PPP1CA Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein phosphatase 1, catalytic subunit, alpha isozyme|The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5499)
External Link http://www.koehn.embl.de/depod/showp.php?gene=PPP1CA
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Genes

43 substrates of the phosphatase PPP1CA from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
AHCYL1 adenosylhomocysteinase-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AURKA aurora kinase A
AXIN1 axin 1
BAD BCL2-associated agonist of cell death
BRCA1 breast cancer 1, early onset
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDC25C cell division cycle 25C
CDK9 cyclin-dependent kinase 9
CEP250 centrosomal protein 250kDa
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
H2AFX H2A histone family, member X
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LMNB1 lamin B1
MAPT microtubule-associated protein tau
MBP myelin basic protein
NCOR1 nuclear receptor corepressor 1
NOS3 nitric oxide synthase 3 (endothelial cell)
PARD3 par-3 family cell polarity regulator
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PTK2 protein tyrosine kinase 2
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RYR1 ryanodine receptor 1 (skeletal)
SMO smoothened, frizzled class receptor
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53