PRDM16 Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description PR domain containing 16|The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 63976)
External Link http://www.ncbi.nlm.nih.gov/gene/63976
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Genes

117 target genes of the PRDM16 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
ACSM1 acyl-CoA synthetase medium-chain family member 1
ADAM12 ADAM metallopeptidase domain 12
ADAMTSL1 ADAMTS-like 1
ADD3 adducin 3 (gamma)
AHDC1 AT hook, DNA binding motif, containing 1
ASB15 ankyrin repeat and SOCS box containing 15
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASXL1 additional sex combs like transcriptional regulator 1
AXDND1 axonemal dynein light chain domain containing 1
BAG1 BCL2-associated athanogene
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C1ORF115 chromosome 1 open reading frame 115
C1RL complement component 1, r subcomponent-like
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCDC148 coiled-coil domain containing 148
CCDC159 coiled-coil domain containing 159
CCDC6 coiled-coil domain containing 6
CCDC91 coiled-coil domain containing 91
CEP78 centrosomal protein 78kDa
CHIT1 chitinase 1 (chitotriosidase)
CHN1 chimerin 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSNK1G1 casein kinase 1, gamma 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CWC22 CWC22 spliceosome-associated protein
CYGB cytoglobin
DAB2IP DAB2 interacting protein
DAZAP2 DAZ associated protein 2
DCDC2 doublecortin domain containing 2
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP6 dipeptidyl-peptidase 6
DYNLRB1 dynein, light chain, roadblock-type 1
EIF3J eukaryotic translation initiation factor 3, subunit J
EPC1 enhancer of polycomb homolog 1 (Drosophila)
FAM109B family with sequence similarity 109, member B
FAM53A family with sequence similarity 53, member A
FAM53B family with sequence similarity 53, member B
FAM73B family with sequence similarity 73, member B
FHIT fragile histidine triad
FKBP15 FK506 binding protein 15, 133kDa
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLB1L galactosidase, beta 1-like
HACD2 3-hydroxyacyl-CoA dehydratase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFT80 intraflagellar transport 80
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGA9 integrin, alpha 9
KDR kinase insert domain receptor
KHK ketohexokinase (fructokinase)
KIF15 kinesin family member 15
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LONRF1 LON peptidase N-terminal domain and ring finger 1
LRRC2 leucine rich repeat containing 2
LRRC7 leucine rich repeat containing 7
LTBP4 latent transforming growth factor beta binding protein 4
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBNL2 muscleblind-like splicing regulator 2
MCM10 minichromosome maintenance complex component 10
MCTP1 multiple C2 domains, transmembrane 1
METTL15 methyltransferase like 15
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCBPAP MYCBP associated protein
NALCN sodium leak channel, non selective
NCL nucleolin
NEK11 NIMA-related kinase 11
NFX1 nuclear transcription factor, X-box binding 1
NPAS2 neuronal PAS domain protein 2
NPAT nuclear protein, ataxia-telangiectasia locus
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OFCC1 orofacial cleft 1 candidate 1
OSBPL1A oxysterol binding protein-like 1A
PCCB propionyl CoA carboxylase, beta polypeptide
PDIA5 protein disulfide isomerase family A, member 5
PGM5 phosphoglucomutase 5
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGR polymeric immunoglobulin receptor
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTAR1 protein prenyltransferase alpha subunit repeat containing 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP3 RAB11 family interacting protein 3 (class II)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
RTEL1 regulator of telomere elongation helicase 1
RYR1 ryanodine receptor 1 (skeletal)
SARNP SAP domain containing ribonucleoprotein
SF3A3 splicing factor 3a, subunit 3, 60kDa
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SLMAP sarcolemma associated protein
SNORD82 small nucleolar RNA, C/D box 82
SORCS1 sortilin-related VPS10 domain containing receptor 1
SPAG6 sperm associated antigen 6
STAMBPL1 STAM binding protein-like 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SYT9 synaptotagmin IX
TENM4 teneurin transmembrane protein 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TPD52L1 tumor protein D52-like 1
TRAPPC9 trafficking protein particle complex 9
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIO trio Rho guanine nucleotide exchange factor
TSC22D1 TSC22 domain family, member 1
TSSK1B testis-specific serine kinase 1B
TXNRD3 thioredoxin reductase 3
UBE2F ubiquitin-conjugating enzyme E2F (putative)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
ZNF423 zinc finger protein 423