| Dataset | CM4AI KOLF21J CRISPRi Gene Perturbation Atlas |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | protein phosphatase 2, regulatory subunit A, alpha|This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 5518) |
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63 genes differentially expressed following the PPP2R1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
| Symbol | Name | Standardized Value |
|---|---|---|
| GOLGA8H | golgin A8 family, member H | 2.12815 |
| SLC10A2 | solute carrier family 10 (sodium/bile acid cotransporter), member 2 | 2.12815 |
| NMUR2 | neuromedin U receptor 2 | 2.12815 |
| HMX2 | H6 family homeobox 2 | 2.12815 |
| MFAP5 | microfibrillar associated protein 5 | 2.12815 |
| FRMD1 | FERM domain containing 1 | 2.12815 |
| DUSP15 | dual specificity phosphatase 15 | 2.12815 |
| PKP1 | plakophilin 1 | 2.12815 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 2.12815 |
| GJA9 | gap junction protein, alpha 9, 59kDa | 2.12815 |
| CES3 | carboxylesterase 3 | 2.12815 |
| IRF9 | interferon regulatory factor 9 | 2.12815 |
| LOC122539214 | Zinc finger protein LOC122539214 | 2.12815 |
| DISP3 | dispatched RND transporter family member 3 | 2.12815 |
| NPIPB2 | nuclear pore complex interacting protein family member B2 | 2.12815 |
| GPR78 | G protein-coupled receptor 78 | 2.12815 |
| GLB1L | galactosidase, beta 1-like | 2.12815 |
| CLTRN | collectrin, amino acid transport regulator | 2.12815 |
| KCNA7 | potassium channel, voltage gated shaker related subfamily A, member 7 | 2.12815 |
| IFI35 | interferon-induced protein 35 | 2.12815 |
| CRYBA4 | crystallin, beta A4 | 2.12815 |
| SLC22A24 | solute carrier family 22, member 24 | 2.12815 |
| NIPAL4 | NIPA-like domain containing 4 | 2.12815 |
| PLET1 | placenta expressed transcript 1 | 2.12815 |
| CDK11A | cyclin-dependent kinase 11A | 2.12815 |
| DNAJB13 | DnaJ (Hsp40) homolog, subfamily B, member 13 | 2.12815 |
| DACT3 | dishevelled-binding antagonist of beta-catenin 3 | 2.12815 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | 2.12815 |
| ADAM21 | ADAM metallopeptidase domain 21 | 2.12815 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 2.12815 |
| SMAD5 | SMAD family member 5 | 2.09068 |
| C1R | complement component 1, r subcomponent | 2.08224 |
| WHRN | whirlin | 2.06512 |
| TMEM33 | transmembrane protein 33 | 2.06512 |
| ICA1L | islet cell autoantigen 1,69kDa-like | 2.06512 |
| Symbol | Name | Standardized Value |
|---|---|---|
| N4BP2L1 | NEDD4 binding protein 2-like 1 | -2.12815 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.12815 |
| MCOLN3 | mucolipin 3 | -2.12815 |
| FBXO4 | F-box protein 4 | -2.12815 |
| FGD3 | FYVE, RhoGEF and PH domain containing 3 | -2.12815 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | -2.12815 |
| NHSL2 | NHS-like 2 | -2.12815 |
| BEST4 | bestrophin 4 | -2.12815 |
| ANO7 | anoctamin 7 | -2.12815 |
| SINHCAF | SIN3-HDAC complex associated factor | -2.12815 |
| H2BC12 | H2B clustered histone 12 | -2.12815 |
| TMEM81 | transmembrane protein 81 | -2.12815 |
| CCDC74A | coiled-coil domain containing 74A | -2.12815 |
| SHLD3 | shieldin complex subunit 3 | -2.12815 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | -2.12815 |
| APOM | apolipoprotein M | -2.12815 |
| EFHD1 | EF-hand domain family, member D1 | -2.12815 |
| ACE | angiotensin I converting enzyme | -2.12815 |
| ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | -2.12815 |
| CNBD2 | cyclic nucleotide binding domain containing 2 | -2.12815 |
| RAPGEF3 | Rap guanine nucleotide exchange factor (GEF) 3 | -2.12815 |
| TSACC | TSSK6 activating co-chaperone | -2.12815 |
| IL20RB | interleukin 20 receptor beta | -2.12815 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | -2.08394 |
| MBNL1 | muscleblind-like splicing regulator 1 | -2.08201 |
| ARMCX4 | armadillo repeat containing, X-linked 4 | -2.06631 |
| S100A4 | S100 calcium binding protein A4 | -2.06512 |
| FGD5 | FYVE, RhoGEF and PH domain containing 5 | -2.01033 |
