PPOX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protoporphyrinogen oxidase|This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5498)
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Genes

340 genes differentially expressed following the PPOX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GJA5 gap junction protein, alpha 5, 40kDa 2.65057
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.65057
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.65057
TAL2 T-cell acute lymphocytic leukemia 2 2.65057
MYOM3 myomesin 3 2.65057
GUCY2F guanylate cyclase 2F, retinal 2.65057
TMEM217 transmembrane protein 217 2.65057
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.65057
S100A1 S100 calcium binding protein A1 2.65057
LARP4 La ribonucleoprotein domain family, member 4 2.65057
OLFM4 olfactomedin 4 2.65057
XCL1 chemokine (C motif) ligand 1 2.65057
MBD3L1 methyl-CpG binding domain protein 3-like 1 2.65057
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.65057
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.65057
ZNF492 zinc finger protein 492 2.65057
DUXB double homeobox B 2.65057
IGFL3 IGF-like family member 3 2.65057
DNASE1L2 deoxyribonuclease I-like 2 2.65057
MYBPC3 myosin binding protein C, cardiac 2.65057
DUSP15 dual specificity phosphatase 15 2.65057
MTTP microsomal triglyceride transfer protein 2.65057
MISP mitotic spindle positioning 2.65057
RHO rhodopsin 2.65057
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 2.65057
SPDEF SAM pointed domain containing ETS transcription factor 2.65057
NPR3 natriuretic peptide receptor 3 2.65057
MEIG1 meiosis/spermiogenesis associated 1 2.65057
PASD1 PAS domain containing 1 2.65057
LOXL4 lysyl oxidase-like 4 2.65057
AOC1 amine oxidase, copper containing 1 2.65057
FOXG1 forkhead box G1 2.65057
IL33 interleukin 33 2.65057
TECTB tectorin beta 2.65057
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.65057
SPAG6 sperm associated antigen 6 2.65057
TAS2R13 taste receptor, type 2, member 13 2.65057
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.65057
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.65057
GYS2 glycogen synthase 2 (liver) 2.65057
MYL7 myosin, light chain 7, regulatory 2.65057
THEMIS thymocyte selection associated 2.65057
NDP Norrie disease (pseudoglioma) 2.65057
EVPL envoplakin 2.65057
IL18R1 interleukin 18 receptor 1 2.65057
IL37 interleukin 37 2.65057
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.65057
MAGIX MAGI family member, X-linked 2.65057
GATA6 GATA binding protein 6 2.65057
KL klotho 2.65057
STAC2 SH3 and cysteine rich domain 2 2.65057
LRRN4CL LRRN4 C-terminal like 2.65057
LTF lactotransferrin 2.65057
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.65057
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.65057
LRRC73 leucine rich repeat containing 73 2.65057
TTR transthyretin 2.65057
TCERG1L transcription elongation regulator 1-like 2.65057
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.65057
AGA-DT AGA divergent transcript 2.65057
LOC124903233 uncharacterized LOC124903233 2.65057
DEFB131A defensin beta 131A 2.65057
ALKAL1 ALK and LTK ligand 1 2.65057
VXN vexin 2.65057
MSANTD5 Myb/SANT DNA binding domain containing 5 2.65057
CFAP119 cilia and flagella associated protein 119 2.65057
H1-6 H1.6 linker histone, cluster member 2.65057
ERVW-1 endogenous retrovirus group W, member 1 2.65057
MTMR11 myotubularin related protein 11 2.65057
RGS22 regulator of G-protein signaling 22 2.65057
CD79A CD79a molecule, immunoglobulin-associated alpha 2.65057
SCN10A sodium channel, voltage gated, type X alpha subunit 2.65057
THPO thrombopoietin 2.65057
MAGEB1 melanoma antigen family B1 2.65057
TMEM98 transmembrane protein 98 2.65057
LIPK lipase, family member K 2.65057
ISM2 isthmin 2 2.65057
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.65057
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.65057
C10ORF67 chromosome 10 open reading frame 67 2.65057
IL6 interleukin 6 2.65057
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.65057
TACR2 tachykinin receptor 2 2.65057
SBSN suprabasin 2.65057
CCR4 chemokine (C-C motif) receptor 4 2.65057
CCR3 chemokine (C-C motif) receptor 3 2.65057
EXOC3L1 exocyst complex component 3-like 1 2.65057
LENG1 leukocyte receptor cluster (LRC) member 1 2.65057
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.65057
FAM186B family with sequence similarity 186, member B 2.65057
PGD phosphogluconate dehydrogenase 2.65057
HNF4A hepatocyte nuclear factor 4, alpha 2.65057
TREH trehalase (brush-border membrane glycoprotein) 2.65057
GTF2A1L general transcription factor IIA, 1-like 2.65057
CST7 cystatin F (leukocystatin) 2.65057
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.65057
LCT lactase 2.65057
EDN3 endothelin 3 2.65057
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.65057
IGFBP1 insulin-like growth factor binding protein 1 2.65057
GLYATL3 glycine-N-acyltransferase-like 3 2.65057
HK3 hexokinase 3 (white cell) 2.65057
NPPA natriuretic peptide A 2.65057
PCDHGB2 protocadherin gamma subfamily B, 2 2.65057
VAX2 ventral anterior homeobox 2 2.65057
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.65057
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.65057
FGR FGR proto-oncogene, Src family tyrosine kinase 2.65057
FCRLB Fc receptor-like B 2.65057
S100A14 S100 calcium binding protein A14 2.65057
PIH1D2 PIH1 domain containing 2 2.65057
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.65057
TTC9B tetratricopeptide repeat domain 9B 2.65057
CCDC185 coiled-coil domain containing 185 2.65057
CER1 cerberus 1, DAN family BMP antagonist 2.65057
SERINC4 serine incorporator 4 2.65057
CALHM1 calcium homeostasis modulator 1 2.65057
MKRN3 makorin ring finger protein 3 2.65057
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.65057
IL21R interleukin 21 receptor 2.65057
KLHL41 kelch-like family member 41 2.65057
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.65057
HSPA1L heat shock 70kDa protein 1-like 2.65057
GCOM1 GRINL1A complex locus 1 2.65057
CTAGE9 CTAGE family, member 9 2.65057
PLA1A phospholipase A1 member A 2.65057
CLRN1 clarin 1 2.65057
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.65057
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.65057
ANGPTL6 angiopoietin-like 6 2.65057
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.65057
MT1B metallothionein 1B 2.65057
STARD5 StAR-related lipid transfer (START) domain containing 5 2.65057
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.65057
GCM2 glial cells missing homolog 2 (Drosophila) 2.65057
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.65057
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.65057
DRC7 dynein regulatory complex subunit 7 2.65057
CIB4 calcium and integrin binding family member 4 2.65057
SYT8 synaptotagmin VIII 2.65057
GJC2 gap junction protein, gamma 2, 47kDa 2.65057
AMDHD1 amidohydrolase domain containing 1 2.65057
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.65057
PTCH2 patched 2 2.65057
ADAM29 ADAM metallopeptidase domain 29 2.65057
SLC36A3 solute carrier family 36, member 3 2.65057
ADGRF4 adhesion G protein-coupled receptor F4 2.65057
ETV3L ets variant 3-like 2.65057
SLC7A4 solute carrier family 7, member 4 2.65057
SLC38A3 solute carrier family 38, member 3 2.65057
PHOSPHO1 phosphatase, orphan 1 2.65057
RBBP8NL RBBP8 N-terminal like 2.65057
TSPAN32 tetraspanin 32 2.65057
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.65057
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.65057
DBX2 developing brain homeobox 2 2.65057
PTGDR prostaglandin D2 receptor (DP) 2.65057
TBC1D26 TBC1 domain family, member 26 2.65057
IGIP IgA-inducing protein 2.65057
PRAM1 PML-RARA regulated adaptor molecule 1 2.65057
MSMP microseminoprotein, prostate associated 2.65057
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.65057
CYBRD1 cytochrome b reductase 1 2.62416
LONRF2 LON peptidase N-terminal domain and ring finger 2 2.60605
CD86 CD86 molecule 2.60605
PCDH12 protocadherin 12 2.54275
DLX4 distal-less homeobox 4 2.54275
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.54275
EFNA4 ephrin-A4 2.51101
PYDC1 PYD (pyrin domain) containing 1 2.5084
RAD52 RAD52 homolog (S. cerevisiae) 2.4755
GAMT guanidinoacetate N-methyltransferase 2.46544
AKAP9 A kinase (PRKA) anchor protein 9 2.46544
COL4A2 collagen, type IV, alpha 2 2.46424
PMFBP1 polyamine modulated factor 1 binding protein 1 2.46236
MITD1 MIT, microtubule interacting and transport, domain containing 1 2.4326
GOLGA6L7 golgin A6 family like 7 2.43001
PTK6 protein tyrosine kinase 6 2.43001
SRP54 signal recognition particle 54kDa 2.43001
CISH cytokine inducible SH2-containing protein 2.39022
SERF2 small EDRK-rich factor 2 2.38101
TMED4 transmembrane emp24 protein transport domain containing 4 2.3685
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.36705
ZNG1C Zn regulated GTPase metalloprotein activator 1C 2.36705
DYNC2I2 dynein 2 intermediate chain 2 2.3429
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.342
LYAR Ly1 antibody reactive 2.33339
UBE2G1 ubiquitin-conjugating enzyme E2G 1 2.31196
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.3109
ARFRP1 ADP-ribosylation factor related protein 1 2.30372
STX12 syntaxin 12 2.29108
TENT5A terminal nucleotidyltransferase 5A 2.28894
ZSCAN21 zinc finger and SCAN domain containing 21 2.28242
NPY1R neuropeptide Y receptor Y1 2.27734
STX6 syntaxin 6 2.24763
STK39 serine threonine kinase 39 2.23026
TSLIG2 tRNA splicing ligase complex subunit 2 2.21914
MED1 mediator complex subunit 1 2.19302
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.18882
MED11 mediator complex subunit 11 2.16265
KIAA0232 KIAA0232 2.15715
UROD uroporphyrinogen decarboxylase 2.14368
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 2.12691
EDNRA endothelin receptor type A 2.12691
NFIB nuclear factor I/B 2.10823
TJP3 tight junction protein 3 2.10823
ZNF22 zinc finger protein 22 2.10467
BRD3OS BRD3 opposite strand 2.10349
EBPL emopamil binding protein-like 2.09142
ZNF550 zinc finger protein 550 2.08965
TONSL tonsoku-like, DNA repair protein 2.08784
RNASEH2A ribonuclease H2, subunit A 2.07253
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.06926
MFN1 mitofusin 1 2.06926
LPAR3 lysophosphatidic acid receptor 3 2.06722
RSKR ribosomal protein S6 kinase related 2.06198
HLA-E major histocompatibility complex, class I, E 2.06186
ATXN7L3B ataxin 7-like 3B 2.06095
SLCO1A2 solute carrier organic anion transporter family, member 1A2 2.05858
ACOT11 acyl-CoA thioesterase 11 2.03408
TINAGL1 tubulointerstitial nephritis antigen-like 1 2.03245
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.00559

decreased expression

Symbol Name Standardized Value
MUSK muscle, skeletal, receptor tyrosine kinase -2.65057
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.65057
ACAN aggrecan -2.65057
LOC390937 Ets2 repressor factor-like -2.65057
XYLT1 xylosyltransferase I -2.65057
PTPRB protein tyrosine phosphatase, receptor type, B -2.65057
SERTAD3 SERTA domain containing 3 -2.65057
MMP3 matrix metallopeptidase 3 -2.65057
SH3RF2 SH3 domain containing ring finger 2 -2.65057
COL6A3 collagen, type VI, alpha 3 -2.65057
CCDC92 coiled-coil domain containing 92 -2.65057
CPO carboxypeptidase O -2.65057
SSUH2 ssu-2 homolog (C. elegans) -2.65057
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.65057
MST1R macrophage stimulating 1 receptor -2.65057
ZNF597 zinc finger protein 597 -2.65057
ASPG asparaginase -2.65057
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -2.65057
ADAMTSL2 ADAMTS-like 2 -2.65057
CD151 CD151 molecule (Raph blood group) -2.65057
CD164L2 CD164 sialomucin-like 2 -2.65057
CD68 CD68 molecule -2.65057
SLC46A2 solute carrier family 46, member 2 -2.65057
CCDC38 coiled-coil domain containing 38 -2.65057
COL15A1 collagen, type XV, alpha 1 -2.65057
SLC16A6 solute carrier family 16, member 6 -2.65057
FAM167B family with sequence similarity 167, member B -2.65057
RHOV ras homolog family member V -2.65057
TBX22 T-box 22 -2.65057
EBF3 early B-cell factor 3 -2.65057
GRID1 glutamate receptor, ionotropic, delta 1 -2.65057
FYB2 FYN binding protein 2 -2.65057
TCTA T-cell leukemia translocation altered -2.65057
GLRB glycine receptor, beta -2.65057
GBX2 gastrulation brain homeobox 2 -2.65057
AMN amnion associated transmembrane protein -2.65057
JAML junction adhesion molecule like -2.65057
INPP1 inositol polyphosphate-1-phosphatase -2.65057
SCD5 stearoyl-CoA desaturase 5 -2.65057
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.65057
FOXN4 forkhead box N4 -2.65057
RANBP3L RAN binding protein 3-like -2.65057
DUSP13B dual specificity phosphatase 13B -2.65057
METTL6 methyltransferase like 6 -2.65057
FAM240C family with sequence similarity 240 member C -2.65057
DGCR6 DiGeorge syndrome critical region gene 6 -2.65057
RTBDN retbindin -2.65057
PARVG parvin, gamma -2.65057
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.65057
RIN3 Ras and Rab interactor 3 -2.65057
BDKRB2 bradykinin receptor B2 -2.65057
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.65057
ARHGAP35 Rho GTPase activating protein 35 -2.62282
WNT3A wingless-type MMTV integration site family, member 3A -2.60036
CORO1A coronin, actin binding protein, 1A -2.60036
ZNF841 zinc finger protein 841 -2.60036
C1ORF74 chromosome 1 open reading frame 74 -2.60036
CRTC2 CREB regulated transcription coactivator 2 -2.60036
CCDC39 coiled-coil domain containing 39 -2.55988
BEND4 BEN domain containing 4 -2.55988
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.54412
C12ORF76 chromosome 12 open reading frame 76 -2.54271
RBBP6 retinoblastoma binding protein 6 -2.53909
PMVK phosphomevalonate kinase -2.5295
EID3 EP300 interacting inhibitor of differentiation 3 -2.525
ZNF511 zinc finger protein 511 -2.46386
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.46236
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.44819
ERCC1 excision repair cross-complementation group 1 -2.44819
RIF1 replication timing regulatory factor 1 -2.36804
TTC7A tetratricopeptide repeat domain 7A -2.34999
GLIS3 GLIS family zinc finger 3 -2.3424
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -2.34183
RCE1 Ras converting CAAX endopeptidase 1 -2.33569
UBAP1L ubiquitin associated protein 1-like -2.33339
PUM1 pumilio RNA-binding family member 1 -2.33339
CD46 CD46 molecule, complement regulatory protein -2.31383
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.30494
BAIAP2L1 BAI1-associated protein 2-like 1 -2.30161
BBX bobby sox homolog (Drosophila) -2.29108
ZNF506 zinc finger protein 506 -2.28242
DPP4 dipeptidyl-peptidase 4 -2.27734
ZNF593 zinc finger protein 593 -2.24763
BBOF1 basal body orientation factor 1 -2.24018
PHACTR1 phosphatase and actin regulator 1 -2.22847
MOXD1 monooxygenase, DBH-like 1 -2.22057
FASN fatty acid synthase -2.21914
MROH6 maestro heat-like repeat family member 6 -2.19855
PWWP3B PWWP domain containing 3B -2.19302
SPATA32 spermatogenesis associated 32 -2.19302
COL6A6 collagen, type VI, alpha 6 -2.19302
COX5B cytochrome c oxidase subunit Vb -2.18528
MTMR10 myotubularin related protein 10 -2.17267
RELT RELT tumor necrosis factor receptor -2.16388
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.16388
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.14368
BTBD6 BTB (POZ) domain containing 6 -2.14327
IDNK idnK, gluconokinase homolog (E. coli) -2.14327
ADGRF3 adhesion G protein-coupled receptor F3 -2.14105
DNAH11 dynein, axonemal, heavy chain 11 -2.13791
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 -2.13222
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.12754
PROSER2 proline and serine rich 2 -2.12754
PPP4R1 protein phosphatase 4, regulatory subunit 1 -2.12242
PGM3 phosphoglucomutase 3 -2.10823
CCDC59 coiled-coil domain containing 59 -2.10823
PTPRS protein tyrosine phosphatase, receptor type, S -2.10781
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -2.08965
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.08766
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 -2.07634
SELENOV selenoprotein V -2.06926
ZBTB4 zinc finger and BTB domain containing 4 -2.06125
ZNF43 zinc finger protein 43 -2.06095
RBM10 RNA binding motif protein 10 -2.05938
MARCHF8 membrane associated ring-CH-type finger 8 -2.05858
GPSM1 G-protein signaling modulator 1 -2.0522
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.0522
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.02433