PPIB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peptidylprolyl isomerase B (cyclophilin B)|The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 5479)
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Genes

272 genes differentially expressed following the PPIB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ISL2 ISL LIM homeobox 2 2.27398
SOSTDC1 sclerostin domain containing 1 2.27398
LKAAEAR1 LKAAEAR motif containing 1 2.27398
GH1 growth hormone 1 2.27398
APOH apolipoprotein H (beta-2-glycoprotein I) 2.27398
LGSN lengsin, lens protein with glutamine synthetase domain 2.27398
TAS1R1 taste receptor, type 1, member 1 2.27398
TMC2 transmembrane channel-like 2 2.27398
SSTR1 somatostatin receptor 1 2.27398
AADACL3 arylacetamide deacetylase-like 3 2.27398
FFAR4 free fatty acid receptor 4 2.27398
F2 coagulation factor II (thrombin) 2.27398
PADI3 peptidyl arginine deiminase, type III 2.27398
GDNF glial cell derived neurotrophic factor 2.27398
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.27398
RPS21-DT RPS21 divergent transcript 2.27398
CD68 CD68 molecule 2.27398
LGALS2 lectin, galactoside-binding, soluble, 2 2.27398
CHCT1 CHD1 helical C-terminal domain containing 1 2.27398
CHI3L2 chitinase 3-like 2 2.27398
CD5 CD5 molecule 2.25457
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.25457
GPR6 G protein-coupled receptor 6 2.25457
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.25457
FRMD7 FERM domain containing 7 2.25457
HPR haptoglobin-related protein 2.25457
DAO D-amino-acid oxidase 2.25457
ITK IL2-inducible T-cell kinase 2.25457
CFAP99 cilia and flagella associated protein 99 2.25457
NKX2-6 NK2 homeobox 6 2.25457
RAB44 RAB44, member RAS oncogene family 2.25457
ZNF436 zinc finger protein 436 2.25457
PTTG2 pituitary tumor-transforming 2 2.25457
PVRIG poliovirus receptor related immunoglobulin domain containing 2.25457
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.25457
UCN urocortin 2.25457
RXFP2 relaxin/insulin-like family peptide receptor 2 2.25457
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.25457
PEAR1 platelet endothelial aggregation receptor 1 2.25457
IQCC IQ motif containing C 2.25457
PROB1 proline-rich basic protein 1 2.25457
LRRC37B leucine rich repeat containing 37B 2.25457
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.25457
PAX8 paired box 8 2.25457
UPB1 ureidopropionase, beta 2.25457
PNMA5 paraneoplastic Ma antigen family member 5 2.25457
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.25457
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.25457
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.25457
KNG1 kininogen 1 2.25457
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.25457
PRICKLE4 prickle homolog 4 (Drosophila) 2.25457
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.25457
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.25457
GPR151 G protein-coupled receptor 151 2.25457
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.25457
SPATA31G1 SPATA31 subfamily G member 1 2.25457
RPL10L ribosomal protein L10-like 2.25457
ZAR1 zygote arrest 1 2.25457
GPX2 glutathione peroxidase 2 2.25457
AANAT aralkylamine N-acetyltransferase 2.25457
CXCL13 chemokine (C-X-C motif) ligand 13 2.25457
ELOVL3 ELOVL fatty acid elongase 3 2.25457
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.25457
MLN motilin 2.25457
WDR64 WD repeat domain 64 2.25457
NHLH1 nescient helix loop helix 1 2.25457
RIPOR2 RHO family interacting cell polarization regulator 2 2.25457
LOC122539214 Zinc finger protein LOC122539214 2.25457
LOC114841035 uncharacterized LOC114841035 2.25457
PNMA6F PNMA family member 6F 2.25457
NOTCH2NLB notch 2 N-terminal like B 2.25457
AKR1C8 aldo-keto reductase family 1 member C8 2.25457
GSTT4 glutathione S-transferase theta 4 2.25457
SPATA46 spermatogenesis associated 46 2.25457
MINAR2 membrane integral NOTCH2 associated receptor 2 2.25457
CFAP119 cilia and flagella associated protein 119 2.25457
CCN5 cellular communication network factor 5 2.25457
P3R3URF PIK3R3 upstream open reading frame 2.25457
ASB9 ankyrin repeat and SOCS box containing 9 2.25457
MIOX myo-inositol oxygenase 2.25457
S100B S100 calcium binding protein B 2.25457
GJD2 gap junction protein, delta 2, 36kDa 2.25457
ARMS2 age-related maculopathy susceptibility 2 2.25457
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.25457
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.25457
TPTE transmembrane phosphatase with tensin homology 2.25457
TLR6 toll-like receptor 6 2.25457
PRKCD protein kinase C, delta 2.25457
UROC1 urocanate hydratase 1 2.25457
AMHR2 anti-Mullerian hormone receptor, type II 2.25457
MPPED1 metallophosphoesterase domain containing 1 2.25457
IL1R1 interleukin 1 receptor, type I 2.25457
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.25457
LY6K lymphocyte antigen 6 complex, locus K 2.25457
GATA6 GATA binding protein 6 2.25457
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 2.25457
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.25457
DUSP18 dual specificity phosphatase 18 2.25457
IL16 interleukin 16 2.25457
PRG4 proteoglycan 4 2.25457
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.25457
SAMD11 sterile alpha motif domain containing 11 2.25457
ANXA10 annexin A10 2.25457
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.25457
IHH indian hedgehog 2.25457
S100Z S100 calcium binding protein Z 2.25457
KRT222 keratin 222, type II 2.25457
LCN8 lipocalin 8 2.25457
KLF1 Kruppel-like factor 1 (erythroid) 2.25457
WFDC8 WAP four-disulfide core domain 8 2.25457
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.25457
CD53 CD53 molecule 2.25457
C2CD4D C2 calcium-dependent domain containing 4D 2.25457
PCDHGA3 protocadherin gamma subfamily A, 3 2.25457
AQP7 aquaporin 7 2.25457
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.25457
CLDN34 claudin 34 2.25457
HSF4 heat shock transcription factor 4 2.25457
KRT15 keratin 15, type I 2.25457
CPO carboxypeptidase O 2.25457
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.25457
VAX2 ventral anterior homeobox 2 2.25457
COIL coilin 2.25457
ZSCAN4 zinc finger and SCAN domain containing 4 2.25457
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.25457
OPRK1 opioid receptor, kappa 1 2.25457
BAHCC1 BAH domain and coiled-coil containing 1 2.25457
MUC13 mucin 13, cell surface associated 2.25457
MORN5 MORN repeat containing 5 2.25457
BCL2L15 BCL2-like 15 2.25457
TRIM7 tripartite motif containing 7 2.25457
WNT10B wingless-type MMTV integration site family, member 10B 2.25457
CCNA1 cyclin A1 2.25457
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.25457
ADAM18 ADAM metallopeptidase domain 18 2.25457
TEX26 testis expressed 26 2.25457
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.25457
NT5DC4 5'-nucleotidase domain containing 4 2.25457
TF transferrin 2.25457
ITGA10 integrin, alpha 10 2.25457
VWA7 von Willebrand factor A domain containing 7 2.25457
TRHR thyrotropin-releasing hormone receptor 2.25457
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.25457
SLC22A24 solute carrier family 22, member 24 2.25457
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.25457
MRPL12 mitochondrial ribosomal protein L12 2.25457
UNCX UNC homeobox 2.25457
PRPH peripherin 2.25457
SVOP SV2 related protein homolog (rat) 2.25457
BCL2A1 BCL2-related protein A1 2.25457
TMEM71 transmembrane protein 71 2.25457
SPAG8 sperm associated antigen 8 2.25457
ZNF804A zinc finger protein 804A 2.25457
PRSS21 protease, serine, 21 (testisin) 2.25457
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.25457
NRSN1 neurensin 1 2.25457
C5ORF46 chromosome 5 open reading frame 46 2.25457
NLRP3 NLR family, pyrin domain containing 3 2.25457
MYOZ2 myozenin 2 2.25457
STOML3 stomatin (EPB72)-like 3 2.25457
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.25457
SPACA1 sperm acrosome associated 1 2.25457
LCN12 lipocalin 12 2.25457
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.25457
CRH corticotropin releasing hormone 2.25457
C8ORF74 chromosome 8 open reading frame 74 2.25457
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.25457
NLRP10 NLR family, pyrin domain containing 10 2.25457
OXT oxytocin/neurophysin I prepropeptide 2.25457
MYO1A myosin IA 2.25457
SPHKAP SPHK1 interactor, AKAP domain containing 2.25457
AHSG alpha-2-HS-glycoprotein 2.25457
NPAS4 neuronal PAS domain protein 4 2.25457
SLC7A4 solute carrier family 7, member 4 2.25457
LACTBL1 lactamase, beta-like 1 2.25457
LPAR5 lysophosphatidic acid receptor 5 2.25457
FGF16 fibroblast growth factor 16 2.25457
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.25457
CLCA1 chloride channel accessory 1 2.25457
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.25457
TBC1D26 TBC1 domain family, member 26 2.25457
BIN2 bridging integrator 2 2.25457
FGF17 fibroblast growth factor 17 2.25457
SDSL serine dehydratase-like 2.25457
THEM5 thioesterase superfamily member 5 2.25457
TMPRSS11D transmembrane protease, serine 11D 2.25164
SNX4 sorting nexin 4 2.25164
SPAG16 sperm associated antigen 16 2.24528
CD96 CD96 molecule 2.15342
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.15342
TMEM35B transmembrane protein 35B 2.13812
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.13371
SHOX short stature homeobox 2.13371
DPH5 diphthamide biosynthesis 5 2.13252
LRRC66 leucine rich repeat containing 66 2.11082
VMA12 vacuolar ATPase assembly factor VMA12 2.11039
L2HGDH L-2-hydroxyglutarate dehydrogenase 2.10327
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 2.09606
SH3BGR SH3 domain binding glutamate-rich protein 2.04937
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 2.04682
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.03568
BLM Bloom syndrome, RecQ helicase-like 2.03128
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 2.02661
SMIM24 small integral membrane protein 24 2.01815
ABHD5 abhydrolase domain containing 5 2.01397
ETV4 ets variant 4 2.00879
ATP5F1D ATP synthase F1 subunit delta 2.00879
MYG1 MYG1 exonuclease 2.00282
PLD5 phospholipase D family, member 5 2.00119

decreased expression

Symbol Name Standardized Value
S100A16 S100 calcium binding protein A16 -2.27398
OTOA otoancorin -2.27398
HYPK huntingtin interacting protein K -2.27398
LOC122526780 uncharacterized LOC122526780 -2.27398
MYBPC1 myosin binding protein C, slow type -2.25457
UBE2Z ubiquitin-conjugating enzyme E2Z -2.25457
ZSCAN25 zinc finger and SCAN domain containing 25 -2.25457
CCDC38 coiled-coil domain containing 38 -2.25457
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.25457
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.25457
TMC3 transmembrane channel-like 3 -2.25457
ETV2 ets variant 2 -2.25457
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -2.25457
PPARA peroxisome proliferator-activated receptor alpha -2.25457
KY kyphoscoliosis peptidase -2.25457
TNIK TRAF2 and NCK interacting kinase -2.25457
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -2.25457
LIN28B lin-28 homolog B (C. elegans) -2.25457
MRPL32 mitochondrial ribosomal protein L32 -2.25457
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.25457
RIT1 Ras-like without CAAX 1 -2.25457
AGTR1 angiotensin II receptor, type 1 -2.25457
ACADL acyl-CoA dehydrogenase, long chain -2.25457
MUC16 mucin 16, cell surface associated -2.25457
NDFIP2 Nedd4 family interacting protein 2 -2.25457
MROH7 maestro heat-like repeat family member 7 -2.25457
WBP4 WW domain binding protein 4 -2.25457
PRR35 proline rich 35 -2.25457
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.25457
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -2.25457
ACAN aggrecan -2.25457
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.25457
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -2.25457
ADRA2A adrenoceptor alpha 2A -2.25457
PGM5 phosphoglucomutase 5 -2.25457
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.25164
ATG4A autophagy related 4A, cysteine peptidase -2.23283
CBY1 chibby homolog 1 (Drosophila) -2.22954
CENPVL3 centromere protein V like 3 -2.22387
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.20327
DTWD1 DTW domain containing 1 -2.19953
RNF146 ring finger protein 146 -2.15791
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.15584
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.14603
RAD51C RAD51 paralog C -2.14603
AK3 adenylate kinase 3 -2.14603
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.13062
DCHS2 dachsous cadherin-related 2 -2.1175
CCDC148 coiled-coil domain containing 148 -2.10344
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.10045
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.10045
NTAN1 N-terminal asparagine amidase -2.07214
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -2.05436
COA3 cytochrome c oxidase assembly factor 3 -2.0527
NFYB nuclear transcription factor Y, beta -2.04937
ARID1A AT rich interactive domain 1A (SWI-like) -2.04391
PBX1 pre-B-cell leukemia homeobox 1 -2.04216
HIP1R huntingtin interacting protein 1 related -2.03979
NMRK2 nicotinamide riboside kinase 2 -2.03946
SLC25A39 solute carrier family 25, member 39 -2.0262
NOP53 NOP53 ribosome biogenesis factor -2.0262
NUDCD1 NudC domain containing 1 -2.00879