PPFIA3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3|The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8541)
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Genes

333 genes differentially expressed following the PPFIA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CHRM4 cholinergic receptor, muscarinic 4 2.94621
STX11 syntaxin 11 2.94621
FGR FGR proto-oncogene, Src family tyrosine kinase 2.94621
ANXA1 annexin A1 2.94621
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.94621
PCDHGB3 protocadherin gamma subfamily B, 3 2.94621
TGM2 transglutaminase 2 2.94621
RANBP3L RAN binding protein 3-like 2.94621
TREH trehalase (brush-border membrane glycoprotein) 2.94621
HKDC1 hexokinase domain containing 1 2.94621
CELA3B chymotrypsin-like elastase family, member 3B 2.94621
CXCR2 chemokine (C-X-C motif) receptor 2 2.94621
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.94621
MIP major intrinsic protein of lens fiber 2.94621
TMEM121 transmembrane protein 121 2.94621
C3AR1 complement component 3a receptor 1 2.94621
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.94621
SST somatostatin 2.94621
MEIS1 Meis homeobox 1 2.94621
TREML1 triggering receptor expressed on myeloid cells-like 1 2.92597
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.92597
SPAG8 sperm associated antigen 8 2.92597
CELF6 CUGBP, Elav-like family member 6 2.92597
ADRB2 adrenoceptor beta 2, surface 2.92597
TMEM132C transmembrane protein 132C 2.92597
RAX retina and anterior neural fold homeobox 2.92597
FAM9B family with sequence similarity 9, member B 2.92597
MELK maternal embryonic leucine zipper kinase 2.92597
IGFL3 IGF-like family member 3 2.92597
GJB5 gap junction protein, beta 5, 31.1kDa 2.92597
CARD16 caspase recruitment domain family, member 16 2.92597
LRRD1 leucine-rich repeats and death domain containing 1 2.92597
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.92597
TMPRSS11F transmembrane protease, serine 11F 2.92597
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.92597
KCNU1 potassium channel, subfamily U, member 1 2.92597
OR5K3 olfactory receptor, family 5, subfamily K, member 3 2.92597
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.92597
TAS2R13 taste receptor, type 2, member 13 2.92597
ZNF467 zinc finger protein 467 2.92597
SMIM5 small integral membrane protein 5 2.92597
OR13C3 olfactory receptor, family 13, subfamily C, member 3 2.92597
HCRTR2 hypocretin (orexin) receptor 2 2.92597
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.92597
RSPO1 R-spondin 1 2.92597
MPL MPL proto-oncogene, thrombopoietin receptor 2.92597
BMP5 bone morphogenetic protein 5 2.92597
C21ORF140 chromosome 21 open reading frame 140 2.92597
KRT24 keratin 24, type I 2.92597
SPACA3 sperm acrosome associated 3 2.92597
OIT3 oncoprotein induced transcript 3 2.92597
PNMA5 paraneoplastic Ma antigen family member 5 2.92597
SSTR1 somatostatin receptor 1 2.92597
PI16 peptidase inhibitor 16 2.92597
PPIAL4H peptidylprolyl isomerase A like 4H 2.92597
SLURP2 secreted LY6/PLAUR domain containing 2 2.92597
ROPN1B rhophilin associated tail protein 1B 2.92597
HTRA4 HtrA serine peptidase 4 2.92597
STMN4 stathmin-like 4 2.92597
KRT81 keratin 81, type II 2.92597
SPATA31H1 SPATA31 subfamily H member 1 2.92597
SAG S-antigen; retina and pineal gland (arrestin) 2.92597
ASB4 ankyrin repeat and SOCS box containing 4 2.92597
MAB21L4 mab-21 like 4 2.92597
MINAR2 membrane integral NOTCH2 associated receptor 2 2.92597
GNG5B G protein subunit gamma 5B 2.92597
GLYATL1B glycine-N-acyltransferase like 1B 2.92597
TUBB8B tubulin beta 8B 2.92597
ARMH2 armadillo like helical domain containing 2 2.92597
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.92597
CATSPERZ catsper channel auxiliary subunit zeta 2.92597
BNIP5 BCL2 interacting protein 5 2.92597
RTL9 retrotransposon Gag like 9 2.92597
WNT16 wingless-type MMTV integration site family, member 16 2.92597
FCMR Fc fragment of IgM receptor 2.92597
TSPAN1 tetraspanin 1 2.92597
CDSN corneodesmosin 2.92597
TLR7 toll-like receptor 7 2.92597
C11ORF24 chromosome 11 open reading frame 24 2.92597
OR6C4 olfactory receptor, family 6, subfamily C, member 4 2.92597
TUBA3E tubulin, alpha 3e 2.92597
PTPRC protein tyrosine phosphatase, receptor type, C 2.92597
PCDHA2 protocadherin alpha 2 2.92597
ATP13A4 ATPase type 13A4 2.92597
BARX2 BARX homeobox 2 2.92597
SAMD11 sterile alpha motif domain containing 11 2.92597
SPATA25 spermatogenesis associated 25 2.92597
SPATA22 spermatogenesis associated 22 2.92597
KHDC1L KH homology domain containing 1-like 2.92597
ZNF705D zinc finger protein 705D 2.92597
CNTN6 contactin 6 2.92597
SOAT2 sterol O-acyltransferase 2 2.92597
FGFBP1 fibroblast growth factor binding protein 1 2.92597
FMR1NB fragile X mental retardation 1 neighbor 2.92597
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.92597
LRRC24 leucine rich repeat containing 24 2.92597
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.92597
ANKRD61 ankyrin repeat domain 61 2.92597
CLRN2 clarin 2 2.92597
CNTF ciliary neurotrophic factor 2.92597
NIM1K NIM1 serine/threonine protein kinase 2.92597
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.92597
VAX2 ventral anterior homeobox 2 2.92597
SLC25A52 solute carrier family 25, member 52 2.92597
CA5A carbonic anhydrase VA, mitochondrial 2.92597
PRSS55 protease, serine, 55 2.92597
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.92597
PLGLB2 plasminogen-like B2 2.92597
USP17L7 ubiquitin specific peptidase 17-like family member 7 2.92597
GH1 growth hormone 1 2.92597
CHRM1 cholinergic receptor, muscarinic 1 2.92597
GPBAR1 G protein-coupled bile acid receptor 1 2.92597
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.92597
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.92597
CPA2 carboxypeptidase A2 (pancreatic) 2.92597
FAM209A family with sequence similarity 209, member A 2.92597
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.92597
EVI2A ecotropic viral integration site 2A 2.92597
LMX1A LIM homeobox transcription factor 1, alpha 2.92597
CAPSL calcyphosine-like 2.92597
DEFB135 defensin, beta 135 2.92597
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.92597
GSC2 goosecoid homeobox 2 2.92597
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.92597
PENK proenkephalin 2.92597
GPR62 G protein-coupled receptor 62 2.92597
PRSS38 protease, serine, 38 2.92597
TH tyrosine hydroxylase 2.92597
OCM oncomodulin 2.92597
TTC16 tetratricopeptide repeat domain 16 2.92597
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.92597
SAXO3 stabilizer of axonemal microtubules 3 2.92597
VWA3B von Willebrand factor A domain containing 3B 2.92597
SDSL serine dehydratase-like 2.92597
ASCL3 achaete-scute family bHLH transcription factor 3 2.92597
SOST sclerostin 2.92597
TPH1 tryptophan hydroxylase 1 2.92597
WFDC13 WAP four-disulfide core domain 13 2.92597
RBP4 retinol binding protein 4, plasma 2.92597
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.92597
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.92597
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.92597
CD34 CD34 molecule 2.92597
SSX1 synovial sarcoma, X breakpoint 1 2.92597
ZPLD1 zona pellucida-like domain containing 1 2.92597
RNASE7 ribonuclease, RNase A family, 7 2.92597
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.92597
PCDHGA12 protocadherin gamma subfamily A, 12 2.92597
RBM45 RNA binding motif protein 45 2.92313
ZNF396 zinc finger protein 396 2.87787
PLPP4 phospholipid phosphatase 4 2.87787
ARR3 arrestin 3, retinal (X-arrestin) 2.87787
NIBAN3 niban apoptosis regulator 3 2.87787
LONRF1 LON peptidase N-terminal domain and ring finger 1 2.85354
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.81796
NUBP1 nucleotide binding protein 1 2.77391
ZNF573 zinc finger protein 573 2.77391
TMED3 transmembrane emp24 protein transport domain containing 3 2.77346
GCC2 GRIP and coiled-coil domain containing 2 2.77051
RGS22 regulator of G-protein signaling 22 2.72552
UBOX5 U-box domain containing 5 2.72552
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.70924
TRAPPC11 trafficking protein particle complex 11 2.7051
SYNRG synergin, gamma 2.68047
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2.63794
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.61649
NKAIN4 Na+/K+ transporting ATPase interacting 4 2.60949
ACOT11 acyl-CoA thioesterase 11 2.60949
CRY1 cryptochrome circadian clock 1 2.59458
MREG melanoregulin 2.54393
CHN2 chimerin 2 2.53646
HP1BP3 heterochromatin protein 1, binding protein 3 2.53121
JAK1 Janus kinase 1 2.52098
ALDOC aldolase C, fructose-bisphosphate 2.50875
USP26 ubiquitin specific peptidase 26 2.50875
MRPS25 mitochondrial ribosomal protein S25 2.45502
STX5 syntaxin 5 2.41218
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.4074
VLDLR very low density lipoprotein receptor 2.40461
DCAF16 DDB1 and CUL4 associated factor 16 2.39426
HIC2 hypermethylated in cancer 2 2.37639
CFAP57 cilia and flagella associated protein 57 2.37639
TSC1 tuberous sclerosis 1 2.35486
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.3386
PEAK3 PEAK family member 3 2.31834
POLG polymerase (DNA directed), gamma 2.31133
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.29775
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.24979
ZNF518A zinc finger protein 518A 2.23289
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.21725
IFRD1 interferon-related developmental regulator 1 2.21725
CP ceruloplasmin (ferroxidase) 2.20891
TPBG trophoblast glycoprotein 2.19367
NIN ninein (GSK3B interacting protein) 2.19192
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 2.19068
LRRC2 leucine rich repeat containing 2 2.17915
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.17905
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.1443
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.14341
C1R complement component 1, r subcomponent 2.13572
STRN3 striatin, calmodulin binding protein 3 2.12701
SHISA9 shisa family member 9 2.12481
NARS1 asparaginyl-tRNA synthetase 1 2.09939
RFWD3 ring finger and WD repeat domain 3 2.09524
NFE2 nuclear factor, erythroid 2 2.09252
LOC112694756 uncharaterized LOC112694756 2.09252
ECPAS Ecm29 proteasome adaptor and scaffold 2.09252
ZNF670 zinc finger protein 670 2.08636
NES nestin 2.07751
ARHGAP35 Rho GTPase activating protein 35 2.07751
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.07751
DBN1 drebrin 1 2.05121
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.04019
EFNA4 ephrin-A4 2.04019
HYKK hydroxylysine kinase 2.03271
WNK3 WNK lysine deficient protein kinase 3 2.03271
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.01887
RIOX1 ribosomal oxygenase 1 2.01887
PARD3B par-3 family cell polarity regulator beta 2.01297
ZNF333 zinc finger protein 333 2.00413

decreased expression

Symbol Name Standardized Value
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.94621
EFCAB8 EF-hand calcium binding domain 8 -2.94621
MXRA5 matrix-remodelling associated 5 -2.94621
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.92597
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.92597
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.92597
SOX7 SRY (sex determining region Y)-box 7 -2.92597
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.92597
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.92597
ASPG asparaginase -2.92597
IL16 interleukin 16 -2.92597
RIMS2 regulating synaptic membrane exocytosis 2 -2.85407
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.77391
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.77391
CD8A CD8a molecule -2.77391
UROC1 urocanate hydratase 1 -2.77391
ALLC allantoicase -2.77391
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.77391
DEFB134 defensin, beta 134 -2.77391
CCDC82 coiled-coil domain containing 82 -2.77391
ACTL8 actin-like 8 -2.77391
FAM167A family with sequence similarity 167, member A -2.77391
CARD18 caspase recruitment domain family, member 18 -2.77391
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.77391
GPR26 G protein-coupled receptor 26 -2.77391
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.77391
CXCL2 chemokine (C-X-C motif) ligand 2 -2.77391
TDRD6 tudor domain containing 6 -2.77391
SRL sarcalumenin -2.77391
ISM2 isthmin 2 -2.77391
OVCH2 ovochymase 2 (gene/pseudogene) -2.77391
NR0B1 nuclear receptor subfamily 0, group B, member 1 -2.77391
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.77391
QRFP pyroglutamylated RFamide peptide -2.77391
CNR1 cannabinoid receptor 1 (brain) -2.77391
CLEC4G C-type lectin domain family 4, member G -2.77391
LRRK2 leucine-rich repeat kinase 2 -2.77391
C2CD4B C2 calcium-dependent domain containing 4B -2.77391
PCDHGA7 protocadherin gamma subfamily A, 7 -2.77391
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.77391
MYPN myopalladin -2.77391
CTXN2 cortexin 2 -2.77391
CFAP61 cilia and flagella associated protein 61 -2.77391
EPHA5 EPH receptor A5 -2.77391
ATP5MGL ATP synthase membrane subunit g like -2.77391
SLC38A3 solute carrier family 38, member 3 -2.77391
GATA2 GATA binding protein 2 -2.77391
ARHGAP20 Rho GTPase activating protein 20 -2.77391
EDN1 endothelin 1 -2.77391
H4C14 H4 clustered histone 14 -2.77391
MAMDC4 MAM domain containing 4 -2.77391
PRDM7 PR domain containing 7 -2.77391
AMIGO1 adhesion molecule with Ig-like domain 1 -2.77391
EPC1 enhancer of polycomb homolog 1 (Drosophila) -2.76765
GPR156 G protein-coupled receptor 156 -2.68503
MT1X metallothionein 1X -2.64793
PRDM1 PR domain containing 1, with ZNF domain -2.64787
MACO1 macoilin 1 -2.62355
ZFYVE19 zinc finger, FYVE domain containing 19 -2.61086
PROKR2 prokineticin receptor 2 -2.60688
TUFT1 tuftelin 1 -2.58727
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -2.57306
EQTN equatorin, sperm acrosome associated -2.53885
THYN1 thymocyte nuclear protein 1 -2.52334
ARHGAP27 Rho GTPase activating protein 27 -2.48247
CENPV centromere protein V -2.46912
LEKR1 leucine, glutamate and lysine rich 1 -2.4159
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.4074
SYN2 synapsin II -2.39023
ULK4 unc-51 like kinase 4 -2.34732
WDR20 WD repeat domain 20 -2.34034
SGMS2 sphingomyelin synthase 2 -2.33957
ZNF641 zinc finger protein 641 -2.31834
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.31243
LAMA4 laminin, alpha 4 -2.29775
LINC02798 long intergenic non-protein coding RNA 2798 -2.22756
TULP4 tubby like protein 4 -2.22756
ATF2 activating transcription factor 2 -2.21725
SOX13 SRY (sex determining region Y)-box 13 -2.19608
LURAP1 leucine rich adaptor protein 1 -2.19608
NUCLEOLIN nucleolin multifunctional protein -2.1931
ARFGEF3 ARFGEF family member 3 -2.19231
COG3 component of oligomeric golgi complex 3 -2.19029
CCPG1 cell cycle progression 1 -2.17876
YLPM1 YLP motif containing 1 -2.17834
TMEM203 transmembrane protein 203 -2.17834
BORCS6 BLOC-1 related complex subunit 6 -2.17009
RILPL1 Rab interacting lysosomal protein-like 1 -2.16991
ARL5A ADP-ribosylation factor-like 5A -2.1541
TMEM106B transmembrane protein 106B -2.14784
CDA cytidine deaminase -2.11526
CCDC24 coiled-coil domain containing 24 -2.09841
RSPO4 R-spondin 4 -2.09252
SCAF4 SR-related CTD-associated factor 4 -2.08746
OTUD5 OTU deubiquitinase 5 -2.07892
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -2.07786
OSMR oncostatin M receptor -2.07751
PNP purine nucleoside phosphorylase -2.07751
TMSB15B thymosin beta 15B -2.07751
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.07751
COL9A1 collagen, type IX, alpha 1 -2.07751
SCN3B sodium channel, voltage gated, type III beta subunit -2.07751
MAGEA4 melanoma antigen family A4 -2.07751
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.07515
AFP alpha-fetoprotein -2.05956
BRMS1 breast cancer metastasis suppressor 1 -2.05956
TIGD1 tigger transposable element derived 1 -2.0523
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.05196
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3 -2.05121
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.04412
SFXN4 sideroflexin 4 -2.03271
TFR2 transferrin receptor 2 -2.01488
CDC45 cell division cycle 45 -2.01216