PPFIBP1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description PTPRF interacting protein, binding protein 1 (liprin beta 1)|The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8496)
External Link http://www.ncbi.nlm.nih.gov/gene/8496
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196 interacting proteins for PPFIBP1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
ALMS1 Alstrom syndrome protein 1
AMER1 APC membrane recruitment protein 1
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
AMPD2 adenosine monophosphate deaminase 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC5 anaphase promoting complex subunit 5
APC adenomatous polyposis coli
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAD BCL2-associated agonist of cell death
BAG2 BCL2-associated athanogene 2
BAG5 BCL2-associated athanogene 5
BAIAP2 BAI1-associated protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CCDC77 coiled-coil domain containing 77
CCDC88C coiled-coil domain containing 88C
CDC25C cell division cycle 25C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP192 centrosomal protein 192kDa
CEP250 centrosomal protein 250kDa
CEP295 centrosomal protein 295kDa
CEP72 centrosomal protein 72kDa
CEP76 centrosomal protein 76kDa
CEP85 centrosomal protein 85kDa
CEP89 centrosomal protein 89kDa
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CNTROB centrobin, centrosomal BRCA2 interacting protein
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
EDC3 enhancer of mRNA decapping 3
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ELAVL1 ELAV like RNA binding protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERC1 ELKS/RAB6-interacting/CAST family member 1
EXO1 exonuclease 1
FOXO3 forkhead box O3
GAPVD1 GTPase activating protein and VPS9 domains 1
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GRIP1 glutamate receptor interacting protein 1
GRK5 G protein-coupled receptor kinase 5
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNF4A hepatocyte nuclear factor 4, alpha
INADL InaD-like (Drosophila)
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KLC2 kinesin light chain 2
KLC4 kinesin light chain 4
KSR1 kinase suppressor of ras 1
LARP1 La ribonucleoprotein domain family, member 1
LATS2 large tumor suppressor kinase 2
LIMA1 LIM domain and actin binding 1
LMO7 LIM domain 7
LUZP1 leucine zipper protein 1
LZTS2 leucine zipper, putative tumor suppressor 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MIA3 melanoma inhibitory activity family, member 3
MPDZ multiple PDZ domain protein
MPHOSPH9 M-phase phosphoprotein 9
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MTMR12 myotubularin related protein 12
NADK NAD kinase
NAV1 neuron navigator 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NINL ninein-like
NOTCH1 notch 1
NOTCH2 notch 2
NUP160 nucleoporin 160kDa
OFD1 oral-facial-digital syndrome 1
ONECUT1 one cut homeobox 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP8 poly (ADP-ribose) polymerase family, member 8
PCM1 pericentriolar material 1
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKP2 plakophilin 2
PKP4 plakophilin 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPRM protein tyrosine phosphatase, receptor type, M
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
REEP4 receptor accessory protein 4
RICTOR RPTOR independent companion of MTOR, complex 2
RTKN rhotekin
S100A4 S100 calcium binding protein A4
SACK1B scaffolding CK1 anchoring protein B
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SDCCAG3 serologically defined colon cancer antigen 3
SEC16A SEC16 homolog A (S. cerevisiae)
SFN stratifin
SH3KBP1 SH3-domain kinase binding protein 1
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHKBP1 SH3KBP1 binding protein 1
SHROOM3 shroom family member 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK3 serine/threonine kinase 3
STXBP4 syntaxin binding protein 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TCHP trichoplein, keratin filament binding
TNRC6B trinucleotide repeat containing 6B
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRIM27 tripartite motif containing 27
TRIM32 tripartite motif containing 32
TRIM37 tripartite motif containing 37
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
VCP valosin containing protein
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WNK1 WNK lysine deficient protein kinase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2