PPM1D Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein phosphatase, Mg2+/Mn2+ dependent, 1D|The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8493)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_PPM1D
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26 co-expressed genes for PPM1D from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ANKRD50 ankyrin repeat domain 50
C11ORF95 chromosome 11 open reading frame 95
CELF1 CUGBP, Elav-like family member 1
CEP170 centrosomal protein 170kDa
ESRRG estrogen-related receptor gamma
EXOC5 exocyst complex component 5
KAT6B K(lysine) acetyltransferase 6B
KAT7 K(lysine) acetyltransferase 7
LMNB1 lamin B1
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PARP6 poly (ADP-ribose) polymerase family, member 6
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PTBP2 polypyrimidine tract binding protein 2
RBM4B RNA binding motif protein 4B
SMC3 structural maintenance of chromosomes 3
SPAST spastin
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYNC syncoilin, intermediate filament protein
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
USP37 ubiquitin specific peptidase 37
VEZF1 vascular endothelial zinc finger 1
WBP11 WW domain binding protein 11
ZHX1 zinc fingers and homeoboxes 1
ZNF566 zinc finger protein 566