PRDM16 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PR domain containing 16|The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 63976)
Similar Terms
Downloads & Tools

Genes

348 genes differentially expressed following the PRDM16 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NPIPA7 nuclear pore complex interacting protein family, member A7 3.22152
PABPC4L poly(A) binding protein, cytoplasmic 4-like 3.22152
CARD6 caspase recruitment domain family, member 6 3.22152
BEAN1 brain expressed, associated with NEDD4, 1 3.22152
VTCN1 V-set domain containing T cell activation inhibitor 1 3.22152
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.22152
CXCL16 chemokine (C-X-C motif) ligand 16 3.22152
RERGL RERG/RAS-like 3.22152
PAX6 paired box 6 3.22152
TLR7 toll-like receptor 7 3.22152
GPR83 G protein-coupled receptor 83 3.22152
C10ORF90 chromosome 10 open reading frame 90 3.22152
HCK HCK proto-oncogene, Src family tyrosine kinase 3.22152
ADGRG3 adhesion G protein-coupled receptor G3 3.22152
ALOX15B arachidonate 15-lipoxygenase, type B 3.22152
TMIE transmembrane inner ear 3.22152
C11ORF96 chromosome 11 open reading frame 96 3.22152
KRT17 keratin 17, type I 3.22152
TSHZ1 teashirt zinc finger homeobox 1 3.22152
LOC124906010 uncharacterized LOC124906010 3.22152
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.22152
CD1D CD1d molecule 3.22152
SHKBP1 SH3KBP1 binding protein 1 3.21879
DNASE1L2 deoxyribonuclease I-like 2 3.18467
IGFL3 IGF-like family member 3 3.18467
PKP1 plakophilin 1 3.18467
TNNI2 troponin I type 2 (skeletal, fast) 3.18467
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.18467
SLC35G5 solute carrier family 35, member G5 3.18467
CELF3 CUGBP, Elav-like family member 3 3.18467
NANOS3 nanos homolog 3 (Drosophila) 3.18467
TSGA13 testis specific, 13 3.18467
HES7 hes family bHLH transcription factor 7 3.18467
TGIF2LX TGFB-induced factor homeobox 2-like, X-linked 3.18467
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.18467
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.18467
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.18467
TAS2R19 taste receptor, type 2, member 19 3.18467
TP53TG5 TP53 target 5 3.18467
KLLN killin, p53-regulated DNA replication inhibitor 3.18467
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.18467
PRR29 proline rich 29 3.18467
EVPL envoplakin 3.18467
NLRP3 NLR family, pyrin domain containing 3 3.18467
S100A2 S100 calcium binding protein A2 3.18467
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.18467
GJB3 gap junction protein, beta 3, 31kDa 3.18467
C12ORF71 chromosome 12 open reading frame 71 3.18467
FFAR4 free fatty acid receptor 4 3.18467
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.18467
KCNRG potassium channel regulator 3.18467
CA6 carbonic anhydrase VI 3.18467
OTUD6A OTU deubiquitinase 6A 3.18467
FAM221B family with sequence similarity 221, member B 3.18467
TMEM132C transmembrane protein 132C 3.18467
SMOC1 SPARC related modular calcium binding 1 3.18467
SMIM32 small integral membrane protein 32 3.18467
PROP1 PROP paired-like homeobox 1 3.18467
BEND2 BEN domain containing 2 3.18467
ADGRG7 adhesion G protein-coupled receptor G7 3.18467
TMPRSS6 transmembrane protease, serine 6 3.18467
TMEM40 transmembrane protein 40 3.18467
C10ORF53 chromosome 10 open reading frame 53 3.18467
LY6H lymphocyte antigen 6 complex, locus H 3.18467
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 3.18467
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.18467
GBP6 guanylate binding protein family, member 6 3.18467
ARX aristaless related homeobox 3.18467
FAM240A family with sequence similarity 240 member A 3.18467
CIMAP1B ciliary microtubule associated protein 1B 3.18467
H4C12 H4 clustered histone 12 3.18467
RHEX regulator of hemoglobinization and erythroid cell expansion 3.18467
STPG3 sperm-tail PG-rich repeat containing 3 3.18467
CFAP119 cilia and flagella associated protein 119 3.18467
TBXT T-box transcription factor T 3.18467
PLAAT2 phospholipase A and acyltransferase 2 3.18467
CCN3 cellular communication network factor 3 3.18467
OSTN osteocrin 3.18467
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.18467
NDP Norrie disease (pseudoglioma) 3.18467
SPMAP1 sperm microtubule associated protein 1 3.18467
TSGA10IP testis specific, 10 interacting protein 3.18467
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.18467
ITK IL2-inducible T-cell kinase 3.18467
CLDN9 claudin 9 3.18467
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.18467
DNAI2 dynein, axonemal, intermediate chain 2 3.18467
FPR2 formyl peptide receptor 2 3.18467
FPR1 formyl peptide receptor 1 3.18467
UROC1 urocanate hydratase 1 3.18467
NPIPB9 nuclear pore complex interacting protein family, member B9 3.18467
HNF1B HNF1 homeobox B 3.18467
GDF7 growth differentiation factor 7 3.18467
CLDN22 claudin 22 3.18467
NPFF neuropeptide FF-amide peptide precursor 3.18467
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.18467
TBX3 T-box 3 3.18467
IL5 interleukin 5 3.18467
IL6 interleukin 6 3.18467
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.18467
PDILT protein disulfide isomerase-like, testis expressed 3.18467
PALMD palmdelphin 3.18467
CETP cholesteryl ester transfer protein, plasma 3.18467
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.18467
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.18467
PCDHGA4 protocadherin gamma subfamily A, 4 3.18467
SYTL3 synaptotagmin-like 3 3.18467
TEX35 testis expressed 35 3.18467
SHISA8 shisa family member 8 3.18467
EVPLL envoplakin-like 3.18467
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.18467
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.18467
VWA7 von Willebrand factor A domain containing 7 3.18467
IL1A interleukin 1, alpha 3.18467
POU5F1 POU class 5 homeobox 1 3.18467
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.18467
PKDREJ polycystin (PKD) family receptor for egg jelly 3.18467
GAL3ST2 galactose-3-O-sulfotransferase 2 3.18467
GFI1B growth factor independent 1B transcription repressor 3.18467
LCNL1 lipocalin-like 1 3.18467
CST9 cystatin 9 (testatin) 3.18467
ZMYND15 zinc finger, MYND-type containing 15 3.18467
CD177 CD177 molecule 3.18467
HHATL hedgehog acyltransferase-like 3.18467
ADAMDEC1 ADAM-like, decysin 1 3.18467
ERICH6B glutamate-rich 6B 3.18467
CSTA cystatin A (stefin A) 3.18467
LPAR5 lysophosphatidic acid receptor 5 3.18467
TDRD10 tudor domain containing 10 3.18467
GCM1 glial cells missing homolog 1 (Drosophila) 3.18467
PCDH12 protocadherin 12 3.18467
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.18467
SLC38A3 solute carrier family 38, member 3 3.18467
CD226 CD226 molecule 3.18467
LHX9 LIM homeobox 9 3.18467
LHX2 LIM homeobox 2 3.18467
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.18467
CLEC4A C-type lectin domain family 4, member A 3.18467
CD28 CD28 molecule 3.18467
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.18467
SNAI2 snail family zinc finger 2 3.18467
MOBP myelin-associated oligodendrocyte basic protein 3.18467
CYSRT1 cysteine-rich tail protein 1 3.18467
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.18467
SIDT1 SID1 transmembrane family, member 1 3.18467
NLRP5 NLR family, pyrin domain containing 5 3.18467
TGM5 transglutaminase 5 3.18467
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.18467
KLK14 kallikrein-related peptidase 14 3.18467
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.18467
IGF2 insulin-like growth factor 2 3.18467
SPATA9 spermatogenesis associated 9 3.18467
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.18467
ZC3H12D zinc finger CCCH-type containing 12D 3.18467
RNASE6 ribonuclease, RNase A family, k6 3.18467
SMIM17 small integral membrane protein 17 3.18467
PRSS33 protease, serine, 33 3.18467
RAB7B RAB7B, member RAS oncogene family 3.18467
SYT14 synaptotagmin XIV 3.17298
FOLR1 folate receptor 1 (adult) 3.06486
CCDC163 CCDC163 homolog 3.06486
ENKD1 enkurin domain containing 1 3.03614
CCN1 cellular communication network factor 1 3.02519
SMIM36 small integral membrane protein 36 3.01426
COX6C cytochrome c oxidase subunit VIc 2.91895
TRUB2 TruB pseudouridine (psi) synthase family member 2 2.91895
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.88132
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.87613
THAP7 THAP domain containing 7 2.80916
ZC2HC1A zinc finger, C2HC-type containing 1A 2.76806
ORAI1 ORAI calcium release-activated calcium modulator 1 2.6392
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.61899
NAPRT nicotinate phosphoribosyltransferase 2.51324
RIOK2 RIO kinase 2 2.45644
TMEM191C transmembrane protein 191C 2.42463
PGA5 pepsinogen 5, group I (pepsinogen A) 2.42463
IFT22 intraflagellar transport 22 2.42171
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2.39307
PCSK6 proprotein convertase subtilisin/kexin type 6 2.38872
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.38872
ATOH7 atonal homolog 7 (Drosophila) 2.38872
POLR1F RNA polymerase I subunit F 2.38872
TGDS TDP-glucose 4,6-dehydratase 2.38872
LKAAEAR1 LKAAEAR motif containing 1 2.38872
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.38872
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.38788
CDON cell adhesion associated, oncogene regulated 2.37019
TSLP thymic stromal lymphopoietin 2.35992
BHLHE40 basic helix-loop-helix family, member e40 2.35992
PLXNA3 plexin A3 2.3523
ZNF106 zinc finger protein 106 2.34694
SUSD2 sushi domain containing 2 2.32124
AMDHD1 amidohydrolase domain containing 1 2.32124
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.30762
CDPF1 cysteine-rich, DPF motif domain containing 1 2.30486
NPHP4 nephronophthisis 4 2.30486
ZNF30 zinc finger protein 30 2.28218
SMC6 structural maintenance of chromosomes 6 2.27823
RWDD2A RWD domain containing 2A 2.24871
KXD1 KxDL motif containing 1 2.24871
JPT1 Jupiter microtubule associated homolog 1 2.2414
MYOZ3 myozenin 3 2.21769
RABL3 RAB, member of RAS oncogene family-like 3 2.21769
PIGBOS1 PIGB opposite strand 1 2.21664
STX3 syntaxin 3 2.20233
NCK2 NCK adaptor protein 2 2.16931
HIPK3 homeodomain interacting protein kinase 3 2.16885
TMEM74 transmembrane protein 74 2.14695
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 2.14138
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.13921
CDC123 cell division cycle 123 2.13582
SPN sialophorin 2.13582
LRRC36 leucine rich repeat containing 36 2.13582
MUC16 mucin 16, cell surface associated 2.13582
NELL1 NEL-like 1 (chicken) 2.13582
C1ORF202 chromosome 1 open reading frame 202 2.13582
PCDHGC3 protocadherin gamma subfamily C, 3 2.13582
C9ORF43 chromosome 9 open reading frame 43 2.13582
DSC2 desmocollin 2 2.13582
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.13582
RGS6 regulator of G-protein signaling 6 2.13401
TMEM250 transmembrane protein 250 2.13401
SLC25A48 solute carrier family 25, member 48 2.1283
NKIRAS1 NFKB inhibitor interacting Ras-like 1 2.10078
SCGB3A2 secretoglobin, family 3A, member 2 2.10016
HOOK2 hook microtubule-tethering protein 2 2.09987
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.09006
FOXRED1 FAD-dependent oxidoreductase domain containing 1 2.08295
KLF10 Kruppel-like factor 10 2.07928
WASHC5 WASH complex subunit 5 2.07928
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 2.07861
TMEM37 transmembrane protein 37 2.06656
NMT1 N-myristoyltransferase 1 2.03715
KEAP1 kelch-like ECH-associated protein 1 2.0359
KLHL3 kelch-like family member 3 2.02597
PRLR prolactin receptor 2.02597
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2.01346

decreased expression

Symbol Name Standardized Value
RASGRP4 RAS guanyl releasing protein 4 -3.22152
ADORA1 adenosine A1 receptor -3.22152
ZNF763 zinc finger protein 763 -3.22152
ZNF230 zinc finger protein 230 -3.22152
DCST2 DC-STAMP domain containing 2 -3.21879
TTLL10 tubulin tyrosine ligase-like family member 10 -3.21879
ZNF528 zinc finger protein 528 -3.19732
ERAS ES cell expressed Ras -3.18467
WSCD2 WSC domain containing 2 -3.18467
SRRM5 serine/arginine repetitive matrix 5 -3.18467
PIWIL3 piwi-like RNA-mediated gene silencing 3 -3.18467
S100A14 S100 calcium binding protein A14 -3.18467
BTNL8 butyrophilin-like 8 -3.18467
LOC105378220 macrophage receptor MARCO-like -3.18467
NDRG1 N-myc downstream regulated 1 -3.18467
BTLA B and T lymphocyte associated -3.18467
LGALS4 lectin, galactoside-binding, soluble, 4 -3.18467
TTLL9 tubulin tyrosine ligase-like family member 9 -3.18467
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.18467
MMP10 matrix metallopeptidase 10 -3.18467
SDSL serine dehydratase-like -3.18467
VRK3 vaccinia related kinase 3 -3.18467
FCRL5 Fc receptor-like 5 -3.18467
GYPE glycophorin E (MNS blood group) -3.18467
UTS2 urotensin 2 -3.18467
RTBDN retbindin -3.18467
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -3.18467
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.18467
LY96 lymphocyte antigen 96 -3.18467
SMIM41 small integral membrane protein 41 -3.18467
PCDHA13 protocadherin alpha 13 -3.18467
GCNA germ cell nuclear acidic peptidase -3.18467
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -3.18467
BAHCC1 BAH domain and coiled-coil containing 1 -3.18467
CSAG3 CSAG family, member 3 -3.18467
ALX1 ALX homeobox 1 -3.18467
F2RL2 coagulation factor II (thrombin) receptor-like 2 -3.18467
ESPNL espin-like -3.18467
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.18467
DRC1 dynein regulatory complex subunit 1 -3.18467
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -3.18467
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.18467
ESYT1 extended synaptotagmin-like protein 1 -3.08432
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -3.06542
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -3.06542
ZNF454 zinc finger protein 454 -3.06266
ATF2 activating transcription factor 2 -2.94656
SCAI suppressor of cancer cell invasion -2.91322
TIGD7 tigger transposable element derived 7 -2.69063
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.66939
ZEB1 zinc finger E-box binding homeobox 1 -2.66939
CYBC1 cytochrome b-245 chaperone 1 -2.63909
JMJD1C jumonji domain containing 1C -2.63344
TM7SF3 transmembrane 7 superfamily member 3 -2.59471
DVL2 dishevelled segment polarity protein 2 -2.50361
KAT14 lysine acetyltransferase 14 -2.50215
HIPK1 homeodomain interacting protein kinase 1 -2.47138
FBXO9 F-box protein 9 -2.47138
SYTL2 synaptotagmin-like 2 -2.44651
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.44378
ELMOD1 ELMO/CED-12 domain containing 1 -2.44378
INHBE inhibin, beta E -2.44313
ARF3 ADP-ribosylation factor 3 -2.43248
FXR2 fragile X mental retardation, autosomal homolog 2 -2.43248
PRMT5 protein arginine methyltransferase 5 -2.42383
CD36 CD36 molecule (thrombospondin receptor) -2.39916
RTP1 receptor (chemosensory) transporter protein 1 -2.39916
NBDY negative regulator of P-body association -2.39543
GMPPA GDP-mannose pyrophosphorylase A -2.38872
HSPG2 heparan sulfate proteoglycan 2 -2.33556
TMEM121B transmembrane protein 121B -2.32025
KCNIP3 Kv channel interacting protein 3, calsenilin -2.31524
JPH2 junctophilin 2 -2.31524
PRMT3 protein arginine methyltransferase 3 -2.28452
GPR87 G protein-coupled receptor 87 -2.28218
ANKRD23 ankyrin repeat domain 23 -2.28218
PCDHB16 protocadherin beta 16 -2.28218
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.28218
SERTAD4 SERTA domain containing 4 -2.28218
COPS6 COP9 signalosome subunit 6 -2.28218
CIMAP3 ciliary microtubule associated protein 3 -2.28145
WNK3 WNK lysine deficient protein kinase 3 -2.28145
ARRDC3 arrestin domain containing 3 -2.28145
ZNF135 zinc finger protein 135 -2.27823
ELOVL7 ELOVL fatty acid elongase 7 -2.25811
BLVRB biliverdin reductase B -2.23301
PARPBP PARP1 binding protein -2.23114
HSPA12A heat shock 70kDa protein 12A -2.22882
CCDC134 coiled-coil domain containing 134 -2.22195
TBL2 transducin (beta)-like 2 -2.2115
GFM2 G elongation factor, mitochondrial 2 -2.20233
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.20233
GID8 GID complex subunit 8 -2.16885
KCTD13 potassium channel tetramerization domain containing 13 -2.16885
FABP3 fatty acid binding protein 3, muscle and heart -2.16885
LCN2 lipocalin 2 -2.14946
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.14443
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.14443
SCARF1 scavenger receptor class F, member 1 -2.14443
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -2.13582
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.1283
ZNF730 zinc finger protein 730 -2.09947
LPAR4 lysophosphatidic acid receptor 4 -2.09947
TMEM184B transmembrane protein 184B -2.09179
UNC79 unc-79 homolog (C. elegans) -2.07936
GLIPR1L1 GLI pathogenesis-related 1 like 1 -2.07861
TMEM259 transmembrane protein 259 -2.05898
FOS FBJ murine osteosarcoma viral oncogene homolog -2.05898
CIC capicua transcriptional repressor -2.02597
H2AC6 H2A clustered histone 6 -2.02543
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -2.00077