PRDM16 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description PR domain containing 16|The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 63976)
External Link http://www.ncbi.nlm.nih.gov/gene/63976
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Genes

79 interacting proteins for PRDM16 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CLOCK clock circadian regulator
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ESRRA estrogen-related receptor alpha
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
INADL InaD-like (Drosophila)
INO80E INO80 complex subunit E
MBD2 methyl-CpG binding domain protein 2
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTA3 metastasis associated 1 family, member 3
NAV3 neuron navigator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PKNOX1 PBX/knotted 1 homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
RAD50 RAD50 homolog (S. cerevisiae)
RAN RAN, member RAS oncogene family
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SIN3B SIN3 transcription regulator family member B
SKI SKI proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOGA3 SOGA family member 3
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THYN1 thymocyte nuclear protein 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TTF2 transcription termination factor, RNA polymerase II
UBC ubiquitin C
UBP1 upstream binding protein 1 (LBP-1a)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USF2 upstream transcription factor 2, c-fos interacting
VRK1 vaccinia related kinase 1
WIZ widely interspaced zinc finger motifs
YEATS2 YEATS domain containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZZZ3 zinc finger, ZZ-type containing 3