.42905
MEOX1 mesenchyme homeobox 1 3.42905
CALCA calcitonin-related polypeptide alpha 3.42905
HPR haptoglobin-related protein 3.42905
PCDHA3 protocadherin alpha 3 3.42905
ZAN zonadhesin (gene/pseudogene) 3.42905
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.42905
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.42905
TSPAN8 tetraspanin 8 3.42905
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.42905
FAM107A family with sequence similarity 107, member A 3.42905
PXDC1 PX domain containing 1 3.42905
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.42905
VCX3B variable charge, X-linked 3B 3.42905
PGA3 pepsinogen 3, group I (pepsinogen A) 3.42905
MTMR11 myotubularin related protein 11 3.42905
SBSN suprabasin 3.42905
ACTL8 actin-like 8 3.42905
CD22 CD22 molecule 3.42905
HAMP hepcidin antimicrobial peptide 3.42905
DES desmin 3.42905
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.42905
MAGEB17 melanoma antigen family B17 3.42905
PRSS54 protease, serine, 54 3.42905
TBC1D28 TBC1 domain family, member 28 3.42905
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.42905
PRR15L proline rich 15-like 3.42905
ALOX15B arachidonate 15-lipoxygenase, type B 3.42905
ACKR3 atypical chemokine receptor 3 3.42905
NUTM2F NUT family member 2F 3.42905
POU3F2 POU class 3 homeobox 2 3.42905
ZCCHC18 zinc finger, CCHC domain containing 18 3.42905
POTEF POTE ankyrin domain family, member F 3.42905
GH2 growth hormone 2 3.42905
CHRM1 cholinergic receptor, muscarinic 1 3.42905
CFI complement factor I 3.42905
ZNF534 zinc finger protein 534 3.42905
IL13 interleukin 13 3.42905
ISL2 ISL LIM homeobox 2 3.42905
C18ORF63 chromosome 18 open reading frame 63 3.42905
THTPA thiamine triphosphatase 3.42905
CXCR5 chemokine (C-X-C motif) receptor 5 3.42905
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.42905
CDHR4 cadherin-related family member 4 3.42905
CCL25 chemokine (C-C motif) ligand 25 3.42905
TIGD3 tigger transposable element derived 3 3.42905
MAGEA2B melanoma antigen family A2B 3.42905
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.42905
OAZ3 ornithine decarboxylase antizyme 3 3.42905
CLEC4E C-type lectin domain family 4, member E 3.42905
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 3.42905
FIBIN fin bud initiation factor homolog (zebrafish) 3.42905
ODF4 outer dense fiber of sperm tails 4 3.42905
LRRC36 leucine rich repeat containing 36 3.42905
VWA3A von Willebrand factor A domain containing 3A 3.42905
PMP2 peripheral myelin protein 2 3.42905
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.42905
EMILIN1 elastin microfibril interfacer 1 3.42905
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.42905
TSPAN16 tetraspanin 16 3.42905
CHRDL2 chordin-like 2 3.42905
LAMB3 laminin, beta 3 3.42905
VWC2L von Willebrand factor C domain containing protein 2-like 3.42905
NLRP1 NLR family, pyrin domain containing 1 3.42905
NLRP9 NLR family, pyrin domain containing 9 3.42905
ASCL2 achaete-scute family bHLH transcription factor 2 3.42905
ETV3L ets variant 3-like 3.42905
C1ORF185 chromosome 1 open reading frame 185 3.42905
DEFB126 defensin, beta 126 3.42905
TEX29 testis expressed 29 3.42905
GOLGA8K golgin A8 family, member K 3.42905
ANKRD30B ankyrin repeat domain 30B 3.42905
TSSK1B testis-specific serine kinase 1B 3.42905
CCDC170 coiled-coil domain containing 170 3.42905
QRFP pyroglutamylated RFamide peptide 3.42905
SLC38A3 solute carrier family 38, member 3 3.42905
CDCP2 CUB domain containing protein 2 3.42905
GTF2A1L general transcription factor IIA, 1-like 3.42905
APOL6 apolipoprotein L, 6 3.42905
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.42905
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.42905
PCDHA13 protocadherin alpha 13 3.42905
TEX38 testis expressed 38 3.42905
KLK7 kallikrein-related peptidase 7 3.42905
TBX1 T-box 1 3.42905
PADI1 peptidyl arginine deiminase, type I 3.42905
PADI6 peptidyl arginine deiminase, type VI 3.42905
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.42905
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.42905
TGM4 transglutaminase 4 3.42905
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.42905
POU5F2 POU domain class 5, transcription factor 2 3.42905
ADAM29 ADAM metallopeptidase domain 29 3.42905
RGPD6 RANBP2-like and GRIP domain containing 6 3.30459
TNNI3 troponin I type 3 (cardiac) 3.25657
VASN vasorin 3.11231
SYNE1 spectrin repeat containing, nuclear envelope 1 3.10309
ZFP30 ZFP30 zinc finger protein 3.04494
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.95235
ADCY5 adenylate cyclase 5 2.84808
PRDM5 PR domain containing 5 2.78583
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.72586
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.7135
ERMARD ER membrane-associated RNA degradation 2.58046
KCTD2 potassium channel tetramerization domain containing 2 2.54402
PNO1 partner of NOB1 homolog (S. cerevisiae) 2.50204
RIMS1 regulating synaptic membrane exocytosis 1 2.47952
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.41518
THAP3 THAP domain containing, apoptosis associated protein 3 2.40759
IGIP IgA-inducing protein 2.40043
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.3921
CFAP53 cilia and flagella associated protein 53 2.38688
TENM4 teneurin transmembrane protein 4 2.38636
TDRD3 tudor domain containing 3 2.33801
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.33609
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.32861
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.32861
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 2.32861
IL32 interleukin 32 2.32861
BEND7 BEN domain containing 7 2.31511
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 2.27386
JAG2 jagged 2 2.27386
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 2.26061
KY kyphoscoliosis peptidase 2.26061
IL17D interleukin 17D 2.26061
SUSD2 sushi domain containing 2 2.26061
PLCL2 phospholipase C-like 2 2.26061
LYPD1 LY6/PLAUR domain containing 1 2.26061
FAM78A family with sequence similarity 78, member A 2.26061
ZFP36 ZFP36 ring finger protein 2.26061
ARL4D ADP-ribosylation factor-like 4D 2.23791
USP1 ubiquitin specific peptidase 1 2.21735
SLC25A53 solute carrier family 25, member 53 2.21735
ATL2 atlastin GTPase 2 2.18461
ZNF322 zinc finger protein 322 2.18461
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.17591
RBBP7 retinoblastoma binding protein 7 2.16167
STRADA STE20-related kinase adaptor alpha 2.11681
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.08588
MOK MOK protein kinase 2.05818
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2.05818
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.05818
C21ORF58 chromosome 21 open reading frame 58 2.05775
LAGE3 L antigen family, member 3 2.05122
VRK1 vaccinia related kinase 1 2.03052
CSMD2 CUB and Sushi multiple domains 2 2.02386

decreased expression

Symbol Name Standardized Value
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -3.42905
STAR steroidogenic acute regulatory protein -3.42905
GDA guanine deaminase -3.42905
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.42905
MRLN myoregulin -3.42905
IGFBP7 insulin-like growth factor binding protein 7 -3.42905
MAGEA4 melanoma antigen family A4 -3.42905
MBOAT4 membrane bound O-acyltransferase domain containing 4 -3.42905
ZNF597 zinc finger protein 597 -3.42905
ADAM21 ADAM metallopeptidase domain 21 -3.42905
GREM2 gremlin 2, DAN family BMP antagonist -3.42905
LTC4S leukotriene C4 synthase -3.42905
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -3.42905
NR2E3 nuclear receptor subfamily 2, group E, member 3 -3.42905
ELF4 E74-like factor 4 (ets domain transcription factor) -3.42905
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -3.42905
SYTL4 synaptotagmin-like 4 -3.42905
REEP6 receptor accessory protein 6 -3.42905
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -3.42905
SOST sclerostin -3.42905
TREH trehalase (brush-border membrane glycoprotein) -3.42905
ARSI arylsulfatase family, member I -3.42905
LHX6 LIM homeobox 6 -3.42905
IBSP integrin-binding sialoprotein -3.42905
UBXN10 UBX domain protein 10 -3.42905
SPMIP3 sperm microtubule inner protein 3 -3.42905
NMBR neuromedin B receptor -3.42905
FAM240C family with sequence similarity 240 member C -3.42905
FGFR3 fibroblast growth factor receptor 3 -3.42905
MORN5 MORN repeat containing 5 -3.42905
TTLL13 tubulin tyrosine ligase like 13 -3.42905
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -3.42905
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -3.42905
MLANA melan-A -3.42905
SYTL5 synaptotagmin-like 5 -3.42905
NBEAL1 neurobeachin-like 1 -3.42905
MTTP microsomal triglyceride transfer protein -3.42905
EPHA5 EPH receptor A5 -3.42905
TUBGCP6 tubulin, gamma complex associated protein 6 -3.42294
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -3.34908
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -3.32658
CHMP2B charged multivesicular body protein 2B -3.27699
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 -3.06632
TSEN15 TSEN15 tRNA splicing endonuclease subunit -3.00911
KDM2A lysine (K)-specific demethylase 2A -3.00638
BTBD17 BTB (POZ) domain containing 17 -2.96043
CCDC60 coiled-coil domain containing 60 -2.96043
TAOK2 TAO kinase 2 -2.94075
METTL22 methyltransferase like 22 -2.8463
CD320 CD320 molecule -2.81082
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.77794
PDCD5 programmed cell death 5 -2.72929
WDR5 WD repeat domain 5 -2.6703
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.66552
TMEM177 transmembrane protein 177 -2.63436
ANPEP alanyl (membrane) aminopeptidase -2.58048
CTRL chymotrypsin-like -2.58048
BMAL2 basic helix-loop-helix ARNT like 2 -2.58048
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.53411
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.40636
IL12RB2 interleukin 12 receptor, beta 2 -2.38636
DCAF4 DDB1 and CUL4 associated factor 4 -2.35098
CD47 CD47 molecule -2.34138
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.33609
ENDOD1 endonuclease domain containing 1 -2.32861
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.32861
TRAPPC14 trafficking protein particle complex subunit 14 -2.32861
PCNX2 pecanex 2 -2.32861
SIAE sialic acid acetylesterase -2.32861
TFEB transcription factor EB -2.32861
RNF207 ring finger protein 207 -2.32861
SRPRA SRP receptor subunit alpha -2.30628
CSRNP3 cysteine-serine-rich nuclear protein 3 -2.27386
GBA2 glucosidase, beta (bile acid) 2 -2.27386
DLAT dihydrolipoamide S-acetyltransferase -2.26764
GALNS galactosamine (N-acetyl)-6-sulfatase -2.26061
UBQLN2 ubiquilin 2 -2.26061
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.26061
TSPAN10 tetraspanin 10 -2.25051
TMEM208 transmembrane protein 208 -2.23791
BTBD1 BTB (POZ) domain containing 1 -2.23782
UFL1 UFM1-specific ligase 1 -2.21735
SCN1B sodium channel, voltage gated, type I beta subunit -2.21735
MTFMT mitochondrial methionyl-tRNA formyltransferase -2.21302
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.2098
MTRF1L mitochondrial translational release factor 1-like -2.18461
SHANK1 SH3 and multiple ankyrin repeat domains 1 -2.18461
CMSS1 cms1 ribosomal small subunit homolog (yeast) -2.18461
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.18461
VMA22 vacuolar ATPase assembly factor VMA22 -2.18461
INO80C INO80 complex subunit C -2.16052
CDK7 cyclin-dependent kinase 7 -2.15888
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.13939
C9ORF78 chromosome 9 open reading frame 78 -2.10442
TOR1B torsin family 1, member B (torsin B) -2.07073
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -2.07073
ZNF512B zinc finger protein 512B -2.06442
ASXL1 additional sex combs like transcriptional regulator 1 -2.06415
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.04838
TRIO trio Rho guanine nucleotide exchange factor -2.04076
CGGBP1 CGG triplet repeat binding protein 1 -2.03506
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.01978
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -2.00268