PPP5C Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protein phosphatase 5, catalytic subunit|This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 5536)
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Genes

331 genes differentially expressed following the PPP5C gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LURAP1L leucine rich adaptor protein 1-like 3.29339
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.29339
NPSR1 neuropeptide S receptor 1 3.29339
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.29339
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.29339
MUSK muscle, skeletal, receptor tyrosine kinase 3.29339
ASPA aspartoacylase 3.29339
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.29339
SHCBP1L SHC SH2-domain binding protein 1-like 3.29339
NME8 NME/NM23 family member 8 3.29339
CABS1 calcium-binding protein, spermatid-specific 1 3.29339
OSR2 odd-skipped related transciption factor 2 3.29339
MAP3K7CL MAP3K7 C-terminal like 3.29339
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.29339
CAMP cathelicidin antimicrobial peptide 3.29339
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.29339
GPR151 G protein-coupled receptor 151 3.29339
PGBDF plakoglobin binding and degradation factor 3.29339
TCHH trichohyalin 3.29339
IL5RA interleukin 5 receptor, alpha 3.29339
ADAD2 adenosine deaminase domain containing 2 3.29339
REN renin 3.29339
CLEC14A C-type lectin domain family 14, member A 3.29339
CPLX4 complexin 4 3.29339
HIC1 hypermethylated in cancer 1 3.29339
SNAI2 snail family zinc finger 2 3.29339
SPDEF SAM pointed domain containing ETS transcription factor 3.29339
NRSN1 neurensin 1 3.29339
RHOJ ras homolog family member J 3.29339
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.29339
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.29339
TAS2R13 taste receptor, type 2, member 13 3.29339
LARP4 La ribonucleoprotein domain family, member 4 3.29339
TRIM74 tripartite motif containing 74 3.29339
BIRC3 baculoviral IAP repeat containing 3 3.29339
ADAMTSL5 ADAMTS-like 5 3.29339
ACTL7A actin-like 7A 3.29339
OCSTAMP osteoclast stimulatory transmembrane protein 3.29339
PLK5 polo-like kinase 5 3.29339
CCDC38 coiled-coil domain containing 38 3.29339
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.29339
DCST1 DC-STAMP domain containing 1 3.29339
LOC124900192 uncharacterized LOC124900192 3.29339
PNLIPRP3 pancreatic lipase-related protein 3 3.29339
VN1R2 vomeronasal 1 receptor 2 3.29339
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.29339
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.29339
SAG S-antigen; retina and pineal gland (arrestin) 3.29339
FOXC2 forkhead box C2 3.29339
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.29339
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.29339
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.29339
ROPN1L rhophilin associated tail protein 1-like 3.29339
GBP6 guanylate binding protein family, member 6 3.29339
LY6S lymphocyte antigen 6 family member S 3.29339
SLC67A1 solute carrier family 67 member 1 3.29339
LRRC8C-DT LRRC8C divergent transcript 3.29339
H4C14 H4 clustered histone 14 3.29339
LHFPL7 LHFPL tetraspan subfamily member 7 3.29339
H2AC1 H2A clustered histone 1 3.29339
DEFB131B defensin beta 131B 3.29339
SMIM41 small integral membrane protein 41 3.29339
DLK2 delta-like 2 homolog (Drosophila) 3.29339
PNPLA1 patatin-like phospholipase domain containing 1 3.29339
C3ORF80 chromosome 3 open reading frame 80 3.29339
MAG myelin associated glycoprotein 3.29339
IRF5 interferon regulatory factor 5 3.29339
ACOT1 acyl-CoA thioesterase 1 3.29339
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 3.29339
ERAS ES cell expressed Ras 3.29339
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.29339
TSSK4 testis-specific serine kinase 4 3.29339
OLAH oleoyl-ACP hydrolase 3.29339
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 3.29339
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.29339
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.29339
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.29339
SAMD11 sterile alpha motif domain containing 11 3.29339
PP2D1 protein phosphatase 2C-like domain containing 1 3.29339
S100G S100 calcium binding protein G 3.29339
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.29339
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.29339
GDF10 growth differentiation factor 10 3.29339
CD274 CD274 molecule 3.29339
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.29339
HK3 hexokinase 3 (white cell) 3.29339
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.29339
HSPB2 heat shock 27kDa protein 2 3.29339
CTXN2 cortexin 2 3.29339
LY96 lymphocyte antigen 96 3.29339
PTGDS prostaglandin D2 synthase 21kDa (brain) 3.29339
PAGE2B P antigen family, member 2B 3.29339
SLC7A4 solute carrier family 7, member 4 3.29339
VAV1 vav 1 guanine nucleotide exchange factor 3.29339
ADGRF5 adhesion G protein-coupled receptor F5 3.29339
DLX1 distal-less homeobox 1 3.29339
LYZ lysozyme 3.29339
PRAP1 proline-rich acidic protein 1 3.29339
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.29339
TBX2 T-box 2 3.29339
KLK15 kallikrein-related peptidase 15 3.29339
CYSLTR1 cysteinyl leukotriene receptor 1 3.29339
OPRK1 opioid receptor, kappa 1 3.29339
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.29339
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.29339
KLF1 Kruppel-like factor 1 (erythroid) 3.29339
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.29339
MYF6 myogenic factor 6 (herculin) 3.29339
GFI1B growth factor independent 1B transcription repressor 3.29339
GOLGA6A golgin A6 family, member A 3.29339
FAM209A family with sequence similarity 209, member A 3.29339
PCDHGB4 protocadherin gamma subfamily B, 4 3.29339
CRHR1 corticotropin releasing hormone receptor 1 3.29339
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.29339
PTCRA pre T-cell antigen receptor alpha 3.29339
OTOP2 otopetrin 2 3.29339
CDCP2 CUB domain containing protein 2 3.29339
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.29339
IL17F interleukin 17F 3.29339
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 3.29339
GOLGA8K golgin A8 family, member K 3.29339
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.29339
SEZ6L seizure related 6 homolog (mouse)-like 3.29339
POPDC2 popeye domain containing 2 3.29339
NLRP8 NLR family, pyrin domain containing 8 3.29339
CFB complement factor B 3.29339
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.29339
POU5F1B POU class 5 homeobox 1B 3.29339
ITGAD integrin, alpha D 3.29339
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.29339
IL37 interleukin 37 3.29339
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.29339
CGA glycoprotein hormones, alpha polypeptide 3.29339
HOXA7 homeobox A7 3.29339
DAW1 dynein assembly factor with WDR repeat domains 1 3.29339
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.29339
TMPRSS13 transmembrane protease, serine 13 3.29339
TEX38 testis expressed 38 3.29339
RGS4 regulator of G-protein signaling 4 3.29339
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.29339
TGM3 transglutaminase 3 3.29339
C1ORF105 chromosome 1 open reading frame 105 3.29339
KLHDC1 kelch domain containing 1 3.29339
LRRN4 leucine rich repeat neuronal 4 3.29339
CD226 CD226 molecule 3.29339
APOA1 apolipoprotein A-I 3.24862
BAIAP2 BAI1-associated protein 2 3.21086
ZNF324 zinc finger protein 324 3.14417
RPL3L ribosomal protein L3-like 3.14417
MANF mesencephalic astrocyte-derived neurotrophic factor 3.14417
TAS2R46 taste receptor, type 2, member 46 3.0739
SGK1 serum/glucocorticoid regulated kinase 1 3.03741
ZNF140 zinc finger protein 140 3.01598
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.91171
EBF4 early B-cell factor 4 2.84503
PRSS51 protease, serine, 51 2.76485
KLF16 Kruppel-like factor 16 2.72173
TTI2 TELO2 interacting protein 2 2.68261
SUMO4 small ubiquitin-like modifier 4 2.58802
CELF1 CUGBP, Elav-like family member 1 2.58051
ZNF253 zinc finger protein 253 2.56157
TGM1 transglutaminase 1 2.53992
TINCR tissue differentiation-inducing non-protein coding RNA 2.53992
H2AC12 H2A clustered histone 12 2.50174
SEC23IP SEC23 interacting protein 2.48562
CRAMP1 cramped chromatin regulator homolog 1 2.41554
ARHGAP17 Rho GTPase activating protein 17 2.41319
LRRC4C leucine rich repeat containing 4C 2.3633
KAT7 K(lysine) acetyltransferase 7 2.35024
MOCOS molybdenum cofactor sulfurase 2.34882
MRPL45 mitochondrial ribosomal protein L45 2.33899
FXYD2 FXYD domain containing ion transport regulator 2 2.32235
ZNF3 zinc finger protein 3 2.31998
PTCD1 pentatricopeptide repeat domain 1 2.31395
GALT galactose-1-phosphate uridylyltransferase 2.28378
NMI N-myc (and STAT) interactor 2.27986
WWOX WW domain containing oxidoreductase 2.23248
JOSD1 Josephin domain containing 1 2.23113
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.21069
TOP1 topoisomerase (DNA) I 2.17887
TFRC transferrin receptor 2.16146
IPO7 importin 7 2.13433
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 2.13419
CPED1 cadherin-like and PC-esterase domain containing 1 2.12864
SAXO5 stabilizer of axonemal microtubules 5 2.12864
ARSL arylsulfatase L 2.12864
JAZF1 JAZF zinc finger 1 2.12219
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.11194
LIMD1 LIM domains containing 1 2.11084
STX5 syntaxin 5 2.11084
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.07979
RIC8B RIC8 guanine nucleotide exchange factor B 2.07867
NET1 neuroepithelial cell transforming 1 2.07521
SCAPER S-phase cyclin A-associated protein in the ER 2.07521
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.06456
KIAA0753 KIAA0753 2.05556
SUSD1 sushi domain containing 1 2.05556
RIOX1 ribosomal oxygenase 1 2.04501
ZNF354A zinc finger protein 354A 2.04364
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.04364
ZNF75A zinc finger protein 75a 2.02753
MAN2B1 mannosidase, alpha, class 2B, member 1 2.01859
PXDN peroxidasin 2.01859
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 2.01859
GID8 GID complex subunit 8 2.01859
MTRF1L mitochondrial translational release factor 1-like 2.01673
AUTS2 autism susceptibility candidate 2 2.00922
MIF4GD MIF4G domain containing 2.00635
CDK8 cyclin-dependent kinase 8 2.00333
KIAA1143 KIAA1143 2.00333

decreased expression

Symbol Name Standardized Value
TMEM79 transmembrane protein 79 -3.29339
NACA2 nascent polypeptide-associated complex alpha subunit 2 -3.29339
FNDC9 fibronectin type III domain containing 9 -3.29339
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -3.29339
PKP1 plakophilin 1 -3.29339
SYNM synemin, intermediate filament protein -3.29339
NCMAP noncompact myelin associated protein -3.29339
SV2C synaptic vesicle glycoprotein 2C -3.29339
PIH1D2 PIH1 domain containing 2 -3.29339
EGFL6 EGF-like-domain, multiple 6 -3.29339
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.29339
UNC13C unc-13 homolog C (C. elegans) -3.29339
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -3.29339
CRYGN crystallin, gamma N -3.29339
SPHK1 sphingosine kinase 1 -3.29339
OVCH2 ovochymase 2 (gene/pseudogene) -3.29339
C1ORF146 chromosome 1 open reading frame 146 -3.29339
NFE2 nuclear factor, erythroid 2 -3.29339
GREM2 gremlin 2, DAN family BMP antagonist -3.29339
TAL2 T-cell acute lymphocytic leukemia 2 -3.29339
SLITRK3 SLIT and NTRK-like family, member 3 -3.29339
GFAP glial fibrillary acidic protein -3.29339
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -3.29339
MAGED4 melanoma antigen family D4 -3.29339
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -3.29339
GJA4 gap junction protein, alpha 4, 37kDa -3.29339
PRB3 proline-rich protein BstNI subfamily 3 -3.29339
ARR3 arrestin 3, retinal (X-arrestin) -3.29339
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -3.29339
MISP3 MISP family member 3 -3.29339
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -3.29339
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.29339
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -3.29339
HTRA3 HtrA serine peptidase 3 -3.29339
CDK20 cyclin-dependent kinase 20 -3.29339
CCDC78 coiled-coil domain containing 78 -3.29339
KLHL35 kelch-like family member 35 -3.29339
BCL2A1 BCL2-related protein A1 -3.29339
PCDHGA1 protocadherin gamma subfamily A, 1 -3.29339
NBPF20 neuroblastoma breakpoint family, member 20 -3.29339
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -3.29339
CCDC194 coiled-coil domain containing 194 -3.29339
CELF5 CUGBP, Elav-like family member 5 -3.2328
LPAR3 lysophosphatidic acid receptor 3 -3.22779
MRPS23 mitochondrial ribosomal protein S23 -3.09056
FKBPL FK506 binding protein like -3.0739
GLRA1 glycine receptor, alpha 1 -3.0739
SFRP1 secreted frizzled-related protein 1 -3.05772
LHFPL2 lipoma HMGIC fusion partner-like 2 -3.0047
SV2A synaptic vesicle glycoprotein 2A -2.97668
TSSK3 testis-specific serine kinase 3 -2.97068
SLC25A43 solute carrier family 25, member 43 -2.94922
TBPL1 TBP-like 1 -2.70678
RENBP renin binding protein -2.66369
METTL18 methyltransferase like 18 -2.62037
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -2.51447
ITGAV integrin, alpha V -2.49771
ZNF432 zinc finger protein 432 -2.4878
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.44961
BEST2 bestrophin 2 -2.44961
TFF3 trefoil factor 3 (intestinal) -2.44961
MYL5 myosin, light chain 5, regulatory -2.44961
ZNF862 zinc finger protein 862 -2.44961
CCDC183 coiled-coil domain containing 183 -2.44961
CLUL1 clusterin-like 1 (retinal) -2.44961
TMEM61 transmembrane protein 61 -2.44961
METTL27 methyltransferase like 27 -2.41554
LYRM1 LYR motif containing 1 -2.41464
FANCM Fanconi anemia, complementation group M -2.40021
RGPD1 RANBP2-like and GRIP domain containing 1 -2.39798
NTSR1 neurotensin receptor 1 (high affinity) -2.39798
ZIK1 zinc finger protein interacting with K protein 1 -2.38972
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.38391
RPS21 ribosomal protein S21 -2.34882
ATRN attractin -2.33899
PCDH17 protocadherin 17 -2.33899
ARF1 ADP-ribosylation factor 1 -2.33899
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.33899
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -2.33899
HYAL1 hyaluronoglucosaminidase 1 -2.33899
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -2.32235
PURA purine-rich element binding protein A -2.3202
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.30814
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.29727
PCDH11X protocadherin 11 X-linked -2.2716
SPC24 SPC24, NDC80 kinetochore complex component -2.26604
ZNF423 zinc finger protein 423 -2.24372
FZD3 frizzled class receptor 3 -2.23248
TMEM141 transmembrane protein 141 -2.23113
CDH20 cadherin 20, type 2 -2.23113
CLCN7 chloride channel, voltage-sensitive 7 -2.23113
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -2.2197
RNASEH2B ribonuclease H2, subunit B -2.2197
TXN2 thioredoxin 2 -2.20869
WIF1 WNT inhibitory factor 1 -2.19523
ESRRA estrogen-related receptor alpha -2.183
TOMM70 translocase of outer mitochondrial membrane 70 -2.183
TMEM243 transmembrane protein 243, mitochondrial -2.1787
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.16399
NRL neural retina leucine zipper -2.16222
HINFP histone H4 transcription factor -2.15884
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.15661
SCAND1 SCAN domain containing 1 -2.15499
SERTAD3 SERTA domain containing 3 -2.12219
GPR183 G protein-coupled receptor 183 -2.08483
ZNF577 zinc finger protein 577 -2.07521
CANT1 calcium activated nucleotidase 1 -2.07521
SPRY2 sprouty homolog 2 (Drosophila) -2.07521
C2CD2 C2 calcium-dependent domain containing 2 -2.07411
C15ORF61 chromosome 15 open reading frame 61 -2.07411
EFNA5 ephrin-A5 -2.06456
SLC25A53 solute carrier family 25, member 53 -2.0573
TMEM14A transmembrane protein 14A -2.04364
FAM53B family with sequence similarity 53, member B -2.04109
BTD biotinidase -2.04109
CCDC33 coiled-coil domain containing 33 -2.0361
PSD pleckstrin and Sec7 domain containing -2.02069
RAB42 RAB42, member RAS oncogene family -2.01859
RPS6 ribosomal protein S6 -2.01673
WWTR1 WW domain containing transcription regulator 1 -2.00635
HINT2 histidine triad nucleotide binding protein 2 -2.00333