PRCC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description papillary renal cell carcinoma (translocation-associated)|This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 5546)
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Genes

363 genes differentially expressed following the PRCC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.61601
PTX3 pentraxin 3, long 2.61601
CD200R1L CD200 receptor 1-like 2.61601
ALS2CL ALS2 C-terminal like 2.61601
TECTA tectorin alpha 2.61601
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.61601
CEL carboxyl ester lipase 2.61601
VIRMA vir like m6A methyltransferase associated 2.61601
CCDC9B coiled-coil domain containing 9B 2.61601
GATA3 GATA binding protein 3 2.61601
GCSAML germinal center-associated, signaling and motility-like 2.61601
MT1M metallothionein 1M 2.61601
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.61601
GRHL3 grainyhead-like 3 (Drosophila) 2.61601
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.61601
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.61601
ESYT2 extended synaptotagmin-like protein 2 2.61601
CARD16 caspase recruitment domain family, member 16 2.61601
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.61601
PLAC1 placenta-specific 1 2.61601
CHCT1 CHD1 helical C-terminal domain containing 1 2.61601
WASL-DT WASL divergent transcript 2.61601
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.61601
C17ORF113 chromosome 17 open reading frame 113 2.61601
MCOLN3 mucolipin 3 2.61601
PCDHAC1 protocadherin alpha subfamily C, 1 2.61601
TAL2 T-cell acute lymphocytic leukemia 2 2.61601
EFCAB12 EF-hand calcium binding domain 12 2.61601
ZNF610 zinc finger protein 610 2.61601
PRTN3 proteinase 3 2.61601
GNRHR gonadotropin-releasing hormone receptor 2.61601
UBXN10 UBX domain protein 10 2.61601
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.53395
TLX2 T-cell leukemia homeobox 2 2.53395
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.53395
MAPRE2 microtubule-associated protein, RP/EB family, member 2 2.53395
MYO7A myosin VIIA 2.53395
NKX2-5 NK2 homeobox 5 2.53395
CAPN14 calpain 14 2.53395
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.53395
LOC390937 Ets2 repressor factor-like 2.53395
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.53395
CES3 carboxylesterase 3 2.53395
PLVAP plasmalemma vesicle associated protein 2.53395
CCDC85B coiled-coil domain containing 85B 2.53395
FER1L6 fer-1-like family member 6 2.53395
TMPRSS11E transmembrane protease, serine 11E 2.53395
KLHL31 kelch-like family member 31 2.53395
ZNF503 zinc finger protein 503 2.53395
TM4SF5 transmembrane 4 L six family member 5 2.53395
TMEM151A transmembrane protein 151A 2.53395
PKD1L1 polycystic kidney disease 1 like 1 2.53395
GFAP glial fibrillary acidic protein 2.53395
ANKRD34A ankyrin repeat domain 34A 2.53395
SLC25A41 solute carrier family 25, member 41 2.53395
NME8 NME/NM23 family member 8 2.53395
DSG3 desmoglein 3 2.53395
AADACL3 arylacetamide deacetylase-like 3 2.53395
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.53395
CD160 CD160 molecule 2.53395
TUBB8 tubulin, beta 8 class VIII 2.53395
COLEC11 collectin sub-family member 11 2.53395
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.53395
FOLR3 folate receptor 3 (gamma) 2.53395
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.53395
HCRTR1 hypocretin (orexin) receptor 1 2.53395
PRELP proline/arginine-rich end leucine-rich repeat protein 2.53395
NXPH3 neurexophilin 3 2.53395
ADRB2 adrenoceptor beta 2, surface 2.53395
LRRC56 leucine rich repeat containing 56 2.53395
CLDN9 claudin 9 2.53395
LOC124900192 uncharacterized LOC124900192 2.53395
SQOR sulfide quinone oxidoreductase 2.53395
CCN1 cellular communication network factor 1 2.53395
PTH1R parathyroid hormone 1 receptor 2.53395
OTOA otoancorin 2.53395
RAG2 recombination activating gene 2 2.53395
YPEL4 yippee-like 4 (Drosophila) 2.53395
CAPN9 calpain 9 2.53395
DUSP9 dual specificity phosphatase 9 2.53395
GIPR gastric inhibitory polypeptide receptor 2.53395
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.53395
MYZAP myocardial zonula adherens protein 2.53395
ODAD1 outer dynein arm docking complex subunit 1 2.53395
DNAAF4 dynein axonemal assembly factor 4 2.53395
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.53395
FAM90A12 family with sequence similarity 90 member A12 2.53395
LHFPL7 LHFPL tetraspan subfamily member 7 2.53395
CIBAR2 CBY1 interacting BAR domain containing 2 2.53395
DUSP29 dual specificity phosphatase 29 2.53395
RNF227 ring finger protein 227 2.53395
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.53395
ODAD4 outer dynein arm docking complex subunit 4 2.53395
TBXT T-box transcription factor T 2.53395
DERPC DERPC proline and glycine rich nuclear protein 2.53395
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.53395
TMPRSS6 transmembrane protease, serine 6 2.53395
ASB9 ankyrin repeat and SOCS box containing 9 2.53395
ZNF446 zinc finger protein 446 2.53395
PRR4 proline rich 4 (lacrimal) 2.53395
INSRR insulin receptor-related receptor 2.53395
PRRT4 proline-rich transmembrane protein 4 2.53395
ESR1 estrogen receptor 1 2.53395
BLNK B-cell linker 2.53395
RPL18 ribosomal protein L18 2.53395
C1ORF162 chromosome 1 open reading frame 162 2.53395
UROC1 urocanate hydratase 1 2.53395
CD48 CD48 molecule 2.53395
AMBP alpha-1-microglobulin/bikunin precursor 2.53395
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.53395
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.53395
CCR7 chemokine (C-C motif) receptor 7 2.53395
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.53395
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.53395
ASIC4 acid sensing (proton gated) ion channel family member 4 2.53395
GPR83 G protein-coupled receptor 83 2.53395
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.53395
ARMC12 armadillo repeat containing 12 2.53395
VCX3A variable charge, X-linked 3A 2.53395
C7 complement component 7 2.53395
SAA4 serum amyloid A4, constitutive 2.53395
C7ORF57 chromosome 7 open reading frame 57 2.53395
CCR9 chemokine (C-C motif) receptor 9 2.53395
TEX101 testis expressed 101 2.53395
NAP1L4 nucleosome assembly protein 1-like 4 2.53395
INHA inhibin, alpha 2.53395
SERINC4 serine incorporator 4 2.53395
CD248 CD248 molecule, endosialin 2.53395
PEBP4 phosphatidylethanolamine-binding protein 4 2.53395
SNX30 sorting nexin family member 30 2.53395
C22ORF42 chromosome 22 open reading frame 42 2.53395
C2CD4B C2 calcium-dependent domain containing 4B 2.53395
VWA7 von Willebrand factor A domain containing 7 2.53395
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.53395
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.53395
ETNPPL ethanolamine-phosphate phospho-lyase 2.53395
C11ORF91 chromosome 11 open reading frame 91 2.53395
HSPB8 heat shock 22kDa protein 8 2.53395
ACE angiotensin I converting enzyme 2.53395
TTBK1 tau tubulin kinase 1 2.53395
ZNF365 zinc finger protein 365 2.53395
CCDC154 coiled-coil domain containing 154 2.53395
ERICH6 glutamate-rich 6 2.53395
AMIGO1 adhesion molecule with Ig-like domain 1 2.53395
CST7 cystatin F (leukocystatin) 2.53395
MT2A metallothionein 2A 2.53395
DAPK3 death-associated protein kinase 3 2.53395
TEX12 testis expressed 12 2.53395
ZNF596 zinc finger protein 596 2.53395
NIM1K NIM1 serine/threonine protein kinase 2.53395
ADGRD1 adhesion G protein-coupled receptor D1 2.53395
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.53395
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.53395
SLA Src-like-adaptor 2.53395
LMAN1L lectin, mannose-binding, 1 like 2.53395
PLA2G2C phospholipase A2, group IIC 2.53395
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.53395
C22ORF31 chromosome 22 open reading frame 31 2.53395
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.53395
DAPL1 death associated protein-like 1 2.53395
CTSE cathepsin E 2.53395
KLK5 kallikrein-related peptidase 5 2.53395
PDHB pyruvate dehydrogenase (lipoamide) beta 2.53395
UTS2R urotensin 2 receptor 2.53395
EPHA10 EPH receptor A10 2.53395
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.53395
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.53395
AMH anti-Mullerian hormone 2.53395
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.53395
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.53395
DMRT1 doublesex and mab-3 related transcription factor 1 2.53395
SEZ6L seizure related 6 homolog (mouse)-like 2.53395
MAPK11 mitogen-activated protein kinase 11 2.53395
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.53395
ICAM2 intercellular adhesion molecule 2 2.53395
C5ORF46 chromosome 5 open reading frame 46 2.53395
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.53395
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.53395
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.53395
ANXA1 annexin A1 2.53395
ADAM20 ADAM metallopeptidase domain 20 2.53395
MAGEA12 melanoma antigen family A12 2.53395
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.53395
CPLX1 complexin 1 2.53395
NPC1L1 NPC1-like 1 2.53395
C16ORF54 chromosome 16 open reading frame 54 2.53395
STEAP4 STEAP family member 4 2.53395
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.53395
SPAG8 sperm associated antigen 8 2.53395
EPHB3 EPH receptor B3 2.53395
SIMC1 SUMO-interacting motifs containing 1 2.53395
LHX6 LIM homeobox 6 2.53395
SPDEF SAM pointed domain containing ETS transcription factor 2.53395
ATG4B autophagy related 4B, cysteine peptidase 2.53395
PSD2 pleckstrin and Sec7 domain containing 2 2.53395
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.53395
TBC1D26 TBC1 domain family, member 26 2.53395
CA9 carbonic anhydrase IX 2.53395
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.53395
MAEL maelstrom spermatogenic transposon silencer 2.53395
POSTN periostin, osteoblast specific factor 2.53395
TST thiosulfate sulfurtransferase (rhodanese) 2.53395
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) 2.53395
MST1 macrophage stimulating 1 2.53395
PRR15L proline rich 15-like 2.53395
MAGEA9B melanoma antigen family A9B 2.53395
ZNF534 zinc finger protein 534 2.53395
RLN3 relaxin 3 2.53395
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.53395
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.53395
CD80 CD80 molecule 2.53395
SLITRK6 SLIT and NTRK-like family, member 6 2.53395
PYGM phosphorylase, glycogen, muscle 2.49501
TLK2 tousled-like kinase 2 2.49391
CERS6 ceramide synthase 6 2.45897
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 2.45897
AMOTL2 angiomotin like 2 2.43929
EOLA2 endothelium and lymphocyte associated ASCH domain 2 2.43296
ROR1 receptor tyrosine kinase-like orphan receptor 1 2.40854
SGF29 SAGA complex associated factor 29 2.38856
ABITRAM actin binding transcription modulator 2.36815
MYBPC2 myosin binding protein C, fast type 2.36188
PRUNE2 prune homolog 2 (Drosophila) 2.34966
SSBP3 single stranded DNA binding protein 3 2.34533
FANCF Fanconi anemia, complementation group F 2.33925
ZEB1 zinc finger E-box binding homeobox 1 2.25931
TIGD6 tigger transposable element derived 6 2.25931
SH3GL3 SH3-domain GRB2-like 3 2.25277
PRKCD protein kinase C, delta 2.23333
KRABD2 KRAB domain containing 2 2.18187
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.16189
ITGA9 integrin, alpha 9 2.12047
RGMA repulsive guidance molecule family member a 2.10803
MRM2 mitochondrial rRNA methyltransferase 2 2.09054
ZFP82 ZFP82 zinc finger protein 2.08409
RBBP9 retinoblastoma binding protein 9 2.08409
NEK1 NIMA-related kinase 1 2.07235
LOC122455342 testis-specific serine/proline-rich protein 2.07219
SMIM12 small integral membrane protein 12 2.06449
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.05399
TEAD2 TEA domain family member 2 2.0325
CWC22 CWC22 spliceosome-associated protein 2.02904
COMTD1 catechol-O-methyltransferase domain containing 1 2.02785
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4 2.02172
RGS9 regulator of G-protein signaling 9 2.01101
GSK3A glycogen synthase kinase 3 alpha 2.00824

decreased expression

Symbol Name Standardized Value
KYAT3 kynurenine aminotransferase 3 -2.61601
DPYD dihydropyrimidine dehydrogenase -2.61601
PRXL2C peroxiredoxin like 2C -2.61601
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.61601
DNAI3 dynein axonemal intermediate chain 3 -2.61601
ZBTB48 zinc finger and BTB domain containing 48 -2.61601
CCDC62 coiled-coil domain containing 62 -2.61601
TRIM73 tripartite motif containing 73 -2.53395
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.53395
GRM1 glutamate receptor, metabotropic 1 -2.53395
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -2.53395
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -2.53395
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.53395
IPO7 importin 7 -2.53395
FAM167B family with sequence similarity 167, member B -2.53395
CDH9 cadherin 9, type 2 (T1-cadherin) -2.53395
PCDHB3 protocadherin beta 3 -2.53395
UQCRHL ubiquinol-cytochrome c reductase hinge protein-like -2.53395
OFD1 oral-facial-digital syndrome 1 -2.53395
CA11 carbonic anhydrase XI -2.53395
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -2.53395
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.53395
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.53395
OVCH2 ovochymase 2 (gene/pseudogene) -2.53395
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.53395
LMAN2 lectin, mannose-binding 2 -2.53395
MGST1 microsomal glutathione S-transferase 1 -2.53395
SNPH syntaphilin -2.53395
TLL1 tolloid-like 1 -2.53395
TSPYL2 TSPY-like 2 -2.53395
H4C4 H4 clustered histone 4 -2.53395
TMEM225B transmembrane protein 225B -2.53395
SMIM38 small integral membrane protein 38 -2.53395
SLC66A3 solute carrier family 66 member 3 -2.53395
CCDC196 coiled-coil domain containing 196 -2.53395
KLK14 kallikrein-related peptidase 14 -2.53395
LRRC17 leucine rich repeat containing 17 -2.53395
FAM13C family with sequence similarity 13, member C -2.53395
PYY peptide YY -2.53395
FAM222A family with sequence similarity 222, member A -2.53395
ZFP3 ZFP3 zinc finger protein -2.53395
SMIM45 small integral membrane protein 45 -2.53395
CD70 CD70 molecule -2.53395
GBX2 gastrulation brain homeobox 2 -2.53395
DLG5 discs, large homolog 5 (Drosophila) -2.53395
GUSB glucuronidase, beta -2.52284
TET2 tet methylcytosine dioxygenase 2 -2.4912
DNLZ DNL-type zinc finger -2.48472
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.46944
H4C16 H4 histone 16 -2.4663
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -2.46247
ZNF771 zinc finger protein 771 -2.44038
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.43399
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -2.38074
EFNB3 ephrin-B3 -2.38074
TRIB2 tribbles pseudokinase 2 -2.36815
LAMP1 lysosomal-associated membrane protein 1 -2.36188
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 -2.35444
EPN1 epsin 1 -2.34533
PLEKHO1 pleckstrin homology domain containing, family O member 1 -2.33934
HOOK3 hook microtubule-tethering protein 3 -2.31888
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.30959
PGAP1 post-GPI attachment to proteins 1 -2.30802
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) -2.30017
CAMK2D calcium/calmodulin-dependent protein kinase II delta -2.30017
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -2.30017
FAM117B family with sequence similarity 117, member B -2.30017
RAB23 RAB23, member RAS oncogene family -2.29956
MORN3 MORN repeat containing 3 -2.29475
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.27688
KDM5B lysine (K)-specific demethylase 5B -2.26525
ZNF763 zinc finger protein 763 -2.26525
TMEM50B transmembrane protein 50B -2.2625
BBOF1 basal body orientation factor 1 -2.2625
IFI16 interferon, gamma-inducible protein 16 -2.25792
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -2.25792
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.25792
BTN3A1 butyrophilin, subfamily 3, member A1 -2.25792
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.25407
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.24506
BKGD beta-keto-L-gulonate decarboxylase -2.24281
FOXK1 forkhead box K1 -2.2426
RNF149 ring finger protein 149 -2.2426
ZMYM5 zinc finger, MYM-type 5 -2.2384
SORCS2 sortilin-related VPS10 domain containing receptor 2 -2.2338
DPH5 diphthamide biosynthesis 5 -2.22253
TIMELESS timeless circadian clock -2.2195
RPL22L1 ribosomal protein L22-like 1 -2.21429
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -2.21421
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.19134
PLAAT5 phospholipase A and acyltransferase 5 -2.18187
RNF32 ring finger protein 32 -2.18187
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.16189
DGCR2 DiGeorge syndrome critical region gene 2 -2.16189
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -2.14307
GAB2 GRB2-associated binding protein 2 -2.12365
UBE2H ubiquitin-conjugating enzyme E2H -2.12305
BMAL2 basic helix-loop-helix ARNT like 2 -2.1208
TSC22D1 TSC22 domain family, member 1 -2.10803
DGKH diacylglycerol kinase, eta -2.10751
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.09798
TPD52 tumor protein D52 -2.09054
WDR25 WD repeat domain 25 -2.07821
ECT2 epithelial cell transforming 2 -2.07821
TMEM147 transmembrane protein 147 -2.07219
TOP1 topoisomerase (DNA) I -2.06136
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.04872
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -2.04251
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit -2.0387
DOC2B double C2-like domains, beta -2.0325
SPDYE2 speedy/RINGO cell cycle regulator family member E2 -2.0325
PLPPR4 phospholipid phosphatase related 4 -2.0325
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -2.0124
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -2.01113
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.01101
IKZF4 IKAROS family zinc finger 4 (Eos) -2.00824
AARS2 alanyl-tRNA synthetase 2, mitochondrial -2.00088