PPIA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peptidylprolyl isomerase A (cyclophilin A)|This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5478)
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Genes

314 genes differentially expressed following the PPIA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SMYD1 SET and MYND domain containing 1 3.16062
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 3.16062
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.16062
AOC3 amine oxidase, copper containing 3 3.16062
ADAM7 ADAM metallopeptidase domain 7 3.16062
FOLR1 folate receptor 1 (adult) 3.16062
IL16 interleukin 16 3.16062
LPA lipoprotein, Lp(a) 3.16062
VCX3A variable charge, X-linked 3A 3.16062
FRG2C FSHD region gene 2 family, member C 3.16062
MYF6 myogenic factor 6 (herculin) 3.16062
S100B S100 calcium binding protein B 3.16062
TBX20 T-box 20 3.16062
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.16062
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.16062
ZAR1 zygote arrest 1 3.16062
CRH corticotropin releasing hormone 3.16062
LRRC10B leucine rich repeat containing 10B 3.16062
MANSC4 MANSC domain containing 4 3.16062
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.16062
DMRTC1B DMRT-like family C1B 3.16062
C20ORF204 chromosome 20 open reading frame 204 3.16062
EMP1 epithelial membrane protein 1 3.16062
TM4SF19 transmembrane 4 L six family member 19 3.16062
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.11997
FOXL1 forkhead box L1 3.11997
PLVAP plasmalemma vesicle associated protein 3.11997
SIGLEC5 sialic acid binding Ig-like lectin 5 3.11997
COL19A1 collagen, type XIX, alpha 1 3.11997
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.11997
SHCBP1L SHC SH2-domain binding protein 1-like 3.11997
TSGA10IP testis specific, 10 interacting protein 3.11997
MTNR1B melatonin receptor 1B 3.11997
LOC390937 Ets2 repressor factor-like 3.11997
TLX2 T-cell leukemia homeobox 2 3.11997
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.11997
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.11997
ASB18 ankyrin repeat and SOCS box containing 18 3.11997
OLAH oleoyl-ACP hydrolase 3.11997
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.11997
SCN2B sodium channel, voltage gated, type II beta subunit 3.11997
HEATR9 HEAT repeat containing 9 3.11997
SLC35G5 solute carrier family 35, member G5 3.11997
GLYAT glycine-N-acyltransferase 3.11997
CCL5 chemokine (C-C motif) ligand 5 3.11997
PDE7B phosphodiesterase 7B 3.11997
GJB1 gap junction protein, beta 1, 32kDa 3.11997
CSTL1 cystatin-like 1 3.11997
PI16 peptidase inhibitor 16 3.11997
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.11997
ALB albumin 3.11997
CST11 cystatin 11 3.11997
SLC10A5 solute carrier family 10, member 5 3.11997
SELPLG selectin P ligand 3.11997
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.11997
NAPSA napsin A aspartic peptidase 3.11997
APOA2 apolipoprotein A-II 3.11997
SLC16A6 solute carrier family 16, member 6 3.11997
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.11997
SIM2 single-minded family bHLH transcription factor 2 3.11997
CATSPERH catsper channel auxiliary subunit eta 3.11997
ROPN1L rhophilin associated tail protein 1-like 3.11997
CLDN16 claudin 16 3.11997
CAPN9 calpain 9 3.11997
PNLIPRP3 pancreatic lipase-related protein 3 3.11997
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.11997
CXCL13 chemokine (C-X-C motif) ligand 13 3.11997
ACER1 alkaline ceramidase 1 3.11997
HTRA4 HtrA serine peptidase 4 3.11997
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.11997
MCHR2 melanin-concentrating hormone receptor 2 3.11997
OTOA otoancorin 3.11997
SPMAP2L sperm microtubule associated protein 2 like 3.11997
SPATA31H1 SPATA31 subfamily H member 1 3.11997
FAM240C family with sequence similarity 240 member C 3.11997
CPNE8-AS1 CPNE8 antisense RNA 1 3.11997
SMIM43 small integral membrane protein 43 3.11997
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.11997
MINDY4B MINDY family member 4B 3.11997
H2BW2 H2B.W histone 2 3.11997
VEGFD vascular endothelial growth factor D 3.11997
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.11997
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.11997
ASB5 ankyrin repeat and SOCS box containing 5 3.11997
GTSF1 gametocyte specific factor 1 3.11997
CLDN22 claudin 22 3.11997
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.11997
OR2L5 olfactory receptor, family 2, subfamily L, member 5 3.11997
LOC122539214 Zinc finger protein LOC122539214 3.11997
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.11997
TPTE transmembrane phosphatase with tensin homology 3.11997
BHLHA9 basic helix-loop-helix family, member a9 3.11997
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.11997
SAMD15 sterile alpha motif domain containing 15 3.11997
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.11997
WNT16 wingless-type MMTV integration site family, member 16 3.11997
RAB36 RAB36, member RAS oncogene family 3.11997
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.11997
SPATA22 spermatogenesis associated 22 3.11997
IMPG1 interphotoreceptor matrix proteoglycan 1 3.11997
KL klotho 3.11997
CSAG3 CSAG family, member 3 3.11997
PRG3 proteoglycan 3 3.11997
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.11997
IL5 interleukin 5 3.11997
ARL17A ADP-ribosylation factor-like 17A 3.11997
FAM25G family with sequence similarity 25, member G 3.11997
CCDC154 coiled-coil domain containing 154 3.11997
FNDC9 fibronectin type III domain containing 9 3.11997
AKR1B15 aldo-keto reductase family 1, member B15 3.11997
RSAD2 radical S-adenosyl methionine domain containing 2 3.11997
C18ORF63 chromosome 18 open reading frame 63 3.11997
LRTM2 leucine-rich repeats and transmembrane domains 2 3.11997
CXCR4 chemokine (C-X-C motif) receptor 4 3.11997
CDHR4 cadherin-related family member 4 3.11997
NPPA natriuretic peptide A 3.11997
MORC1 MORC family CW-type zinc finger 1 3.11997
TBC1D28 TBC1 domain family, member 28 3.11997
ABHD1 abhydrolase domain containing 1 3.11997
ECM1 extracellular matrix protein 1 3.11997
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.11997
ZMYND15 zinc finger, MYND-type containing 15 3.11997
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.11997
SMIM22 small integral membrane protein 22 3.11997
IPP intracisternal A particle-promoted polypeptide 3.11997
FAM163A family with sequence similarity 163, member A 3.11997
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.11997
SPATA3 spermatogenesis associated 3 3.11997
QRFP pyroglutamylated RFamide peptide 3.11997
LRRC25 leucine rich repeat containing 25 3.11997
LGALS12 lectin, galactoside-binding, soluble, 12 3.11997
KRTAP10-1 keratin associated protein 10-1 3.11997
MYADML2 myeloid-associated differentiation marker-like 2 3.11997
TSPAN16 tetraspanin 16 3.11997
CASQ2 calsequestrin 2 (cardiac muscle) 3.11997
GOLGA8T golgin A8 family, member T 3.11997
NCR3 natural cytotoxicity triggering receptor 3 3.11997
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.11997
TREH trehalase (brush-border membrane glycoprotein) 3.11997
PAGE4 P antigen family, member 4 (prostate associated) 3.11997
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.11997
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.11997
ISL2 ISL LIM homeobox 2 3.11997
COMP cartilage oligomeric matrix protein 3.11997
DHH desert hedgehog 3.11997
THBD thrombomodulin 3.11997
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.11997
TECRL trans-2,3-enoyl-CoA reductase-like 3.11997
MAEL maelstrom spermatogenic transposon silencer 3.11997
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.11997
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.11997
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.11997
KRT72 keratin 72, type II 3.11997
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.11997
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.11997
ACOT12 acyl-CoA thioesterase 12 3.11997
ATOH1 atonal homolog 1 (Drosophila) 3.11997
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.11997
IRX4 iroquois homeobox 4 3.11997
CFI complement factor I 3.11997
LGALS2 lectin, galactoside-binding, soluble, 2 3.11997
MYL5 myosin, light chain 5, regulatory 3.11997
DEFB134 defensin, beta 134 3.11997
GLT6D1 glycosyltransferase 6 domain containing 1 3.11997
CD80 CD80 molecule 3.11997
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.11997
DNAH8 dynein, axonemal, heavy chain 8 3.11997
UBA7 ubiquitin-like modifier activating enzyme 7 3.11997
USP51 ubiquitin specific peptidase 51 3.04145
PEBP4 phosphatidylethanolamine-binding protein 4 3.00538
CLCN1 chloride channel, voltage-sensitive 1 2.99789
TYK2 tyrosine kinase 2 2.93146
TRAPPC9 trafficking protein particle complex 9 2.82759
BRI3BP BRI3 binding protein 2.72389
PCTP phosphatidylcholine transfer protein 2.71713
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.66028
WDR86 WD repeat domain 86 2.65263
MED8 mediator complex subunit 8 2.63497
RBL2 retinoblastoma-like 2 2.61815
LDLR low density lipoprotein receptor 2.61319
KLHL5 kelch-like family member 5 2.60791
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.59135
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.58698
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 2.57977
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.55587
MCM3 minichromosome maintenance complex component 3 2.54572
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.54572
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 2.54417
POU6F2 POU class 6 homeobox 2 2.53159
SCART1 scavenger receptor protein family member 2.51036
ZNF804B zinc finger protein 804B 2.51036
EFR3A EFR3 homolog A (S. cerevisiae) 2.45463
RB1 retinoblastoma 1 2.40496
WIPF3 WAS/WASL interacting protein family, member 3 2.35953
SPATA17 spermatogenesis associated 17 2.35895
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.33007
TM2D1 TM2 domain containing 1 2.32996
SRSF11 serine/arginine-rich splicing factor 11 2.31157
ASCC3 activating signal cointegrator 1 complex subunit 3 2.31157
NRXN1 neurexin 1 2.31142
CARMIL1 capping protein regulator and myosin 1 linker 1 2.31142
RGS3 regulator of G-protein signaling 3 2.30343
PTX3 pentraxin 3, long 2.30164
NOMO1 NODAL modulator 1 2.26244
CXORF38 chromosome X open reading frame 38 2.20781
RHOXF2 Rhox homeobox family, member 2 2.1912
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.16892
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.16892
STON1 stonin 1 2.16289
BDNF brain-derived neurotrophic factor 2.11103
NRBF2 nuclear receptor binding factor 2 2.05481
METTL15 methyltransferase like 15 2.05236
COBL cordon-bleu WH2 repeat protein 2.04922
ZNF319 zinc finger protein 319 2.04437
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.04437
MINAR1 membrane integral NOTCH2 associated receptor 1 2.04437
NACAD NAC alpha domain containing 2.04437
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.04437
TMOD4 tropomodulin 4 (muscle) 2.04437

decreased expression

Symbol Name Standardized Value
FBP2 fructose-1,6-bisphosphatase 2 -3.16062
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -3.16062
PPIA peptidylprolyl isomerase A (cyclophilin A) -3.16062
MEI1 meiosis inhibitor 1 -3.16062
EFCAB5 EF-hand calcium binding domain 5 -3.11997
MAMDC4 MAM domain containing 4 -3.11997
TNR tenascin R -3.11997
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -3.11997
ACSM1 acyl-CoA synthetase medium-chain family member 1 -3.11997
PRRX1 paired related homeobox 1 -3.11997
XCL1 chemokine (C motif) ligand 1 -3.11997
KLHL35 kelch-like family member 35 -3.11997
PTGER4 prostaglandin E receptor 4 (subtype EP4) -3.11997
RNF149 ring finger protein 149 -3.11997
RGPD3 RANBP2-like and GRIP domain containing 3 -3.11997
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -3.11997
S100A14 S100 calcium binding protein A14 -3.11997
LGALS7B lectin, galactoside-binding, soluble, 7B -3.11997
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -3.11997
CISD2 CDGSH iron sulfur domain 2 -3.11997
DNAI2 dynein, axonemal, intermediate chain 2 -3.11997
ALDOB aldolase B, fructose-bisphosphate -3.11997
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta -3.11997
TF transferrin -3.11997
KLHL33 kelch-like family member 33 -3.11997
TMEM229A transmembrane protein 229A -3.11997
EPHB3 EPH receptor B3 -3.11997
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.11997
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 -3.11997
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -3.11997
OSR2 odd-skipped related transciption factor 2 -3.11997
RUNX3 runt-related transcription factor 3 -3.11997
PMP22 peripheral myelin protein 22 -3.09238
ZNF699 zinc finger protein 699 -3.09238
STEAP1 six transmembrane epithelial antigen of the prostate 1 -3.07086
RPH3A rabphilin 3A -3.02024
CRTAC1 cartilage acidic protein 1 -3.02024
TRAPPC2B trafficking protein particle complex 2B -2.99358
FCHO1 FCH domain only 1 -2.83412
RNF141 ring finger protein 141 -2.6613
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -2.6571
ZBTB38 zinc finger and BTB domain containing 38 -2.58281
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.54572
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.5309
LEMD3 LEM domain containing 3 -2.517
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.51036
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -2.51032
FBXL6 F-box and leucine-rich repeat protein 6 -2.50893
ZFAND6 zinc finger, AN1-type domain 6 -2.43561
PLA2G10 phospholipase A2, group X -2.43141
ZNF843 zinc finger protein 843 -2.40496
FAM178B family with sequence similarity 178, member B -2.40496
PROKR2 prokineticin receptor 2 -2.40496
QRFPR pyroglutamylated RFamide peptide receptor -2.40496
TMEM240 transmembrane protein 240 -2.37972
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -2.37683
BZW2 basic leucine zipper and W2 domains 2 -2.3734
H2AC21 H2A clustered histone 21 -2.36074
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -2.33007
NBPF10 neuroblastoma breakpoint family, member 10 -2.32826
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.32826
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.3167
MMD2 monocyte to macrophage differentiation-associated 2 -2.31142
C16ORF54 chromosome 16 open reading frame 54 -2.31142
PEX12 peroxisomal biogenesis factor 12 -2.31142
SCAMP5 secretory carrier membrane protein 5 -2.29999
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.26876
SHF Src homology 2 domain containing F -2.26404
ANO4 anoctamin 4 -2.24414
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -2.18614
SCHIP1 schwannomin interacting protein 1 -2.17845
ZCCHC3 zinc finger, CCHC domain containing 3 -2.17669
SLC71A2 solute carrier family 71 member 2 -2.17391
LMO1 LIM domain only 1 (rhombotin 1) -2.16892
TSPO translocator protein (18kDa) -2.16289
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.15915
PELI2 pellino E3 ubiquitin protein ligase family member 2 -2.13623
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.13389
KLHDC4 kelch domain containing 4 -2.118
SLC25A44 solute carrier family 25, member 44 -2.11103
PHF2 PHD finger protein 2 -2.11103
MRPS15 mitochondrial ribosomal protein S15 -2.10724
PFDN6 prefoldin subunit 6 -2.0966
MTA3 metastasis associated 1 family, member 3 -2.0966
LTAP1 lipid transport auxiliary protein 1 -2.08555
MSRB1 methionine sulfoxide reductase B1 -2.08555
ATXN7L2 ataxin 7-like 2 -2.06964
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.06964
CCDC78 coiled-coil domain containing 78 -2.06964
MSN moesin -2.06682
RNF135 ring finger protein 135 -2.05481
SLC19A1 solute carrier family 19 (folate transporter), member 1 -2.04474
LAMA2 laminin, alpha 2 -2.04437
DPP7 dipeptidyl-peptidase 7 -2.02586
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -2.01753