PPFIA4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4|PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 8497)
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Genes

360 genes differentially expressed following the PPFIA4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PKDREJ polycystin (PKD) family receptor for egg jelly 2.72408
TAFA3 TAFA chemokine like family member 3 2.72408
TFEB transcription factor EB 2.72408
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.72408
SQOR sulfide quinone oxidoreductase 2.72408
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.72408
GGN gametogenetin 2.72408
BCAS1 breast carcinoma amplified sequence 1 2.72408
CFAP47 cilia and flagella associated protein 47 2.72408
NLRP10 NLR family, pyrin domain containing 10 2.72408
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.72408
MUCL3 mucin like 3 2.72408
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.72408
FLRT3 fibronectin leucine rich transmembrane protein 3 2.72408
DRC5 dynein regulatory complex subunit 5 2.72408
SCIN scinderin 2.72408
CYSRT1 cysteine-rich tail protein 1 2.72408
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.72408
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.72408
FOXP2 forkhead box P2 2.72408
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.66141
PRELP proline/arginine-rich end leucine-rich repeat protein 2.66141
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.66141
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.66141
MBLAC1 metallo-beta-lactamase domain containing 1 2.66141
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.66141
GLUD2 glutamate dehydrogenase 2 2.66141
CABP4 calcium binding protein 4 2.66141
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.66141
CARD18 caspase recruitment domain family, member 18 2.66141
NPAP1 nuclear pore associated protein 1 2.66141
VTN vitronectin 2.66141
C1ORF52 chromosome 1 open reading frame 52 2.66141
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.66141
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.66141
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.66141
HEATR9 HEAT repeat containing 9 2.66141
CD160 CD160 molecule 2.66141
KIAA2012 KIAA2012 2.66141
C8ORF74 chromosome 8 open reading frame 74 2.66141
KYNU kynureninase 2.66141
ATOH8 atonal homolog 8 (Drosophila) 2.66141
AVP arginine vasopressin 2.66141
JCHAIN joining chain of multimeric IgA and IgM 2.66141
ASGR2 asialoglycoprotein receptor 2 2.66141
KLLN killin, p53-regulated DNA replication inhibitor 2.66141
TMEM39A transmembrane protein 39A 2.66141
SPAG6 sperm associated antigen 6 2.66141
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.66141
C16ORF86 chromosome 16 open reading frame 86 2.66141
C8ORF48 chromosome 8 open reading frame 48 2.66141
CXORF65 chromosome X open reading frame 65 2.66141
CCDC62 coiled-coil domain containing 62 2.66141
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.66141
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.66141
NUGGC nuclear GTPase, germinal center associated 2.66141
MYOM2 myomesin 2 2.66141
PECAM1 platelet/endothelial cell adhesion molecule 1 2.66141
KCNRG potassium channel regulator 2.66141
LHX1 LIM homeobox 1 2.66141
OR11H4 olfactory receptor, family 11, subfamily H, member 4 2.66141
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.66141
LOC112694756 uncharaterized LOC112694756 2.66141
GIPC3 GIPC PDZ domain containing family, member 3 2.66141
ZNF74 zinc finger protein 74 2.66141
ANKRD36B ankyrin repeat domain 36B 2.66141
OTOF otoferlin 2.66141
AVPR1B arginine vasopressin receptor 1B 2.66141
GPX5 glutathione peroxidase 5 2.66141
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.66141
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.66141
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.66141
SPATA46 spermatogenesis associated 46 2.66141
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.66141
LITAFD LITAF domain containing 2.66141
CIMAP1C ciliary microtubule associated protein 1C 2.66141
NOTCH2NLB notch 2 N-terminal like B 2.66141
TMT1B thiol methyltransferase 1B 2.66141
LOC124900467 uncharacterized LOC124900467 2.66141
H4C15 H4 clustered histone 15 2.66141
GREP1 glycine rich extracellular protein 1 2.66141
H3-7 H3.7 histone (putative) 2.66141
MEIOSIN meiosis initiator 2.66141
H2AC1 H2A clustered histone 1 2.66141
COL3A1 collagen, type III, alpha 1 2.66141
WNT16 wingless-type MMTV integration site family, member 16 2.66141
DOK2 docking protein 2, 56kDa 2.66141
MEOX2 mesenchyme homeobox 2 2.66141
MFSD2B major facilitator superfamily domain containing 2B 2.66141
BBS5 Bardet-Biedl syndrome 5 2.66141
FAM3D family with sequence similarity 3, member D 2.66141
WEE2 WEE1 homolog 2 (S. pombe) 2.66141
PDILT protein disulfide isomerase-like, testis expressed 2.66141
TSSK6 testis-specific serine kinase 6 2.66141
NDRG1 N-myc downstream regulated 1 2.66141
CFHR5 complement factor H-related 5 2.66141
UPK3B uroplakin 3B 2.66141
MTMR1 myotubularin related protein 1 2.66141
TACSTD2 tumor-associated calcium signal transducer 2 2.66141
LY6H lymphocyte antigen 6 complex, locus H 2.66141
OSTN osteocrin 2.66141
SAMD15 sterile alpha motif domain containing 15 2.66141
PTH parathyroid hormone 2.66141
C7 complement component 7 2.66141
TACR2 tachykinin receptor 2 2.66141
TOM1 target of myb1 (chicken) 2.66141
C1QL2 complement component 1, q subcomponent-like 2 2.66141
SLC45A2 solute carrier family 45, member 2 2.66141
GDF10 growth differentiation factor 10 2.66141
INHBC inhibin, beta C 2.66141
CCDC83 coiled-coil domain containing 83 2.66141
IL12A interleukin 12A 2.66141
THTPA thiamine triphosphatase 2.66141
CRYBB2 crystallin, beta B2 2.66141
NOX1 NADPH oxidase 1 2.66141
RTBDN retbindin 2.66141
KLF4 Kruppel-like factor 4 (gut) 2.66141
GOLGA6A golgin A6 family, member A 2.66141
ITSN2 intersectin 2 2.66141
CGB7 chorionic gonadotropin, beta polypeptide 7 2.66141
AMIGO1 adhesion molecule with Ig-like domain 1 2.66141
EXTL1 exostosin-like glycosyltransferase 1 2.66141
IGFBP1 insulin-like growth factor binding protein 1 2.66141
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.66141
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.66141
KRT17 keratin 17, type I 2.66141
APOH apolipoprotein H (beta-2-glycoprotein I) 2.66141
FNDC1 fibronectin type III domain containing 1 2.66141
GFI1B growth factor independent 1B transcription repressor 2.66141
CCL21 chemokine (C-C motif) ligand 21 2.66141
SOWAHD sosondowah ankyrin repeat domain family member D 2.66141
C22ORF42 chromosome 22 open reading frame 42 2.66141
C2CD4B C2 calcium-dependent domain containing 4B 2.66141
LMOD3 leiomodin 3 (fetal) 2.66141
IDI2 isopentenyl-diphosphate delta isomerase 2 2.66141
ORM2 orosomucoid 2 2.66141
FAIM2 Fas apoptotic inhibitory molecule 2 2.66141
ERVV-1 endogenous retrovirus group V, member 1 2.66141
KLHDC4 kelch domain containing 4 2.66141
LMX1A LIM homeobox transcription factor 1, alpha 2.66141
FKBP1C FK506 binding protein 1C 2.66141
TTC22 tetratricopeptide repeat domain 22 2.66141
TAGAP T-cell activation RhoGTPase activating protein 2.66141
MORN5 MORN repeat containing 5 2.66141
NT5DC4 5'-nucleotidase domain containing 4 2.66141
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.66141
COL17A1 collagen, type XVII, alpha 1 2.66141
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.66141
ZCCHC12 zinc finger, CCHC domain containing 12 2.66141
NTF3 neurotrophin 3 2.66141
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.66141
SPEF1 sperm flagellar 1 2.66141
RBM24 RNA binding motif protein 24 2.66141
TEX29 testis expressed 29 2.66141
LIN52 lin-52 DREAM MuvB core complex component 2.66141
PRAP1 proline-rich acidic protein 1 2.66141
FXYD3 FXYD domain containing ion transport regulator 3 2.66141
GALP galanin-like peptide 2.66141
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.66141
IFITM10 interferon induced transmembrane protein 10 2.66141
ICAM2 intercellular adhesion molecule 2 2.66141
ASCL2 achaete-scute family bHLH transcription factor 2 2.66141
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.66141
FCRLB Fc receptor-like B 2.66141
FOXP3 forkhead box P3 2.66141
TMPRSS15 transmembrane protease, serine 15 2.66141
MMP12 matrix metallopeptidase 12 2.66141
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.66141
FRMPD1 FERM and PDZ domain containing 1 2.66141
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.66141
RHAG Rh-associated glycoprotein 2.66141
SOST sclerostin 2.66141
MEIG1 meiosis/spermiogenesis associated 1 2.66141
VTCN1 V-set domain containing T cell activation inhibitor 1 2.66141
PLGLB2 plasminogen-like B2 2.66141
HRG histidine-rich glycoprotein 2.66141
TSKS testis-specific serine kinase substrate 2.66141
GPR78 G protein-coupled receptor 78 2.66141
FBXL4 F-box and leucine-rich repeat protein 4 2.66141
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.6578
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.63694
USP30 ubiquitin specific peptidase 30 2.5936
WFDC2 WAP four-disulfide core domain 2 2.59236
ANAPC11 anaphase promoting complex subunit 11 2.58667
FAT4 FAT atypical cadherin 4 2.55565
ZNF22 zinc finger protein 22 2.53013
MEN1 multiple endocrine neoplasia I 2.52074
CCNT1 cyclin T1 2.52074
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.49852
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.49803
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 2.46269
BGLAP bone gamma-carboxyglutamate (gla) protein 2.43709
H4C13 H4 clustered histone 13 2.43709
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.43709
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.40083
OGDHL oxoglutarate dehydrogenase-like 2.36422
AIG1 androgen-induced 1 2.35927
APLP1 amyloid beta (A4) precursor-like protein 1 2.35048
DENND2B DENN domain containing 2B 2.34008
LMNB2 lamin B2 2.33745
SCAP SREBF chaperone 2.32251
NGEF neuronal guanine nucleotide exchange factor 2.3005
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.27369
PMP22 peripheral myelin protein 22 2.27273
SCRG1 stimulator of chondrogenesis 1 2.27273
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.27153
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.26413
FGFR1OP2 FGFR1 oncogene partner 2 2.26413
ZCCHC10 zinc finger, CCHC domain containing 10 2.26413
CAV3 caveolin 3 2.22694
PHF10 PHD finger protein 10 2.21586
TMED1 transmembrane emp24 protein transport domain containing 1 2.21558
CCSAP centriole, cilia and spindle-associated protein 2.20379
FSTL4 follistatin-like 4 2.19235
FCF1 FCF1 rRNA-processing protein 2.16905
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.16678
SPTBN2 spectrin, beta, non-erythrocytic 2 2.15833
GRM4 glutamate receptor, metabotropic 4 2.155
CNOT7 CCR4-NOT transcription complex, subunit 7 2.13774
DPY19L4 dpy-19-like 4 (C. elegans) 2.13456
AFF1 AF4/FMR2 family, member 1 2.12404
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 2.12177
TMEM268 transmembrane protein 268 2.11898
RSPRY1 ring finger and SPRY domain containing 1 2.11898
CSK c-src tyrosine kinase 2.11898
OSBPL6 oxysterol binding protein-like 6 2.11074
SRD5A3 steroid 5 alpha-reductase 3 2.10563
CLCN6 chloride channel, voltage-sensitive 6 2.09006
AGO3 argonaute RISC catalytic component 3 2.08828
MTG2 mitochondrial ribosome-associated GTPase 2 2.08688
FEM1C fem-1 homolog c (C. elegans) 2.08584
ZNF546 zinc finger protein 546 2.08584
PRKD3 protein kinase D3 2.08584
PROCA1 protein interacting with cyclin A1 2.08584
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.07968
CCDC15 coiled-coil domain containing 15 2.07074
KIF14 kinesin family member 14 2.06808
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.06511
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.06197
FBXO41 F-box protein 41 2.06002
ZNF865 zinc finger protein 865 2.03856
CDA cytidine deaminase 2.02447
MRE11 MRE11 homolog, double strand break repair nuclease 2.02108
TRIM17 tripartite motif containing 17 2.01215
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.01071

decreased expression

Symbol Name Standardized Value
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.72408
PCDHA9 protocadherin alpha 9 -2.72408
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -2.72408
MUC4 mucin 4, cell surface associated -2.72408
OTOGL otogelin-like -2.72408
SFT2D3 SFT2 domain containing 3 -2.72408
ASB16 ankyrin repeat and SOCS box containing 16 -2.72408
LRRC75B leucine rich repeat containing 75B -2.72408
ACTG2 actin, gamma 2, smooth muscle, enteric -2.72408
DHDH dihydrodiol dehydrogenase (dimeric) -2.66141
TCF15 transcription factor 15 (basic helix-loop-helix) -2.66141
NPIPA2 nuclear pore complex interacting protein family, member A2 -2.66141
NOD2 nucleotide-binding oligomerization domain containing 2 -2.66141
LITAF lipopolysaccharide-induced TNF factor -2.66141
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.66141
EPHB4 EPH receptor B4 -2.66141
CLCF1 cardiotrophin-like cytokine factor 1 -2.66141
BTBD18 BTB (POZ) domain containing 18 -2.66141
IFI27 interferon, alpha-inducible protein 27 -2.66141
DBP D site of albumin promoter (albumin D-box) binding protein -2.66141
ZFP36 ZFP36 ring finger protein -2.66141
WNT5B wingless-type MMTV integration site family, member 5B -2.66141
LRRC63 leucine rich repeat containing 63 -2.66141
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.66141
LIPT2-AS1 LIPT2 antisense RNA 1 -2.66141
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -2.66141
DUSP9 dual specificity phosphatase 9 -2.66141
F8 coagulation factor VIII, procoagulant component -2.66141
ZNF777 zinc finger protein 777 -2.66141
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.66141
PRH1-TAS2R14 PRH1-TAS2R14 readthrough -2.66141
ICOSLG inducible T-cell co-stimulator ligand -2.66141
PANX2 pannexin 2 -2.66141
PRB2 proline-rich protein BstNI subfamily 2 -2.66141
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.66141
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.66141
AKAP14 A kinase (PRKA) anchor protein 14 -2.66141
LRRTM1 leucine rich repeat transmembrane neuronal 1 -2.66141
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.66141
NXPH4 neurexophilin 4 -2.66141
TMEM278 transmembrane protein 278 -2.66141
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.66141
APOB apolipoprotein B -2.66141
HSF1 heat shock transcription factor 1 -2.66141
RORC RAR-related orphan receptor C -2.66141
TTC24 tetratricopeptide repeat domain 24 -2.66141
HEG1 heart development protein with EGF-like domains 1 -2.66141
KIF4A kinesin family member 4A -2.66141
CDHR4 cadherin-related family member 4 -2.66141
ZDHHC11B zinc finger, DHHC-type containing 11B -2.66141
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.66141
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.66141
NOX3 NADPH oxidase 3 -2.66141
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.66141
SERP2 stress-associated endoplasmic reticulum protein family member 2 -2.62759
ZNG1A Zn regulated GTPase metalloprotein activator 1A -2.54545
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.49143
XXYLT1 xyloside xylosyltransferase 1 -2.48135
ZSCAN1 zinc finger and SCAN domain containing 1 -2.43696
FMNL1 formin-like 1 -2.41713
CDK6 cyclin-dependent kinase 6 -2.41291
RFK riboflavin kinase -2.41193
UBE3C ubiquitin protein ligase E3C -2.40112
UBQLN1 ubiquilin 1 -2.40108
ACLY ATP citrate lyase -2.37928
GPC5 glypican 5 -2.37788
TMEM92 transmembrane protein 92 -2.35397
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -2.33851
SRCIN1 SRC kinase signaling inhibitor 1 -2.33373
LRRC4B leucine rich repeat containing 4B -2.32109
NECTIN2 nectin cell adhesion molecule 2 -2.32109
VASN vasorin -2.29462
KIAA1549L KIAA1549-like -2.29349
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) -2.27823
OGFRL1 opioid growth factor receptor-like 1 -2.27273
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.27273
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.27273
PEX12 peroxisomal biogenesis factor 12 -2.27273
PHF19 PHD finger protein 19 -2.26413
ANAPC5 anaphase promoting complex subunit 5 -2.25678
SNX15 sorting nexin 15 -2.25343
INO80D INO80 complex subunit D -2.25329
TRIM69 tripartite motif containing 69 -2.25329
CBX4 chromobox homolog 4 -2.25329
BFAR bifunctional apoptosis regulator -2.25329
MANSC1 MANSC domain containing 1 -2.25329
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.25329
COL5A2 collagen, type V, alpha 2 -2.22563
PURG purine-rich element binding protein G -2.21442
PPARG peroxisome proliferator-activated receptor gamma -2.21371
AOPEP aminopeptidase O (putative) -2.1988
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.19235
GCN1 GCN1 activator of EIF2AK4 -2.18691
KDM6B lysine (K)-specific demethylase 6B -2.18562
TRHDE thyrotropin-releasing hormone degrading enzyme -2.15993
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -2.15669
RANBP2 RAN binding protein 2 -2.13744
CBS cystathionine-beta-synthase -2.11857
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -2.11857
DNAL1 dynein, axonemal, light chain 1 -2.09482
ZNF496 zinc finger protein 496 -2.08839
OSBP2 oxysterol binding protein 2 -2.08688
KLHL11 kelch-like family member 11 -2.08584
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.0724
TRIP12 thyroid hormone receptor interactor 12 -2.06725
BTBD6 BTB (POZ) domain containing 6 -2.06507
DUSP4 dual specificity phosphatase 4 -2.06244
DIPK2A divergent protein kinase domain 2A -2.04229
AJAP1 adherens junctions associated protein 1 -2.04229
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.03824
OSGEP O-sialoglycoprotein endopeptidase -2.02591
PLAC8L1 PLAC8-like 1 -2.02447
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -2.00539
TEX10 testis expressed 10 -2.00505
HOMER1 homer scaffolding protein 1 -2.00244