PPIF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peptidylprolyl isomerase F|The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10105)
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Genes

338 genes differentially expressed following the PPIF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CIB3 calcium and integrin binding family member 3 4.06839
NLRP4 NLR family, pyrin domain containing 4 4.06839
PRR18 proline rich 18 4.06839
CLEC2A C-type lectin domain family 2, member A 4.06839
CLEC2B C-type lectin domain family 2, member B 4.06839
LKAAEAR1 LKAAEAR motif containing 1 4.06839
MEIG1 meiosis/spermiogenesis associated 1 4.06839
KCNT1 potassium channel, sodium activated subfamily T, member 1 4.06839
IGFL3 IGF-like family member 3 4.06839
COL19A1 collagen, type XIX, alpha 1 4.06839
CCDC83 coiled-coil domain containing 83 4.06839
FGF8 fibroblast growth factor 8 (androgen-induced) 4.06839
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 4.06839
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 4.06839
MIP major intrinsic protein of lens fiber 4.06839
OIT3 oncoprotein induced transcript 3 4.06839
CDSN corneodesmosin 4.06839
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 4.06839
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 4.06839
SOAT2 sterol O-acyltransferase 2 4.06839
CLCNKB chloride channel, voltage-sensitive Kb 4.06839
FRK fyn-related Src family tyrosine kinase 4.06839
ARGFX arginine-fifty homeobox 4.06839
ST18 suppression of tumorigenicity 18, zinc finger 4.06839
LHB luteinizing hormone beta polypeptide 4.06839
PADI4 peptidyl arginine deiminase, type IV 4.06839
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 4.06839
VCX3A variable charge, X-linked 3A 4.06839
SLC26A4 solute carrier family 26 (anion exchanger), member 4 4.06839
TACR2 tachykinin receptor 2 4.06839
SBSN suprabasin 4.06839
KCNK15 potassium channel, two pore domain subfamily K, member 15 4.06839
IL37 interleukin 37 4.06839
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 4.06839
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 4.06839
TLR6 toll-like receptor 6 4.06839
GYPB glycophorin B (MNS blood group) 4.06839
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 4.06839
ASB17 ankyrin repeat and SOCS box containing 17 4.06839
AXDND1 axonemal dynein light chain domain containing 1 4.06839
DNASE1L2 deoxyribonuclease I-like 2 4.06839
GFAP glial fibrillary acidic protein 4.06839
KLHL33 kelch-like family member 33 4.06839
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 4.06839
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 4.06839
RLBP1 retinaldehyde binding protein 1 4.06839
CELA3B chymotrypsin-like elastase family, member 3B 4.06839
TAS2R3 taste receptor, type 2, member 3 4.06839
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.06839
PNMA5 paraneoplastic Ma antigen family member 5 4.06839
TAS2R5 taste receptor, type 2, member 5 4.06839
TRIM74 tripartite motif containing 74 4.06839
TRIM77 tripartite motif containing 77 4.06839
PTGFR prostaglandin F receptor (FP) 4.06839
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 4.06839
TRPC5OS TRPC5 opposite strand 4.06839
ANXA13 annexin A13 4.06839
KRT72 keratin 72, type II 4.06839
SPINK4 serine peptidase inhibitor, Kazal type 4 4.06839
NPIPA7 nuclear pore complex interacting protein family, member A7 4.06839
MAGEA2 melanoma antigen family A2 4.06839
CALCA calcitonin-related polypeptide alpha 4.06839
CRX cone-rod homeobox 4.06839
MOGAT3 monoacylglycerol O-acyltransferase 3 4.06839
GOLGA6L4 golgin A6 family-like 4 4.06839
MROH2B maestro heat-like repeat family member 2B 4.06839
GMFG glia maturation factor, gamma 4.06839
DEFB124 defensin, beta 124 4.06839
BAAT bile acid CoA:amino acid N-acyltransferase 4.06839
PCDHB4 protocadherin beta 4 4.06839
DPRX divergent-paired related homeobox 4.06839
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 4.06839
THBD thrombomodulin 4.06839
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 4.06839
DNTT DNA nucleotidylexotransferase 4.06839
BCO1 beta-carotene oxygenase 1 4.06839
TRIM50 tripartite motif containing 50 4.06839
HAO2 hydroxyacid oxidase 2 (long chain) 4.06839
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 4.06839
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 4.06839
GBP4 guanylate binding protein 4 4.06839
SH2D4B SH2 domain containing 4B 4.06839
AKNAD1 AKNA domain containing 1 4.06839
GPX6 glutathione peroxidase 6 4.06839
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 4.06839
TAS2R10 taste receptor, type 2, member 10 4.06839
HRH1 histamine receptor H1 4.06839
PMIS2 PMIS2 transmembrane protein 4.06839
VEGFD vascular endothelial growth factor D 4.06839
LY6S-AS1 LY6S antisense RNA 1 4.06839
DRC7 dynein regulatory complex subunit 7 4.06839
LINC02798 long intergenic non-protein coding RNA 2798 4.06839
CFAP97D2 CFAP97 domain containing 2 4.06839
H3C14 H3 clustered histone 14 4.06839
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 4.06839
MYADML2 myeloid-associated differentiation marker-like 2 4.06839
ORM2 orosomucoid 2 4.06839
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 4.06839
NOBOX NOBOX oogenesis homeobox 4.06839
CTSF cathepsin F 4.06839
PRH2 proline-rich protein HaeIII subfamily 2 4.06839
CFAP276 cilia and flagella associated protein 276 4.06839
NFILZ NFIL3 like basic leucine zipper 4.06839
TBXT T-box transcription factor T 4.06839
FAM135B family with sequence similarity 135, member B 4.06839
CDHR5 cadherin-related family member 5 4.06839
SPI1 Spi-1 proto-oncogene 4.06839
GRAP2 GRB2-related adaptor protein 2 4.06839
MORC1 MORC family CW-type zinc finger 1 4.06839
LRRD1 leucine-rich repeats and death domain containing 1 4.06839
ANKRD62 ankyrin repeat domain 62 4.06839
MYL10 myosin, light chain 10, regulatory 4.06839
OR52E4 olfactory receptor, family 52, subfamily E, member 4 4.06839
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 4.06839
TBC1D26 TBC1 domain family, member 26 4.06839
APOH apolipoprotein H (beta-2-glycoprotein I) 4.06839
NUTM2F NUT family member 2F 4.06839
POTEI POTE ankyrin domain family, member I 4.06839
ZNF705D zinc finger protein 705D 4.06839
DEFB134 defensin, beta 134 4.06839
FGF18 fibroblast growth factor 18 4.06839
AQP1 aquaporin 1 (Colton blood group) 4.06839
TRPM5 transient receptor potential cation channel, subfamily M, member 5 4.06839
KRT83 keratin 83, type II 4.06839
DQX1 DEAQ box RNA-dependent ATPase 1 4.06839
TNR tenascin R 4.06839
KRT222 keratin 222, type II 4.06839
RD3 retinal degeneration 3 4.06839
SV2C synaptic vesicle glycoprotein 2C 4.06839
PRSS3 protease, serine, 3 4.06839
MR1 major histocompatibility complex, class I-related 4.06839
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 4.06839
SEMG1 semenogelin I 4.06839
TMEM132D transmembrane protein 132D 4.06839
MYBPHL myosin binding protein H-like 4.06839
PCDHGB2 protocadherin gamma subfamily B, 2 4.06839
KRT86 keratin 86, type II 4.06839
S1PR5 sphingosine-1-phosphate receptor 5 4.03001
KIF19 kinesin family member 19 4.03001
ETV7 ets variant 7 4.03001
MEIOB meiosis specific with OB domains 3.62952
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 3.58678
CNGA1 cyclic nucleotide gated channel alpha 1 3.34409
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 3.3154
RGS20 regulator of G-protein signaling 20 3.3154
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 3.21704
SMCO2 single-pass membrane protein with coiled-coil domains 2 3.09665
CD248 CD248 molecule, endosialin 3.09174
TNMD tenomodulin 3.09174
CLIC2 chloride intracellular channel 2 3.09174
IGFL4 IGF-like family member 4 3.09174
FRS3 fibroblast growth factor receptor substrate 3 3.09174
ALX1 ALX homeobox 1 3.09174
FOXJ1 forkhead box J1 3.09174
NT5E 5'-nucleotidase, ecto (CD73) 3.02256
ENTR1 endosome associated trafficking regulator 1 3.01837
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 3.00553
PFKP phosphofructokinase, platelet 2.98843
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.78568
ELMOD3 ELMO/CED-12 domain containing 3 2.77926
PRELID1 PRELI domain containing 1 2.73033
RABL3 RAB, member of RAS oncogene family-like 3 2.68272
COL8A1 collagen, type VIII, alpha 1 2.57862
PWWP3B PWWP domain containing 3B 2.57862
CCDC107 coiled-coil domain containing 107 2.51287
ABHD4 abhydrolase domain containing 4 2.4956
DUSP22 dual specificity phosphatase 22 2.48214
EIF1B eukaryotic translation initiation factor 1B 2.48214
CENPU centromere protein U 2.4567
LMO3 LIM domain only 3 (rhombotin-like 2) 2.45237
TMEM192 transmembrane protein 192 2.43122
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.42243
PNISR PNN-interacting serine/arginine-rich protein 2.41502
CD47 CD47 molecule 2.40259
KCTD2 potassium channel tetramerization domain containing 2 2.39555
ZNF644 zinc finger protein 644 2.39555
NOX1 NADPH oxidase 1 2.39555
SERTM1 serine-rich and transmembrane domain containing 1 2.39555
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.39367
SH2D4A SH2 domain containing 4A 2.38158
ZCCHC24 zinc finger, CCHC domain containing 24 2.35435
CCDC169 coiled-coil domain containing 169 2.34938
DCLK3 doublecortin-like kinase 3 2.34938
RPL18A ribosomal protein L18a 2.34938
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.34938
EFR3B EFR3 homolog B (S. cerevisiae) 2.34938
AADACL3 arylacetamide deacetylase-like 3 2.32685
CHLSN cholesin 2.32685
MAB21L3 mab-21-like 3 (C. elegans) 2.32685
CLDN5 claudin 5 2.30604
ZWILCH zwilch kinetochore protein 2.30604
USP43 ubiquitin specific peptidase 43 2.30078
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.30078
CDC26 cell division cycle 26 2.27994
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.2725
SYNGR1 synaptogyrin 1 2.26945
FZD5 frizzled class receptor 5 2.26061
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.25742
TMEM255B transmembrane protein 255B 2.25393
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.20993
ZNF383 zinc finger protein 383 2.20593
POLR1B polymerase (RNA) I polypeptide B, 128kDa 2.17652
SNED1 sushi, nidogen and EGF-like domains 1 2.16564
SNX12 sorting nexin 12 2.14208
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.13832
DCAF6 DDB1 and CUL4 associated factor 6 2.11884
ZFTRAF1 zinc finger TRAF-type containing 1 2.08642
KNL1 kinetochore scaffold 1 2.08636
PLCH1 phospholipase C, eta 1 2.06352
MIIP migration and invasion inhibitory protein 2.06025
DNAH9 dynein, axonemal, heavy chain 9 2.05912
SLC19A1 solute carrier family 19 (folate transporter), member 1 2.05563
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.04526
SASH1 SAM and SH3 domain containing 1 2.0358
BAIAP2 BAI1-associated protein 2 2.03437
TRABD TraB domain containing 2.02645
LENG9 leukocyte receptor cluster (LRC) member 9 2.02525
MIMS2 mitochondrial inner membrane scaffold 2 2.02426
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 2.02306
ZNF337 zinc finger protein 337 2.01905
RRM2 ribonucleotide reductase M2 2.01896
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 2.01395
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.0115
CRYM crystallin, mu 2.00824
ZNF737 zinc finger protein 737 2.00624
MFN1 mitofusin 1 2.00266

decreased expression

Symbol Name Standardized Value
CXCR5 chemokine (C-X-C motif) receptor 5 -4.06839
FOXP4 forkhead box P4 -4.06839
TP63 tumor protein p63 -4.06839
RANBP3L RAN binding protein 3-like -4.06839
NPNT nephronectin -4.06839
FADS6 fatty acid desaturase 6 -4.06839
RAG1 recombination activating gene 1 -4.06839
OTOA otoancorin -4.06839
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -4.06135
ANKRD44 ankyrin repeat domain 44 -4.03657
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -4.03001
ABRA actin binding Rho activating protein -4.03001
IL17B interleukin 17B -4.03001
AZIN2 antizyme inhibitor 2 -4.03001
FZD1 frizzled class receptor 1 -4.03001
DNAH8 dynein, axonemal, heavy chain 8 -4.03001
ZBED6 zinc finger, BED-type containing 6 -4.03001
NKPD1 NTPase, KAP family P-loop domain containing 1 -4.03001
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 -4.03001
STRIT1 small transmembrane regulator of ion transport 1 -4.03001
IRF2-DT IRF2 divergent transcript -4.03001
NHLH1 nescient helix loop helix 1 -4.03001
CCR9 chemokine (C-C motif) receptor 9 -4.03001
NHLRC4 NHL repeat containing 4 -4.03001
PCDHA3 protocadherin alpha 3 -4.03001
LURAP1L leucine rich adaptor protein 1-like -4.03001
ZNF467 zinc finger protein 467 -4.03001
LRRC63 leucine rich repeat containing 63 -4.03001
SPHK1 sphingosine kinase 1 -4.03001
GYS2 glycogen synthase 2 (liver) -4.03001
FNDC1 fibronectin type III domain containing 1 -4.03001
KCNK7 potassium channel, two pore domain subfamily K, member 7 -4.03001
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -4.03001
JSRP1 junctional sarcoplasmic reticulum protein 1 -4.03001
CAMK2B calcium/calmodulin-dependent protein kinase II beta -4.03001
FAM151A family with sequence similarity 151, member A -4.03001
CXCR2 chemokine (C-X-C motif) receptor 2 -4.03001
KLK6 kallikrein-related peptidase 6 -4.03001
HLA-DMB major histocompatibility complex, class II, DM beta -4.03001
PFN4 profilin family, member 4 -4.03001
ADAM12 ADAM metallopeptidase domain 12 -4.03001
CLEC4C C-type lectin domain family 4, member C -4.03001
KLF4 Kruppel-like factor 4 (gut) -4.03001
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -3.91685
ENKUR enkurin, TRPC channel interacting protein -3.91685
CENPH centromere protein H -3.5375
ZBTB47 zinc finger and BTB domain containing 47 -3.2433
BGLAP bone gamma-carboxyglutamate (gla) protein -3.12181
PPIF peptidylprolyl isomerase F -3.00633
MYL11 myosin light chain 11 -2.96451
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.82633
BMP8A bone morphogenetic protein 8a -2.82633
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.81949
ZNF471 zinc finger protein 471 -2.79872
PER1 period circadian clock 1 -2.78568
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.77926
AFP alpha-fetoprotein -2.75524
GALK2 galactokinase 2 -2.63247
PDZD4 PDZ domain containing 4 -2.58014
TNNC1 troponin C type 1 (slow) -2.55531
TIMP4 TIMP metallopeptidase inhibitor 4 -2.54031
TOMM70 translocase of outer mitochondrial membrane 70 -2.52869
SLC35E4 solute carrier family 35, member E4 -2.51702
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -2.51702
WDR35 WD repeat domain 35 -2.4643
CCDC144A coiled-coil domain containing 144A -2.43786
WDR17 WD repeat domain 17 -2.41348
ISOC2 isochorismatase domain containing 2 -2.40645
TSPAN33 tetraspanin 33 -2.37995
ADGRL2 adhesion G protein-coupled receptor L2 -2.36751
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -2.35652
MCL1 myeloid cell leukemia 1 -2.35652
AK8 adenylate kinase 8 -2.34938
TRIM56 tripartite motif containing 56 -2.34736
RC3H1 ring finger and CCCH-type domains 1 -2.34616
POGK pogo transposable element with KRAB domain -2.32625
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -2.32241
ARF3 ADP-ribosylation factor 3 -2.30078
FN3K fructosamine 3 kinase -2.29504
JRK Jrk homolog (mouse) -2.26552
PCDHGA8 protocadherin gamma subfamily A, 8 -2.25698
PCDHB16 protocadherin beta 16 -2.22732
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.22732
NTF4 neurotrophin 4 -2.22732
ATG101 autophagy related 101 -2.20629
PKDCC protein kinase domain containing, cytoplasmic -2.20593
FNDC7 fibronectin type III domain containing 7 -2.20477
SFTPD surfactant protein D -2.20477
TRAM1L1 translocation associated membrane protein 1-like 1 -2.19948
DEPDC1B DEP domain containing 1B -2.19948
DNAH6 dynein, axonemal, heavy chain 6 -2.19948
CCNT1 cyclin T1 -2.19948
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.18578
SLC35D4 solute carrier family 35 member D4 -2.17485
KIF7 kinesin family member 7 -2.15691
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.14631
MYO18A myosin XVIIIA -2.14631
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.13834
MANBA mannosidase, beta A, lysosomal -2.13796
ALPL alkaline phosphatase, liver/bone/kidney -2.12342
HTRA1 HtrA serine peptidase 1 -2.11884
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.09434
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.08441
TBPL1 TBP-like 1 -2.05912
GOT1 glutamic-oxaloacetic transaminase 1, soluble -2.03771
CEP350 centrosomal protein 350kDa -2.03437
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.02714
ORC6 origin recognition complex, subunit 6 -2.02347
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.01905
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.01896
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.01379
LIMD2 LIM domain containing 2 -2.00266