PRC2_SUZ12_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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379 genes differentially expressed following the PRC2_SUZ12_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACVRL1 activin A receptor type II-like 1
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADCK4 aarF domain containing kinase 4
ADCY2 adenylate cyclase 2 (brain)
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGO2 argonaute RISC catalytic component 2
AIM1L absent in melanoma 1-like
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOXE3 arachidonate lipoxygenase 3
AMBP alpha-1-microglobulin/bikunin precursor
ANK1 ankyrin 1, erythrocytic
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APCS amyloid P component, serum
ARF1P1 ADP-ribosylation factor 1 pseudogene 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARRB2 arrestin, beta 2
ARSD arylsulfatase D
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG2A autophagy related 2A
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBC3 BCL2 binding component 3
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
BTBD7 BTB (POZ) domain containing 7
C22ORF31 chromosome 22 open reading frame 31
CA7 carbonic anhydrase VII
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCL19 chemokine (C-C motif) ligand 19
CCNE1 cyclin E1
CD1B CD1b molecule
CD1D CD1d molecule
CD22 CD22 molecule
CD247 CD247 molecule
CFAP70 cilia and flagella associated protein 70
CGA glycoprotein hormones, alpha polypeptide
CHEK1 checkpoint kinase 1
CHN2 chimerin 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIB1 calcium and integrin binding 1 (calmyrin)
CLDN14 claudin 14
CLEC10A C-type lectin domain family 10, member A
CORO1A coronin, actin binding protein, 1A
CRISP1 cysteine-rich secretory protein 1
CXORF56 chromosome X open reading frame 56
DCC DCC netrin 1 receptor
DCSTAMP dendrocyte expressed seven transmembrane protein
DCX doublecortin
DEFB126 defensin, beta 126
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNAI1 dynein, axonemal, intermediate chain 1
DRP2 dystrophin related protein 2
EFNA5 ephrin-A5
ELP6 elongator acetyltransferase complex subunit 6
EPHX2 epoxide hydrolase 2, cytoplasmic
EPPK1 epiplakin 1
EVPL envoplakin
FGA fibrinogen alpha chain
FMO6P flavin containing monooxygenase 6 pseudogene
FOXJ1 forkhead box J1
FRMD8 FERM domain containing 8
FXYD1 FXYD domain containing ion transport regulator 1
GAS8-AS1 GAS8 antisense RNA 1
GLRA2 glycine receptor, alpha 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GP9 glycoprotein IX (platelet)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HAPLN2 hyaluronan and proteoglycan link protein 2
HAUS5 HAUS augmin-like complex, subunit 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA10 homeobox A10
HOXB1 homeobox B1
HOXC5 homeobox C5
HOXD11 homeobox D11
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HYAL1 hyaluronoglucosaminidase 1
IGKV3D-15 immunoglobulin kappa variable 3D-15 (gene/pseudogene)
IGLL1 immunoglobulin lambda-like polypeptide 1
IL10RA interleukin 10 receptor, alpha
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IMPG2 interphotoreceptor matrix proteoglycan 2
KALRN kalirin, RhoGEF kinase
KAT8 K(lysine) acetyltransferase 8
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KLF15 Kruppel-like factor 15
KLHL11 kelch-like family member 11
KLHL23 kelch-like family member 23
KRT3 keratin 3, type II
KXD1 KxDL motif containing 1
LDB2 LIM domain binding 2
LHX6 LIM homeobox 6
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LINC00588 long intergenic non-protein coding RNA 588
LINC01558 long intergenic non-protein coding RNA 1558
LMNB2 lamin B2
LMOD1 leiomodin 1 (smooth muscle)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC61 leucine rich repeat containing 61
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MAP2K4 mitogen-activated protein kinase kinase 4
MAPT microtubule-associated protein tau
MARK1 MAP/microtubule affinity-regulating kinase 1
MC5R melanocortin 5 receptor
MED20 mediator complex subunit 20
MEIS2 Meis homeobox 2
MYF6 myogenic factor 6 (herculin)
MYH13 myosin, heavy chain 13, skeletal muscle
MYOM1 myomesin 1
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NLGN1 neuroligin 1
NPFFR1 neuropeptide FF receptor 1
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
ONECUT2 one cut homeobox 2
OPCML opioid binding protein/cell adhesion molecule-like
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OR6A2 olfactory receptor, family 6, subfamily A, member 2
ORC1 origin recognition complex, subunit 1
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PARK2 parkin RBR E3 ubiquitin protein ligase
PAX1 paired box 1
PF4 platelet factor 4
PGAP1 post-GPI attachment to proteins 1
PGK2 phosphoglycerate kinase 2
PHOX2B paired-like homeobox 2b
PKP1 plakophilin 1
PNPLA3 patatin-like phospholipase domain containing 3
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRSS8 protease, serine, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
PTTG2 pituitary tumor-transforming 2
PYCRL pyrroline-5-carboxylate reductase-like
RAD54L RAD54-like (S. cerevisiae)
RAVER2 ribonucleoprotein, PTB-binding 2
RECQL4 RecQ protein-like 4
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RITA1 RBPJ interacting and tubulin associated 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL37A ribosomal protein L37a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNDC3A RUN domain containing 3A
SCHIP1 schwannomin interacting protein 1
SDCCAG3 serologically defined colon cancer antigen 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLITRK3 SLIT and NTRK-like family, member 3
SOAT2 sterol O-acyltransferase 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRSF11 serine/arginine-rich splicing factor 11
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STAU2 staufen double-stranded RNA binding protein 2
STXBP2 syntaxin binding protein 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYN3 synapsin III
T T, brachyury homolog (mouse)
TACR1 tachykinin receptor 1
TCAP titin-cap
TFEC transcription factor EC
TINAGL1 tubulointerstitial nephritis antigen-like 1
TM4SF20 transmembrane 4 L six family member 20
TNNT2 troponin T type 2 (cardiac)
TRAC T cell receptor alpha constant
TSPAN12 tetraspanin 12
UBQLN3 ubiquilin 3
UPK1A uroplakin 1A
USP2 ubiquitin specific peptidase 2
WFDC1 WAP four-disulfide core domain 1
WRN Werner syndrome, RecQ helicase-like
ZIC4 Zic family member 4
ZNF695 zinc finger protein 695
ZNF696 zinc finger protein 696
ZWILCH zwilch kinetochore protein

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ACTL8 actin-like 8
ADIRF adipogenesis regulatory factor
AGO4 argonaute RISC catalytic component 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALX4 ALX homeobox 4
ANKRD46 ankyrin repeat domain 46
ANXA2P3 annexin A2 pseudogene 3
AOC4P amine oxidase, copper containing 4, pseudogene
ARL4C ADP-ribosylation factor-like 4C
ATXN1 ataxin 1
BFSP1 beaded filament structural protein 1, filensin
BMP3 bone morphogenetic protein 3
BRDT bromodomain, testis-specific
BTN3A2 butyrophilin, subfamily 3, member A2
C1ORF21 chromosome 1 open reading frame 21
C2ORF27A chromosome 2 open reading frame 27A
CA11 carbonic anhydrase XI
CA6 carbonic anhydrase VI
CAB39L calcium binding protein 39-like
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CALML4 calmodulin-like 4
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX7 chromobox homolog 7
CBX8 chromobox homolog 8
CCDC87 coiled-coil domain containing 87
CCK cholecystokinin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNK cyclin K
CCNT1 cyclin T1
CD70 CD70 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CFB complement factor B
CH25H cholesterol 25-hydroxylase
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIDEA cell death-inducing DFFA-like effector a
CLEC4E C-type lectin domain family 4, member E
CNPY4 canopy FGF signaling regulator 4
COCH cochlin
COL13A1 collagen, type XIII, alpha 1
CTSS cathepsin S
CXCR3 chemokine (C-X-C motif) receptor 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DACH1 dachshund family transcription factor 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCP2 decapping mRNA 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK2 docking protein 2, 56kDa
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERO1L ERO1-like (S. cerevisiae)
ETV4 ets variant 4
FAM182B family with sequence similarity 182, member B
FAT2 FAT atypical cadherin 2
FCHO1 FCH domain only 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF6 fibroblast growth factor 6
FGF9 fibroblast growth factor 9
FMNL1 formin-like 1
FOLR3 folate receptor 3 (gamma)
GAB2 GRB2-associated binding protein 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GATA1 GATA binding protein 1 (globin transcription factor 1)
GGT5 gamma-glutamyltransferase 5
GIMAP4 GTPase, IMAP family member 4
GMIP GEM interacting protein
GPC6 glypican 6
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRP gastrin-releasing peptide
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HIGD1B HIG1 hypoxia inducible domain family, member 1B
HR hair growth associated
IFNA1 interferon, alpha 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1RL2 interleukin 1 receptor-like 2
IPCEF1 interaction protein for cytohesin exchange factors 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0319L KIAA0319-like
KIAA1024 KIAA1024
KRI1 KRI1 homolog (S. cerevisiae)
KRT15 keratin 15, type I
KRT81 keratin 81, type II
LCAT lecithin-cholesterol acyltransferase
LCE2B late cornified envelope 2B
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIME1 Lck interacting transmembrane adaptor 1
LOC155060 AI894139 pseudogene
LYPD1 LY6/PLAUR domain containing 1
MCTP1 multiple C2 domains, transmembrane 1
MRS2 MRS2 magnesium transporter
MT4 metallothionein 4
MTMR10 myotubularin related protein 10
MTRF1 mitochondrial translational release factor 1
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYT1 myelin transcription factor 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NGB neuroglobin
NKX6-1 NK6 homeobox 1
NMRK2 nicotinamide riboside kinase 2
NPY4R neuropeptide Y receptor Y4
NR0B2 nuclear receptor subfamily 0, group B, member 2
NUPL1 nucleoporin like 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSTM1 osteopetrosis associated transmembrane protein 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAQR6 progestin and adipoQ receptor family member VI
PCBP3 poly(rC) binding protein 3
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PKD2L1 polycystic kidney disease 2-like 1
PLEK2 pleckstrin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMEPA1 prostate transmembrane protein, androgen induced 1
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
POU2F1 POU class 2 homeobox 1
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPIEL peptidylprolyl isomerase E-like pseudogene
PRKG2 protein kinase, cGMP-dependent, type II
PRKY protein kinase, Y-linked, pseudogene
PRSS50 protease, serine, 50
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTCD2 pentatricopeptide repeat domain 2
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RBM4 RNA binding motif protein 4
REST RE1-silencing transcription factor
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPL3L ribosomal protein L3-like
SCG5 secretogranin V
SCTR secretin receptor
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPTB spectrin, beta, erythrocytic
SRPK3 SRSF protein kinase 3
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STAB2 stabilin 2
STAT5A signal transducer and activator of transcription 5A
TAS2R13 taste receptor, type 2, member 13
TET3 tet methylcytosine dioxygenase 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM187 transmembrane protein 187
TMEM245 transmembrane protein 245
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOM1L2 target of myb1-like 2 (chicken)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM58 tripartite motif containing 58
TRPC6 transient receptor potential cation channel, subfamily C, member 6
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPK3B uroplakin 3B
USP46 ubiquitin specific peptidase 46
VILL villin-like
WDR25 WD repeat domain 25
XK X-linked Kx blood group
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZNF177 zinc finger protein 177
ZNF208 zinc finger protein 208
ZNF324 zinc finger protein 324
ZNF471 zinc finger protein 471
ZNF550 zinc finger protein 550
ZNF76 zinc finger protein 76
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1