PRDM1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PR domain containing 1, with ZNF domain|This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 639)
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Genes

349 genes differentially expressed following the PRDM1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HRH4 histamine receptor H4 3.01378
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.01378
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 3.01378
ASB10 ankyrin repeat and SOCS box containing 10 3.01378
RSPO1 R-spondin 1 3.01378
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.01378
TNIP3 TNFAIP3 interacting protein 3 3.01378
TRIM74 tripartite motif containing 74 3.01378
RFPL2 ret finger protein-like 2 3.01378
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.01378
HBA1 hemoglobin, alpha 1 3.01378
GSTM5 glutathione S-transferase mu 5 3.01378
FGF21 fibroblast growth factor 21 3.01378
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.01378
WDR87 WD repeat domain 87 3.01378
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.01378
PRICKLE4 prickle homolog 4 (Drosophila) 3.01378
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.01378
PCDHB8 protocadherin beta 8 3.01378
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.01378
UMOD uromodulin 3.01378
PTGFR prostaglandin F receptor (FP) 3.01378
GCKR glucokinase (hexokinase 4) regulator 3.01378
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.01378
OVCH1 ovochymase 1 3.01378
SP6 Sp6 transcription factor 3.01378
LDHC lactate dehydrogenase C 3.01378
STAP1 signal transducing adaptor family member 1 3.01378
FGF9 fibroblast growth factor 9 3.01378
BTBD16 BTB (POZ) domain containing 16 3.01378
NPR3 natriuretic peptide receptor 3 3.01378
RBP4 retinol binding protein 4, plasma 3.01378
ZC2HC1B zinc finger, C2HC-type containing 1B 3.01378
CLEC14A C-type lectin domain family 14, member A 3.01378
ATOH1 atonal homolog 1 (Drosophila) 3.01378
GMFG glia maturation factor, gamma 3.01378
SPP2 secreted phosphoprotein 2, 24kDa 3.01378
RGPD4 RANBP2-like and GRIP domain containing 4 3.01378
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.01378
LGI1 leucine-rich, glioma inactivated 1 3.01378
LONRF2 LON peptidase N-terminal domain and ring finger 2 3.01378
GNRHR gonadotropin-releasing hormone receptor 3.01378
MUC20 mucin 20, cell surface associated 3.01378
TBATA thymus, brain and testes associated 3.01378
CD34 CD34 molecule 3.01378
EPCIP exosomal polycystin 1 interacting protein 3.01378
PLAAT4 phospholipase A and acyltransferase 4 3.01378
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 3.01378
ALDOB aldolase B, fructose-bisphosphate 3.01378
UNC93A unc-93 homolog A (C. elegans) 3.01378
ROPN1L rhophilin associated tail protein 1-like 3.01378
VN1R2 vomeronasal 1 receptor 2 3.01378
FFAR1 free fatty acid receptor 1 3.01378
ELOVL3 ELOVL fatty acid elongase 3 3.01378
SRGN serglycin 3.01378
AJM1 apical junction component 1 homolog 3.01378
RNF227 ring finger protein 227 3.01378
LNC-LBCS lncRNA bladder and prostate cancer suppressor, hnRNPK interacting 3.01378
CIMIP3 ciliary microtubule inner protein 3 3.01378
PRRT1B proline rich transmembrane protein 1B 3.01378
NICOL1 NELL2 interacting cell ontogeny regulator 1 3.01378
TMEM238L transmembrane protein 238 like 3.01378
CALHM4 calcium homeostasis modulator family member 4 3.01378
ACP4 acid phosphatase 4 3.01378
GARIN6 golgi associated RAB2 interactor family member 6 3.01378
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.01378
TBC1D3B TBC1 domain family, member 3B 3.01378
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.01378
ADRB1 adrenoceptor beta 1 3.01378
TLR6 toll-like receptor 6 3.01378
MSX2 msh homeobox 2 3.01378
PTPRC protein tyrosine phosphatase, receptor type, C 3.01378
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.01378
OASL 2'-5'-oligoadenylate synthetase-like 3.01378
ACTL10 actin-like 10 3.01378
LIPK lipase, family member K 3.01378
TAS2R31 taste receptor, type 2, member 31 3.01378
SLC22A14 solute carrier family 22, member 14 3.01378
ESR1 estrogen receptor 1 3.01378
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.01378
ASB4 ankyrin repeat and SOCS box containing 4 3.01378
CLEC6A C-type lectin domain family 6, member A 3.01378
MLANA melan-A 3.01378
HNF1B HNF1 homeobox B 3.01378
HCFC2 host cell factor C2 3.01378
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.01378
VCX3A variable charge, X-linked 3A 3.01378
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.01378
CLDN22 claudin 22 3.01378
CFHR3 complement factor H-related 3 3.01378
CLEC2B C-type lectin domain family 2, member B 3.01378
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.01378
BTNL2 butyrophilin-like 2 3.01378
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 3.01378
LCN1 lipocalin 1 3.01378
HPX hemopexin 3.01378
AKNAD1 AKNA domain containing 1 3.01378
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.01378
PAGE4 P antigen family, member 4 (prostate associated) 3.01378
CCDC27 coiled-coil domain containing 27 3.01378
NXNL1 nucleoredoxin-like 1 3.01378
PHLDA1 pleckstrin homology-like domain, family A, member 1 3.01378
ERICH4 glutamate-rich 4 3.01378
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.01378
SH2D4B SH2 domain containing 4B 3.01378
KRT16 keratin 16, type I 3.01378
ESAM endothelial cell adhesion molecule 3.01378
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.01378
PMP2 peripheral myelin protein 2 3.01378
STAB1 stabilin 1 3.01378
APOF apolipoprotein F 3.01378
C2CD4B C2 calcium-dependent domain containing 4B 3.01378
HSF4 heat shock transcription factor 4 3.01378
MYLK2 myosin light chain kinase 2 3.01378
TSPAN19 tetraspanin 19 3.01378
GPR150 G protein-coupled receptor 150 3.01378
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.01378
ESPNL espin-like 3.01378
PLA2G5 phospholipase A2, group V 3.01378
MZB1 marginal zone B and B1 cell-specific protein 3.01378
PHOX2A paired-like homeobox 2a 3.01378
CSF1R colony stimulating factor 1 receptor 3.01378
SLC38A3 solute carrier family 38, member 3 3.01378
NT5C1A 5'-nucleotidase, cytosolic IA 3.01378
C20ORF144 chromosome 20 open reading frame 144 3.01378
IGF1 insulin-like growth factor 1 (somatomedin C) 3.01378
FAM135B family with sequence similarity 135, member B 3.01378
ZNF596 zinc finger protein 596 3.01378
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.01378
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.01378
BSPH1 binder of sperm protein homolog 1 3.01378
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.01378
ART1 ADP-ribosyltransferase 1 3.01378
IL12A interleukin 12A 3.01378
CIB3 calcium and integrin binding family member 3 3.01378
POU3F2 POU class 3 homeobox 2 3.01378
PAGE2B P antigen family, member 2B 3.01378
CARNS1 carnosine synthase 1 3.01378
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.01378
MMP3 matrix metallopeptidase 3 3.01378
ADAM20 ADAM metallopeptidase domain 20 3.01378
DEFB134 defensin, beta 134 3.01378
IFNE interferon, epsilon 3.01378
PRAP1 proline-rich acidic protein 1 3.01378
DUOXA1 dual oxidase maturation factor 1 3.01378
TEX36 testis expressed 36 3.01378
FCAR Fc fragment of IgA receptor 3.01378
ACKR2 atypical chemokine receptor 2 3.01378
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.01378
CALML6 calmodulin-like 6 3.01378
KIF4B kinesin family member 4B 3.01378
ZNF676 zinc finger protein 676 3.01378
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.01378
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.01378
ASCL5 achaete-scute family bHLH transcription factor 5 3.01378
ASCL2 achaete-scute family bHLH transcription factor 2 3.01378
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.01378
GPR179 G protein-coupled receptor 179 3.01378
MTARC1 mitochondrial amidoxime reducing component 1 3.0106
ATG2A autophagy related 2A 3.0089
HPCAL4 hippocalcin like 4 2.95055
MOCS1 molybdenum cofactor synthesis 1 2.90256
HPSE2 heparanase 2 (inactive) 2.84825
SMC6 structural maintenance of chromosomes 6 2.84825
KLF12 Kruppel-like factor 12 2.84058
MTARC2 mitochondrial amidoxime reducing component 2 2.83154
MID1IP1 MID1 interacting protein 1 2.78814
ATXN7L3B ataxin 7-like 3B 2.72681
FCSK fucose kinase 2.72681
SALL3 spalt-like transcription factor 3 2.69974
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.67817
FASTK Fas-activated serine/threonine kinase 2.63105
SMIM26 small integral membrane protein 26 2.60243
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.60098
RBL1 retinoblastoma-like 1 2.60098
CRIP2 cysteine-rich protein 2 2.60098
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.60098
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.57733
RPL13 ribosomal protein L13 2.55468
CCER2 coiled-coil glutamate-rich protein 2 2.47041
FAM131A family with sequence similarity 131, member A 2.47041
RHOT2 ras homolog family member T2 2.46064
OLFML2B olfactomedin-like 2B 2.43365
MT1F metallothionein 1F 2.38432
LIFR leukemia inhibitory factor receptor alpha 2.3799
FCRL5 Fc receptor-like 5 2.37757
ECM1 extracellular matrix protein 1 2.37757
MED7 mediator complex subunit 7 2.36801
PDE10A phosphodiesterase 10A 2.34686
PPIA peptidylprolyl isomerase A (cyclophilin A) 2.32824
EFL1 elongation factor like GTPase 1 2.31863
GPRIN1 G protein regulated inducer of neurite outgrowth 1 2.31634
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.31232
PHF6 PHD finger protein 6 2.31217
ONECUT2 one cut homeobox 2 2.30743
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.26898
HCCS holocytochrome c synthase 2.26898
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 2.22213
SLC9D1 solute carrier family 9 member D1 2.1995
KLHL24 kelch-like family member 24 2.19204
CCDC92B coiled-coil domain containing 92B 2.17856
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 2.17629
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.15243
ZNF598 zinc finger protein 598 2.15076
THSD1 thrombospondin, type I, domain containing 1 2.14272
MTTP microsomal triglyceride transfer protein 2.14272
DCDC2 doublecortin domain containing 2 2.14272
TMEM177 transmembrane protein 177 2.13975
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.13077
NECTIN2 nectin cell adhesion molecule 2 2.11614
ZNF682 zinc finger protein 682 2.11614
XAB2 XPA binding protein 2 2.10603
GLMN glomulin, FKBP associated protein 2.10435
CD1D CD1d molecule 2.10149
CCDC171 coiled-coil domain containing 171 2.09628
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 2.0872
ARMC7 armadillo repeat containing 7 2.08217
UBA1 ubiquitin-like modifier activating enzyme 1 2.05131
ERAP1 endoplasmic reticulum aminopeptidase 1 2.04239
INF2 inverted formin, FH2 and WH2 domain containing 2.03852
ZYX zyxin 2.02454
GANC glucosidase, alpha; neutral C 2.02167
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.0173
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.00735
OTUD7B OTU deubiquitinase 7B 2.00735

decreased expression

Symbol Name Standardized Value
FYTTD1 forty-two-three domain containing 1 -3.01378
UBXN2B UBX domain protein 2B -3.01378
RGPD6 RANBP2-like and GRIP domain containing 6 -3.01378
C16ORF54 chromosome 16 open reading frame 54 -3.01378
ABHD4 abhydrolase domain containing 4 -3.01378
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -3.01378
LHX6 LIM homeobox 6 -3.01378
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -3.01378
CDHR2 cadherin-related family member 2 -3.01378
TMT1B thiol methyltransferase 1B -3.01378
PPP1R13B protein phosphatase 1, regulatory subunit 13B -3.01378
TTC22 tetratricopeptide repeat domain 22 -3.01378
EGFLAM EGF-like, fibronectin type III and laminin G domains -3.01378
FOXI3 forkhead box I3 -3.01378
RAB1A RAB1A, member RAS oncogene family -3.0106
SUSD2 sushi domain containing 2 -2.86061
GJB3 gap junction protein, beta 3, 31kDa -2.86061
C11ORF87 chromosome 11 open reading frame 87 -2.86061
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.86061
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.86061
PDE7B phosphodiesterase 7B -2.86061
CIITA class II, major histocompatibility complex, transactivator -2.86061
NPIPA8 nuclear pore complex interacting protein family, member A8 -2.86061
S100A2 S100 calcium binding protein A2 -2.86061
PRODH proline dehydrogenase (oxidase) 1 -2.86061
LRTM3 leucine rich repeat transmembrane protein 3 -2.86061
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.86061
OTOA otoancorin -2.86061
CLDN16 claudin 16 -2.86061
AANAT aralkylamine N-acetyltransferase -2.86061
CNTN5 contactin 5 -2.86061
FAM240C family with sequence similarity 240 member C -2.86061
FAM131C family with sequence similarity 131, member C -2.86061
TIMD4 T-cell immunoglobulin and mucin domain containing 4 -2.86061
IL1R1 interleukin 1 receptor, type I -2.86061
GLIPR1L2 GLI pathogenesis-related 1 like 2 -2.86061
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.86061
CXCL14 chemokine (C-X-C motif) ligand 14 -2.86061
CLDN5 claudin 5 -2.86061
MISP3 MISP family member 3 -2.86061
STRIT1 small transmembrane regulator of ion transport 1 -2.86061
GSDMA gasdermin A -2.86061
UBOX5 U-box domain containing 5 -2.86061
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -2.86061
A1CF APOBEC1 complementation factor -2.86061
POU5F2 POU domain class 5, transcription factor 2 -2.86061
SLA2 Src-like-adaptor 2 -2.86061
NMBR neuromedin B receptor -2.86061
MED30 mediator complex subunit 30 -2.86061
EXTL1 exostosin-like glycosyltransferase 1 -2.86061
IP6K3 inositol hexakisphosphate kinase 3 -2.86061
MAMLD1 mastermind-like domain containing 1 -2.86061
WNK4 WNK lysine deficient protein kinase 4 -2.86061
MUC19 mucin 19, oligomeric -2.86061
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -2.86061
CD200R1 CD200 receptor 1 -2.86061
SPATA9 spermatogenesis associated 9 -2.86061
ZNF358 zinc finger protein 358 -2.83082
ZNF347 zinc finger protein 347 -2.78405
BLTP2 bridge-like lipid transfer protein family member 2 -2.75435
KIF2A kinesin heavy chain member 2A -2.74768
CDH23 cadherin-related 23 -2.74424
OCA2 oculocutaneous albinism II -2.73549
SLC44A2 solute carrier family 44 (choline transporter), member 2 -2.67362
TEF thyrotrophic embryonic factor -2.66268
PKP3 plakophilin 3 -2.61128
EVI5 ecotropic viral integration site 5 -2.60098
KLHL10 kelch-like family member 10 -2.5706
NRDC nardilysin convertase -2.5706
IL17D interleukin 17D -2.5706
SCARF1 scavenger receptor class F, member 1 -2.50495
GSDME gasdermin E -2.50234
GATD1 glutamine amidotransferase class 1 domain containing 1 -2.45691
ISG20 interferon stimulated exonuclease gene 20kDa -2.45301
CCDC122 coiled-coil domain containing 122 -2.42253
KIAA1143 KIAA1143 -2.39238
USP33 ubiquitin specific peptidase 33 -2.39206
IER3 immediate early response 3 -2.38057
GPR27 G protein-coupled receptor 27 -2.38057
NALF1 NALCN channel auxiliary factor 1 -2.3799
ZNF283 zinc finger protein 283 -2.3799
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -2.37757
NPTX1 neuronal pentraxin I -2.37757
PASK PAS domain containing serine/threonine kinase -2.36975
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.35876
TK1 thymidine kinase 1, soluble -2.32421
APIP APAF1 interacting protein -2.32157
LRRC69 leucine rich repeat containing 69 -2.31806
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.3148
CNTNAP2 contactin associated protein-like 2 -2.3145
BTBD17 BTB (POZ) domain containing 17 -2.3145
SMAD2 SMAD family member 2 -2.3143
MRAP2 melanocortin 2 receptor accessory protein 2 -2.31217
FKTN fukutin -2.30958
LUZP2 leucine zipper protein 2 -2.30743
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.29963
HMBOX1 homeobox containing 1 -2.2657
CENPP centromere protein P -2.26429
STIL SCL/TAL1 interrupting locus -2.25435
DTX3L deltex 3 like, E3 ubiquitin ligase -2.23132
SDF2 stromal cell-derived factor 2 -2.23132
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.22375
BBS12 Bardet-Biedl syndrome 12 -2.19573
VCF2 VCP nuclear cofactor family member 2 -2.16518
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.16335
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.16335
TMED9 transmembrane emp24 protein transport domain containing 9 -2.15796
SFT2D2 SFT2 domain containing 2 -2.15604
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 -2.15243
SLC35D3 solute carrier family 35, member D3 -2.15243
ZNF571 zinc finger protein 571 -2.15243
IDUA iduronidase, alpha-L- -2.15243
CCDC74B coiled-coil domain containing 74B -2.13701
NCOA1 nuclear receptor coactivator 1 -2.13449
RBBP8 retinoblastoma binding protein 8 -2.09628
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.08217
SAMD8 sterile alpha motif domain containing 8 -2.07288
SPATA12 spermatogenesis associated 12 -2.05791
ZBTB20 zinc finger and BTB domain containing 20 -2.05791
PLCL1 phospholipase C-like 1 -2.05791
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.04684
PRPF4 pre-mRNA processing factor 4 -2.04378
ERBIN erbb2 interacting protein -2.0323
PPARA peroxisome proliferator-activated receptor alpha -2.02561